N. Moura-Coelho

• Doctor of Medicine
• Ophthalmologist / Refractive Surgeon at Grupo IMO

Purpose After 15 years of accumulated experience in the Descemet Membrane Endothelial Keratoplasty (DMEK) technique, this surgical method has demonstrated a high reproducibility and success rate. However, certain ocular conditions such as aphakia and previously vitrectomized eyes remain challenging. We describe a novel technique designed to improve...

This chapter explores the impact of different cap thicknesses in small incision lenticule extraction (SMILE) procedures, a minimally invasive corneal lenticule extraction technique using femtosecond laser technology.

Corneal haze, a consequence of pathological wound healing, manifests as opacity and sometimes irregularity impairing vision. This condition arises from breaches in the epithelial barrier, triggering an inflammatory cascade culminating in myofibroblasts formation. Surgical procedures such as photorefractive keratectomy (PRK), laser in situ keratomil...

Purpose To determine predictive factors of higher levels of best-corrected visual acuity (BCVA) in the long-term after primary Descemet’s membrane endothelial keratoplasty (DMEK). Methods Retrospective, single-surgeon case series of 129 successful primary DMEK eyes without graft failure and with a minimum postoperative follow-up of 12 months. Mixe...

Cataract extraction (CE) is currently one of the most commonly performed surgeries worldwide, since it is a quick procedure that can be performed under topical or local anaesthesia, and since it leads to rapid visual recovery in most cases with significant improvement in vision and increased spectacle independence. With the increasing number of CE...

Purpose: To determine risk factors for intraocular lens opacification (IOLop) after Descemet membrane endothelial keratoplasty (DMEK) and to analyze clinical outcomes after IOL exchange. Methods: Cross-Sectional Study: Analysis of all cases of IOL exchange because of post-DMEK IOLop with a minimum of 6- month postoperative follow-up observed in c...

The efficacy and safety of Descemet's membrane endothelial keratoplasty (DMEK) and ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) have been recently compared in several systematic reviews (SRs). The aim of this study was to assess the evidence quality of such SRs, in order to obtain a scientifically rigorous comparison b...

Objectives: To assess the efficacy and safety of combined phacoemulsification and excimer laser trabeculostomy (ELT) in eyes with cataract and mild controlled glaucoma or ocular hypertension (OHT). Methods: Single-centre analysis of eyes that underwent phacoemulsification and ELT between 2017 and 2021. Change in intraocular pressure (IOP), glauc...

Purpose To analyze the outcomes of Descemet’s membrane endothelial keratoplasty (DMEK) for corneal endothelial failure secondary to phakic intraocular lens implantation (PIOL) at a reference center for corneal transplantation in Spain. Design Retrospective, single-surgeon case series. Methods Single-center analysis of patients who underwent DMEK...

The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and...

Visual rehabilitation of patients with keratoconus (KC) is a clinical challenge; current strategies include conservative and surgical approaches. Phakic intraocular lens (PIOL) implantation is increasingly accepted as a safe and effective strategy in eyes with stable or stabilized KC. The chapter presents a practical, clinically oriented analysis o...

Purpose: Evaluating long-term efficacy, safety, and spectacle independence after the treatment of hyperopic presbyopia with pseudophakic mini-monovision using standard monofocal intraocular lenses (IOLs) following bilateral cataract surgery. Setting: Private practice in Barcelona, Spain. Design: Retrospective, non-comparative case series. Met...

PURPOSE: To assess the efficacy and safety of combined phacoemulsification and excimer laser trabeculostomy (ELT) in eyes with cataract and mild controlled glaucoma or ocular hypertension. METHODS: Single-centre analysis of eyes that underwent phacoemulsification and ELT between 2017 and 2021. Change in intraocular pressure (IOP), glaucoma medicati...

All documented cases of acute corneal allograft rejection following SARS‐CoV‐2 vaccination were examined, to characterize possible risk factors and graft outcomes. Comprehensive search (4 electronic databases: PubMed, CENTRAL, ClinicalTrials.gov, Google Scholar, plus manual search in articles' reference lists) until March 1st 2022 to identify studi...

Purpose: To evaluate long-term efficacy, safety, predictability, and stability of a posterior chamber phakic intraocular lens (Visian implantable collamer lens [ICL]) in eyes with ≥10 years of follow-up. Setting: Instituto de Microcirugía Ocular, Barcelona, Spain. Design: Retrospective study. Methods: Eyes undergoing ICL implantation from 20...

Purpose To report a case of Descemet membrane endothelial keratoplasty (DMEK) for the management of post-laser in situ keratomileusis (LASIK) interface fluid syndrome (IFS) secondary to failed Descemet stripping automated endothelial keratoplasty (DSAEK) graft, and to provide a literature review on endothelial keratoplasty (EK) for this indication....

Free access to full-text article available at the Journal of EuCornea official website, an open-access, online only, peer-reviewed journal with very accessible publication fees https://eucornea.scholasticahq.com/api/v1/articles/34256-case-report-bilateral-presumed-immune-stromal-keratitis-following-sars-cov-2-infection-a-delayed-manifestation.pdf...

Background The main goals of tarsorrhaphy are to protect the cornea and ocular surface and to allow/ promote corneal healing. We present our case series of permanent tarsorrhaphy and provide a literature review on the indications, surgical technique, outcomes, and complications of tarsorrhaphy.

Purpose: Evaluate the long-term efficacy, safety, predictability, and stability of a foldable anterior chamber phakic intraocular lens (Artiflex) in eyes with ≥10-year follow-up. Setting: Instituto de Microcirugía Ocular, Barcelona, Spain. Design: Retrospective study. Methods: Eyes undergoing Artiflex implantation from 2008-2011 with ≥10-yea...

Journal of EuCornea : Open Access Journal A Journal that aims to publish high quality scientific papers in an easy, fast and always open source way. https://eucornea.scholasticahq.com/ Background : Current treatment modalities in the management of dry eye disease (DED) reflect its multifactorial pathophysiology. While dietary modifications have be...

Purpose To evaluate long-term efficacy, safety, predictability and stability (refractive and keratometric) of myopic and myopic astigmatism correction with Small Incision Lenticule Extraction (SMILE). Methods Single center retrospective review of eyes undergoing SMILE from 2012–2015. Forty-two eyes (23 patients) with ≥ 5-year follow-up. Variables...

Purpose To provide the first description of photorefractive keratectomy (PRK) for the correction of mild residual refractive error after Descemet membrane endothelial keratoplasty (DMEK). Methods Case report. Results A 45 year-old woman presenting with phakic intraocular lens (PIOL)-related corneal decompensation underwent staged DMEK surgery fol...

Purpose: To compare the efficacy and safety of manual small incision cataract surgery (mSICS) versus phacoemulsification in a referral center from a low-to-middle-income country. Subjects and Methods: A retrospective cohort of 177 eyes with visually significant cataract and ≤1.0 diopter (D) of keratometric astigmatism was intervened during 2017 by...

Novel concepts in blepharitis and dry eye disease and innovation in in-office treatments for dry eye How to cite (APA): Moura-Coelho, N., Papa, R., Cunha, J. P., Gris, O., & Güell, J. L. (2021). Conceito de Síndrome de Olho Seco e Blefarite e Implicações Terapêuticas. Revista Sociedade Portuguesa De Oftalmologia, 45(4), 225–229. https://doi.org/10...

Background: We review the literature on the efficacy and safety outcomes of secondary Descemet stripping endothelial keratoplasty (DSEK) and Descemet membrane endothelial keratoplasty (DMEK). Methods: Literature search of English-written publications up to 27th September 2020 in PubMed database, using the terms "endothelial keratoplasty" in comb...

Purpose: To evaluate the presence of macular edema secondary to retinal vein occlusion (RVO)—both central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO)—3 years after diagnosis in patients who underwent intravitreal therapy and to identify potential prognostic factors and biomarkers of persistent macular edema. Methods: Nati...

Paracentral acute middle maculopathy (PAMM) is a recently identified spectral-domain optical coherence tomography (SD-OCT) finding characterized by a hyper-reflective band spanning the inner nuclear layer (INL), which typically evolves to INL atrophy in later stages. Typical clinical features include the sudden onset of one or multiple paracentral...

Social media have played an increasing role in medicine with potential applications for both physicians and patients. This trend has also impacted clinical and surgical practice in ophthalmology in a wide range of subspecialties to promote scientific research findings, provide further tools for teaching, and ease communication between ophthalmologi...

In just one hundred years, the world has been through five pandemics. Lessons of the past have not prevented a new virus from being responsible for a fifth wave of deaths worldwide, even with scientific advances and the rapid response of societies that, for the most part, anticipated the political and economic response. A century after the end of t...

Purpose Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by...

Purpose To analyze the clinical results of repeat Descemet membrane endothelial keratoplasty (re-DMEK) for failed primary DMEK graft at a referral center for keratoplasty in Spain. Design Retrospective, interventional, comparative case series. Methods From a single-center, single-surgeon series of 189 consecutive DMEK surgeries, fourteen (7.41%)...

Introduction Image processing of optical coherence tomography scans through binarization techniques represent a non-invasive way to separately asses and measure choroidal components, in vivo. In this review, we systematically search the scientific literature regarding binarization studies published so far. Methods A systematic research was conduct...

The technological advances made in recent years have led to an increase in the number of microsurgeries performed across different surgical specialties. To overcome the potential limitations of conventional microsurgery using the binocular microscope, development of three-dimensional (3D) display systems and their translational use in medicine has...

The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identi...

Leber’s hereditary optic neuropathy (LHON) is an optic neuropathy of mitochondrial inheritance, characterised by incomplete penetrance and variable expressivity. Typically, young male patients present with sequential, severe, rapidly progressive loss of central vision, with characteristic funduscopic findings. However, LHON may present at any age,...

Purpose: To evaluate the structural changes in the neurosensory retina (NSR) in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (WDR), as measured by spectral-domain optical coherence tomography (SD-OCT). Methods: Cross-sectional, non-interventional, comparative study of patients with diagnosis of T2DM WDR against matched...

Purpose: To compare the 1-year efficacy and safety of the XEN45 Stent (Allergan, Irvine, CA) implantation alone versus combined Xen implantation and phacoemulsification (Phaco-Xen) in patients with medically refractory open-angle glaucoma (mrOAG) at a tertiary center for Ophthalmology in Portugal, reporting the initial experience with XEN nationwid...

Purpose: The authors present a case report of age-related macular degeneration (AMD) and provide a review on the clinical and pathological evidence on outer retinal tubulations (ORT) and the clinical utility of spectral-domain optical coherence tomography imaging (SD-OCT) in the evaluation and follow-up of patients with AMD. Methods: Case report an...

AIM: To evaluate and compare the quality of life of patients submitted to XEN® implant or trabeculectomy and the relationship with potentially involved variables. METHODS: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN® (group 1) and trabeculectomy (group 2) between October 2015 and February...

Nanotechnology enabled the development of materials and devices with great utility in different fields of medicine. By using engineered-based nano-devices and structures, human biological systems may be controlled and repaired at a molecular scale, ultimately leading to a biological benefit. In particular, in the field of glaucoma treatment, nanote...

Purpose: To analyze the area of retinal nonperfusion in branch retinal vein occlusion (BRVO) and its relation to retinal ganglion cell (RGC) layer thickness. Procedures: Patients with ischemic BRVO, with no signs of fluid, were evaluated by Cirrus HD-OCT-A, Zeiss. Nonperfusion findings and RGC layer thickness were evaluated in a 6x6 mm area centere...

誗AIM: To investigate the changes in spectral domain optical coherence tomography ( SD - OCT ) quantitative and qualitative parameters in a group of patients with age - related macular degeneration ( AMD ) that underwent bevacizumab intravitreal injections (IV). We assessed if one or more of these parameters can be used as prognostic factors of the...

Alzheimer’s disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic ch...