Nadine Hamieh

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French Institute of Health and Medical Research | Inserm · CERPOP

Background: Racial disparities in prostate cancer incidence and mortality rates are considerable. We previously found in the Health Professionals Follow-up Study (HPFS) that African American men had an 80% higher prostate cancer risk than white men. With 21 additional years of follow-up and four-fold increase in cases, we undertook a contemporary...

Background: Depression is an important risk factor of cardiovascular disease (CVD), a leading cause of death worldwide. One of the reasons underlying this association may be that depression modifies the association between treatable cardiovascular risk factors and cardiac events (angina pectoris or myocardial infarction). We tested this hypothesis...

Aims Depression is associated with increased risk of cardiovascular disease (CVD) and the role of poor medical adherence is mostly unknown. We studied the association between depressive symptoms and non-adherence to medications targeting treatable cardiovascular risk factors in the CONSTANCES population-based French cohort. Methods and results We...

Background: Psychological factors such as hostility and depression have been associated with cardiovascular disease. However, their role in predicting incident cardiac events independently one of another is not clear. Methods: Among 10,304 GAZEL middle-aged workers free of cardiovascular diseases in 1993, 581 incident cardiac events were validat...

Background: Leveraging machine learning on electronic health records offers a promising method for early identification of individuals at risk for dementia and neurodegenerative diseases. Current risk algorithms heavily rely on age, highlighting the need for alternative models with strong predictive power, especially at age 65, a crucial time for e...

Background We examined prospective associations between atypical working hours, substance use and sugar and fat consumption. Methods In the French population-based CONSTANCES cohort, 47,288 men and 53,324 women currently employed included between 2012 and 2017 were annually followed for tobacco and cannabis use; among them, 35,647 men and 39,767 w...

Background This study examined prospective associations between atypical working hours with subsequent tobacco, cannabis and alcohol use as well as sugar and fat consumption. Methods In the French population-based CONSTANCES cohort, 47,288 men and 53,324 women currently employed included between 2012 and 2017 were annually followed for tobacco and...

Introduction Difficult working conditions could be associated with addictive behaviors. Objectives To examine the prospective associations between atypical working hours and substance use, including sugar and fat consumption. Methods In the CONSTANCES cohort, a total of 47,288 men and 53,324 women currently employed were included from 2012-2017 f...

Objective To compare the association between previous local treatment modalities and the progression to castrate-resistant prostate cancer (CRCP) and overall survival (OS) in men with newly diagnosed metastatic prostate cancer. Methods We conducted a retrospective analysis using a nationwide, de-identified electronic health record (EHR)-derived da...

We examined the prospective association of physical exertion at work with subsequent tobacco, cannabis, alcohol use, and sugar and fat consumption. Volunteers of the French population-based CONSTANCES cohort currently employed were included from 2012 to 2017 for tobacco and cannabis outcomes (n = 100,612), and from 2012 to 2016 for alcohol and suga...

Background This study examined the prospective association of physical exertion at work with risk of tobacco, cannabis, alcohol use and sugar and fat consumption. Methods Volunteers of the French population-based CONSTANCES cohort currently employed were included from 2012 to 2017 for tobacco and cannabis outcomes (n = 100,612), and from 2012 to 2...

We examined the prospective association of physical exertion at work with subsequent tobacco, cannabis, alcohol use, and sugar and fat consumption. Volunteers of the French population-based CONSTANCES cohort currently employed were included from 2012–2017 for tobacco and cannabis outcomes (n = 100,612), and from 2012–2016 for alcohol and sugar and...

Introduction: The purpose is to evaluate the prognostic significance of lung parenchymal density during percutaneous coaxial cutting needle lung biopsy (PNLB). Materials and methods: Retrospective analysis of 179 consecutive patients (106 males, 73 females; mean age 59.16 ± 16.34 years) undergoing PNLB was included. Mean lobar parenchymal lung d...

Depression is associated with increased risk of cardiovascular disease, but the mechanisms remain mostly unknown and may involve hostility or poor medical adherence. The objectives were: to examine whether hostile traits explain the prospective association between depressive symptoms and incident cardiac events; to examine whether depressive sympto...

Dementia is a leading cause of dependency and disability among older adults. Minimal knowledge, poor attitudes and negative perceptions are barriers of dementia early screening, diagnosis and treatment. This is the first study that assesses knowledge, attitudes and perceptions of dementia among a Middle Eastern population. Two hundred and fifty-fou...

Purpose: This hybrid retrospective and prospective study performed on 200 consecu¬tive patients undergoing renal CTA, investigates the opacification of renal vasculature, radiation dose, and reader confidence. Materials and methods: 100 patients were assigned retrospectively to protocol A and the other 100 were allocated prospectively to protoco...

Objective To test whether depression modifies the association between treatable cardiovascular risk factors and incident cardiac events (angina pectoris or myocardial infarction) in a population-based cohort of middle-aged workers. Method 10,541 Gazel working men and women free of cardiovascular disease at baseline (1993) were followed-up over 20 y...

Background Despite pain awareness and the development of treatment guidelines, cancer-related pain assessment and management remain suboptimal. Our objectives were to estimate the prevalence and severity of pain and its interference with daily activities, and evaluate adequacy of treatment in cancer patients in Lebanon. Methods A total of 400 canc...

Purpose: The aim of this article was to investigate the opacification of the renal vasculature and the urogenital system during computed tomography urography by using a quadruple-phase contrast media in a triphasic scan protocol. Materials and methods: A total of 200 patients with possible urinary tract abnormalities were equally divided between...

Objective: To evaluate the performance of non-contrast computed tomography (CT) by reporting the difference in attenuation between normal and inflamed renal parenchyma in patients clinically diagnosed with acute pyelonephritis (APN). Material and methods: This is a retrospective study concerned with non-contrast CT evaluation of 74 patients, adm...

Background Our objective was to estimate the overall risk of developing second primary malignancy (SPM) among Middle Eastern men with prostate cancer who underwent surgical extirpation of their prostate. Materials and methods We conducted a retrospective study of 406 patients who underwent radical prostatectomy in a tertiary centre and who had no...

Background: Randomized trials of supplemental folate and observational studies of circulating folate support a positive association with prostate cancer risk. However, epidemiological studies of dietary and synthetic folate intake are conflicting. Given mandatory folic acid fortification of grains in the US beginning in 1998, evaluation of long-ter...

s: Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; September 25-28, 2016; Fort Lauderdale, FL Introduction : There are considerable differences in prostate cancer rates among white, black and Asian men, yet the underlying reasons for these differences are unknown. Our obj...