Nadiah SulaimanUniversiti Kebangsaan Malaysia | ukm · Centre for Tissue Engineering and Regenerative Medicine (CTERM)
Nadiah Sulaiman
Doctor of Philosophy (Translational Health Science)
About
27
Publications
2,935
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109
Citations
Citations since 2017
Additional affiliations
January 2015 - present
February 2008 - April 2014
January 2007 - January 2008
Education
October 2014 - November 2019
September 2009 - September 2012
September 2003 - September 2006
Publications
Publications (27)
Pharmacologists have been emphasizing and applying plant and herbal-based treatments in vascular diseases for decades now. Olives, for example, are a traditional symbol of the Mediterranean diet. Hydroxytyrosol is an olive-derived compound known for its antioxidant and cardioprotective effects. Acknowledging the merit of antioxidants in maintaining...
Xeno-free three-dimensional cultures are gaining attention for mesenchymal stem cell (MSCs) expansion in clinical applications. We investigated the potential of xeno-free serum alternatives, human serum and human platelet lysate, to replace the current conventional use of foetal bovine serum for subsequent MSCs microcarrier cultures. In this study,...
Endometriosis occurs when endometrial-like tissue forms and grows outside the uterus due to oestrogen-induced epithelial-mesenchymal transition in the female reproductive tract. Factors that suppress this event could become potential therapeutic agents against disease occurrence and progression. However, an overview of these studies is still lackin...
As one of the most severe forms of muscle dystrophy, Duchenne muscular dystrophy (DMD) results in progressive muscle wasting, ultimately resulting in premature death due to cardiomyopathy. In the many years of research, the solution to DMD remains palliative. Although numerous studies including clinical trials have provided promising results, appro...
Globally, millions of patients are affected by myocardial infarction or lower limb gangrene/amputation due to atherosclerosis. Available surgical treatment based on vein and synthetic grafts provides sub-optimal benefits. We engineered a highly flexible and mechanically robust nanotextile-based vascular graft (NanoGraft) by interweaving nanofibrous...
Cardiac patch implantation helps maximize the paracrine function of grafted cells and serves as a reservoir of soluble proangiogenic factors required for the neovascularization of infarcted hearts. We have previously fabricated a cardiac patch, EF-HAM, composed of a human amniotic membrane (HAM) coated with aligned PLGA electrospun fibers (EF). In...
The recent advances of nanotechnologies in terms of manufacturing as well as high market demands over nanoscale frameworks have affected various fields includes tissue engineering and regenerative medicine. Tissue engineering and regenerative medicine field involve creating, repairing, or replacing the cells, tissues, and organs using the combinati...
Background
In the area of oral and maxillofacial surgery, regenerative endodontics aims to present alternative options to conventional treatment strategies. With continuous advances in regenerative medicine, the source of cells used for pulp tissue regeneration is not only limited to mesenchymal stem cells as the non-mesenchymal stem cells have sho...
Background: Pax 7 is one of the key factors in the development of tissues and organs during embryogenesis. It has been suggested that Pax7 may play a major role during myogenesis. Our previous study has shown that Pax7 cell is attenuated in the mdx embryo during gestation as well as in dystrophic muscle indicating that an absence of dystrophin in m...
Stem cells can be differentiated into cardiomyocytes by induction with 5-azacytidine (5-aza) but its carcinogenicity is of concern for future translational application. Alternatively, growth factors and hormones such as basic fibroblast growth factor (bFGF) and hydrocortisone have been reported to act as a therapeutic inducer for cardiomyocytes dif...
Developments in tissue engineering techniques have allowed for the creation of biocompatible, non-immunogenic alternative vascular grafts through the decellularization of existing tissues. With an ever-growing number of patients requiring life-saving vascular bypass grafting surgeries, the production of functional small diameter decellularized vasc...
Objective: Hydroxytyrosol (HT), a polyphenol of olive plant is well known for its antioxidant, anti-inflammatory and anti-atherogenic properties. The aim of this systematic search is to highlight the scientific evidence evaluating molecular efficiency of HT in halting the progression of intimal hyperplasia (IH), which is a clinical condition arises...
Human saphenous vein (hSV) and synthetic grafts are commonly used conduits in vascular grafting, despite high failure rates. Decellularising hSVs (D-hSVs) to produce vascular scaffolds might be an effective alternative. We assessed the effectiveness of a detergent-based method using 0% to 1% sodium dodecyl sulphate (SDS) to decellularise hSV. Decel...
Abstract Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pose a limitation for scale-up. The purpose of this review was to systematically assess the application of microcarriers in Mesenchymal...
Anti-atherogenic therapy is crucial in halting the progression of inflammation-induced intimal hyperplasia. The aim of this concise review was to methodically assess the recent findings of the different approaches, mainly on the recruitment of chemokines and/or cytokine and its effects in combating the intimal hyperplasia caused by various risk fac...
Cardiovascular disease is a major public health burden worldwide. Myocardial infarction is the most common form of cardiovascular disease resulting from low blood supply to the heart. It can lead to further complications such as cardiac arrhythmia, toxic metabolite accumulation, and permanently infarcted areas. Honey is one of the most prized medic...
Cell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were used where searched and related studies were selec...
Mesenchymal stem cells (MSCs) reside in the stromal region of various organs that can be triggered to home-in to injured tissues and differentiate into a specific cell type to replace the damaged ones. Many tissues undergo oxygen deprivation during trauma due to the disruption of the existing vascular network that promotes reparative functions invo...
Poster presentation for the BAS/BSCR Basic Science track at BCS 2019. Abstract published here: https://heart.bmj.com/content/105/Suppl_6/A157.1
Introduction
Coronary artery bypass grafting (CABG) primarily uses autologous human saphenous vein (hSV), despite autologous arteries having better patency rates. However, a lack of arteries, and presence of disease in those which are available, has led to the need to develop alternative tissue engineered conduits. Here we aim to arterialise a vein...
Introduction: Autologous saphenous vein (SV) graft failure following coronary artery bypass grafting, occurs in 10-20% of patients within the first year, and ~50% remain patent after 10 years. Tissue engineering strategies have the potential to improve graft patency. We propose that seeding decellularised SV with blood outgrowth cells (BOCs) may yi...
Graft failure and loss of patency following CABG, using autologous saphenous veins (SV), occurs in 10-20% of patients within the first year, with only 50% remaining patent after 10 years. Bypass grafting using autologous arteries results in improved patency; >95% patent after 15-20 years. There is a need to develop bioengineering strategies to impr...
Projects
Projects (4)
Young women with vaginal agenesis (no vagina) usually present with primary amenorrhoea (no menses). However, those with functioning uterus but no vagina, will experience cyclical abdominal pain due to accumulation of blood in the uterus (haematometra) hence require laparoscopic drainage for symptomatic relief. Mainstay of treatment will be a two-steps procedure: creation of vagina (neovagina) and later anastomosis of uterus with the newly created vagina. This allows menstrual outflow and coital function. Several techniques had been described for neovagina using different material such as peritoneum, amnion, buccal mucosa, allogenic epidermal sheets and Interceed to line the vaginal canal. Recently, autologous vaginal mucosa had been shown to have promising result. Hence, we aim to elucidate the correlation between estrogen and Wnt4 signalling in vagina epithelial cells (VECs).
To date, there is no known cure for DMD. The paired box 7 (Pax7) gene that is integral to satellite cells specification and cell-renewal was, however, found to be impaired in DMD patients. This is also concurrent with the mechanistic target of Rapamycin complex 2 (mTORC2), which was found to be inactivated in mdx mouse. Hence, in hopes of discovering novel treatment approaches, there is a need to elucidate the relationship between Pax7 expression and mTORC2 signaling in DMD.
The objective of the study is to elucidate the role of MCP1/VCAM during re-endothelialisation of circulating progenitor cells in the intimal hyperplasia ex-vivo model.
