Musa Vuyisile Mabandla

Musa Vuyisile Mabandla
University of KwaZulu-Natal | ukzn · School of Laboratory Medicine and Medical Sciences

PhD

About

99
Publications
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Introduction

Publications

Publications (99)
Article
Post-traumatic stress disorder (PTSD) is a risk factor in the development and progression of Alzheimer's disease (AD), with unclear underlying mechanisms. Recently, we provided data showing the effect of trauma-like stress on Bin1 and Fkbp5 expression in the prefrontal cortex of Aβ(1-42) lesioned animals. This present work sought to expand the stud...
Article
Introduction: Current models used to study the pathophysiology of major depressive disorder (MDD) are laborious and time consuming. This study examined the effect of a 14-day combined stress model (CS; corticosterone injection and restraint stress) in male Sprague Dawley rats and also compare the effect of CS versus 28-day corticosterone treatment...
Article
Alzheimer's disease (AD) affects several brain areas, including the prefrontal cortex (PFC) involved in execution, working memory, and fear extinction. Despite these critical roles, the PFC is understudied in AD pathology. People with post-traumatic stress disorder (PTSD) have twice the risk of developing AD, and the underlying mechanisms linking t...
Article
Full-text available
Background : Neuroinflammation alters the microenvironment in certain areas of the brain resulting in the development of Parkinson's disease (PD). Mechanisms involving cytokine and non-cytokine induced pathways are activated in the inflammatory response following injury. The proteolytic activity of bromelain appears to eliminate receptors on immune...
Article
Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that develops from exposure to trauma, mostly when normal psychological mechanisms fail. Studies have shown that people who have PTSD are susceptible to developing dementia, mostly Alzheimer's disease (AD), suggesting common underlying risk factors in the comorbidity. However, dat...
Article
Full-text available
Background An animal model of prediabetes that has been developed in our laboratory using a high fat high carbohydrate diet and lack of physical activity displays risk factors for cardiovascular complications. The effect of exercise against these risk factors in this animal model remains unknown. Therefore, we evaluated the effect of intermittent a...
Article
The incidence of HIV-associated neurocognitive disorder (HAND) continues despite the introduction of combination antiretroviral drugs (cART). Several studies have reported the neurotoxicity of individual antiretroviral drugs (monotherapy), while the common approach for HIV treatment is through cART. Hence, the current study investigated the effects...
Research
Episodic memory is a complex cognitive process that allows the encoding, storage and retrieval of unique events associated with the context in which they occurred. The memory function is however affected in Parkinson’s disease (PD) and this is quite associated with the functional loss of brain derived neurotrophic factor (BDNF) which is highly expr...
Article
Episodic memory is a complex cognitive process that allows the encoding, storage and retrieval of unique events associated with the context in which they occurred. The memory function is however affected in Parkinson’s disease (PD) and this is quite associated with the functional loss of brain derived neurotrophic factor (BDNF) which is highly expr...
Article
Full-text available
Febrile seizures, commonly in children between the ages of 3 months to 5 years, are a neurological abnormality characterized by neuronal hyper-excitability, that occur as a result of an increased core body temperature during a fever, which was caused by an underlying systemic infection. Such infections cause the immune system to elicit an inflammat...
Article
Full-text available
Changes associated with cognitive function in the high-fat high-carbohydrate diet-induced prediabetes animal model and effect of exercise remain unclear. Rats were randomly assigned to the following groups (n = 6): non-diabetic (ND), prediabetic (PD), intermittent exercising PD (PD + IE) and regular exercising PD (PD + RE). After exercise cessation...
Article
Emerging evidence indicates that the pathogenesis of Alzheimer’s disease (AD) is not confined to neuronal disruptions but robustly communicates with the brain’s immune system. Genome-wide analysis suggests that several genes, which increase the risk for AD, encode for factors that regulate the glial clearance of misfolded proteins and the inflammat...
Article
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Objectives Growing evidence suggested that antiretroviral drugs (ARV) may promote β-amyloid accumulation in HIV‐1‐infected brain and the persistence of HIV-associated neurocognitive disorders (HAND). It has also been shown that lipid peroxidation upregulates β-site APP-cleaving enzyme 1 (BACE1) expression and subsequent promote β-amyloid peptide pr...
Article
Background Depression is the most significant cause of suicide among neuropsychiatric illnesses. Major depression further affects the quality of life in an individual with epilepsy. The treatment of depression in an epileptic patient could be very challenging because of drug selection or the fact that some antiepileptic drugs are known to cause dep...
Article
Full-text available
Nonmotor symptoms (NMS) such as anxiety, depression, and cognitive deficits are frequently observed in Parkinson’s disease (PD) and precede the onset of motor symptoms by years. We have recently explored the short-term effects of Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) on dopaminergic neurons in a parkinsonian rat model. Here,...
Article
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Prolonged febrile seizures are usually modelled in animals using hyperthermia as an inducer. In this study, a modified simple febrile seizure model using a combination of lipopolysaccharide (LPS) and kainic acid (KA) was used to develop a prolonged febrile seizure animal model, which we used to assess effects on the expression of the sodium– potass...
Article
Full-text available
Alzheimer’s disease is a complex debilitating neurodegenerative disease for which there is no cure. The lack of reliable biomarkers for Alzheimer’s disease has made the evaluation of the efficacy of new treatments difficult and reliant on only clinical symptoms. In an aged population where cognitive function may be deteriorating for other reasons,...
Article
Dysregulation of inflammatory markers like cytokines is implicated in the pathophysiology of Alzheimer's disease (AD). Altered level of these cytokines show that pathogenesis of AD is beyond dysfunction of neurons resulting from amyloid beta accumulation but involves neuroinflammatory mechanisms elicited by the neuroimmune cell. In this study, we i...
Article
Epilepsy is a debilitating neurological illness that affects all aspect of an individual life. Despite advancement in research there is little reduction in the incidence of this disease. Prolonged febrile seizure (PFS) has been linked to epilepsy however, the pathophysiology of this is still not clear. We therefore looked at the effect of PFS on th...
Article
Full-text available
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. The conventional therapeutic measures which include the widely used L-DOPA therapy, are inefficient especially when dopamine loss is severe, and the physical symptoms are full blown. Since neuroinflammation is a core feat...
Article
Full-text available
The impact of febrile seizure has been shown to transcend immediate generation with the alteration of glutamatergic pathway being implicated. However, transgenerational effects of this neurological disorder particularly prolonged febrile seizure (PFS) on neurobehavioral study and methylation profile is unknown. We therefore hypothesized that transg...
Article
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Introduction: Reports indicate that oral administration of plant-derived maslinic acid (MA) exhibits hypoglycemic and renoprotective effects in streptozotocin (STZ)-induced diabetic rats. Challenges with triterpenes such as MA include low bioavailabilty which affects treatment efficacy in experimental animals. The goal of this study was to synthesi...
Conference Paper
Here, we explored the hypothesis that parental cocaine exposure could alter epigenetic machinery in their drugnaive offspring while early postnatal fostering may further modify the accompanied neurochemical and functional components. Variant drug-naive pups were produced from cocaine-exposed or unexposed C57BL/6 female mice that were matched with t...
Article
Full-text available
Here, we explored the hypothesis that parental cocaine exposure could alter epigenetic machinery in their drug-naive offspring while early postnatal fostering may further modify the accompanied neurochemical and functional components. Variant drug-naive pups were produced from cocaine-exposed or unexposed C57BL/6 female mice that were matched with...
Article
Full-text available
Oleanolic acid (OA), a biologically active pentacyclic triterpenoid compound, has been implicated in a number of clinical benefits including antioxidant, and anti-inflammatory properties. OA has been previously shown to ameliorate the toxic effects of 6-hydroxydopamine (6-OHDA), however, the mechanism by which this effect is exhibited is not clearl...
Article
Despite the increasing interest and efforts to prevent, treat, and control epilepsy and its clinical manifestation (seizure), the prevalence has not decreased due to incomplete understanding of its etiology. The present study aimed at determining the effect of prolonged febrile seizure (PFS) on the onset of seizure in pilocarpine rat model of tempo...
Article
Febrile seizures are a paediatric condition which affects 2–5 % of children worldwide with prolonged febrile seizures (PFS) being found to cause long-term complications and predispose patients to other neurological conditions later in life. Febrile seizures occur due to an imbalance between the excitatory neurotransmitter glutamate and the inhibito...
Article
Full-text available
Endophytic fungi isolated from medicinal plants have an important role to play in the search for new bioactive natural compounds. However, despite their potential as repositories of bioactive compounds, the endophytes of African medicinal plants are largely underexplored. The aim of this study was to isolate and identify the endophytic fungi associ...
Conference Paper
Number: 68 Objective: This study presents a novel method of predicting the behavioral pattern in male Sprague-Dawley rats with impaired learning and memory, based on the measurement of the dielectric properties (dielectric constant and conductivity) of blood plasma at microwave frequencies at different time points.
Article
Full-text available
Peripheral neuropathic condition is amongst the classical symptoms of progressed diabetes. An intensive glycemic control with insulin injections has been shown to delay the onset and the progression of this condition in diabetes. In this study, we investigated the effect of pectin-insulin patch application on peripheral neuropathic symptoms in stre...
Article
Full-text available
Human immunodeficiency virus type 1 (HIV-1) affects the central nervous system (CNS) that may lead to the development of HIV-associated neuropathologies. Tat protein is one of the viral proteins that have been linked to the neurotoxic effects of HIV. Since many individuals living with HIV often experience significant adverse circumstances, the pres...
Article
The use of combination antiretroviral therapy (cART) has been successful in suppressing HIV-1 replication and restoring peripheral immune functioning in HIV-infected individuals. Despite these advances in the management of HIV, neurocognitive impairments continue to be diagnosed in HIV-infected patients on treatment, even when the viral load is low...
Article
Full-text available
Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective. The similarity between apomorphine and dopamine with regard to their chemical, pharmacological and toxicological properties provided a basis for inve...
Article
Human immunodeficiency virus type 1 (HIV) has infected more than 40 million people worldwide and is associated with central nervous system (CNS) disruption in at least 30% of these persons. The use of highly active antiretroviral therapy (HAART) has significantly reduced the systemic immunopathology associated with HIV, but the occurrence of neurol...
Article
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Alterations in gene expression within the neural networks of prefrontal cortex (PFC) and hippocampus (HPC) are known to contribute to behavioural phenotypes associated with drug intake. However, the functional consequences of regulated expression patterns of Fosb and Crem (cAMP response element modulator) in both brain regions in response to voliti...
Article
Full-text available
Alzheimer’s disease (AD) is characterized by extracellular deposition of amyloid-β (Aβ) plaques. These protein deposits impair synaptic plasticity thereby producing a progressive decline in cognitive function. Current therapies are merely palliative and only slow cognitive decline. Poly-N-methylated Aβ-Peptide C-Terminal Fragments (MEPTIDES) were r...
Article
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This review aims to shed light on the relationship that involves exposure to early life stress, depression and Parkinson's disease (PD). A systematic literature search was conducted in Pubmed, MEDLINE, EBSCOHost and Google Scholar and relevant data were submitted to a meta-analysis . Early life stress may contribute to the development of depression...
Article
Abstract Background: Medicinal plants play an important role in the search for bioactive strains of endophytic fungi. Objective: To isolate and identify the endophytic fungi associated with Kigelia africana and Warburgia salutaris and evaluate their bioactivity. Methods: Endophytic fungi were isolated from the stem and leaf tissues of Kigelia afric...
Article
Abstract Background: The endophytes of African medicinal plants are largely underexplored despite their potential as repositories of bioactive compounds. Objective: To identify the endophytic fungi associated with Annona senegalensis and evaluate the antimicrobial and antioxidant potential of their crude ethyl acetate extracts. Method: The surface...
Article
Full-text available
Background/aims: Renal damage and dysfunction is attributed to sustained hyperglycaemia in overt diabetes. Subcutaneous insulin injections are beneficial in delaying the progression of renal dysfunction and damage in diabetics. However, the current mode of administration is associated with severe undesirable effects. In this study, we evaluated th...
Article
Full-text available
The detrimental effects of drug abuse are apparently not limited to individuals but may also impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic signatures, early life experience and environmental factors, converge to influence gene expression patterns in addiction phenotypes and consequently may serve as mediato...
Article
Full-text available
Chronic exposure to stress amplifies locomotor deficits and exacerbates dopamine neuron loss in an animal model for Parkinson’s disease. The release of neurotrophic factors such as glial cell-line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) following neuronal injury attenuates exacerbated degeneration of these neurons. In this stud...
Article
Full-text available
Febrile seizures are childhood convulsions resulting from an infection that leads to an inflammatory response and subsequent convulsions. Prenatal stress has been shown to heighten the progression and intensity of febrile seizures. Current medications are costly and have adverse effects associated with prolonged use. Quercetin flavonoid exhibits an...
Article
Full-text available
Exposure to repetitive stress has a negative influence on cognitive-affective functioning, with growing evidence that these effects may be mediated by a dysregulated hypothalamic-pituitary-adrenal (HPA) axis, abnormal neurotrophic factor levels and its subsequent impact on hippocampal function. However, there are few data about the effect of repeti...
Article
Malaria remains a major health problem in many tropical areas. Severe malaria infection is associated with secondary complications including anaemia leading to a need for the search of affordable antimalarial agents that can clear the parasitaemia and ameliorate anaemia during infection. The current study investigated the effects of transdermally d...
Article
Background: Despite the recognition that endophytic fungi are an important source of diverse and unique natural bioactive products, there are no reviews outlining how African researchers have been tapping into this bioresource. Objective: This review aims to consolidate and provide insights into the research on fungal endophytes in Africa during th...
Article
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Purpose: Cardiovascular complications are amongst the leading causes of morbidity and mortality in diabetes mellitus. Despite the beneficial effects of subcutaneous insulin administration, reports suggest that the therapy itself precipitates cardiovascular risks due to the high insulin concentration administered. It is therefore necessary to seek...
Article
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Background: Diabetics are at high risk of developing dementia associated diseases compared to non-diabetics. The learning and memory impairments manifested in diabetes are attributed to sustained hyperglycemia. Insulin injections are beneficial in preventing and attenuating the progression of these impairments. However, undesirable effects associat...
Article
Searsia chirindensis (SC) (Baker F.) (Anacardiaceae) has shown potential for the treatment of many neurological diseases however its effect on other bodily systems in neurotoxic models is not well-documented. In this study we investigated the effects of SC on blood glucose homeostasis, as well as its effect on liver and kidney function by assessing...
Article
Full-text available
The present study investigated the effects of transdermally delivered oleanolic acid (OA) monotherapy and in combination with chloroquine (CHQ) on malaria parasites and glucose homeostasis of P. berghei-infected male Sprague-Dawley rats. Oral glucose test (OGT) responses to OA-pectin patch and CHQ-OA combination matrix patch were monitored in non-i...
Data
Percentage parasitaemia data of P. berghei-infected and treated animals with various formulations. IC- Infected control; O CHQ- Orally administered chloroquine; O OA- Orally administered oleanolic acid; TD OA- Transdermally administered oleanolic acid; TD CHQ-OA- Transdermally administered chloroquine-oleanolic acid combination. (DOCX)
Data
Data obtained from non-infected and P berghei-infected rats following a 4h OGT responses to various treatments. IC- Infected control; O CHQ- Orally administered chloroquine; O OA- Orally administered oleanolic acid; TD OA- Transdermally administered oleanolic acid; TD CHQ-OA- Transdermally administered chloroquine-oleanolic acid combination. (DOCX)
Data
Short-term effects of various treatments on blood glucose concentrations of non-infected and infected animals. IC- Infected control; O CHQ- Orally administered chloroquine; O OA- Orally administered oleanolic acid; TD OA- Transdermally administered oleanolic acid; TD CHQ-OA- Transdermally administered chloroquine-oleanolic acid combination. (DOCX)
Data
Terminal plasma insulin concentrations following a 4h oral glucose tolerance tests. IC- Infected control; O CHQ- Orally administered chloroquine; O OA- Orally administered oleanolic acid; TD OA- Transdermally administered oleanolic acid; TD CHQ-OA- Transdermally administered chloroquine-oleanolic acid combination. (DOCX)
Data
Short-term effects of various treatments on plasma insulin concentrations of non-infected and P. berghei-infected animals. IC- Infected control; O CHQ- Orally administered chloroquine; O OA- Orally administered oleanolic acid; TD OA- Transdermally administered oleanolic acid; TD CHQ-OA- Transdermally administered chloroquine-oleanolic acid combinat...
Data
Liver and muscle glycogen concentrations following oral administration of CHQ (O CHQ), OA (O OA) and transdermal application of OA (TD OA) and or CHQ-OA (TD CHQ-OA). IC- Infected control; O CHQ- Orally administered chloroquine; O OA- Orally administered oleanolic acid; TD OA- Transdermally administered oleanolic acid; TD CHQ-OA- Transdermally admin...
Article
Full-text available
Background Current malaria treatment is either “anti-parasitic”, “anti-infectivity” or both without addressing the pathophysiological derangement (anti-disease aspect) associated with the disease. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory properties whose effect on malarial and accompanying pathophysiol...
Article
Cytokine dysfunction is associated with both depression and Parkinson's disease (PD) pathophysiology. Inflammatory cytokines in neural and behavioral processes are involved in the production and/or maintenance of depression in PD. In this study we looked at how Fluvoxamine treatment regulates depressive-like signs, motor impairments and the express...
Article
Full-text available
Background Glucose homeostasis derangement is a common pathophysiology of malaria whose aetiology is still controversial. The Plasmodium parasite, immunological and inflammatory responses, as well as chemotherapeutics currently used cause hypoglycaemia in malaria. Anti-parasitic and anti-disease drugs are required to combat malaria while ameliorati...
Conference Paper
The majority of studies using animal models to investigate the neuropathological mechanisms underlying addiction are designed in such a way that experiments are performed on individual subjects isolated from their cage mates. This poses a serious shortcoming in these models as humans, in general, practice their addictive behaviours in a social cont...
Article
Full-text available
Exposure to early life stress has been shown to result in anxiety-like symptoms and exacerbates degeneration of dopaminergic neurons in a rat model of Parkinson’s disease (PD). First line treatment for anxiety disorders includes the use of Fluvoxamine maleate (FM). In this study, we investigated whether treating anxiety-like symptoms with FM has an...
Article
Full-text available
Background Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resistance. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory properties with emerging anti-mala...