Nabora Soledad Reyes de Mochel

Nabora Soledad Reyes de Mochel
University of California, San Francisco | UCSF · Division of Pulmonary, Critical Care & Allergy/Immunology

21.2
 · 
Master of Science

About

22
Publications
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363
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Publications

Publications (22)
Preprint
Senescent cells are recognized drivers of aging-related decline in organ function, but deciphering the biology of senescence in vivo has been hindered by the paucity of tools to track and isolate senescent cells in tissues. Deleting senescent cells from transgenic murine models have demonstrated therapeutic benefits in numerous age-related diseases...
Article
Full-text available
Development of quantitative, safe and rapid techniques for assessing embryo quality provides significant advances in Assisted Reproductive Technologies (ART). Instead of assessing the embryo quality by the standard morphologic evaluation, we apply the phasor-FLIM (Fluorescence Lifetime Imaging Microscopy) method to capture endogenous fluorescent bi...
Article
Introduction The standard non-invasive method to assess embryo quality and viabilityrelies on the visual inspection of embryo morphology according to predefined criteria. Development of more quantitative and objective means for assessing embryo qualitythat are simpler, safer, and faster could provide significant advantages in assistedreproduction....
Article
Full-text available
Genome-wide association studies have repeatedly mapped susceptibility loci for emphysema to genes that modify hedgehog signaling, but the functional relevance of hedgehog signaling to this morbid disease remains unclear. In the current study, we identified a broad population of mesenchymal cells in the adult murine lung receptive to hedgehog signal...
Article
Full-text available
Author Summary A critical event in mammalian embryo development is construction of a mass of embryonic stem cells surrounded by a distinct shell that later forms the placenta along with other structures. Despite sustained investigation, multiple hypotheses for what is responsible for this organization persist and it remains unclear what is responsi...
Data
Model simulation. Movie depicting a 2D simulation of the developing blastocyst without gene expression stochasticity. (M4V)
Data
Model simulation. Movie depicting a 2D simulation of the developing blastocyst with gene expression stochasticity. (M4V)
Data
Time lapse imaging of Cdx-eGFP mouse embryos. Transmission video of Cdx2-eGFP embryos demonstrates normal developmental morphology under our imaging and culturing conditions. (AVI)
Data
This file contains all supplementary text describing computational methods and image analysis. It further contains all supplementary tables and figures referenced herein. (PDF)
Data
Live imaging of an early Cdx2-eGFP mouse blastocyst. A Cdx2-eGFP+ cell moves from the outside to the inside of the embryo while decreasing the Cdx2 expression. (AVI)
Article
Full-text available
Background: Analysis of single cells in their native environment is a powerful method to address key questions in developmental systems biology. Confocal microscopy imaging of intact tissues, followed by automatic image segmentation, provides a means to conduct cytometric studies while at the same time preserving crucial information about the spat...
Article
Full-text available
The mechanisms regulating cell division during development of the mouse pre-implantation embryo are poorly understood. We have investigated whether bone morphogenetic protein (BMP) signaling is involved in controlling cell cycle during mouse pre-implantation development. We mapped and quantitated the dynamic activities of BMP signaling through high...
Article
Full-text available
Cellular responses to Bmp ligands are regulated at multiple levels, both extracellularly and intracellularly. Therefore, the presence of these growth factors is not an accurate indicator of Bmp signaling activity. While a common approach to detect Bmp signaling activity is to determine the presence of phosphorylated forms of Smad1, 5 and 8 by immun...
Data
BRE-mediated responsiveness is evolutionary conserved between zebrafish, frog, and mouse. Three transgenic BRE reporter embryos are shown to demonstrate the similar responsiveness to BRE-mediated Bmp signaling activity, particularly in the brain, eyes, heart, and pharyngeal arches, and somites. A wholemount X-gal stained BRE-gal mouse embryo at E9....
Data
BRE-gal reporter activity in the forelimb bud of a mouse embryo at E11.0. The AER shown in (A) divides the ventral and dorsal portions of the limb bud, with ventral on the left and dorsal on the right. A dorsal view of the forelimb is shown in (B), with a corresponding transverse section that is slightly oblique (C). In both (B) and (C), the AER is...
Data
A BRE-gal mouse line generated by pronuclear injection. An independent mouse line was also established by pronuclear injection of the BRE-gal DNA construct. A BRE-gal embryo at E9.5 is shown to demonstrate the similarity in overall X-gal staining patterns in the pharyngeal arches, eyes, and forebrain. It should be noted that staining in the forebra...
Data
Comparison of the BRE sequences from the Xenopus id3 and mouse Id1 promoter regions. Two, short Bmp-responsive sequences from the mouse Id1 regulatory region (−1105/−1080 and −1052/−1032) were designated as the BRE by Korchynskyi and ten Dijke [77]. Comparison of the (−1052/−1032) mouse Id1 BRE fragment shows that the sequence is similar, but diffe...
Article
Full-text available
Apolipoprotein (apo) E4 is an established risk factor for atherosclerosis, but the structural components underlying this association remain unclear. ApoE4 is characterized by 2 biophysical properties: domain interaction and molten globule state. Substituting Arg-61 for Thr-61 in mouse apoE introduces domain interaction without molten globule state,...
Conference Paper
Full-text available
Mammalian development begins with fertilization, followed by multiple cell cleavage events and the transition from maternal to zygotic transcription. All these events work in concert to establish the first and thus highly significant developmental event, lineage differentiation. The first step in establishment of different lineages in the preimplan...
Article
We investigated atheroprotective properties of apolipoprotein (apo) E beyond its ability to lower plasma cholesterol. We hypothesized that apoE reduces atherosclerosis by decreasing lipid accumulation in circulating monocytes and the inflammatory state of monocytes and the vascular endothelium. We developed mice with spontaneous hyperlipidemia with...
Article
Unlabelled: Oxidative stress has been identified as a key mechanism of hepatitis C virus (HCV)-induced pathogenesis. Studies have suggested that HCV increases the generation of hydroxyl radical and peroxynitrite close to the cell nucleus, inflicting DNA damage, but the source of reactive oxygen species (ROS) remains incompletely characterized. We...
Article
Transforming growth factor beta (TGF-beta) stimulates reactive oxygen species (ROS) production in various cell types, which mediates many of the effects of TGF-beta. The molecular mechanisms whereby TGF-beta increases ROS production and ROS modulate the signaling processes of TGF-beta, however, remain poorly defined. In this study, we show that TGF...

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