
Murat ApiInternational School of Medicine, University of Health Sciences · Department of Obstetrics and Gynecology,
Murat Api
Professor MD, PhD, MSci
About
244
Publications
56,244
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Citations
Introduction
Additional affiliations
Education
January 2019 - March 2019
University of Health Sciences, Istanbul, Turkey
Field of study
- Chair International School of Medicine, Department of Obstetrics and Gynecology
April 2016 - October 2016
Publications
Publications (244)
A prospective study was conducted to evaluate the effect of progestogens on the pregnancy outcome of threatened abortion (TA). A total of 251 pregnant women less than 20 weeks of gestational age (GA) were included. Group 1 consisted of women with vaginal bleeding who had already been under treatment with progestogens and Group 2 was composed of wom...
Aims: To determine the factors leading to upgrading in the final pathology result in cases with endometrial cancer. Methods: We retrospectively analyzed the records of patients with endometrioid endometrial adenocarcinoma to evaluate the concordance between FIGO grade in preoperative endometrial sampling and postoperative final pathology grade. As...
Background:
Postoperative pain is a serious problem in gynecological oncology patients. Rectus sheath block (RSB) is increasingly utilized as a part of multimodal analgesia. The purpose of this three blinded, randomized-controlled trial is to compare the analgesic efficacy of ultrasound-guided (US-guided) bilateral rectus sheath block (BRSB) and l...
This study investigates the impact of radiotherapy (RT) on lower urinary tract symptoms (LUTS) in patients with gynecologic malignancies, focusing on those who have undergone surgical treatment. We conducted a cross-sectional study from January to June 2023 at a tertiary hospital’s outpatient polyclinic. Participants included patients with early-st...
Objective: This study aimed to investigate the predictive value of pulmonary pressure parameters detected by Doppler ultra- sonography for respiratory distress syndrome (RDS). Material and Methods: This study was conducted between January 2017 and Decem- ber 2018. Twenty five newborns who were born before 37th gestational week without anomalies and...
Choriocarcinoma is a rare and highly malignant tumor that primarily occurs in women of reproductive age. Choriocarcinoma can be classified as gestational or nongestational, based on its pathogenetic origin. Although primary nongestational choriocarcinoma has been described in the ovaries, it is very rare in the uterus, especially in postmenopausal...
Introduction/Background
Cervical stenosis is the most common serious complication following Loop Electrosurgical Excision Procedure (LEEP) for treatment of cervical dysplasia. Rates of cervical stenosis after LEEP are reported between 1.3 to 19%. We report a case of severe cervical stenosis successfully treated with laparoscopic approach whereby th...
Introduction/Background
Patients with advanced ovarian cancer and some patients with advanced endometrial cancer need repeated drainage before the operation because malignant ascites may cause shortness of breath, bloating, nausea and vomiting, and failed renal function. Although parasynthesis and catheter drainage relieve the symptoms, the questio...
Introduction/Background
Laparoscopic para-aortic lymph node dissection can be performed through the extraperitoneal or transperitoneal approach. Retroperitoneal para-aortic lymphadenectomy was described by Dargent in 2000. Recent evidence has demonstrated that the extraperitoneal approach is associated with a higher number of lymph nodes removed wi...
Introduction/Background
Ureteral endometriosis is a very rare but serious form of infiltrating endometriosis. Ureteral endometriosis occurs in approximately 1% of women with endometriosis. Intrinsic ureteral endometriosis is even rarer, occurring in only one-fifth of all cases of endometriosis of the ureter. In addition, bilateral complete ureteral...
Introduction/Background
Epithelial ovarian cancer ranks fifth in cancer-related deaths among women and is the fourth-most common gynecologic malignancy. In high grade serous ovarian cancers (HGSC), tumoral invasion of the colonic segments, of the greater gastric curvature, of the small bowel and the hepatic or splenic structures can be observed. In...
Introduction/Background
Rectus sheath block (RSB) is increasingly utilised as a part of multimodal analgesia in laparotomy surgeries. We proposed this study to compare the analgesic efficacy of ultrasound-guided bilateral RSB with local anaesthetic (LA) infiltration in patients undergoing midline laparotomy for gynecologic cancer.
Methodology
In o...
Purpose: The purpose of this study was to determine the whitening toothpastes effect of surface roughness in young permanent human enamel. Methods: In this in vitro study, 100 premolars were sectioned, mounted and stored. All teeth were divided into 10 experimental groups (n=10). The specimens were brushed 3600 cycles (equivalent 12-week brushing)...
Introduction/Background
It is a matter of debate whether there are other factors that may affect the results of colposcopic biopsy independent of cytology and humanpapilloma virus (HPV) genotype results. Therefore, we evaluated the effect of age and reproductive status on clinical outcomes in patients who underwent colposcopy.
Methodology
Patients...
Introduction/Background
Complete cytoreduction is the most critical prognosticator for survival in ovarian cancer patients. Prediction of suboptimal cytoreduction surgery for advanced ovarian cancer can prevent unnecessary surgery and morbidity. Therefore, the present study compared the R0 rates of patients with advanced stage ovarian cancer in two...
Introduction/Background
Ovarian cancer is a gynecological tumor that causes the most deaths in developed countries. Early diagnosis is very important in terms of life expectancy. Both clear cell cancer and endometrioid type ovarian cancer from ovarian tumors are associated with endometriosis. Sometimes it is seen in combination with endometriosis,...
Introduction/Background
Tandem vaginal brachytherapy applied immediately after pelvic curative radiotherapy is a treatment that aims to destroy endometrial cancer cells and reduce the risk of recurrence This study retrospectively evaluated patients with endometrioid-type endometrial adenocarcinoma and those receiving adjuvant therapy to evaluate th...
Introduction/Background
To present prevalance of obturator nerve injury, quality of life measures, level sensory and motor dysfunction of adductor muscle and inner thight area, dysability in postoperative period and to discuss the effectiveness of conservative approach in patients whose unilateral obturator nerve injured inadvertently during laparo...
Introduction/Background
Minimally invasive surgery is more frequently getting used in gynecologic operations. The difficult part of the procedure is extracting of an large uterus or an unruptured adnexal mass. Without conversion to a laparotomy for specimen retrieval, urine bag could be used to easily retrieve large specimens through the vaginal ro...
Introduction/Background
There is high incidence of diaphragm involvement in patients with stage IIIC high grade serous ovarian cancer. We evaluated the use of the Makuuchi incision and Thompson retractor system in patients with stage IIIC high-grade serous ovarian carcinoma with diaphragmatic metastases to facilitate liver mobilization and access t...
Background
To evaluate the efficacy of the preoperative ultrasonographic sliding sign in predicting intra-abdominal adhesions.
Methods
This was a single-center, double-blinded, prospective observational study undertaken from March and September 2021 on 110 patients with a history of previous abdominal surgery. All patients who were scheduled for l...
INTRODUCTION: To evaluate the depression, anxiety, and quality of life in gynecologic oncology patients.
METHODS: This cross-sectional study was conducted on patients attending gynecologic oncology outpatient clinic from April to July 2021. A total of 372 patients were interviewed using the European Organization for Research and Treatment of Cancer...
Objective:
The clinical outcome of high-risk HPV (hr-HPV) infection varies according to genotype(s). Patients may harbor either one (s-HPV) or multiple HPV (m-HPV) genotypes. Recently, the relationship between m-HPV infections and high-grade dysplasia has been questioned, and controversial results have been obtained; therefore, its clinical signif...
We aimed to evaluate the psychosexual impact of being diagnosed with human papillomavirus (HPV). A cross-sectional study was conducted to assess the anxiety and depression levels and sexual functions in women with and without HPV between March and May 2021. Beck anxiety inventory (BAI), the Beck depression inventory (BDI), and the Libido scoring sy...
Objective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to eval...
The aim of this study was to investigate the effect of drains used in current clinical practice on operation parameters and post-operative morbidity. The comprehensive data obtained through the prospective design were analysed in detail according to whether abdominal drainage was applied. Abdominal drainage was present in 44.1% of patients who met...
Introduction. This study aimed to determine whether endocervical glandular involvement by squamous intraepithelial lesion would differ with respect to the depth of the excised specimen and analyze the related factors that may define endocervical glandular involvement among cases treated with cone biopsy. Methods. Between April 2016 and December 201...
Purpose:
To evaluate the effects of mechanical bowel preparation (MBP) on the intraoperative visualization of the surgical field, bowel handling, intestinal load, and overall ease of surgery in patients undergoing elective laparoscopic gynecological surgeries.
Methods:
The patients randomized to a MBP group and a no preparation (NMBP) group. The...
Objective: Studies on eosinophils have mostly been directed to parasitic infections and allergic diseases, but the role of eosinophils in oncology has been largely ignored. Eosinophils are an important modulator of the immune response and components of the inflammatory process against the tumor. This study was performed to investigate the pre-opera...
We aimed to evaluate the gynaecological oncology surgeries in the COVID-19 pandemic. A total of 800 operations performed between January and December 2020 were retrieved. Since the COVID-19 pandemic affected operations as of April 1 2020, we compared the cases of the last nine months of the year with the first three months. Of the operations, 265 (...
Objective:
Studies on eosinophils have mostly been directed to parasitic infections and allergic diseases, but the role of eosinophils in oncology has been largely ignored. Eosinophils are an important modulator of the immune response and components of the inflammatory process against the tumor. This study has been done to reveal the relationship...
Abstract Aim: To investigate the CA-125 levels in uterine serous carcinoma (UPSC) patients to predict the extent of disease. Materials and Method: Medical records of patients operated for UPSC/mix serous carcinoma, endometrioid carcinoma; their preoperative CA-125 levels, as well as parameters including age, tumor size, lymph node involvement, lymp...
Amaç: Jinekolojik onkoloji bölümüne sevk edilen adneksiyal kitlesi olan gebeleri değerlendirmeyi amaçladık.
Gereç ve Yöntemler: Jinekolojik onkoloji bölümüne Kasım 2016 ve Haziran 2019 tarihleri arasında sevk edilen şüpheli adneksial kitlesi olan gebelerin demografik özelliklerini, gebelik yaşını, ultrasonografik ve manyetik rezonans görüntüleme bu...
Aim:
To analyze the risk factors of lymph node involvement in pure endometrioid type endometrial cancer and assess factors that necessitate lymphadenectomy.
Methods:
Patients who had been operated on due to endometrial cancer and whose final pathology was reported as pure endometrioid carcinoma between January 2014 and January 2020 were assessed...
Surgery can continue safely during the pandemic in a specialty hospital that does not accept COVID‐19‐positive patients.
Aim
Recurrent pregnancy loss (RPL) poses a challenge in reproductive medicine because the etiology is often unknown. Here we investigated the frequency of mutations in the Factor V Leiden (FVL), prothrombin (FII), and methylene tetrahydrofolate reductase (MTHFR) genes in women with RPL and healthy women.
Methods
Blood samples were obtained from p...
Introduction/Background
Eastern Cooperative Oncology Group performance status (ECOG-PS) is the most widely used measurement of patient's ability to perform daily activities. Although the prognosis and effectiveness on therapies based on the PS are assigned to patients, the reliability is still questionable and manifests great variability among the...
Introduction/Background
To evaluate the rate of combined Pap smear and human papillomavirus test positivity after cervical excisional procedures.
Methodology
This retrospective study included data of 452 patients who undergone cervical cold knife conization or loop electrosurgical excision procedure (LEEP) and post-cone follow-up co-testing. Age,...
Introduction/Background
To investigate the factors related to incomplete excision procedure in abnormal cervical cytology among the different levels of surgical education.
Methodology
From the medical records, data were collected from patients with abnormal cervical cytology and/or positive HPV test who have underwent colposcopic biopsy and requir...
Introduction/Background
Targeted to find the correlation between HPV types and surgical margin positivity in patients exposed the excisional procedure for treatment of precancerous cervical pathologies.
Methodology
We investigated retrospectively 453 patients who recommended Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (...
Introduction/Background
To evaluate adnexial masses at pregnancy whom were referred to gynecologic oncology department.
Methodology
Referred cases their different stages of pregnancy were investigated according to sonographic appearence, magnetic resonance images, blood tumor markers and final pathology.
Results
15 cases referred from perinatolog...
Introduction/Background
To investigate CA-125 levels in uterine papillary serous carcinoma (UPSC) patients.
Methodology
From January 2015 to December 2018, we collected data of UPSC and preoperative CA-125 levels of patients. Subsequent parameters were evaluated; age, preoperative endometrial sampling results, tumor size, lymph node involvement, L...
Introduction/Background
Drain placement remains controversial and there has been nearly no prospective studies evaluating the effectiveness on the gynecologic oncology cases. While some surgeons put on drains most of the cases after surgery, the literature search on general surgery and gynecologic cases suggest that the benefits are questionable. T...
Introduction/Background
Although studies on performance in cancer patients are increasing, there has not been enough efforts to validate the Eastern Cooperative Oncology Group Performance Status (ECOG-PS). Therefore, we aimed to translate and validate the ECOG into Turkish.
Methodology
This was done by drawing on the original version and by employ...
Introduction/Background
The aim of our study was to determine whether endocervical glandular involvement after excisional procedures is related to the depth of the removed conization material.
Methodology
Between April 2016 and December 2019, patients who underwent colposcopy and excisional procedures in the department of gynecologic oncology were...
Objective:The objective of this study was to assess maternal and perinatal outcomes of twin pregnancies with single fetal demise in terms of chorionicity and fetal death time.Material and Methods:All deliveries between January 2008 and July 2015 were reviewed retrospectively and 85 twin pregnancies with single fetal demise were included. These case...
OBJECTIVE: To investigate the difference in the effectiveness of controlled ovarian hyperstimulation and intrauterine insemination (COH+IUI) on pregnancy rates in patients with primary and recurrent endometriomas.
STUDY DESIGN: Multi center, retrospective cohort study done in 3 tertiary referral centers. Included in the study were (1) primary i...
Amaç: Bu çalışmamızda preterm prematür membran rüptürü (PPROM) ile komplikegebeliklerde spontan travaya giren olgularla çeşitli endikasyonlarla doğum indüksiyonu yapılanolguların perinatal sonuçlarını ve latent sürenin bu sonuçlara etkisini araştırmayı amaçladık.Materyel-metod: Ocak 2014-Ocak 2016 yılları arasında kliniğimizde 24-34 gebelik haftala...
Aim
To investigate the effectiveness of ovulation induction and intrauterine insemination (OI + IUI) in female patients with hypogonadotropic hypogonadism (HH), and to compare the outcomes of different stimulation protocols and cycle characteristics.
Material and methods
The outcomes of OI + IUI treatments in patients with HH diagnosed between 201...
Amaç: Kontrollü ovulasyon indüksiyonu ve intrauterin inseminasyon (OI-IUI) tüm dünyada infertil çiftlerde ilk basamak tedavi olarak kullanılmaktadır. Bu çalışmada OI-IUI yapılan nedeni belirlenemeyen infertilite olgularında Hcg günü değerlendirilen endometrial kalınlık ve paternin tedavi başarısına etkisini inceledik.Materyel-metod: Bu çalışmada Şu...
Objective
To evaluate the eligibility of female-to-male (FtM) transgender people as donor candidates with regard to histologic, surgical, and social aspects.
Materials and Methods
In this prospective cohort study, 31 FtM transgender people underwent standard hysterectomy and bilateral salpingo-oophorectomy for gender reassignment upon their reques...
Objectives:
To compare the effects of topical silicone gel and corticosteroid cream for preventing hypertrophic scar and keloid formation following Pfannenstiel incisions.
Material and methods:
Fifty patients operated for benign gynecological diseases through primary Pfannenstiel incision were included. The wounds were randomly allocated to the...
Ureter injuries are uncommon but dreaded complications in gynecologic surgery and a frequent cause of conversion to laparotomy. Recently, a few papers reported the repair of gynecologic ureteral injuries using laparoscopy with encouraging results. In these case reports, we aimed to present two laparoscopically repaired ureter injuries during total...
Objective
The aim of the present study was to compare female sexual function between women who underwent conventional abdominal or laparoscopic hysterectomy.
Materials and Methods
Seventy-seven women who were scheduled to undergo hysterectomy without oophorectomy for benign gynecologic conditions were included in the study. The women were assigned...
Objective:
To determine the efficiency of pre-implantation genetic screening (PGS) among women scheduled to undergo intracytoplasmic sperm injection who had experienced recurrent in vitro fertilization (IVF) failure.
Methods:
The present retrospective cohort study reviewed the medical records of consecutive women who had experienced recurrent IV...
Epidemiology was originated from an idea whether the enviromental factors might be the cause of the disease, which was suggested by Hippocrates and the others 2000 years ago. Epidemiology looks for the cause of the disease by which it means that the removal of the risk of disease when the exposure disappear. Increased risk of a health outcome in th...
Purpose of investigation:
To evaluate the effectiveness of elective cervical cerclage (CC) on the pregnancy outcome of patients with cervical insufficiency.
Material and methods:
A retrospective cohort study was conducted on women with an obstetric history of cervical insufficiency on whom CC was applied or not. The two groups were compared for...
Cesarean scar pregnancy (CSP) is a rare, but life-threatening type of ectopic pregnancy. An exact and early diagnosis of CSP is very important for prognosis. The aim of the present study was to describe 4 women with CSP and discuss their clinical presentations, diagnoses, and various management options along with the published literature. Four wome...
Endometriosis is chronic inflammatory, hormone dependant and a common condition,
which may affect reproductive functions and cause various amount of pelvic pain. This paper
briefly reviews the association between pathogenesis of endometriosis and autoimmune disease and
describes the potential role of inflammation in the development of immunologic t...
Objective: This guideline was prepared by Turkish Endometriosis & Adenomyosis Society to provide guidance regarding clinical practices and our aim of preparing this guideline was to offer best current knowledge on the care of women with endometriosis, including diagnosis, evaluation, medical and surgical treatment. Material and Methods: This guidel...
Background:
Microdose flare-up GnRH agonist and GnRH antagonist have become more popular in the management of poor ovarian responders (POR) in recent years; however, the optimal protocol for POR patients undergoing in vitro fertilization has still been a challenge.
Methods:
In this observational study design, two hundred forty four poor ovarian...
Purpose:
The aim of this study was to assess the effects of preemptive and preclosure analgesia on postoperative pain intensity in patients undergoing different levels of laparoscopic surgery.
Methods:
Two hundred and twenty-six patients who underwent laparoscopic gynecological surgery were enrolled in this quasi-randomized, prospective, placebo...
Objective:
The objective of our study is to evaluate the long-term results of laparoscopic bean vaginoplasty (LBV), which we previously described.
Materials and methods:
From April 2002 to September 2013, 62 patients, who were diagnosed with Mayer-Rokitansky-Kuster-Hauser Syndrome and underwent LBV in Cukurova University School of Medicine Depar...
Psammocarcinoma is a rare variant of ovarian serous carcinoma and similar to carcinomas that exhibit low-malignant potential. A woman aged 38 years was admitted to the gynecology clinic with abdominal distension and amenorrhea. Magnetic resonance imaging (MRI) showed lob-ulated calcified abdomino-pelvic masses and multiple peritoneal implants. The...
We conducted a literature review to evaluate the minimally invasive fertility sparing procedures namely robotic radical trachelectomy (RRT) and laparoscopic radical trachelectomy (LRT) in patients with early stage cervical cancer. We searched Pubmed, Medline, Ovid, Google Scholar and Scopus up to July 2015 by using keywords and their combinations o...
Objective:
To compare and evaluate the influences of expectant and aggressive management of severe preeclampsia on the first year neurologic development of the infants in pregnancies between 27 and 34 weeks of pregnancy.
Methods:
Seventy women with severe preeclampsia between 27 and 34 weeks of gestation were included in the study. 37 patients w...
st Tıp Fak Derg 2015; 78: 1 CASE REPORT/ OLGU SUNUMU J Ist Faculty Med 2015; 78: 1 http://dergipark.ulakbim.gov.tr/iuitfd http://www.journals.istanbul.edu.tr/iuitfd Date received/Dergiye geldiği tarih: 26.02.2015-Dergiye kabul edildiği ABSTRACT Ectopic pregnancy continues to be one of the important reasons for maternal mortality. With the widesprea...
In scientific papers, owing to the absence of any standardization, the greatest anxiety
is associated with writing the authors’ name. The scientific papers, besides announcing a new research
to the readers, benefit to upgrading the authors named in published articles in academic enviroment.
Authorship in scientific papers requires contributing subs...
Fallopian tube cancer is usually asymptomatic and preoperative diagnosis is difficult. Due to its rarity and being detected mostly incidentally, the case mentioned below was evaluated as a case report and literature was reviewed. Patient who was 65-years-old applied to our clinic with ongoing post-menopausal vaginal bleeding for 5-6 months. In ultr...
Background: Microdose flare-up GnRH agonist and GnRH antagonist have become more popular in the management of poor ovarian responders (POR) in recent years; however, the optimal protocol for POR patients undergoing in vitro fertilization has still been a challenge. Methods: In this observational study design, two hundred forty four poor ovarian re-...
Spondylodiscitis is a rare but severe complication of sacral colpopexy (SC) procedure. Although the term 'spondylodiscitis' refers to infection of vertebral body and intervertebral disc space, neither the infecting microorganism could be isolated nor any purulent material could be observed during the second surgery and there was failure of differen...
Several obstetrical complications due to inappropriately healed cesarean scar such as placenta accreta, scar dehiscence and ectopic scar pregnancy are being increasingly reported along with the rising cesarean rates. Furthermore, many gynecological conditions including abnormal uterine bleeding, pelvic pain and infertility are imputed to deficient...
Öz
Ectopic pregnancy continues to be one of the important reasons for maternal mortality. With the widespread and frequent use of Assisted Reproductive Techniques (ART), the frequency of abnormally located pregnancies also rises.
In this article, we presented a case of an ectopic pregnancy occurring in the right tubal stump after an intracytoplasm...
Objective: To evaluate the effect of laparoscopic cystectomy for endometriomas on
ovarian reserve as determined by antral follicle count (AFC) and follicle stimulating hormone (FSH)
level. Material and Methods: In this prospective, observational, operated and non-operated site
comparative study, twenty one women between 20-36 ages with previous his...
To the Editor,In the recent article [1], Hatem Abu Hashim contributed to the promotion of surgical management for polycystic ovary syndrome (PCOS). As the author emphasized the predictors of failure of laparoscopic ovarian drilling (LOD) far more than the predictors of success, the title of the article “Predictors of success of laparoscopic ovarian...