Mustofa Mustofa

• DR., MSc., Pharm., Professor
• Managing Director at Universitas Gadjah Mada

The prevalence of antibiotic-resistant bacteria is increasing every year in Indonesia. This resistance occurs in several antimicrobial categories. A contributing factor to microbial resistance is the capacity of microbes to develop biofilms. Amo.128 is an actinomycete from the Laboratory Biotechnology, BRIN Serpong collection, which is expected to...

The World Health Organization (WHO) has determined a list of pathogens that require the development of new antimicrobials due to resistance problems; these include Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. In addition, Mycobacterium smegmatis has been used for antimycobacterial discovery to address the increasing burden o...

Objective: This study has been carried out with an in silico approach to predict interactions between drug candidates and receptor COX-2 (5IKT) and analysed the Molecular Dynamic (MD) simulation. Methods: The docking procedure was executed with the MolDock algorithm, which was incorporated into Molegro Virtual Docker 5.0, employing the specific doc...

Indonesia is a maritime country with a water area of up to 75%. Microorganisms have a relatively high level of biodiversity, but their potential has yet to be thoroughly explored. The need for raw materials for medicines, especially antibiotics, continues to grow along with the population’s development and increasing antibiotic resistance. Explorat...

This study describes the development of N-benzyl-1,10-phenantrolinium salt as an antiplasmodium agent. The salt, that is, 1-(4-ethoxy-3-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide, was prepared using vanillin as the starting material in four simple synthetic steps. First, the alkylation of vanillin using diethyl sulfate produced 4-ethoxy-3- met...

Senggugu is reported to contain potent antioxidant compounds. This study aims to determine the antioxidant activity, to isolate and to characterize the structure of antioxidant compounds of methanolic extract of senggugu’s root bark. The ground dried root bark was macerated gradually with n-hexane, ethyl acetate and methanol. The methanol extract w...

Protein kinase dysregulation induces cancer cell aggressiveness leading to rapid tumor progression and poor prognosis in TNBC patients. Many small-molecule kinase inhibitors have been tested in clinical trials to treat TNBC patients. In the previous study, we found that N-phenylpyrazoline small molecule acts as a protein kinase inhibitor in cervica...

One of the most typical cancers to affect women worldwide is breast cancer. Multiple routes involving different proteins that control the development of cancer. HER-2 is a protein that contributes to the progression of breast cancer cells. This study uses n-phenyl pyrazoline derivate compounds. The predictive binding of several forms of pyrazoline...

Background: Atypical or second-generation antipsychotic drugs commonly used in the management of schizophrenia include risperidone. Risperidone is linked to the incidence of metabolic syndrome-related adverse effects. Objective: This study aims to investigate the correlation between the administration of risperidone therapy and the incidence of met...

Background Multidrug resistance in various cancer types is a major obstacle in cancer treatment. The concept of a single drug molecular target often causes treatment failure due to the complexity of the cellular processes. Therefore, combination chemotherapy, in which two or more anticancer drugs are co-administered, can overcome this problem becau...

The occurrence of resistance to anticancer and the emergence of serious side effects due to chemotherapy is one of the main problems in cancer treatment, including breast cancer. The need for effective anticancer with a specific target is urgently required. Streptomyces are widely known as the potential producers of new anticancer molecules. Previo...

Candida albicans and Staphylococcus aureus can coexist to form a biofilm, leading to infections associated with biofilms. Actinomycetes produce secondary metabolites known as antibiotics, antifungals, antibiofilm, anticancer, and antimalarials. This study was aimed to explore the antibiofilm activity of secondary metabolites of Actinomycetes InaCC...

The escalating prevalence of diabetes mellitus (DM), a major global health threat and one of the top 10 causes of mortality, is a worrying trend. Prolonged hyperglycemia in people with diabetes triggers oxidative stress, leading to accelerated tissue damage, increased levels of free radicals, and the onset of complications. Our initial exploration...

Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has fimbria as one of the most important virulence factors because it plays a vital role in the pathogenesis of P. gingivalis infection. This bacterium has 2 fimbriae: the major (FimA) and minor (Mfa1) fimbriae. Fimbriae are attractive targets for anti-infective therapy for per...

This study aims to validate the method for measuring metformin hydrochloride plasma concentrations using High-Performance Liquid Chromatography (HPLC). This research performed chromatography on a 250 mm 4.6 mm 5 µm purosphere® Star RP-18 column at ambient temperature with a UV detector system at 233 nm. The mobile phase components were 70% phosphat...

The extracts of five invasive plants were investigated for antifungal and antibiofilm activities against Candida albicans, C. glabrata, C. krusei, and C. parapsilosis. The antifungal activity was evaluated using the microdilution assay and the antibiofilm effect by measurement of the metabolic activity. Ethanol and ethanol‐water extracts of Reynout...

Background Candida albicans causes high-mortality candidiasis. Antifungal drug resistance demands the development of virulence factor-targeting drugs, particularly antibiofilm. This study screened the effects of five invasive plants growing in Indonesia (Mimosa pudica, Lantana camara, Acacia mangium, Ageratina riparia, and Mikania micrantha) agains...

Context: Metastatic breast cancer is still categorized as an incurable disease because all available therapies are palliative treatments to relieve symptoms and increase life expectancy. Our previous study showed that N-pyrazoline-derived compounds have the potential as an antiproliferative drug in cervical cancer cells line. Therefore, virtual scr...

Background: Clozapine, an atypical antipsychotic agent, is effective for relapse or refractory schizophrenia that has failed to respond to other antipsychotic medications. Despite its effectiveness, clozapine has a higher risk of metabolic syndrome than other antipsychotics. Objective: This research aimed to identify the correlation between clozapi...

The marine Streptomyces sp. strain GMY01 was isolated from Indonesian marine sediment. Genome mining analysis revealed that GMY01 has 28 biosynthetic gene clusters, dominated by genes encoding nonribosomal peptide synthetase and polyketide synthase.

Pahira DSJ, Damayanti E, Lisdiyanti P, Mustofa, Hertiani T. 2023. Exploring the potency of Streptomyces koyangensis strain SHP 9-3 isolated from the soil of Enggano Island (Indonesia) as an antibacterial source. Biodiversitas 24: 1460-1466. Streptomyces is a Gram-positive bacterium with the potential a produce beneficial antimicrobials. This study...

Objective: Chalcone-3 has been shown to be cytotoxic and selective against luminal subtype breast cancer cell lines, which are suspected to occur through the mechanism of epidermal growth factor receptors (EGFR) inhibition. However, the cytotoxic effect has never been tested on cell strains from patients with triple negative breast cancer (TNBC),...

Insulin resistance (IR) is the underlying root of type 2 diabetes (T2DM), especially in insulin-targeted tissues (liver and muscles). The increase of free fatty acids, such as palmitate acid (PA) can interfere the insulin signaling. Targeting IR on both tissues can be a promising strategy in T2DM. Swietenia macrophylla King. is traditionally used f...

Insulin resistance, which affects insulin-sensitive tissues, including adipose tissues, skeletal muscle, and the liver, is the central pathophysiological mechanism underlying type 2 diabetes progression. Decreased glucose uptake in insulin-sensitive tissues disrupts insulin signaling pathways, particularly the PI3K/Akt pathway. An in vitro model is...

This study aims to evaluate acute toxicity of the herbal preparation on rats as an early step to evaluate its safety. This study used 25 females Rattus norvegicus strain Sprague Dawley rats aged 8 weeks with a body weight of at least 120 g divided into 5 groups of doses of herbal preparation (0/aquadest, 50, 300, 2,000, 5,000) mg/kg BW. After admin...

Actinobacteria produce active secondary metabolite with medicinal properties, such as antibacterial or anticancer. However, there are some reports about the difficulties in discovering novel secondary metabolites. Therefore, the need for a new approach is obvious. Several factors such as types of nutrients in the culture media or different solvents...

Alzheimer's disease (AD) is the most common type of dementia. Approximately 50 million people suffer from Alzheimer's and it is expected to increase more than 100 million by 2050. According to the Diagnostic and Statistical Manual of Mental Disorders V (DSM-V), the diagnosis of AD has an onset of memory impairment and cognitive decline. Effective t...

Hantap leaves (Sterculia oblongata Mast) has been used traditionally to treat breast cancer in Palu, Central Sulawesi. However, its use is just based on empirical evidences rather than scientific evidences. The study aimed to investigate the cytotoxic activity of hantap leaves extracts against breast cancer cells line. The effect of this extract on...

Biofilm-forming fungi, Candida albicans, are currently a serious problem in infectious disease cases. Soil bacteria Streptomyces sp. GMR22 have a large genome size and antifungal metabolites against C. albicans, but its potential antibiofilm activity is not clearly defined. The aims of this study were to determine the antibiofilm activity of GMR22...

Objective Metastasis causes approximately 90% of cancer-related deaths, including in cervical cancer patients. Uncontrolled cell proliferation, migration, and cancer stemness act as critical events in primary tumor growth and cancer metastasis progression in cervical cancer. Here, we investigated the anti-proliferative, anti-migration, and cancer s...

Coronavirus disease 2019 (COVID-19) is still as global pandemic. No officially drugs to treat COVID-19 are available until now. Increasing number of patients and deaths trigger new antiCOVID-19 discovery efforts. In this study, we have conducted in silico screening employing molecular docking for Indonesian phytochemicals. Docking process was perfo...

Background As the life expectancy of elderly people has drastically increased, the incidence of cardiovascular and cerebrovascular diseases in this population has proportionally grown. Vascular cognitive impairment (VCI) refers to all forms of cognitive disorder associated with cerebrovascular disease. Homocysteine has recently been recognized as a...

Nocardiopsis are actinobacteria which produce active compounds, such as antifungals and volatile compounds. Ganoderma boninense is a pathogenic and aggressive fungus that decreases palm oil yield during production. In this study, we isolated two strains of Nocardia (GME01 and GME22) from airborne contaminants on the actinobacteria culture collectio...

We report the complete genome sequence and annotation of Bacillus velezensis GMEKP1, which was isolated from a hive of stingless bees (Trigona laeviceps). This bacterium has a circular 4,014,839-nucleotide chromosome and two circular plasmids. Genome-mining analysis of the whole-genome sequence revealed that GMEKP1 has 12 biosynthetic gene clusters...

COVID-19 is spreading rapidly yet there is no clinically proven drug available now. Soil-derived Streptomyces sp. GMR22 has a large genome size (11.4 Mbp) and a huge BGCs (Biosynthetic Gene Clusters) encoding secondary metabolites. This bacterium is a potential source for producing a wide variety of compounds which are able to block SARS-CoV-2, the...

We report the complete genome sequence of Streptomyces sp. strain GMY02, isolated from Indonesian marine sediment. This bacterium has a circular 8,512,626-nucleotide chromosome.

BACKGROUND: Insulin resistance (IR) is known as the root cause of type 2 diabetes; hence, it is a substantial therapeutic target. Nowadays, studies have shifted the focus to natural ingredients that have been utilized as a traditional diabetes treatment, including Swietenia macrophylla. Accumulating evidence supports the hypoglycemic activities of...

Objectives: This study explored Indonesian Actinobacteria which were isolated from Curcuma zedoaria endophytic microbes and mangrove ecosystem for new antimycobacterial compounds. Materials and methods: Antimycobacterial activity test was carried out against Mycobacterium tuberculosis H37Rv. Chemical profiling of secondary metabolite using Gas C...

To produce an effect, the agonist drug 2 will bind to the ADRB2 receptor. The effect of agonist 2 shows variation between individuals due to the presence of encoding gene polymorphisms. There are 80 ADRB2 polymorphisms, including Arg16Gly in amino acids 16. The innate ADRB2 genotype is called wildtype, whereas mutated ones is called mutant. The p...

A new upper rim-fuctionalized octaethoxycalix[4]arene has been synthesized, characterized by spectroscopy method and evaluated as the protector for ultraviolet radiation. The target molecule was synthesized in 5 steps. They were synthesis of resorcinarenaldehyde via Riemer-Tiemann reaction of resorcinol and chloroform, followed by O-ethylation, red...

The existence of a large number of mutant p53 in cancer cell nuclei gives a poor prognosis. However, mutant p53 existence creates a challenge to design a new anticancer compound targeted to mutant p53. The 3-carbethoxy-4-phenyl-but-3-en-2-one is a novel compound that was designed as an anticancer agent targeted to mutant p53. Further evaluation of...

Pycnarrhena cauliflora (Miers.) Diels., local name sengkubak, is one of indigenous plants from West Kalimantan that has been used as natural flavor. Pycnorrhena cauliflora is one of species of Menispermaceae family which is rich in bisbenzylisoquinoline alkaloids. This alkaloids are known to have various biological activities including antiprotozoa...

Post-stroke cognitive impairment involves memory, visuoconstructional, and spatial dysfunctions. Centella asiatica L. Urban. and Curcuma longa L. are both well-known herbs in South and South-East Asia countries that are believed to possess neuroprotective properties as memory enhancers. This study aimed to investigate the effects of C. asiatica L....

High resistance to chloroquine in most malaria-endemic area in the world leads to the need for new antimalaria drugs. Marine bacterium Streptomyces is the source for potential new antimalarial molecules. This research aimed to investigate antiplasmodial activity of marine-derived of Streptomyces sp. GMY01 and to identify potential active compounds...

This study's objective was to determine the distribution of allele frequencies of CYP2C9 and CYP2C19 gene polymorphisms among the Papuan population, known as the second-largest ethnic group in Indonesia. According to recent research, there is a decrease in CYP2C9 and CYP2C19 produced by humans globally, including in Indonesia. These gene polymorphi...

Damayanti E, Lisdiyanti P, Sundowo A, Ratnakomala S, Dinoto A, Widada J, Mustofa. 2021. Antiplasmodial activity, biosynthetic gene clusters diversity, and secondary metabolite constituent of selected Indonesian Streptomyces. Biodiversitas 22: 3478-3487. Actinobacteria of the genus Streptomyces are known as the primary candidate antibiotics, but sti...

The aims of this study was to synthesize of C-4-alyloxy-3-methoxyphenylcalix[4]resorcinarene (3). The syntheses was conducted by condensation reaction of resorcinol with 4-allyloxy-3-methoxybenzaldehyde (2) in ethanol with hydrochloric acid as a catalyst. The (2) compound was synthesized by the reaction of the 4-hydroxy-3-methoxybenzaldehyde (vanil...

The previous study showed that xanthone had antiplasmodial activity. Xanthone, with additional hydroxyl groups, was synthesized to increase its antiplasmodial activity. One of the strategies to evaluate a compound that can be developed into an antimalarial drug is by testing its mechanism in inhibiting heme polymerization. In acidic condition, hema...

Objective: In our previous study, we have found many isolates of bacteria from Zingiber officinale rhizosphere in Magelang, Central Java, Indonesia. J4, one of the isolates, has been found to contain metabolites which have antibacterial activity. The active chemical compound was unidentified. This study aims to identify the molecular formula of the...

Overexpression of mutant p53 in cancer cell inactivates the p53 pathways to execute apoptosis and cell cycle arrest. This study aimed to synthesize new kardiena derivative compound, 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one, to reactivate the p53 pathways to execute apoptosis and cell cycle arrest. Characterization of the synthetic...

Setiawati S, Nuryastuti T, Sholikhak EN, Lisdiyanti P, Pratiwi SUT, Sulistiyanti TR, Ratnakomala S, Jumina, Mustofa. 2021. The potency of actinomycetes extracts isolated from Pramuka Island, Jakarta, Indonesia as antimicrobial agents. Biodiversitas 22: 1104-1111. Actinomycetes are one of the Gram-positive bacteria which are widely distributed and p...

Penelitian terdahulu menunjukkan bahwa fraksi ke-6 (F6) merupakan fraksi aktif (F-akt) daun Tithonia diversifolia (Hemsley) A.Gray yang menghambat pertumbuhan Plasmodium. Pertumbuhan parasit ini memerlukan energi yang diperoleh dari aktivitas laktat dehidrogenase (LDH). Penelitian ini bertujuan mengkaji aktivitas antiplasmodium fraksi aktif T. dive...

Low molecular weight (LMW) antiplasmodial compounds isolated from bacteria, particularly Streptomyces have not been widely reported. This study aimed to identify LMW compounds from Streptomyces sp. GMR22 as antiplasmodial. Isolation of the LMW compounds from the supernatant of fermentation culture using solvent of n-hexane:ethylacetate (EtOAc) (85:...

Marine-derived Streptomyces sp. GMY01 is a potential actinobacteria which have anticancer activities. In previous studies, several anticancer agents exhibited antiplasmodial activity. This study aimed to evaluate antiplasmodial activity of GMY01 extract using bioassay guided fractionation. Crude extract of ethyl acetate was obtained from supernatan...

In our previous study, some amino chalcone derivatives have been synthesized and evaluated their cytotoxicity against breast cancer cell line T47D. Among 11 amino chalcone derivatives, ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one)) exhibited the most active compound.This study aimed to investigate cytotoxic activity of the ((E)-1-(4-aminophenyl)-...

Hypertension is a degenerative disease whose prevalence is high and continues to increase over time. Polyherbal tablet have long been used by Indonesian people for hypertension drugs containing garlic (Alium sativum), jelawe (Belericae fructus), temu ireng rhizomes (Curcumae aeruginosae) and kapulaga (Amomi fructus) extracts. This study aims to det...

This research aims to examine the capability of poly-37,40-diallyl-38,39,41,42,-tetrahydroxy-calix[6]arenes as adsorbent for heavy metal cations such as Cd(II), Cr(III) and Cu(II). The adsorption process was carried out by batch method in the variation of acidity (pH), contact time and initial concentration of metal ions. The adsorption kinetics an...

Genome mining study showed that marine-derived Streptomyces sp. GMY01 is a potential actinobacteria with abundant of secondary metabolite and anticancer activity. The study aimed to evaluate bioassay guided fractionation for antiplasmodial screening of GMY01 extract and to predict compound on active fractions. Ethyl acetate fraction was obtained fr...

Background Polyherbal formula (PHF) contains extract of Sauropus androgynous (L.) Merr., Trigonella foenum-graceum L., and Moringa oleifera Lam. considered to induce galactagogue activity. This research aimed to evaluate the galactagogue activity of PHF and its effects on α-lactalbumin (LALBA) as well as aquaporin (AQP) gene expression at messenger...

Harmsiopanax aculeatus leaf, locally name kapur, has been use traditionally to treat malaria in Maluku, Indonesia. However, the scientific evidences that support its use are still limited. This study aimed to investigate antiplasmodial activity of H. aculeatus leaf extract and its cytotoxicity on cancer cells line. Three extracts i.e. methanolic, n...

Ciprofloxacin is recommended for complicated urinary tract infection (UTIs) caused by multidrug-resistant pathogens included Escherichia coli. However, its optimum dose for UTIs remains uncertain that may cause the bacterial resistance. This study was conducted to evaluate the effects of ciprofloxacin concentrations on the resistance of E. coli. Th...

Background: Most of breast cancer patients are estrogen receptor alpha-positive and have high resistance and side effect of chemotherapeutic drug. Therefore, discovering an effective anticancer agent is needed. This research explored the effect of (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one (APE) on miR-18a, Dicer1, and MMP-9 expressions. Meth...

Actinomycetes are filamentous Gram-positive bacteria that potential sources of antimicrobial substances. The aim of this study was to isolate actinomycetes from different soil types in Enggano Island and screened their antimicrobial activity. The phenol method with 802 medium and humic acid vitamin (HVA) medium was used to isolate the actinomycetes...

Background: The ageing process (photoaging) can be caused by sun exposure, especially ultraviolet light. Organic and inorganic sunscreen products are commercially available. Two calixarene organic compounds, namely C-phenylcalix[4]resorcinaryl octacinnamate and C-methylcalix[4]resorcinaryl octabenzoate, have been successfully synthesized. Besides,...

The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its blood pressure-lowering effect on a rat model of hypertension. However, toxicity data were not available for t...

Soursop consumption is beneficial to health, but there have been few clinical studies observing its benefit in human subjects. We investigated the effects of soursop supplementation on blood pressure (BP), serum uric acid (SUA), and kidney function. A total of 143 subjects were included in this randomized controlled trial. Subjects were selected fr...

Background The increasing rate of cancer chemoresistance and adverse side effects of therapy have led to the wide use of various chemotherapeutic combinations in cancer management, including lymphoid malignancy. Objective We investigated the effects of a combination of 1,3,6-trihydroxy-4,5,7-trichloroxanthone (TTX) and doxorubicin on the Raji lymp...

Chlorogenic acid (CGA) is known to have antioxidant potentials, yet the effect of CGA on brain ischemia has not been sufficiently understood. Brain ischemia such as transient global ischemia disrupts many areas of the brain of rats, including the hippocampus. Male Wistar rats were randomly assigned into five groups, that is, sham‐operated (SO), bil...

The synthesis of N-phenylpyrazolines 1-5 was performed by the cyclocondensation of phenylhydrazine and appropriate chalcones that have been synthesized from our previous work. All of the compounds were elucidated for their structure using GC-MS, FTIR, 1H, and 13C-NMR spectrometers. Their anticancer activity was evaluated against breast cancer cell...

The main obstacle in antimycobacterial discovery is the extremely slow growth rates of pathogenic mycobacteria that lead to the long incubation times needed in antimycobacterial screening. Some in vitro testings has been developed and are currently available for antimycobacterial screening. The aim of the study was to compare Resazurin Microplate A...

Background: Diabetes mellitus (DM) is an urgent global health issue with increased annual prevalence. The uncontrolled hyperglycemia may induce an oxidative stress state which could lead to the development of diabetic related complications. Several studies showed that mahogany seed contains 1,4-bis-3,4,5-trimethoxy-phenyl-tetrahydro-furo(3,4-c) fur...

Background: Cervical cancer is one of the most prevalent gynecological cancers worldwide and contributes in high mortality of Indonesian women. The efficacy of chemotherapy as a standart therapy for cervical cancer decreases because it frequenly rises adverse effects. Recent studies have found that metformin has a potential anticancer effect mostl...

Xanthone compounds are of great interest due to their wide range of biological applications. Xanthone compounds can be obtained by structural modification of the substituent on the xanthone rings through various reactions. In this study, the chloro-substituted hydroxyxanthones (4a-c) were prepared by cyclodehydration of acid derivatives and substit...

Dyslipidemia is one of the high-risk factors that cause cardiovascular disease and the prevalence is increasing all the time. Garlic (Alii sativi) has been suggested to reduce serum lipid level. Poly-herbal is herbal medicine that has been widely used in Indonesia, and it contains Alii sativi, Belericae fructus, Curcumae aeroginosae, and Amomi fruc...

Alcohol abuse occurs in the younger generation of Indonesia. ALDH2 gene polymorphisms need to be examined especially regarding its influence on the liver function status of alcohol drinkers in Indonesia. This study aimed to determine the effect of the ALDH2 types on the liver function status of alcohol drinkers in Indonesia. This study used a cross...

Chloro chalcone derivatives 1-5 were synthesized by the conventional and sonochemical method. A significant enhancing effect in reaction time was observed in chalcones synthesis under ultrasound irradiation. Characterization of all chalcones was conducted by GC-MS, FTIR and NMR spectrometers. Anticancer evaluation displayed that chalcone 3 has high...

Background. One of methoxy aminochalcone derivatives, (E)-1-(4-aminophenyl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one has been synthesized and proven it's in vitro antiplasmodial activity. In this study, we reported in vivo antiplasmodial activity of this compound against Plasmodium berghei infected mice. Its effect on the haemozoin and erythrocytes s...

Objective: The study aimed to investigate the blood pressure lowering effect of the polyherbal preparation contains Allium sativum, Belericae fructus, Curcuma aeruginosa, and Amomi fructus in the animal model of hypertension. Methods: Deoxycorticosterone acetate uninephrectomy salt rat model was used to develop hypertension model. Hypertensive rats...

Background: Chemotherapy is a common treatment for leukemia as well as in other cancer treatment. The lack of tumor selectivity and development of multi-drug resistance by chemotherapy caused the development of new strategy in cancer treatment become a pressing need. This study was performed to evaluate the anticancer activity and selectivity of se...

Telah diketahui bahwa fraksi metanol akar pasak bumi mempunyai aktivitas antiplasmodium in vitro yang kuat. Namun belum diketahui isolat yang manakah yang aktif sebagai antiplasmodium. Penelitian ini bertujuan untuk menguji aktivitas antiplasmodium dan sitotoksisitas 5 isolat yang diisolasi dari fraksi metanol akar pasak bumi. Uji aktivitas antipla...

Previous research revealed that the extracts and fractions of Tithonia diversifolia (Hemsley) A.Gray leaves had antiplasmodial activity in vitro. For further development as an antiplasmodial agent, the mechanisms of action and safety of compounds are important to disclose. Heme polymerization inhibition is one of the main targets of antiplasmodial...

This research was conducted to evaluate the anticancer activity of new compounds of benzyl-1,10-phenanthroline derivatives and their selectivity. In vitro anticancer activity of 11 benzyl-1,10-phenanthroline derivatives were conducted on three human cancer cell lines, cervical cancer (HeLa), myeloma (NS-1), and breast cancer (MCF-7) using MTT-based...

Purpose: To investigate the antiplasmodial and onset of growth inhibitory activities of T. diversifolia fractions against Plasmodium falciparum FCR3 strain. Methods: Seven fractions of T. diversifolia (F1-F7) were used in this study. Phytochemical analysis was conducted to identify the major compounds in the fractions. Various concentrations of fra...

This paper describes synthesis and Heme Polymerization Inhibitory Assay of a new arylamino alcohol derivative compound from methyl eugenol. The synthesis has done through epoxidation of methyl eugenol using peracetic acid. The epoxide of methyl eugenol then was converted to arylaminoalcohol derivative by opening epoxide moiety with aniline. The str...

Objective: Cervical cancer is the second most common cancer among women worldwide, with a high mortality rate especially in developing countries. Insufficient treatment for cervical cancer, multiple side effects, and high drug prices encourage researchers to look for effective and selective cancer drugs with appropriate molecular targets. This stud...