Nabila Abdelmeguid

• PhD
• Professor at Alexandria University

Water pollution has been increased by the discharge of several polycyclic aromatic hydrocarbons including Benzo (a) pyrene (BaP), which may affect aquatic animal lives and threaten human health. Common sole, Solea solea was selected as a bioindicator benthic fish to monitor pollution from El-Maadeya (one of the industrially polluted areas in Egypt)...

The potentiality of using two novel aqua-derived meals from fish waste biomass in either nonfermented (FW) or fermented (FFW) form as dietary partial fishmeal (FM) substitutes for juvenile European seabass, Dicentrarchus labrax, (IBW, 29 g) was investigated. FW meal (40% crude protein, 20% lipids, and 7.5% ash) was fermented using the marine fungus...

Worldwide, hepatocellular carcinoma (HCC) is considered the sixth most prevalent cancer and ranked third in causes leading to death. Pterostilbene (PTE), a dimethylated analog of resveratrol, is a phytochemical found in fruits such as blueberries and grapes, and is known for its anticancer effect. The current study intended to investigate the effec...

Epigallocatechin 3-gallate (EGCG) is a natural polyphenolic antioxidant in green tea leaves with well-known health-promoting properties. However, the influence of EGCG on a chronic animal model of depression remains to be fully investigated, and the details of the molecular and cellular changes are still unclear. Therefore, the present study aimed...

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases characterized by a progressive loss of memory and other cognitive functions among elder people. Nowadays, natural antioxidants have been used to recover the quality of life for those with AD. In this study, we investigated, for the first time, the combined effect of docos...

Green synthesis of nanoparticles (NPs) is a safe, eco-friendly, and relatively inexpensive alternative to conventional routes of NPs production. These methods require natural resources such as cyanobacteria, algae, plants, fungi, lichens, and naturally extracted biomolecules such as pigments, vitamins, polysaccharides, proteins, and enzymes to redu...

Colostrum, the sole diet for newborns, is an emerging nutraceutical. To date, the chemopreventive effect of Bovine Colostrum against liver injury induced by the potent carcinogen, 7,12-dimethyl-Benz[a]anthracene (DMBA) is unexplored. Humans are daily exposed to DMBA which is a highly lipophilic environmental organic pollutant. The study aimed to in...

Several studies suggest that neurons from the lateral region of the SuM (SuML) innervating the dorsal dentate gyrus (DG) display a dual GABAergic and glutamatergic transmission and are specifically activated during paradoxical (REM) sleep (PS). The objective of the present study is to characterize the anatomical, neurochemical and electrophysiologi...

This study was undertaken to assess the effects of dietary sodium propionate (SP) supplementation on the growth, haemato-immunological parameters, gut microbiota, and intestinal histology of European seabass (Dicentrarchus labrax) fry. In total, four diets were evaluated during a 90-day growth trial: a control (CTRL) diet without SP supplementation...

Background The emergence of multi drug-resistant (MDR) bacterial infections and cancer has necessitated the development and discovery of alternative eco-safe antibacterial and anticancer agents. Biogenic fabrication of metallic nanoparticles is an emerging discipline for production of nanoproducts that exert potent anticancer and antibacterial acti...

Several studies suggest that neurons from the lateral region of the SuM (SuML) innervating the dorsal dentate gyrus (DG) display a dual GABAergic and glutamatergic transmission and are specifically activated during paradoxical (REM) sleep (PS). The objective of the present study is to fully characterize the anatomical, neurochemical and electrophys...

The rats treated with leek (Allium kurrat) extract before and after their hepatotoxicity induction by aflatoxins (AFs) B1 and B2 showed a significant decrease in the levels of the oxidation radicals and a significant increase in the level of these hepatic enzymes compared to their corresponding values of the AF-treatment. These levels approached to...

A feeding trial was conducted to evaluate response of European seabass (ESB, Dicentrarchus labrax) fry to graded levels of the dietary organic salt, sodium butyrate (SB). ESB with 0.45 g were fed four experimental diets contained: 0, 0.1, 0.2 and 0.3% SB and assigned as: control (CTRL), SB1, SB2 and SB3 respectively for 12-weeks. Results showed a s...

In this study the land snail (Eobania vermiculata), one of the most abundant gastropod of Egyptian farms, was investigated to deter-mine the lethal toxic action of methomyl and methiocarb and to identify the biochemical and histochemical changes as a function of sublethal dose or concentration on the digestive gland of this snail under laboratory c...

Ammonia is a metabolite of aquatic organisms which might reach deleterious levels in intensive fish farms. The aim of the present study was to determine median lethal concentrations (96-h LC50) of total ammonia nitrogen (TA-N) on marbled spinefoot rabbitfish (Siganus rivulatus) and chronic effects of TA-N on survival, growth and behaviour of juveni...

Abstract: The world’s population is increasing while levels of capture fisheries remain roughly stable with limited potential of increase. The only choice to meet the world's increasing demand of fish is by farming them. Aquaculture is a developing industry and a large proportion of the industry is using aquaculture technology. A consequence of hig...

Autism is a pervasive neurodevelopmental disorder that appears in the first 3 years of life. Causes of autism have not yet been recognized and for unknown reason the brain’s normal development of social and communication skills is affected. In view of the fact that some individuals might show only slight disturbances in behavior or mild development...

The aim of the study was to investigate the role of aqueous extract of Nigella sativa seed, Nigella sativa oil and thymoquinone in ameliorating the cellular damage produced in pancreatic cells by streptozotocin (STZ). Five equal sized groups of male Sprague-Dawley rats were used in this study. The groups included; control, STZ induced diabetic, STZ...

The present study investigated the effects of Nigella sativa aqueous extract and oil, as well as thymoquinone, on serum insulin and glucose concentrations in streptozotocin (STZ) diabetic rats. Rats were divided into five experimental groups (control, untreated STZ-diabetic, and aqueous extract-, oil-, or thymoquinone-treated diabetic rats). Treate...

Cisplatin (CDDP) is a potent anticancer agents used for the treatment of solid tumors. However, its clinical use is often limited by its adverse effects including nephrotoxicity. The present study was designed to estimate if silymarin, a bioflavonoid with antioxidant potential can inhibit or at least ameliorate the alteration in some renal structur...

The benefit of silymarin, a plant extract with strong antioxidant activity against hepatotoxicity induced by cisplatin in rats was investigated in this study. Cisplatin is one of the most effective chemotherapeutic drugs, yet it alone does not achieve a satisfactory therapeutic outcome and at high doses it can produce undesirable side effects. Five...

The aim of this study was to determine the effects of Polyaromatic Hydrocarbons (PAHs) on the fine structure of the hepatopancreas of Palaemon serratus . For this purpose, shrimps were intramuscularly injected with sublethal dose (100 ng μL<SUP>-1</SUP>) of perylene, christen and benzo (a) pyrene. Samples of hepatopancreas were then taken for elect...

The present study was designed to investigate the neuropathological effect of the two carbamate pesticides: methomyl and methiocarb on the neurons of the buccal ganglia in the land snail Eobania vermiculata using topical application and baiting technique. Their in vivo effects on acetylcholinesterase (AChE, EC 3.1.1.7) activity were also investigat...

In this study the land snail (Eobania vermiculata), one of the most abundant gastropod of Egyptian farms, was investigated to determine the lethal toxic action of methomyl and methiocarb and to identify the biochemical and histochemical changes as a function of sublethal dose or concentration on the digestive gland of this snail under laboratory co...

The mammary gland cells of Sprague Dawley rats treated with melatonin and/or tamoxifen were analyzed for apoptosis and ultrastructural damage using transmission electron microscopy. The alterations of p53 expression were determined by western blotting. The experiment lasted for 8 weeks where animals were subcutaneously injected with melatonin (0.5...

The main purpose of the present study was to determine the mechanism by which captopril induces its toxic effect. The study also aimed to determine whether furosemide (a diuretic drug) inhibits or promotes the side effects produced by captopril administration. Two dose levels of captopril were used; low dose (0.01 mg for six days a week, for four w...

Terrestrial snails are destructive agricultural pests as they cause a great damage to vegetables and crops. The present study was designed to evaluate the toxic action of two carbamate molluscicides, methomyl and methiocarb on the digestive gland of the land snail E. vermiculata which is the main site of accumulation and biotransformation of xenobi...

In the present report, we have determined the gonadal free amino acid compositions in Oreochromis niloticus collected from three sites in Lake Mariut: SE basin (less polluted), main basin (moderately polluted) and SW basin (highly polluted), in an attempt to develop sensitive biomarker to evaluate pollution effects from multiple sources. Variations...

This investigation was designed to evaluate reproductive impairment of tilapia (as a bioindicator organism), inhabiting three sites in Lake Mariut which varied in nature and degree of physicochemical and organic criteria. It is concerned with monitoring bioaccumulation of metal in sperms of Oreochromis niloticus using SEM-X-ray microanalysis and il...

Chemical analysis of surface water samples collected randomly from three locations in lake Mary?dicated a considerable rise of certain heavy metals and bad water quality in polluted locations (Moharrem Bey and Merghim basin), with elevated chemical and biological oxygen demands (BOD) as compared to reference area (Fish farm) characterized with less...

Acrylamide, a widely used vinyl monomer, is known to induce central-peripheral axonopathy. In the present study, investigate the effect of acrylamide (ACR) on the neuromuscular junctions of the Swiss albino mice. Animals were given acrylamide (10 and 20mg Kg‾¹) interapertioneally 6 days weekly for 4 weeks. Intoxication with ACR at t...

Chemical analysis of surface water samples collected randomly from three locations in lakeMary?dicated a considerable rise of certain heavy metals and bad water quality inpolluted locations (Moharrem Bey and Merghim basin), with elevated chemical andbiological oxygen demands (BOD) as compared to reference area (Fish farm) characterizedwith lesser m...

Chloramphenicol has been associated with the development of aplastic anaemia. As it is still widely used in Egypt, we studied its effect on 100 Egyptian toads (Bufo regularis) given a dose of chloramphenicol of 5 mg/40 g body weight for 12 weeks. We found it induced numerous, severe ultrastructural changes in almost all types of leukocytes. These c...

Environmental factors play an important role in the etiology of several types of cancer, this discovery has led to a great deal of interest in the role of diet in cancer etiology. Fed the Egyptian toad with 0.5 ml corn oil and 0.2 mg DMBA toad/3, 3 times/week increased the incidence of liver tumor (22 out of 50 cases) in comparison with toads treat...

Liver tumors were induced in the toads, Bufo regularis , , in 16 out of 50 cases by the administration of 0.2 mg DMBA/toad, 3 times / week for 12 weeks. Light and electron microscopic photographs demonstrate that these hepatocytes of DMBA - treated toads showed criteria of malignancy. In contrast, toads treated with DMBA at the same dose level and...

Helicobacter pylori infection appears to be the most important cause of gastritis, gastric and duodenal ulcer. Biopsy specimens of gastric mucosa of patients with chronic gastritis proven by bacteriological test and endoscopy assessed the presence of organisms in lumen of numerous glands. Light and electron micrographs revealed curved organism, qui...

This study was initiated to evaluate the effect of hazardous exposure to water pollutants on Tilapia zilli Gerv inhabiting Lake Maryût at 3 different sites with varying degrees of physicochemical and organic criteria. As compared to other sites, the lower water turbidity and alkalinity plus lesser metal content in site #1, signify its picking as re...

Toads fed with 0.5 mg 7,12-dimethylbenz(a)anthracene twice a week for 12 weeks displayed liver tumors in 27 out of 100 cases. Electron micrographs of liver tumors showed some criteria of malignancy, such as the presence of nuclear pockets, pseudoinclusions, dilatation of the cisternae of rough endoplasmic reticulum and loss of cell junctions. These...

Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those obse...

Griseofulvin is a valuable oral antifungal drug, used extensively in the treatment of superficial fungal infections of man and animals. Electron microscopical studies of peripheral blood of toads force-fed with griseofulvin revealed pronounced alterations of the blood cells more or less similar to the criteria of monocytic leukaemia and were all co...

The foot of the desert snail, Eremina ehrenbergi, is supplied by branches of the pedal nerves which enter a coarse-meshed peripheral neural plexus. Light and electron microscopic preparations revealed the presence of ganglionic knots embedded in the foot musculature. In these knots the neural cell bodies are found to be situated on the periphery of...

Ultrastructural differences between cardiac and striated muscle fibres observed in the ocellated skink (Chalcides ocellatus ocellatus) indicate that functional differences have a structural correlate in the muscle cells. Although the myofibrils of both the cardiac and skeletal muscles displayed the same typical band pattern, differences in mean nuc...

Acrylamide (ACR), a widely used vinyl monomer, is well known as a neurotoxin to both laboratory animals and man. The experiment reported has demonstrated that ACR induces ultrastructural changes in the parasitic ciliate Nyctotheroides puytoraci, after injecting the host Bufo regularis with 1 mg ACR per toad (single dose). After 1 week of ACR inject...

The effect of neutron doses from a D-T compact neutron generator on the liver cells of adult male and female albino Swiss mice was investigated. Fast neutrons (14.5 MeV) were delivered to the whole body in a single dose or in two, four, six or eight equal doses separated by 3-day intervals. The lowest dose, 100 rem, was given for an exposure time o...

Cytoenzymological changes were observed in parasitic ciliates (Nyctotheroides puytoraci) and flagellates (Opalina sudafricana and Protoopalina sp.) after injection of their host, Bufo regularis, with a single dose of 0.5 mg beta-naphthylamine (BNA) per toad. The experiment was carried out during the host's pre-breeding season. Trophozoites of the g...

Changes in the Golgi bodies and in hydrolytic enzymes were observed in parasitic ciliates (Nyctotheroides puytoraci) and flagellates (Opalina sudafricana and Protoopalina sp.) after the administration of a single dose of 0.5 mg beta-naphthylamine (BNA) to their host, Bufo regularis. The experiment was carried out during the host's pre-breeding seas...

Skin papillomas were observed in the majority of toads when painted with 1 mg of 7,12-dimethyl-benz (alpha) anthracene (DMBA) dialy for 8 weeks. Animals injected with 10 mg/kg/day of ascorbic acid into the dorsal lymph sac showed tumor inhibition when painted with the same dose level of DMBA for 8 weeks. Tumor regression occurred in those animals r...