Myungwon Seo

Korea Research Institute of Chemical Technology · Chemical Analysis Center

To develop the risk prediction technology for mixture toxicity, a reliable and extensive dataset of experimental results is required. However, most published literature only provides data on combinations containing two or three substances, resulting in a limited dataset for predicting the toxicity of complex mixtures. Complex mixtures may have diff...

The chemical risk assessment paradigm is shifting from “substance-based” to “product/mixture-based” and from “animal testing” to “alternative testing” under chemical regulations. Organisms and the environment may be exposed to mixtures rather than a single substance. Conducting toxicity tests for all possible combinations is impractical due to the...

During emission, TiO2 nanoparticles (NPs) might meet various chemicals, including metal ions and organic compounds in aquatic environments (e.g., surface water, sediments). At environmentally safe concentrations, combinations of both TiO2 NPs and those chemicals might cause cocktail effects (i.e., mixture toxicity) to aquatic organisms. Previous mo...

The adverse outcome pathway (AOP) was introduced as an alternative method to avoid unnecessary animal tests. Under the AOP framework, an in silico methods, molecular initiating event (MIE) modeling is used based on the ligand-receptor interaction. Recently, the intersecting AOPs (AOP 347), including two MIEs, namely peroxisome proliferator-activate...

Global regulations of biocides have been continuously enhanced for protecting human health and the environment from potentially harmful biocidal products. Such regulations consider the combined toxicity caused by mixture components in a biocidal product of which approval and authorization are to be enhanced. Although the combined exposure scenarios...

Abstract Computer-aided research on the relationship between molecular structures of natural compounds (NC) and their biological activities have been carried out extensively because the molecular structures of new drug candidates are usually analogous to or derived from the molecular structures of NC. In order to express the relationship physically...

Ecotoxicological assays have examined the risk of nanoparticles (NPs) to Daphnia magna (D.magna). However, significant inconsistencies in assay results have been found among studies conducted according to D.magna test guidelines (TGs) issued from OECD (Organization for Economic Co-operation and Development) and US EPA (United States Environmental P...

Nanomaterials represent one of the most exciting new technologies and increasing uses are inevitable. However, adverse effects may remain to be unveiled. Collation of the toxicity information is needed to ensure safe usage. One of the efforts to fill those information gaps is the idea of using the concept of (Q)SAR, known as effective method for th...