Nadia Zamora Gonzalez

• MD student at Universitätsklinikum Carl Gustav Carus Dresden

Small interfering RNAs (siRNAs) are widely used in biomedical research and in clinical trials. Here, we demonstrate that siRNA treatment is commonly associated with significant sensitization to ferroptosis, independently of the target protein knockdown. Genetically targeting mitochondrial antiviral-signaling protein (MAVS) reversed the siRNA-mediat...

Diabetic nephropathy is the most common condition that requires a chronic renal replacement therapy, such as haemodialysis, peritoneal dialysis, kidney transplantation or simultaneous kidney-pancreas transplantation. Chronic kidney disease progression, that is the loss of nephrons which causes the continuous decline of the eGFR, underlies the patho...

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, and stroke, all of which are triggered by glutathion...

Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement of necroptosis is well characterized, genetic evidence supporting the contribution of ferroptosis is lacking. Here, we demonstrate that...