Mustafa Cengiz

Mustafa Cengiz
Hacettepe University · Faculty of Medicine

Professor

About

192
Publications
12,782
Reads
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2,179
Citations
Citations since 2017
31 Research Items
874 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
Introduction
Skills and Expertise

Publications

Publications (192)
Chapter
Baş-boyun kanserleri, genel olarak tüm kanserlerin yaklaşık %3'ünü oluşturmaktadır. Yılda, dünyada 650.000 yeni vaka görülmekte ve bu hastaların yaklaşık %50'si hastalığa bağlı olarak hayatını kaybetmektedir. Lokal yineleme, tedavi modalitelerindeki gelişmelere rağmen baş-boyun kanserli hastaların %15-50'sinde görülmektedir ve hastaların önemli bir...
Article
Purpose/Objective(s) To investigate the clinical outcomes of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy (CRT). Materials/Methods The clinical data of 180 patients received concurrent CRT between April 2005 and September 2021 at 17 institutions were retrospectively analyzed. All patients were treated with curat...
Article
Purpose/Objective(s) In patients with nasopharyngeal carcinoma (NPC), induction chemotherapy (IC) is an appealing option in case of bulky lymphadenopathy. In our institution, we prefer IC followed by chemoradiotherapy in these patients. When delineating the lymphatic target volumes, we define the gross tumor volume (GTV) lymph node according to the...
Article
Objectives In metastatic and recurrent head and neck cancer (M/R HN-SCC), the median survival is less than a year and locoregional recurrence is the main cause of death. Our aim was to evaluate the results of concurrent stereotactic body radiotherapy (SBRT) and immunotherapy (ICI) in these patients. Materials and methods Fifteen patients diagnosed...
Article
Full-text available
The aim of the study is to investigate factors that may cause radiation-induced lung disease (RILD) in patients undergoing stereotactic body radiotherapy (SBRT) for lung tumors. Medical records of patients treated between May 2018 and June 2019 with SBRT were retrospectively evaluated. All patients should have a diagnosis of either primary non-smal...
Article
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Purpose: Stereotactic body radiotherapy (SBRT) is an effective treatment option for patients with early-stage non-small cell lung cancer (NSCLC). In this study, we evaluated the treatment results using two different SBRT techniques and the effect of beam-on time (BOT) on treatment outcomes. Methods: Between July 2007 and January 2018, 142 patien...
Article
Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These tumors are rare and only make bone metastases at a rate of 5%. Case summary: A 31-year-old male with a GIST presented with solitary bone metastasis at the right iliac bone. We performed stereotactic ablative radiotherap...
Article
Full-text available
OBJECTIVE To assess the validity and reliability of the EORTC-QLQ-HN35 in Turkish head and neck cancer (HNC) patients. METHODS EORTC QLQ-C30 and QLQ-HN35 scales were completed by patients at the beginning, middle and end of radiotherapy. Internal consistency was assessed by Cronbach alpha and test-retest reliability by intra- class correlation coef...
Article
Purpose: To evaluate the efficacy and toxicity of hypofractionated radiotherapy in non-metastatic soft tissue and bone sarcomas. Patients and methods: Thirty patients underwent hypofractionated radiotherapy between 2007 and 2015. Overall, 17 patients underwent primary hypofractionated radiotherapy, nine underwent hypofractionated radiotherapy fo...
Article
The study aimed to show the changes on artrokinematic parameters of the neck and swallowing function after radiotherapy (RT) in head and neck cancer (HNC) patients. The fourty patients with HNC have been evaluated before, 1 and 3 months after RT. The pos- ture, normal joint movement, muscle strength and endurance of the neck were evaluated as artro...
Chapter
This chapter on gastrointestinal cancers is aiming to summarize the evidence-based current management for esophagus, gastric, pancreas, rectum and anal cancers. We hope to ease the understanding in the appropriate delineation of tumor volumes/fields along with related case presentations covering diagnostic images, contouring, slice by slice final p...
Article
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Bedük Esen ÇS, Gültekin M, Aydın GB, Akyüz C, Karlı Oğuz K, Orhan D, Cengiz M, Gürkaynak M, Yıldız F. Ewing sarcoma in an infant and review of the literature. Turk J Pediatr 2019; 61: 760-764. Ewing sarcoma (ES) is a rare tumor in infants and prognosis is controversial. There are no standard recommendations for treatment in such very young patients...
Article
Introduction: There are numerous diseases that are claimed to have a correlation with AB0 blood groups. Analysis on distribution of blood groups in primary brain tumors and clinical value has revealed conflicting results. The purpose of this study is to evaluate the association between AB0 blood groups and glial neoplasms (GN) and their effects on...
Article
Full-text available
Treatment options for recurrent/metastatic sinonasal cancer (RMSNC) patients are limited. We present two cases with RMSNC treated with a combination of immune checkpoint blockade and hypo-fractionated stereotactic radiotherapy (HSRT). Case 1 presented with RMSNC three months after the primary treatment. The patient progressed under first-line chemo...
Article
Full-text available
Background: The aim of this study was to determine the HPV positivity rate in patients with laryngeal cancer, and to determine the effect of HPV positivity on survival. An additional aim was to determine if patients with HPV positive laryngeal cancer are more sensitive to chemotherapy and if such sensitivity differs according to chemotherapy proto...
Article
Purpose: To estimate the radiobiological parameters of three popular NTCP models, which describe the dose-response relations of carotid blowout syndrome (CBOS) after stereotactic body radiotherapy (SBRT). To evaluate the goodness-of-fit and the correlation of those models with CBOS. Methods: The study included 61 patients with inoperable locally...
Article
Objective: To assess whether delineation courses for radiation oncologists improve interobserver variability in target volume delineation for postoperative gastric cancer radiotherapy planning. Methods: Twenty-nine radiation oncologists delineated target volumes in a gastric cancer patient. An experienced radiation oncologist lectured about deli...
Conference Paper
Full-text available
Introduction: There are numerous diseases that are claimed to have a correlation with ABO blood groups. The association with malignancy, especially with exocrine pancreas malignancy, has been documented. Analysis on distribution of blood groups in primary brain tumors and clinical value has revealed conflicting results. The purpose of this study i...
Article
Background and aims: Oral mucositis and esophagitis are common acute toxicities of radiotherapy (RT) for head and neck cancer (HNC). In order to decrease the rates of these toxicities, we compared quality of life in HNC patients that did and did not receive a glutamine and arginine-enriched solution (GAES) during RT. Methods: A total of 29 patie...
Article
Background: This study aimed to evaluate the efficacy and safety of hypofractionated stereotactic radiotherapy for reirradiation of recurrent pediatric tumors. Methods and materials: The study included 23 pediatric patients who were reirradiated using hypofractionated stereotactic radiotherapy in the radiation oncology department between January...
Article
Full-text available
Background The effects of spinal implants on dose distribution have been studied for conformal treatment plans. However, the dosimetric impact of spinal implants in stereotactic body radiotherapy (SBRT) treatments has not been studied in spatial orientation. In this study we evaluated the effect of spinal implants placed in sawbone vertebra models...
Article
Purpose To evaluate the impact of leg position on the dose distribution during intracavitary brachytherapy for cervical cancer. Patients and methods This prospective study was performed on 11 women with cervical cancer who underwent intracavitary brachytherapy. After insertion of the brachytherapy applicator, two sets of computed tomography slices...
Article
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Purpose: The aim of this study was to report the outcome in children with high-grade astrocytoma outside the brain stem and spinal cord that were treated at a single center. Materials and methods: The study included 26 patients with anaplastic astrocytoma and 37 patients with glioblastoma; all patients were aged ≤18 years. At initial diagnosis,...
Article
Aim: To determine the methylation pattern of the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene in laryngeal cancer and normal laryngeal mucosa samples using pyrosequencing, and to determine the relationship between the methylation pattern of MGMT, and tumor stage, survival, recurrence, and chemosensitivity in patients w...
Article
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OBJECTIVE: The purpose of the present study was to investigate dosimetric and mechanical stability of CyberKnife Robotic Radiosurgery System (Accuray Inc.,Sunnyvale, CA, USA) in short- and longterm period. METHODS: Output factor measurements and automated quality assurance (AQA) tests performed on CyberKnife unit 2009-2013 at radiation oncology dep...
Article
Full-text available
Purpose: The aim of the study was to determine the changes in swallowing function and quality of life in early period after radiotherapy in head and neck cancer (HNC) patients. Methods: Fourty patients with HNC were included in the study. Swallowing function was evaluated by Modified Barium Swallowing Study. Penetration-Aspiration Scale was used to...
Conference Paper
Purpose/Objective(s) The aim of this study is to assess whether ‘contouring courses’ improve interobserver variability between radiation oncologists in target volume delineation for postoperative gastric cancer radiation therapy planning. Materials/Methods Twenty-nine radiation oncologists, who attended contouring courses were asked to delineate cl...
Chapter
A 62-year-old female with no history of cigarette smoking or alcohol use was admitted to the hospital with a complaint of a wound in the right part of oral tongue for nearly 6 months. She did not have any additional symptoms. She had diabetes type II, and it was under control with oral antidiabetic use.
Chapter
A 63-year-old male applied with left facial nerve paralysis, presenting for nearly 7 months. There was no response to steroids. In his second attack of paralysis, he also felt numbness in the lower part of the left side of his face. He had a history of social alcohol consumption for nearly 40 years but no cigarette smoking.
Chapter
A 27-year old male admitted to the hospital with swelling and redness in the left eye. He was also suffering from headache in the frontal region periodically. There was no vision loss or diplopia. He had no significant medical history other than an adenoidectomy 20 years ago.
Article
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Violence in the workplace is an increasing occupational health concern worldwide. Health care workers are at high risk of assault. To develop, monitor, and manage prevention policies, baseline data should be available. This cross-sectional study was designed to determine the current extent of workplace violence nationwide in Turkey. The study popul...
Article
To evaluate the radioprotective efficacy of amifostine on irradiated mature rat retina. A total of 108 Wistar albino rats were categorized into 3 groups, namely, apoptosis (n = 48), acute effects (n = 40), and late changes in retinal cell layers (n = 20). Each group was further subcategorized into 4 arms: control, amifostine (A), radiotherapy + pla...
Article
The prognosis of small cell lung cancer (SCLC) has been improving with the advances in diagnostic and therapeutic modalities. Positron emission tomography/computed tomography (FDG-PET/CT) which has been studied in non-small cell lung cancer (NSCLC) for a long time, and it has only recently been applied to SCLC. Therefore we sought to observe firstl...
Article
The aim of this study was to evaluate the efficacy and toxicity of robotic CyberKnife (Accuray Incorporated, Sunnyvale, California)-based stereotactic body radiation therapy (SBRT) in patients with recurrent or metastatic abdominopelvic tumors. A total of 69 patients treated between May 2008 and January 2011 were evaluated retrospectively. Indicati...
Article
Full-text available
The standard treatment of local advanced nasopharyngeal cancer is chemoradiotherapy. There is a lack of data concerning induction therapy. In this study we retrospectively examined patients treated with induction therapy and chemoradiotherapy. Locally advanced nasopharyngeal cancer patients treated between 1996 and 2013 in our clinic were included...
Chapter
Once the tumor spreads into a lymph node, it expands the node, and the spherical node becomes rounded. Then, the capsule is invaded, leading to extension to adjacent tissues which is called extracapsular extension. Extracapsular extension impacts prognosis and survival of patients with head and neck cancers significantly.
Article
Treatment choices for recurrent glioblastoma patients are sparse and the results are not satisfactory. In this retrospective analysis, we evaluated the results of re-irradiation of locally recurrent glioblastoma patients with an image-guided, fractionated, frameless stereotactic radiotherapy (SRT) technique. We treated 37 patients with the diagnosi...
Article
Full-text available
Objective: The aim of this study was to find the most appropriate technique for postmastectomy chest wall (CW) and lymphatic irradiation. Materials and methods: Partially wide tangent, 30/70 photon/electron mix, 20/80 photon/electron mix and CW and internal mammary en face electron field, were studied on computerized tomography (CT) scans of 10...
Article
Full-text available
Aims and background: The aim of the study was to review the current clinical practices of radiation oncologists involved in the treatment of oropharyngeal cancer. Methods and study design: The daily practices of radiation oncology centers for patients diagnosed with oropharyngeal cancer in 2010 were evaluated by a two-part questionnaire that sep...
Article
Full-text available
The aim of the study was to review the current clinical practices of radiation oncologists involved in the treatment of oropharyngeal cancer.
Article
Despite radical radiotherapy and chemotherapy (CT), the prognosis of locally advanced nonsmall cell lung cancer (NSCLC) is poor. New prognostic indicators are being looked forward to improve the survival. [18F]-fluorodeoxyglucose (FDG) uptake on PET/CT has been observed as a prognostic marker mainly in early-stage disease. Our aim was to examine th...
Article
Introduction: The incidence of glioblastoma increases with advancing age. In this study we evaluated our therapeutic results in elderly patients with glioblastoma. Materials and Method: The charts of 65 patients age ≥65 and treated between January 2002 and December 2011 in our department were assessed. Forty-five patients were male and the median a...
Article
Full-text available
This study aimed to compare the therapeutic outcomes and fatal carotid blow out syndrome (CBOS) incidence rates between two different stereotactic body radiotherapy (SBRT) protocols. The study included 75 patients with inoperable locally recurrent head and neck cancer treated with SBRT in our department between June 2007 and March 2011. The first 4...
Article
Full-text available
The aim of this retrospective study is to evaluate our therapeutic results in patients with paranasal sinus (PNS) or nasal cavity (NC) malignancies treated with robotic stereotactic radiosurgery (SRS). Between August 2007 and October 2008, 27 patients with PNS or NC tumors were treated in our department using SRS. Median age was 53 years (range, 27...
Article
Chordomas are uncommon neoplasms and there is still controversy regarding establishment of diagnosis and management. The aim of this study was to evaluate efficacy and toxicity of fractionated stereotactic radiosurgery (FSRS) in skull base chordomas. There were 4 female (36%) and 7 male (64%) patients. FSRS was delivered with CyberKnife (Accuray In...
Article
Purpose: The authors evaluated the absorbed dose received by the gonads during robotic stereotactic radiosurgery (SRS) for the treatment of different tumor localizations. Methods: The authors measured the gonad doses during the treatment of head and neck, thoracic, abdominal, or pelvic tumors in both RANDO phantom and actual patients. The comput...
Article
Sinonasal mucosal melanoma (SNMM) is a rare entity originating from melanocytes of the sinonasal mucosa. Postoperative radiotherapy is recommended in all cases to increase local control. However, external radiotherapy is rarely used as a definitive treatment modality. In this report, we present 4 cases of SNMM treated with CyberKnife (Accuray, Sunn...
Data
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Local tumor persistence in the pelvis is the major cause of death in patients with recurrent gynecological cancer. Pelvic exenterati-on has been the only treatment option providing a chance for cure in selected patients. The aim of this study is to analyze the effi-cacy of stereotactic body radiosurgery (SBRS) in patients with recurrent gynecologic...
Article
Full-text available
CNS metastases usually appears late in the progression of metastatic breast cancer. Classical approach is evaluating and treating them when symptoms become evident. We evaluated the survival and described clinicopathologic characteristics of patients in whom the brain metastases after adjuvant treatment or at initial diagnosis are the first and the...
Article
We evaluated the treatment results of robotic stereotactic radiosurgery (SRS) in our patients with unresectable glomus jugulare tumors (GJTs). The medical charts of fourteen patients with GJT, who were treated with robotic SRS, were retrospectively evaluated. The gross tumor volume was described as the clinical target volume. The median dose to the...
Article
The purpose of this study was to investigate the prognostic factors and treatment results of T1N0M0 glottic laryngeal carcinoma irradiated with 2.3 Gray (Gy) per fraction. A total of 183 patients with glottic carcinoma treated between June 1998 and January 2007 were retrospectively evaluated. Of the 183 patients, 163 patients (89%) had T1a and 20 p...
Article
Purpose: In this study, the neutron measurements were performed in free in air and RW3 solid water phantom to estimate the secondary malignancy risk for three dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiotherapy (IMRT) techniques in prostate cancer treatment. Methods: Neutron dose were measured in 18 MV Elekta Synergy Pl...
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Full-text available
We assessed the efficacy and toxicity of ifosfamide and doxorubicin combination chemotherapy (CT) regimen retrospectively in Turkish patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) previously treated with platinum-based chemotherapy. A total of thirty patients who had received cisplatin based chemotherapy/chemoradiotherapy as a...