Murat Tuncel

Murat Tuncel
Hacettepe University · Department of Nuclear Medicine

Professor of Nuclear Medicine

About

155
Publications
13,500
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1,301
Citations
Introduction
Research interest: Thyroid cancer, prostate cancer, neuroendocrine tumors, theranostics Methods: PET-CT, ultrasonography, scintigraphy, computed tomography
Additional affiliations
October 2005 - October 2006
Technische Universität München
Position
  • PET-CT fellow
November 2000 - present
Hacettepe University
Position
  • Professor (Associate)
Education
June 1993 - August 2000
Hacettepe University
Field of study
  • Medicine

Publications

Publications (155)
Article
Background Trastuzumab emtansine (T-DM1) is a novel therapy for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer, combining the targeted action of trastuzumab with the cytotoxic effects of emtansine. Although T-DM1 has demonstrated greater efficacy and safety compared to traditional therapies, concerns about hepatot...
Article
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Background The successful integration of artificial intelligence (AI) in healthcare depends on the global perspectives of all stakeholders. This study aims to answer the research question: What are the attitudes of medical, dental, and veterinary students towards AI in education and practice, and what are the regional differences in these perceptio...
Preprint
Full-text available
The successful implementation of artificial intelligence (AI) in healthcare is dependent upon the acceptance of this technology by key stakeholders, particularly patients, who are the primary beneficiaries of AI-driven outcomes. This international, multicenter, cross-sectional study assessed the attitudes of hospital patients towards AI in healthca...
Chapter
Many studies, from in-vitro and in-vivo to population-based studies, demonstrate undesirable effects of higher thyroid hormone levels on the development of cancer, as well as its prognosis and consequently an outcome of cancer patients. Thyroid hormones mediate cancer cells' growth, proliferation, and metastatic diffusion. Current data demonstrate...
Article
Objectives An accurate prognostic assessment is pivotal to adequately inform and individualize follow-up and management of patients with differentiated thyroid cancer (DTC). We aimed to develop a predictive model for recurrent disease in DTC patients treated by surgery and ¹³¹ I by adopting a decision tree model. Methods Age, sex, histology, T sta...
Article
A 56-year-old man with thoracal mass suspected of solitary plasmacytoma was referred for 18F-FDG PET-CT scan. His PET-CT revealed FDG-avid rib mass and cervical lesion at level 2. He also underwent 18F- fluorocholine (FCH) PET-CT to evaluate possible metastatic spread of the dis- ease. FCH PET-CT showed increased uptake at the rib mass, while the c...
Article
Molecular imaging is pivotal in evaluating and managing patients with different thyroid cancer histotypes. The existing, pathology-based, risk stratification systems can be usefully refined, by incorporating tumor-specific molecular and molecular imaging biomarkers with theranostic value, allowing patient-specific treatment decisions. Molecular ima...
Article
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The European Thyroid Association (ETA) has recently published clinical practice guidelines for thyroid nodule management [1]. This is a promising development aiming towards a streamlined and homogene interdisciplinary approach in the management of thyroid nodules. However, several important aspects of nuclear medicine approaches were not adequately...
Article
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Introduction Primary hyperparathyroidism (PHP) and malignancies are the most common causes of hypercalcemia. Nevertheless, PHP might be observed in coexisting with malignancies. We aimed to present a patient who underwent surgery for PHP and was diagnosed with thyroid MALToma. Clinical Case A 65-year-old female presented with fatigue for one year....
Article
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Simple Summary Thyroid nodules are commonly detected in daily clinical practice, and their diagnosis and therapy usually involve different specialists and various diagnostic and therapeutic methods. Thyroid nodule management requires the integration of laboratory, imaging, and pathology examinations to achieve a proper diagnosis. It enables the eli...
Preprint
Full-text available
Objective 2-[¹⁸F]fluoro-D-glucose (FDG) Positron Emission Tomograpy/Computed Tomography (PET/CT) may help to evaluate the tumor heterogeneity in patients with metastatic castration-resistant prostate cancer (mCRPC) and determine treatment eligibility for Prostate Specific Membrane Antigen (PSMA) targeted radioligand therapy (PSMA-RLT). The aim of t...
Article
Medical Imaging is one of the most intriguing, forward-looking and ever-evolving technologies used to view human anatomy and physiology to monitor, diagnose or treat medical conditions. Medical Imaging technologies use non-invasive methods to visualize such conditions of the interior body. Various imaging technologies use ionizing radiation such as...
Article
Objective: Studies concerning the frequency of BRAF V600E , TERT promoter, and NRAS mutations, RET/PTC and PAX8/PPARγ rearrangements, and their correlations with distant metastasis and several clinicopathological parameters are lacking in Turkish papillary thyroid carcinoma (PTC) patients. Methods: Mutations were detected by real-time polymerase ch...
Conference Paper
Aim/Introduction: Perineural spread(PNS) refers to tumour growth along large nerves. It most commonly occurs in head and neck cancers(HNC). Accurate detection of PNS is crucial since it changes treatment plans and prognosis. However accuracy of PET/CT in detection of PNS is not extensively studied. Therefore, our study aimed to retrospectively anal...
Conference Paper
Aim/Introduction: Diffuse sclerosing subtype of papillary thyroid cancer(DSS-PTC) is a rare subtype of PTC.It is well known for its aggressive behavior at presentation,but its response to surgery& radioiodine(RAI)therapy and overall prognosis are not well studied.Therefore we aimed to describe its RAI avidity and clinical outcomes. Materials and Me...
Article
Lymphoscintigraphy is a safe, minimally invasive, and well-established imaging modality for evaluating lymphatic drainage in patients with suspected lymphedema. We report a case of an 8-year-old girl with lymphangioma circumscriptum of the labium majora. She was referred to lymphoscintigraphy for swelling of the lower extremities. Scintigraphy show...
Article
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Simple Summary Radioiodine therapy is the main treatment option for metastatic differentiated thyroid cancer (DTC). However, only half of these patients achieve (partial or complete) remission or have stable disease during long-term follow-up. In the remaining ones, disease progresses mainly as they become radioiodine-refractory. The diagnostics of...
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Abstract: Background: A biochemical recurrence (BCR) risk model was created based on pretest prostate specific antigen (PSA) and groupings by restaging prostate specific membrane antigen (PSMA) PET/CT. Methods: A cohort of 1216 BCR patients were analyzed for overall survival (OS) according to the PSA threshold and restaging PSMA PET/CT. A Cox regre...
Chapter
İleri evre, kemik metastazlı hastalarda radyofarmasötik tedavi, kemik ağrısı palyasyonu için uzun yıllardır kullanılmaktadır. Bu tedavilerin en büyük başarısı ağrı palyasyonu olmakla birlikte son yıllardaki çalışmalarda sağ kalımda artış olduğu da bildirilmiştir. Alfa yayıcı radyonüklitler ile hazırlanan radyofarmasötikler bu amaçla kullanılan en u...
Article
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Objectives: This prospective study was planned to compare the predictive value of dynamic 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in locally advanced breast cancer patients (LABC) receiving neoadjuvant chemotherapy (NAC). Methods: Twenty seven patients with LABC [median age: 47, (26-66)] underwent a...
Conference Paper
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Recently, utilizing of PET radiopharmaceuticals are investigating as an alternative to SPECT radiopharmaceuticals due to the advantage of the high resolution of PET imaging and the difficulties in commercial obtaining of Tc-99m. Among the PET radioisotopes, Ga-68 has the great potential to become as useful for PET as Tc-99m has proved for SPECT ima...
Article
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Purpose: An accurate postoperative assessment is pivotal to inform postoperative 131I treatment in patients with differentiated thyroid cancer (DTC). We developed a predictive model for post-treatment whole-body scintigraphy (PT-WBS) results (as a proxy for persistent disease) by adopting a decision tree model. Methods: Age, sex, histology, T st...
Article
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Background: Metastatic castration‐resistant prostate cancer (mCRPC) is characterized by heterogeneity among patients as well as therapy responses due to diverse genetic, epigenetic differences, and resistance mechanisms. At this stage of the disease, therapy modalities should be individualized in light of the patients' clinical state, symptoms, and...
Article
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Introduction Therapeutic options for metastatic paraganglioma (PGL) are limited, especially in the presence of uncontrolled secondary hypertension (HTN). Early findings from Lutetium-177 (Lu-177) DOTATE show promise for efficacy, although data on HTN control and survival are uncertain. Herein, we presented the successful treatment of a patient with...
Article
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Aim: There is a need to evaluate the treatment response in patients who have undergone radioiodine treatment (RIT) for differentiated thyroid cancer. Diagnostic tests that are used for this purpose include radioiodine whole-body scan (WBS) and serum thyroglobulin (Tg) measurement, which are most accurate during thyroid-stimulating hormone (TSH) sti...
Article
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An individual patient meta-analysis followed 1216 patients with PSA-only recurrence (biochemical recurrence, BCR) restaged with [68Ga]Ga-PSMA-11 PET/CT before the salvage treatment for median 3.5 years and analyzed the overall survival (OS). A new risk model included a good risk group with a prescan PSA < 0.5 ng/mL (26%), an intermediate risk group...
Article
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We investigated the prognostic value of interim and post-neoadjuvant chemotherapy (NAC) 18F FDG PET/CT and the complete pathological and metabolical response after NAC for disease-free survival (DFS) and overall survival (OS) in patients with locally advanced breast cancer (LABC) receiving NAC. Patients who were decided to receive NAC were evaluate...
Chapter
The most commonly used modalities in the treatment of cancer patients include radiation therapy and immunotherapy. Radiation therapy is performed externally, via devices outside the patient or by administering radiopharmaceuticals targeted to a specific receptor or antigen used in nuclear medicine. Unlike external radiotherapy (ERTx), radiation giv...
Article
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99m Tc-MIBI (MIBI) imaging is able to exclude malignancy of hypofunctioning thyroid nod-ules (TNs) with high probability but false positive results are frequent due to low specificity. Therefore , pre-test selection of appropriate TNs is crucial. For image evaluation visual and semiquantita-tive methods (Washout index, WOInd) are used. Aim of this...
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PurposeNeck dissection (ND), whether therapeutic or elective, is an essential component of the treatment of head and neck squamous cell carcinoma (HNSCC). Due to altered anatomy and fibrosis caused by initial treatments, surgeons face challenges during salvage ND. A combination of Technetium-99 m and indocyanine green (ICG) previously used in the s...
Article
Large vessel vasculitis (LVV) is a heterogeneous group of disorders characterized by inflammation of large and medium-sized blood vessels. When not properly diagnosed and treated, it may lead to severe morbidity due to ischemic events. 18F-florodeoxyglucose (FDG) PET/CT can be helpful in the assessment of disease activity before treatment as well a...
Article
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OBJECTIVE Neoadjuvant chemotherapy (NAC) is applied in locally advanced breast cancers (LABCs). Pathological complete response (PCR) after NAC is associated with prognosis. This prospective study aimed to compare the predictive value of semi-quantitative parameters obtained by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and d...
Preprint
Full-text available
Purpose: There is a need to evaluate the treatment response in patients who have undergone radioiodine treatment (RIT) for differentiated thyroid cancer. Our study aimed to show thyroid hormone withdrawal (THW) effects on quality of life and psychological symptoms in female patients with low-risk, well-differentiated papillary thyroid cancer. Metho...
Chapter
Positron emission tomography-computed tomography (PET-CT) performed with new radiopharmaceuticals has revolutionized the imaging area in prostate cancer (Pca). 68Ga/18F-labeled prostate-specific membrane antigen (PSMA) has been the most promising radiotracer for staging and restaging of Pca. PSMA-based imaging outperformed conventional imaging (CI)...
Article
A 47-year-old woman with atypical pituitary adenoma was referred to the neurosurgery department due to recent back pain. She had multiple transsphenoidal surgery, stereotactic body radiation, and 177Lu-DOTATATE therapy. Her spinal MRI showed multiple spinal masses. The patient underwent 68Ga-DOTATATE PET/CT to confirm the metastatic spread of the d...
Preprint
Full-text available
Objective: There is a need to evaluate the treatment response in patients who have undergone radioiodine treatment (RIT) for differentiated thyroid cancerDiagnostic tests that are used for this purpose include radioiodine whole body scan (sWBS) and serum thyroglobulin (Tg) measurement which are most accurate during thyroid-stimulating hormone (TSH)...
Article
Full-text available
Purpose Molecular imaging with 99m Tc-methoxy-isobutyl-isonitrile ( 99m Tc-MIBI, MIBI) has been used in the assessment of thyroid nodules (TNs) for more than two decades. Many studies showed that MIBI imaging is a suitable tool to rule-out malignancy when negative. However, relatively low specificity and accuracy have been described, thus, limiting...
Article
Glucagonomas are rare types of pancreatic neuroendocrine tumors. They may present with a clinical entity called glucagonoma syndrome, which includes necrolytic migratory erythema as a skin component. Here we present a 26-year-old woman experiencing ongoing skin lesions, excessive weight loss, and nausea. She was diagnosed with metastatic glucagonom...
Article
Background: Defining the extent of disease spread with imaging modalities is crucial for therapeutic decision-making and definition of treatment. This study aimed to investigate whether clinical parameters and nomograms predict prostate-specific membrane antigen (PSMA)-positive lymph nodes in treatment-naïve nonmetastatic prostate cancer (PC) pati...
Article
Introduction: Postoperative complications following thoracic procedures are a major cause of morbidity and mortality. Alveolar air leaks and/or bronchopleural fistulas are associated with increased risk of infection, prolonged chest tube, and hospital stay duration and therefore generate economical concern for health care providers. A variety of s...
Article
Ultrasonography is the most commonly used and most effective imaging modality in thyroid cancer imaging. It is the most successful method for evaluating primary tumor and local disease. I-131 scintigraphy is also a useful method in evaluating the whole body, but lacks anatomical detail. The absence of radioiodine uptake in 30-40% of patients also r...
Article
Objective: Tumor sink effect (TSE) has been defined as; decreased uptake in healthy tissue with increased tumor sequestration of the radiopharmaceuticals. It enables us to give high tumoral radiation doses while resulting in lower absorbed radiation to critical organs. However, the factors which influence this effect are yet to be defined. In this...
Article
NSCLC is the most common type of lung cancer. However, non-specific contrast agents, radiopharmaceuticals, and treatment methods are insufficient in early diagnosis and eradication of all tumor tissue. Therefore, the formulation of a novel, targeted, specific theranostic agents possess critical importance. In our previous study, paclitaxel and vino...
Article
A 60-year-old woman with recurrent urinary tract infection who had several operations for colorectal carcinoma underwent 99mTc-DMSA renal scintigraphy which showed an unexpected accumulation of radiotracer in the colon. When symptoms were reviewed, we noticed that she was suffering from pneumaturia and fecaluria which raised the suspicion of entero...
Conference Paper
Purpose: To investigate whether clinical parameters, prostate-specific membrane antigen (PSMA) uptake, and clinical nomograms can predict PSMA-positive lymph node metastasis in treatment-naïve non-metastatic prostate cancer (PC) patients. Materials and Methods: The clinical data of 368 PC patients (83% high-risk and 17% intermediate-risk) treated w...
Article
Objectives: Gallium-68-labeled prostate-specific membrane antigen (Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) is a valuable diagnostic tool for the detection of bone metastases in patients with prostate cancer (PCa). However, bone scintigraphy (BS) with technetium-labeled diphosphonates is cheap and widely available for t...
Conference Paper
68Ga-PSMA PET/CT plays a pivotal role in patients with prostate cancer. It changes treatment plans and guides new therapy options. Although the sensitivity of PSMA PET is higher than other PET tracers, FDG PET/CT may detect PSMA-negative disease, in patients with metastatic castration-resistant prostate cancer(mCRPC) and change treatment decisions....
Conference Paper
Aim/Introduction: Medullary thyroid cancer(MTC) arises from the neuroendocrine C cells of the thyroid. There is no single diagnostic imaging method to reveal all MTC recurrences or metastases.[68Ga]Ga-DOTA-TATE is an alternative PET-radiotracer that showed acceptable efficacy in the detection of MTC. In this study, we aimed to reveal the clinical i...
Conference Paper
Aim/Introduction: Lu-177 labeled prostate-specific membrane antigen(PSMA) radioligand therapy is an emerging treatment in metastatic castration-resistant prostate cancer(mCRPC). The study aims to share our experience on clinical, biochemical, and PET response rates of the mCRPC patients treated with at least two cycles of Lu-177-PSMA-617 therapy. M...
Conference Paper
Aim/Introduction: There is an ongoing debate over the optimal post-peptide receptor radionuclide therapy(PRRT) imaging strategies. This study aimed to compare therapy response patterns of Ga-68-DOTATATE-PET/CT with post- PRRT whole-body scans(PT-WBS) and evaluate whether PTWBS alone could play a decisive role in therapy response. Materials and Meth...
Article
Introduction Despite the increasing accuracy of imaging modalities, the rate of benign renal tumors misclassified as malignant before surgery still non-negligible. Tc-99m sestamibi was demonstrated to be a possible reliable agent in discriminating oncocytoma from renal cell carcinoma (RCC). We aimed to study the efficacy of Tc-99m MIBI tumor scinti...
Article
Purpose To evaluate the distribution of metastatic lymph nodes (LN) detected on ⁶⁸Ga-PSMA-positron emission tomography/computed tomography (PET/CT) in treatment-naïve prostate cancer (PC) patients and to analyze the LN coverage rates of the pelvic fields defined in the GETUG trial and RTOG guidelines and a pelvic field extending superiorly from the...
Article
Prostate cancer (Pca) is the most common cancer and the second leading cause of death among men. Although conventional bone scans and abdominal CT are preferred in most of the guidelines and clinical trials, PET/CT has already started to become the inevitable part of Pca management because of its higher sensitivity and specificity. Radio-tracers us...
Article
Purpose: Medullary thyroid cancer (MTC) arises from neuroendocrine C cells of the thyroid. There is no single diagnostic imaging method that can reveal all MTC recurrences or metastases. 68Ga-DOTATATE is an alternative PET radiotracer that showed acceptable efficacy in the detection of MTC. In this study, we aimed to reveal the clinical efficacy a...
Article
Objective In patients with non-Hodgkin lymphoma (NHL), we investigated 18F FDG PET/computed tomography (CT) parameters, clinical findings, laboratory parameters, and bone marrow involvement (BMI) status for predictive methods in progression-free survival (PFS) and overall survival (OS), and whether 18F FDG PET/CT could take the place of bone marro...
Article
Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These tumors are rare and only make bone metastases at a rate of 5%. Case summary: A 31-year-old male with a GIST presented with solitary bone metastasis at the right iliac bone. We performed stereotactic ablative radiotherap...
Article
Full-text available
Purpose: Primary vaginal cancer and pelvic organ prolapse (POP) combination is extremely rare. Although definitive chemoradiotherapy (CRT) and brachytherapy (BT) is the standard treatment for advanced stage primary vaginal cancer, there is a limited data about the treatment of primary vaginal cancer combined with POP due to its rarity. In addition,...
Conference Paper
Purpose/Objective(s): The pelvic field irradiation field has been previously defined by consensus statement and guidelines have been published for defining pelvic lymphatic field. However, whether target volumes defined by guidelines for pelvic filed encompass the metastatic lymph nodes detected with 68Ga-PSMA-PET/CT is still unknown. In this study...
Article
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Abstract Background and Aim: Defective vascularisation may be important in thyroid nodular disease. In this study, we aimed to investigate serum vascular endothelial growth factor (VEGF) levels in dyslipidemic patients with thyroid nodules and the effect of statin therapy. Materials and Methods: We included 37 dyslipidemic patients with thyroid nod...
Article
Full-text available
Purpose Well planned re-surgery is critical for recurrent/persistent thyroid cancer (TC). We aimed to investigate the clinical outcome of radioguided-occult lesion localization (ROLL) guided surgery in patients with recurrent/persistent TC. Methods This study includes 29 patients [F/M: 22/7, median age 43 ± 12 years (18–58)] with a diagnosis of TC...
Article
Full-text available
Background ⁶⁸Ga-PSMA Positron Emission Tomography/Computerized Tomography (PET/CT) has shown promising results for the detection of recurrent prostate cancer (RPCa). However, the diagnostic value of this method is yet to be validated. The aim of this study was to determine the influence of clinical and biochemical variables on the detection rate of...
Article
The skeleton is one of the most common sites for metastases from hematogenic spread. The presence of bone metastases is associated with prognosis and survival. 18 F-NaF offers diagnostic advantages over conventional bone scintigraphy. Increased accuracy is due to superior pharmacokinetic properties of 18 F-NaF and superior imaging characteristics o...
Article
Cancer is the major burden of disease worldwide. The folate receptor, as a specific tumor target, is over-expressed in many types of cancer including ovarian carcinomas, breast, colon, renal, and lung tumors. Nuclear medicine hybrid imaging modalities, such as SPECT/CT, provide both metabolic and anatomic information. Therefore, specific contrast a...
Article
A 70-year-old female with the diagnosis of the metastatic neuroendocrine tumor was referred to our clinic with new abdominal lymph nodes in computed tomography (CT). This finding was considered as the disease progression, and Capecitabine along with Temozolomide was added to her current Lanreotide therapy. The origin of the new lymph nodes was unce...
Conference Paper
Purpose/Objective(s): The treatment strategy is arranged according to risk group in prostate cancer patients. For this reason, accurate staging is essential for radiation therapy (RT) planning and target volume definition. In this study, we analyzed the role of 68Ga-PSMA-PET/CT in RT planning and defining target volumes. Materials/Methods: The clin...
Conference Paper
The Role of FDG PET/CT Detecting Bone Marrow Involvement in Non-Hodgkin’s Lymphoma Patient
Conference Paper
CLINICAL OUTCOME OF RADIO-GUIDED OCCULT LESION LOCALIZATION (ROLL) GUIDED SURGERY FOR PATIENTS WITH RECURRENT THYROID CANCER
Conference Paper
SLOWLY PROGRESSIVE DISEASE A NEW THERAPY RESPONSE CRITERIA? LESSONS FROM TYROSINE KINASE INHIBITOR THERAPY
Article
Resumen Paciente de 54 años de edad con cáncer de próstata al que se realizó estudio PET/TC con ⁶⁸Ga-PSMA que mostró afectación linfática y metástasis óseas. Después de 2 ciclos de tratamiento con ¹⁷⁷Lu-PSMA, una nueva PET/TC mostró disminución de la captación en los ganglios linfáticos y las lesiones óseas, pero aparecieron nuevas lesiones compati...