Murat Tuncel

Murat Tuncel
Hacettepe University · Department of Nuclear Medicine

Professor of Nuclear Medicine

About

116
Publications
8,290
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970
Citations
Introduction
Research interest: Thyroid cancer, prostate cancer, neuroendocrine tumors, theranostics Methods: PET-CT, ultrasonography, scintigraphy, computed tomography
Additional affiliations
October 2005 - October 2006
Technische Universität München
Position
  • PET-CT fellow
November 2000 - present
Hacettepe University
Position
  • Professor (Associate)
Education
June 1993 - August 2000
Hacettepe University
Field of study
  • Medicine

Publications

Publications (116)
Chapter
The most commonly used modalities in the treatment of cancer patients include radiation therapy and immunotherapy. Radiation therapy is performed externally, via devices outside the patient or by administering radiopharmaceuticals targeted to a specific receptor or antigen used in nuclear medicine. Unlike external radiotherapy (ERTx), radiation giv...
Article
Full-text available
99m Tc-MIBI (MIBI) imaging is able to exclude malignancy of hypofunctioning thyroid nod-ules (TNs) with high probability but false positive results are frequent due to low specificity. Therefore , pre-test selection of appropriate TNs is crucial. For image evaluation visual and semiquantita-tive methods (Washout index, WOInd) are used. Aim of this...
Article
Full-text available
PurposeNeck dissection (ND), whether therapeutic or elective, is an essential component of the treatment of head and neck squamous cell carcinoma (HNSCC). Due to altered anatomy and fibrosis caused by initial treatments, surgeons face challenges during salvage ND. A combination of Technetium-99 m and indocyanine green (ICG) previously used in the s...
Article
We investigated the prognostic value of interim and post-neoadjuvant chemotherapy (NAC) 18F FDG PET/CT and the complete pathological and metabolical response after NAC for disease-free survival (DFS) and overall survival (OS) in patients with locally advanced breast cancer (LABC) receiving NAC. Patients who were decided to receive NAC were evaluate...
Chapter
Positron emission tomography-computed tomography (PET-CT) performed with new radiopharmaceuticals has revolutionized the imaging area in prostate cancer (Pca). 68Ga/18F-labeled prostate-specific membrane antigen (PSMA) has been the most promising radiotracer for staging and restaging of Pca. PSMA-based imaging outperformed conventional imaging (CI)...
Article
A 47-year-old woman with atypical pituitary adenoma was referred to the neurosurgery department due to recent back pain. She had multiple transsphenoidal surgery, stereotactic body radiation, and 177Lu-DOTATATE therapy. Her spinal MRI showed multiple spinal masses. The patient underwent 68Ga-DOTATATE PET/CT to confirm the metastatic spread of the d...
Article
Full-text available
Purpose Molecular imaging with 99m Tc-methoxy-isobutyl-isonitrile ( 99m Tc-MIBI, MIBI) has been used in the assessment of thyroid nodules (TNs) for more than two decades. Many studies showed that MIBI imaging is a suitable tool to rule-out malignancy when negative. However, relatively low specificity and accuracy have been described, thus, limiting...
Article
Glucagonomas are rare types of pancreatic neuroendocrine tumors. They may present with a clinical entity called glucagonoma syndrome, which includes necrolytic migratory erythema as a skin component. Here we present a 26-year-old woman experiencing ongoing skin lesions, excessive weight loss, and nausea. She was diagnosed with metastatic glucagonom...
Article
Background: Defining the extent of disease spread with imaging modalities is crucial for therapeutic decision-making and definition of treatment. This study aimed to investigate whether clinical parameters and nomograms predict prostate-specific membrane antigen (PSMA)-positive lymph nodes in treatment-naïve nonmetastatic prostate cancer (PC) pati...
Article
Introduction: Postoperative complications following thoracic procedures are a major cause of morbidity and mortality. Alveolar air leaks and/or bronchopleural fistulas are associated with increased risk of infection, prolonged chest tube, and hospital stay duration and therefore generate economical concern for health care providers. A variety of s...
Article
Ultrasonography is the most commonly used and most effective imaging modality in thyroid cancer imaging. It is the most successful method for evaluating primary tumor and local disease. I-131 scintigraphy is also a useful method in evaluating the whole body, but lacks anatomical detail. The absence of radioiodine uptake in 30-40% of patients also r...
Article
Objective: Tumor sink effect (TSE) has been defined as; decreased uptake in healthy tissue with increased tumor sequestration of the radiopharmaceuticals. It enables us to give high tumoral radiation doses while resulting in lower absorbed radiation to critical organs. However, the factors which influence this effect are yet to be defined. In this...
Article
NSCLC is the most common type of lung cancer. However, non-specific contrast agents, radiopharmaceuticals, and treatment methods are insufficient in early diagnosis and eradication of all tumor tissue. Therefore, the formulation of a novel, targeted, specific theranostic agents possess critical importance. In our previous study, paclitaxel and vino...
Article
A 60-year-old woman with recurrent urinary tract infection who had several operations for colorectal carcinoma underwent 99mTc-DMSA renal scintigraphy which showed an unexpected accumulation of radiotracer in the colon. When symptoms were reviewed, we noticed that she was suffering from pneumaturia and fecaluria which raised the suspicion of entero...
Conference Paper
Purpose: To investigate whether clinical parameters, prostate-specific membrane antigen (PSMA) uptake, and clinical nomograms can predict PSMA-positive lymph node metastasis in treatment-naïve non-metastatic prostate cancer (PC) patients. Materials and Methods: The clinical data of 368 PC patients (83% high-risk and 17% intermediate-risk) treated w...
Article
Objectives: Gallium-68-labeled prostate-specific membrane antigen (Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) is a valuable diagnostic tool for the detection of bone metastases in patients with prostate cancer (PCa). However, bone scintigraphy (BS) with technetium-labeled diphosphonates is cheap and widely available for t...
Conference Paper
68Ga-PSMA PET/CT plays a pivotal role in patients with prostate cancer. It changes treatment plans and guides new therapy options. Although the sensitivity of PSMA PET is higher than other PET tracers, FDG PET/CT may detect PSMA-negative disease, in patients with metastatic castration-resistant prostate cancer(mCRPC) and change treatment decisions....
Conference Paper
Aim/Introduction: Medullary thyroid cancer(MTC) arises from the neuroendocrine C cells of the thyroid. There is no single diagnostic imaging method to reveal all MTC recurrences or metastases.[68Ga]Ga-DOTA-TATE is an alternative PET-radiotracer that showed acceptable efficacy in the detection of MTC. In this study, we aimed to reveal the clinical i...
Conference Paper
Aim/Introduction: Lu-177 labeled prostate-specific membrane antigen(PSMA) radioligand therapy is an emerging treatment in metastatic castration-resistant prostate cancer(mCRPC). The study aims to share our experience on clinical, biochemical, and PET response rates of the mCRPC patients treated with at least two cycles of Lu-177-PSMA-617 therapy. M...
Conference Paper
Aim/Introduction: There is an ongoing debate over the optimal post-peptide receptor radionuclide therapy(PRRT) imaging strategies. This study aimed to compare therapy response patterns of Ga-68-DOTATATE-PET/CT with post- PRRT whole-body scans(PT-WBS) and evaluate whether PTWBS alone could play a decisive role in therapy response. Materials and Meth...
Article
Introduction Despite the increasing accuracy of imaging modalities, the rate of benign renal tumors misclassified as malignant before surgery still non-negligible. Tc-99m sestamibi was demonstrated to be a possible reliable agent in discriminating oncocytoma from renal cell carcinoma (RCC). We aimed to study the efficacy of Tc-99m MIBI tumor scinti...
Article
Purpose To evaluate the distribution of metastatic lymph nodes (LN) detected on ⁶⁸Ga-PSMA-positron emission tomography/computed tomography (PET/CT) in treatment-naïve prostate cancer (PC) patients and to analyze the LN coverage rates of the pelvic fields defined in the GETUG trial and RTOG guidelines and a pelvic field extending superiorly from the...
Article
Prostate cancer (Pca) is the most common cancer and the second leading cause of death among men. Although conventional bone scans and abdominal CT are preferred in most of the guidelines and clinical trials, PET/CT has already started to become the inevitable part of Pca management because of its higher sensitivity and specificity. Radio-tracers us...
Article
Purpose: Medullary thyroid cancer (MTC) arises from neuroendocrine C cells of the thyroid. There is no single diagnostic imaging method that can reveal all MTC recurrences or metastases. 68Ga-DOTATATE is an alternative PET radiotracer that showed acceptable efficacy in the detection of MTC. In this study, we aimed to reveal the clinical efficacy a...
Article
Objective In patients with non-Hodgkin lymphoma (NHL), we investigated 18F FDG PET/computed tomography (CT) parameters, clinical findings, laboratory parameters, and bone marrow involvement (BMI) status for predictive methods in progression-free survival (PFS) and overall survival (OS), and whether 18F FDG PET/CT could take the place of bone marro...
Article
Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These tumors are rare and only make bone metastases at a rate of 5%. Case summary: A 31-year-old male with a GIST presented with solitary bone metastasis at the right iliac bone. We performed stereotactic ablative radiotherap...
Article
Full-text available
Purpose: Primary vaginal cancer and pelvic organ prolapse (POP) combination is extremely rare. Although definitive chemoradiotherapy (CRT) and brachytherapy (BT) is the standard treatment for advanced stage primary vaginal cancer, there is a limited data about the treatment of primary vaginal cancer combined with POP due to its rarity. In addition,...
Conference Paper
Purpose/Objective(s): The pelvic field irradiation field has been previously defined by consensus statement and guidelines have been published for defining pelvic lymphatic field. However, whether target volumes defined by guidelines for pelvic filed encompass the metastatic lymph nodes detected with 68Ga-PSMA-PET/CT is still unknown. In this study...
Article
Full-text available
Abstract Background and Aim: Defective vascularisation may be important in thyroid nodular disease. In this study, we aimed to investigate serum vascular endothelial growth factor (VEGF) levels in dyslipidemic patients with thyroid nodules and the effect of statin therapy. Materials and Methods: We included 37 dyslipidemic patients with thyroid nod...
Article
Full-text available
Purpose Well planned re-surgery is critical for recurrent/persistent thyroid cancer (TC). We aimed to investigate the clinical outcome of radioguided-occult lesion localization (ROLL) guided surgery in patients with recurrent/persistent TC. Methods This study includes 29 patients [F/M: 22/7, median age 43 ± 12 years (18–58)] with a diagnosis of TC...
Article
Full-text available
Background ⁶⁸Ga-PSMA Positron Emission Tomography/Computerized Tomography (PET/CT) has shown promising results for the detection of recurrent prostate cancer (RPCa). However, the diagnostic value of this method is yet to be validated. The aim of this study was to determine the influence of clinical and biochemical variables on the detection rate of...
Article
The skeleton is one of the most common sites for metastases from hematogenic spread. The presence of bone metastases is associated with prognosis and survival. 18 F-NaF offers diagnostic advantages over conventional bone scintigraphy. Increased accuracy is due to superior pharmacokinetic properties of 18 F-NaF and superior imaging characteristics o...
Article
Cancer is the major burden of disease worldwide. The folate receptor, as a specific tumor target, is over-expressed in many types of cancer including ovarian carcinomas, breast, colon, renal, and lung tumors. Nuclear medicine hybrid imaging modalities, such as SPECT/CT, provide both metabolic and anatomic information. Therefore, specific contrast a...
Article
A 70-year-old female with the diagnosis of the metastatic neuroendocrine tumor was referred to our clinic with new abdominal lymph nodes in computed tomography (CT). This finding was considered as the disease progression, and Capecitabine along with Temozolomide was added to her current Lanreotide therapy. The origin of the new lymph nodes was unce...
Conference Paper
Purpose/Objective(s): The treatment strategy is arranged according to risk group in prostate cancer patients. For this reason, accurate staging is essential for radiation therapy (RT) planning and target volume definition. In this study, we analyzed the role of 68Ga-PSMA-PET/CT in RT planning and defining target volumes. Materials/Methods: The clin...
Conference Paper
The Role of FDG PET/CT Detecting Bone Marrow Involvement in Non-Hodgkin’s Lymphoma Patient
Conference Paper
CLINICAL OUTCOME OF RADIO-GUIDED OCCULT LESION LOCALIZATION (ROLL) GUIDED SURGERY FOR PATIENTS WITH RECURRENT THYROID CANCER
Conference Paper
SLOWLY PROGRESSIVE DISEASE A NEW THERAPY RESPONSE CRITERIA? LESSONS FROM TYROSINE KINASE INHIBITOR THERAPY
Article
Resumen Paciente de 54 años de edad con cáncer de próstata al que se realizó estudio PET/TC con ⁶⁸Ga-PSMA que mostró afectación linfática y metástasis óseas. Después de 2 ciclos de tratamiento con ¹⁷⁷Lu-PSMA, una nueva PET/TC mostró disminución de la captación en los ganglios linfáticos y las lesiones óseas, pero aparecieron nuevas lesiones compati...
Article
Full-text available
ABS TRACT Lung cancer is the most common cause of cancer deaths in men and women. Most important factors for treatment success are staging and evaluation of the treatment response. Conventional imaging modalities like direct radiography and computed tomography are anatomical imaging modalities and show structural changes caused by disease. However,...
Article
Full-text available
ABSTRACT Positronemissiontomography-computedtomography (PET / CT) imagingwith fluorine- 18-fluorodeoxy-D-glucose (FDG) plays an important role in pre-treatmentanded follow-up of head and neck cancer patients. It also provides guidance during treatment planning and delineation of target volumes in radiotherapy planning. PET/CT provides more comprehe...
Article
Resumen Paciente de 54 años de edad con cáncer de próstata al que se realizó estudio PET/TC con ⁶⁸Ga-PSMA que mostró afectación linfática y metástasis óseas. Después de 2 ciclos de tratamiento con ¹⁷⁷Lu-PSMA, una nueva PET/TC mostró disminución de la captación en los ganglios linfáticos y las lesiones óseas, pero aparecieron nuevas lesiones compati...
Article
Full-text available
Background/aim: Breast lesions that are not palpable on physical examination but considered suspicious for malignancy on mammography or ultrasonography should be marked before surgery. Wire-guided localization (WGL) is the most frequently used method for preoperative marking of nonpalpable breast lesions (NPBLs). An alternative is marking by a rad...
Article
Purpose: The recent addition of single photon emission computed tomography (SPECT)-CT into bone scintigraphy (BS), increased the accuracy of the test. The objective of this study was to define the main problematic scintigraphic patterns that were solved with the contribution of SPECT-CT and serve as a guide to the medical oncologist who will refer...
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Full-text available
Secondary involvement of the adrenal gland with non-Hodgkin’s lymphoma has been reported to occur in up to 25% of patients during the course of the disease. A 45-year-old man presented with a several month history of nausea, fatigue and weight loss. His medical history was unremarkable. Abdominal computed tomography (CT) was performed and showed bi...
Article
Theranostics labeled with Y-90 or Lu-177 are highly efficient therapeutic approaches for the systemic treatment of various cancers including neuroendocrine tumors and prostate cancer. Peptide receptor radionuclide therapy (PRRT) has been used for many years for metastatic or inoperable neuroendocrine tumors. However, renal and hematopoietic toxicit...
Article
Nuclear medicine has an important role in the management of many cancers in pediatric age group with multiple imaging modalities and radiopharmaceuticals targeting various biological uptake mechanisms. 18-Flourodeoxyglucose is the radiotracer of choice especially in patients with sarcoma and lymphoma. 18FDG-PET, for sarcoma and lymphomas, is proved...
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Full-text available
Background Non-Hodgkin’s lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumo...
Article
Aim To evaluate the use of intraoperative gamma probe survey (IGPS) and frozen section (FS) in the surgical treatment of parathyroid adenoma (PA) in children. Patients and methods Children operated for PA between 2000 and 2015 were evaluated for age, sex, clinical features, presenting symptoms, diagnostic methods and results of surgical treatment...
Article
Full-text available
Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial...
Chapter
Nuclear medicine techniques are increasingly used in the diagnosis and treatment of musculoskeletal system diseases. Among these, bone scintigraphy has been used for many years in the diagnosis and follow-up of benign and malignant diseases. The introduction of SPECT-CT improved the specificity of the test and increased utilization. Molecular imagi...
Article
Full-text available
DCE-MRI provides information about the perfusion of tumours together with morphological details. Perfusion of tumour could be assessed by dynamic 18FDG PET/CT (dFDG/PET), in addition to metabolic information. This study was planned to compare the semi-quantitative parameters of DCE-MRI) and dFDG/PET in locally advanced breast cancer. Forty patient...
Article
Full-text available
Among currently used cancer imaging methods, nuclear medicine modalities provide metabolic information, whereas modalities in radiology provide anatomical information. However, different modalities, having different acquisition times in separate machines, decrease the specificity and accuracy of images. To solve this problem, hybrid imaging modalit...
Article
The aim of the study was to determine the possible role of Chernobyl disaster on changing clinical features of thyroid carcinoma (TC) in a moderately iodine deficient region. We retrospectively reviewed demographical features, presenting symptoms, tumor size, histopathological diagnosis and distant metastates in 160 patients with TC diagnosed betwe...
Article
Full-text available
Scintigraphic imaging is a useful screening tool for patients with suspected gastroesophageal reflux. New scintigraphic interpretation methods have recently been introduced. This study was undertaken to evaluate the efficiency of various scintigraphic interpretation methods in the detection of gastroesophageal reflux and to measure their influence...
Article
Osteopoikilosis (OPK) is a rare disease with an unknown etiology. Although a benign condition, it may lead to diagnostic problems when the patient undergoes diagnostic imaging of the skeletal system due to various reasons like malignancy. Herein, we report 2 cases with OPK causing difficulties in the final diagnosis of the cases which was resolved...
Article
The objective of this study is to determine whether 2-deoxy-2-[18F] fluoro-D: -glucose with positron emission tomography (FDG-PET) imaging and quantitative PET parameters can predict outcome and differentiate patients with limited disease (LD) from extensive disease (ED) in patients with small cell lung cancer (SCLC). We retrospectively evaluated d...