N R M Nelumdeniya

General Sir John Kotelawala Defence University · Department of Pharmacy

Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials a...

The development of anti-inflammatory and antibacterial drugs is mainly dependent on the discovery of novel compounds from natural sources. This study aims to assess the in vitro anti-inflammatory and antibacterial activity of methanol and aqueous extracts of leaf, bark and combination (leaf and bark) extracts of the plant Horsfieldia iryaghedhi (RU...

Phyllanthus amarus, Barringtonia racemosa and Curcuma longa are well-known herbal plants with anti-inflammatory activity that are used in traditional medicine. An attempt was made first to determine the in-vitro anti-inflammatory activity of the combination of methanolic extracts of dried leaves P. amarus and B. racemosa and fresh juice of C. longa...

Cyclea peltata (Kahipiththan in Sinhala) (C. peltata) is a climbing shrub that belongs to the family Menispermaceae. When the leaf extract is mixed with water, it forms an edible gel that is consumed to treat gastrointestinal ulcers in traditional medicine. Since there is no scientific evidence of its use in peptic ulcer disease (PUD), this prelimi...

Cyclodextrins (CDs) are cyclic oligosaccharides composed of glucopyranose units bonded together to form a truncated cone that can make inclusion complexes with guest molecules. The α, β, and γ-CDs, which respectively comprise six, seven or eight glucopyranose units, are used extensively in pharmaceutical formulations as functional excipients. The c...

Cyclodextrins (CDs) are cyclic oligosaccharides composed of glucopyranose units bonded together to form a truncated cone that can make inclusion complexes either engulfing part or the whole guest molecule. The α, β and γ-CDs, which consist of six, seven and eight glucopyranose units are used extensively in pharmaceutical formulations as a functiona...

Patient counselling is an important task to improve medication management in non-communicable diseases. A prospective interventional pre-post study was conducted in the medical clinic at University Hospital- KDU to investigate the impact of pharmacists-led patient counselling on Knowledge, Attitude, and Practice (KAP) based lifestyle changes and tr...

Cyclodextrins (CDs) are cyclic oligosaccharides that are used as functional excipients to modify the physical, chemical, and biological properties of drugs via forming inclusion complexes. The outer surface of CDs is more hydrophilic than the interior and hence entrap guest molecules in the cavity. Among three natural CDs (α, β, and γ), β-CD is wid...

Exceptionally high quoted unit prices of antimalarials and the non-availability of World Health Organization (WHO) pre-qualified registered suppliers were two main challenges in procuring antimalarials in Sri Lanka. As such, having bioequivalence/ biowaiver studies to ensure the therapeutic performance of generics is of paramount importance since t...

Background: Drug interactions (DIs) are one of the top reasons for adverse drug reactions, leading to loss of compliance for medications. Polypharmacy has been identified as one of the top reasons for DIs. Even though DIs on prescriptions are preventable, due to different reasons they are undiagnosed, and may lead to unacceptable complications. Obj...

cd

Cyclodextrins (CDs) are cyclic oligosaccharides with glucopyranose units bonded together with 1-4 linkages to form a truncated cone. The cavity within this cone can make inclusion complexes with various molecules; either engulfing part or the whole molecule. The outer surface of CDs is more hydrophilic than the interior. β-CDs, which consist of sev...

Poloxamers are amphiphilic triblock copolymers with a central hydrophobic polypropylene oxide (polyPO) block connected on either end to two hydrophilic polyethylene oxide (PolyEO) blocks. These polymers are widely used in medical applications, foaming, detergency, dispersion and stabilization. Computer simulations can provide support in characteriz...

This study evaluated the in vitro antibacterial effect and the phytochemical profile of aqueous extract of fresh mature leaves of Asystasia variabilis, a Sri Lankan indigenous plant, against four common wound infective bacteria (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli) using Kirby-Bauer disk diffusion t...

With the lifestyle change, new diseases have emerged in the human population as a malady over the past few centuries. Some of the widespread epidemic diseases have caused huge impact on the global socioeconomic structure. Further increasing drug resistance amongst the pathogens have rendered many antibiotics and drugs ineffective in treating and co...

Safe and effective delivering of medications are a paramount interest in pharmaceutics. Cyclodextrins (CD) are a class of cyclic oligosaccharides which have a cone-shaped structure, capable of hosting a number of molecules with therapeutic potential. However, the development of CD based therapeutics has largely been driven by trial-and-error. Here...

This study accessed the antibacterial potential in vitro of hexane, chloroform and methanol extracts made from leaves, stem bark, flowers, seeds or roots of Sri Lankan grown Acronychia pedunculata plant against two Gram positive bacteria, Staphylococus aureus (ATCC 25923) and Bacilus cereus (ATCC 11778), and two Gram negative bacteria, Pseudomonas...

By 2020, 79.6 million people worldwide will have either open-angle or angle-closure glaucoma and 11.2 million will be bilaterally blind (Quigley & Broman 2006). Around 87% of visually impaired people live in developing countries (Abba, 2009), where eye health care provision is desperately inadequate. Glaucoma accounts for 6% of all cases of blindne...

Abstract Objective: An attempt was made to assess the quality and stability of generic and branded products of Metformin Hydrochloride tablets B.P.500mg marketed in Sri Lanka. Method: two generic and three branded products including the brand leader were used in this study. Three batches were selected randomly from each of the five products. Three...