Myeongsu Seong

• Doctor of Philosophy
• Professor (Assistant) at Xi’an Jiaotong-Liverpool University

Accurate estimation of ambient PM2.5 concentrations is crucial for assessing air quality and health risks, particularly in regions with limited ground-based monitoring. Satellite-retrieved data products, such as top-of-atmosphere reflectance (TOAR) and aerosol optical depth (AOD), are widely used for PM2.5 estimation. However, complex atmospheric c...

Chiral metasurfaces exploit structural asymmetry to control circular polarized light, presenting new possibilities for the design of optical devices, specifically in the dynamic control of light and enhanced optical sensing fields. This study employed theoretical and computational methods to examine the chiroptical properties of a bilayer crescent...

Background and objective: Diffuse correlation spectroscopy (DCS) is an optical blood flow monitoring technology that has been utilized in various biomedical applications. In signal processing of DCS, nonlinear fitting of the experimental data and the theoretical model can be a hindrance in real-time blood flow monitoring. As one of the approaches...

Chirality, the absence of mirror symmetry, is predominant in nature. The chiral nature of the electromagnetic field behaves differently with chiral matter for left circularly polarized and right circularly polarized light. The chiroptical behavior in the sensing of naturally occurring chiral objects is weak, and improving the chiroptical response e...

The level of triglyceride (TG) in blood is essential to human health, and hypertriglyceridemia (TG level > 150 mg/dL) would lead to cardiovascular disease and acute pancreatitis that threaten human life. Routine methods for measuring the TG level in blood depend on a lipid panel blood test, which is invasive and not convenient. Here, we use photoac...

The spatial representativeness (SR) of air quality monitoring stations is an important parameter when using site observations for air quality evaluation and health assessment. In this study, by using daily 1-km-resolution PM2.5 concentrations from China High Air Pollutants dataset from 2016 to 2020, we adopted a Concentration Similarity Frequency m...

Individual identification and authentication techniques are merged into many aspects of human life with various applications, including access control, payment or banking transfer, and healthcare. Yet conventional identification and authentication methods such as passwords, biometrics, tokens, and smart cards suffer from inconvenience and/or insecu...

Alzheimer’s disease is one of the most critical brain diseases. The prevalence of the disease keeps rising due to increasing life spans. This study aims to examine the use of hemodynamic signals during hypoxic respiratory challenge for the differentiation of Alzheimer’s disease (AD) and wild-type (WT) mice. Diffuse optical spectroscopy, an optical...

Satellite-based PM2.5 estimation has been widely used to assess health impact associated with PM2.5 exposure and might be affected by spatial resolutions of satellite input data, e.g., aerosol optical depth (AOD). Here, based on Multi-Angle Implementation of Atmospheric Correction (MAIAC) AOD in 2020 over the Yangtze River Delta (YRD) and three PM2...

Background and Objective Diffuse correlation spectroscopy (DCS) is an optical technique widely used to monitor blood flow. Recently, efforts have been made to derive new signal processing methods to minimize the systems used and shorten the signal processing time. Herein, we propose alternative approaches to obtain blood flow information via DCS by...

Air pollution measurements from monitoring stations are widely used in health assessment, and it is important to take into account the spatial representativeness (SR) of stations when quantifying population exposure to air pollution measured in these stations. Using high-quality satellite-derived PM2.5 data with 1-km spatial resolution over Yangtze...

Nonlinear photoacoustic microscopy (PAM) is a novel approach to enhance contrast and resolution. In this study, a low-cost infrared (IR) lamp as a simple approach for nonlinear PAM is demonstrated. Numerical simulations are first performed to verify the nonlinear photoacoustic effect under steady heating for two cases: (i) Differentiation of absorb...

Introduction Female sexual arousal disorder (FSAD) can be caused by the change in vaginal structure due to the decline of estrogen and one of the main symptoms is vaginal dryness. FSAD is a prevalent problem afflicting women all over the world and thus the interest is growing on the matter, but related studies of monitoring FSAD using a non-invasiv...

A miniature endoscope capable of imaging multiple tissue contrasts in high resolution is highly attractive, because it can provide complementary and detailed tissue information of internal organs. Here we present a photoacoustic (PA)-fluorescence (FL) endoscope for optical-resolution PA microscopy (PAM) and FL microscopy (FLM). The endoscope with a...

Photoacoustic (PA) technology has wide applications in cell study. However, photoacoustics from cancer cells lacks adequate understanding. Here, we establish two modified models for theoretical investigation of photoacoustics from cancer cells. The first model is based on endogenous absorbers of cancer cells, which can be measured by label-free PA...

Air pollution may trigger systemic lupus erythematosus (SLE). However, few studies have investigated the associations between air pollution and complications of SLE, such as lupus nephritis (LN). In this study, multicenter longitudinal data from 13 hospitals in China, including 8552 SLE patients with 24762 visits, were used. Based on the generalize...

Photoacoustic imaging (PAI) is an emerging technology that has been dramatically developed in the last decade. PAI, a combination of optical illumination and ultrasound detection, allows us to achieve fine resolution and obtain fruitful information of endogenous and exogenous chromophores. Among PAI imaging techniques, photoacoustic computed tomogr...

An optical probe was developed to measure the change of oxy-hemoglobin (OHb), deoxy- hemoglobin (RHb), and total hemoglobin (THb) along with temperature from the vaginal wall of female rats. Apomorphine (APO, 80 μg/kg) was administered to elicit sexual arousal in female Sprague Dawley rats (SD, 180–200 g). The behavior changes caused by APO adminis...

Blood oxygenation and flow are both important parameters in a living body. In this Letter, we introduce a simple configuration to simultaneously measure blood flow and oxygenation using an off-the-shelf spectrometer. With the integration time of 10 ms, flow phantom measurements, a liquid blood phantom test, and an arm cuff occlusion paradigm were p...

The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-op...

Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor response from chemotherapy by monito...

We report a low-cost compact diffuse speckle contrast flowmeter (DSCF) consisting of a small laser diode and a bare charge-coupled-device (CCD) chip, which can be used for contact measurements of blood flow variations in relatively deep tissues (up to ∼ 8 mm). Measurements of large flow variations by the contact DSCF probe are compared to a noncont...

A combined diffuse speckle contrast analysis (DSCA)-near-infrared spectroscopy (NIRS) system is proposed to simultaneously measure qualitative blood flow and blood oxygenation changes in human tissue. The system employs an optical switch to alternate two laser sources at two different wavelengths and a CCD camera to capture the speckle image. There...

Appropriate oxygen supply and blood flow are important in coordination of body functions and maintaining a life. To measure both oxygen supply and blood flow simultaneously, we developed a system that combined near-infrared spectroscopy (NIRS) and diffuse speckle contrast analysis (DSCA). Our system is more cost effective and compact than such comb...

Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study,...