Nadia Alrawaiq

Sebha University · Department of Pharmacology

Certain dietary chemicals influenced the expression of chemopreventive genes through the Nrf2-Keap1 pathway. However, the difference in Nrf2 activation potency of these chemicals is not well studied. This study is aimed at determining the difference in the potency of liver Nrf2 nuclear translocation induced by the administration of equal doses of s...

Background and Objective: Superoxide Dismutase (SOD) is responsible for thedismutationof superoxide radicals and protect cells from toxic impairment due to excessive oxygen exposure. Overexpression of the superoxide dismutase 3 isoenzyme (SOD3) had been suggested to prevent cancer growth. Tocotrienols are the more potent members of the vitamin E fa...

Novel quinazoline derivatives were synthesized via the reaction of unsaturated carbonyl compound subsidiaries with 3-aminotriazole. These compounds are convenient and important intermediates for the synthesis of a range of useful and novel heterocyclic compounds. The structures of these compounds were characterized using elemental analysis and IR,...

Cancer remains a worrying cause of fatality worldwide despite the advancement in medicine. Among the dietary phytonutrients, tocotrienols have been extensively studied for their bioactivity against cancer. Palm oil is a rich source of tocotrienols. The most common formulation of tocotrienols is the tocotrienol-rich fraction of palm oil (TRF). The a...

Background: The most common preparation of tocotrienols is the tocotrienol-rich fraction (TRF). This study aimed to investigate whether TRF induced liver Nrf2 nuclear translocation and influenced the expression of Nrf2-regulated genes. Methods: In the Nrf2 induction study, mice were divided into control, 2000 mg/kg TRF and diethyl maleate treate...

Objective: Dietary chemicals, which are generally found in vegetables, fruits and spices, have been reported to protect against cancer based on their ability to activate endogenous defenses by inducing the expression of phase II detoxification and antioxidant enzymes such as NAD(P)H:quinone Oxidoreductase 1 (NQO1) and Heme Oxygenase-1 (HO-1). The o...

Background: Dietary chemicals, which are generally found in vegetables, fruits and spices, have been reported to protect against cancer based on their ability to activate endogenous defenses by inducing the expression of phase II detoxification and antioxidant enzymes such as NAD(P)H:quinone Oxidoreductase 1 (NQO1) and Heme Oxygenase-1 (HO-1). The...

The most common preparation of tocotrienols is the tocotrienol-rich fraction (TRF). Previous studies had indicated that tocotrienols administration increased the activities of cytoprotective enzymes. No in vivo studies have been performed to observe the effect of tocotrienols on Nrf2 activation in mice liver. The objective of this study was to i...

Objective: Heme oxygenase-1 (HO-1) is enzyme that possesses antioxidant, anti-inflammatory, and cytoprotective functions. Induction of HO-1 occurs as an adaptive and beneficial response to various injurious stimuli such as oxidative stress. This study is aimed at monitoring the effects of administration of equal doses (50 mg/kg) of sulforaphane (SF...

Background. Heme oxygenase-1 (HO-1) is an enzyme that possesses anti-oxidant, anti-inflammatory and cytoprotective functions. lnduction of HO-1 occurs as an adaptive and beneficial response to various injurious stimuli such as oxidative stress. This study is aimed at monitoring the effects of equal doses (50 mg/kg) of sulforaphane, curcumin, querce...

Glutathione S-transferase isoenzymes (GSTs) catalyze the conjugation reaction between glutathione and electrophilic compounds. GSTs are involved in the detoxification of toxic and carcinogenic compounds, thus protecting the body from toxic injuries. Tocotrienols are part of the vitamin E family and is believed to possess potent antioxidant activity...

Potency Of Several Dietary Chemicals In Inducing Heme Oxygenase-1 Expression In Mice Liver. - Regional Conference On Non-Communicable Diseases 2018 (RCNCD 2018)

Heme Oxygenase-1 (HO-1) is an enzyme that possess anti-oxidant, anti-inflammatory and cytoprotective functions. Induction of HO-1 occurs as an adaptive and beneficial response to various injurious stimuli such as oxidative stress. This study aimed at monitoring the effects of administration of equal doses (50 mg/kg) of sulforaphane, curcumin and qu...

The antioxidant activities of tocotrienols are more robust than that of tocopherols. Palm oil is a rich natural source of tocotrienols. Heme oxygenase-1 (HO-1) is an enzyme that has antioxidant, anti-inflammatory and cytoprotective functions. The objective of this study is to determine the effects of different doses of TRF oral supplementation on H...

Objective: NAD(P)H: quinone oxidoreductase 1 (NQO1) is important in xenobiotic and carcinogenic detoxifications. NQO1-mediated detoxification of quinones is thought to be an important strategy for cancer chemoprevention. The objective of this study was to determine the expressional levels of liver NQO1 that could be observed by administration of an...

Introduction: Tocotrienols are part of the vitamin E family and has been reported to possess potent antioxidant activity. Palm oil is a rich natural source of tocotrienols. Heme oxygenase-1 (HO-1) is an enzyme that possess antioxidant, anti-inflammatory and cytoprotective functions. Methods: The objective of this study is to determine the effects o...

Increased Expression Of Liver Glutathione S-Transferase Isoenzymes Through Supplementation Of Palm Oil Tocotrienol Rich Fraction (TRF) In Mice

Introduction: Tocotrienols are part of the vitamin E family and has been reported to possess potent antioxidant activity. Palm oil is a rich natural source of tocotrienols. Heme oxygenase-1 (HO-1) is an enzyme that possess antioxidant, anti-inflammatory and cytoprotective functions. Method: The objective of this study is to determine the effects o...

NAD(P)H: quinone oxidoreductase 1 (NQO1) is important in xenobiotic and carcinogenic detoxifications. NQO1-mediated detoxification of quinones is thought to be an important strategy for cancer chemoprevention. The objective of this study was to determine the expressional levels of liver NQO1 that could be observed by administration of an equal dose...

Vitamin E refers to a family of eight different isomers that belong to two classes i.e. α, β, γ, and δ tocopherols and α, β, γ, and δ tocotrienols (Sylvester & Theriault 2003). All forms of vitamin E possess antioxidant activity, with, tocotrienols shown to have stronger antioxidant potential than tocopherols (Pruthi et al. 2001). Tocopherols are a...

The Potency Of Sulforaphane, Curcumin And Quercetin In Inducing Heme Oxygenase 1 Gene Expression In Mice Liver

A diet rich in tocotrienols has been shown to be beneficial for health. However, its detailed mechanism of action is still not fully understood. NAD(P)H:quinone oxidoreductase 1 (NQO1) is important in cellular defence due to its ability to detoxify reactive quinones and quinoneimines to their less toxic hydroquinones forms. The objective of this st...

The effect of palm oil-derived tocotrienol rich fraction (TRF) treatment on body weight and food consumption in male ICR white mice was investigated in this study. Mice were randomly divided into 4 groups (n=10 for each group). The first group is designated as control group. The other three groups were given TRFby oral gavage at concentrations of 2...

Glutamate-cysteine ligase catalytic subunit (Gclc) is an enzyme that in mouse is encoded by the Gclc gene. Glutamate-cysteine ligase is the first rate limiting enzyme of glutathione synthesis. The objective of this study is to determine the effects of administration of equal dose (50 mg/kg) of several dietary chemicals on the gene and protein expre...

Heme oxygenase-1 (HO-1) is an enzyme that possesses anti-oxidant, anti-inflammatory and cytoprotective functions. Induction of HO-1 occurs as an adaptive and beneficial response to various injurious stimuli such as oxidative stress. This study is aimed at monitoring the effects of equal doses (50 mg/kg body weight) of sulforaphane, curcumin and que...

The Effects Of Equal Doses Of Sulforaphane, Curcumin And Quercetin On Heme Oxygenase 1 Gene Expression In Mice Liver

Tocotrienol is a hydrophobic fat soluble compound belonging to vitamin E family and has been reported to possess potent antioxidant activity

ARTICLE INFO ABSTRACT Article history: Received on: 30/10/2014 Revised on: 18/11/2014 Accepted on: 01/12/2014 Available online: 29/12/2014 NAD(P)H:quinone-oxidoreductase-1 (NQO1) is a cytosolic enzyme that catalyses two-or four-electron reduction of many endogenous and environmental quinones using flavin adenine dinucleotide (FAD) as a cofactor. It...

Essential hypertension isa complex traitto whichmultifactorial origin arising from an interaction between genetic and environmental factorscontribute interactively. Consequently, the identification of genes related to hypertension is complicated by the heterogeneity of its causes and the possibility that various genes with moderate impacts, probabl...

Flavonoids belong to a category of polyphenolic compounds that are produced exclusively in plants. These compounds are able to bring about various biological and pharmacological activities in animal cells. It is generally believed that most mammals need to consume polyphenols from plants due to their antioxidant properties in order to stay healthy....

Flavonoids belong to a category of polyphenolic compounds that are produced exclusively in plants. These compounds are able to bring about various biological and pharmacological activities in animal cells. It is generally believed that most mammals need to consume polyphenols from plants due to their antioxidant properties in order to stay healthy....

Curcumin (diferuloymethane), a yellow colouring agent present in the rhizome of Curcuma longa Linn (Zingiberaceae), has been reported to possess anti-inflammatory, antioxidant and anticarcinogenic activities. Despite such significant anti-tumor efficacies and bio-safety profiles of curcumin, its poor systemic bioavailability originating from sub-op...

This research examines sulforaphane (SFN), a phytochemical element that is found in certain plants and vegetables. SFN has particular biological behaviours and roles to combat many diseases. It can be found mainly in vegetables such as Brussels sprouts, kale, cauliflower, and broccoli. SFN is a nutritional isothiocyanate compound and is known as a...

Nuclear transcription factor erythroid 2p45-related factor 2 (Nrf2) plays a crucial role in regulating phase-2 detoxifying/antioxidant gene induction. Under physiological conditions, NRF2 is mainly located in the cytoplasm. However, in response to oxidative stress, NRF2 translocates to the nucleus and binds to specific DNA sites, termed "antioxidan...

Carcinogenesis involves multiple steps ranging from the transition of normal to pre-initiated cells to invasive carcinoma. Thus, carcinogenesis provides ample opportunities for chemoprevention. In this context, many naturally occurring dietary compounds found in fruits and vegetables that are consumed daily have been shown to possess cancer-prevent...