Mvuwo Tshavhungwe

Mvuwo Tshavhungwe
University of Cape Town | UCT · Division of Neurosurgery

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2
Publications
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1
Citation
Introduction
My current research interests include paediatric tuberculous meningitis and neuropharmacology. My PhD data collection entailed use of a pharmacokinetics sparse sampling approach of blood and clinically indicated lumbar and ventricular cerebrospinal fluid obtained during neurosurgical procedures. It also includes target site kinetics through use of intracerebral microdialysis as part of multimodality monitoring approach in my division.

Publications

Publications (2)
Article
Full-text available
Tuberculous meningitis (TBM) is the most fatal form of tuberculosis and frequently occurs in children. The inflammatory process initiates secondary brain injury processes that lead to death and disability. Much remains unknown about this cerebral inflammatory process, largely because of the difficulty in studying the brain. To date, studies have ty...
Article
Full-text available
Purpose A better understanding of the complex pathophysiology of traumatic brain injury (TBI) is needed to improve our current therapies. Cerebral microdialysis (CMD) is an advanced method to monitor the brain, but little is known about its parameters in children. Brain glycerol, one of the CMD variables, is an essential component of the phospholip...

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Projects

Project (1)
Project
To determine if rifampicin, a key drug in treatment of tuberculous meningitis reaches optimal concentrations closest to the target site of infection in the brain.