Mustafa Steve Kassem

Mustafa Steve Kassem
Neuroscience Research Australia · Paxinos Group

PhD

About

8
Publications
2,095
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289
Citations

Publications

Publications (8)
Article
Background Since Cajal’s visualisations of the synaptic spine, this feature of the neuron has been of interest to neuroscientists and has been investigated usually in reference to degeneration or proliferation of dendrites and their neurons. Synaptic spine measurement often forms a critical element of any study investigating neuronal morphology. Ho...
Book
Neuroanatomical reference work, a chemoarchitectonic atlas of the rat brain - brain sections seen with 8 different stains, every section annotated with all visible nuclei and structures.
Article
Few animal models exist that successfully reproduce several core associative and non-associative behaviours relevant to post-traumatic stress disorder (PTSD), such as long-lasting fear reactions, hyperarousal, and subtle attentional and cognitive dysfunction. As such, these models may lack the face validity required to adequately model pathophysiol...
Article
Background and objective Alterations in the gray matter volume of several brain regions have been reported in people with chronic pain. The most consistent observation is a decrease of gray matter volume in the medial prefrontal cortex. These findings are important as the medial prefrontal cortex plays a critical role in emotional and cognitive pro...
Article
One neuropathological feature of schizophrenia is a diminished number of dendritic spines in the prefrontal cortex and hippocampus. The neuregulin 1 (Nrg1) system is involved in the plasticity of dendritic spines, and chronic stress decreases dendritic spine densities in the prefrontal cortex and hippocampus. Here, we aimed to assess whether Nrg1 d...
Article
Background: High resolution neuronal information is extraordinarily useful in understanding the brain's functionality. The development of the Golgi-Cox stain allowed observation of the neuron in its entirety with unrivalled detail. Recently tissue clearing techniques, e.g., CLARITY and CUBIC, provide the potential to observe entire neuronal circui...
Article
Full-text available
Stress has been linked to the pathogenesis of schizophrenia. Genetic variation in neuregulin 1 (NRG1) increases the risk of developing schizophrenia and may help predict which high-risk individuals will transition to psychosis. NRG1 also modulates sensorimotor gating, a schizophrenia endophenotype. We used an animal model to demonstrate that partia...
Article
Full-text available
Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and to identify the cellular consti...

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