Murat Akkus

• Dicle University

Purpose: In this study, placental histological differences between the control group and the PROM+preeclampsia group were evaluated. Materials and Methods: In our study, placentas were obtained from a total of 90 pregnant patients (regardless of age), including 45 control and 45 PROM+Preeclampsia pregnant patients, by obtaining informed consent for...

Aim: This study aims to evaluate the placental expression levels of two recently discovered proteins, adrenomedullin (ADM) and soluble endoglin (sEng), in preeclamptic pregnancies. Materials and Methods: Placental tissue sections were obtained from 20 preeclamptic and 20 normotensive patients and processed for paraffin embedding. Hematoxylin-eosin...

Objectives: The main aim of this study was to investigate the effect of Ceratonia siliqua L (carob) plant added to the culture medium to reduce the negative effect on sperm parameters as a result of cryodamage occurring in sperm during human sperm cryopreservation. Materials and methods: Semen samples obtained with consent from 50 infertile men age...

Aim: In approximately 20% of infertile couples, the male factor is the only main cause. In recent years, it has been hypothesized that sperm DNA integrity may be a better indicator than routine semen analysis. Although the effects of smoking on male infertility have not yet been proven, smoking is considered a reasonable risk factor for infertility...

This study investigates histopathological changes in ovarian tissues of rats subjected to ischemia-reperfusion (I/R) injury, a condition where restored blood flow causes cellular stress and potential damage. Rats were divided into three groups: control, ischemia, and ischemia-reperfusion. Histological analysis revealed that ischemic ovaries exhibit...

Objective: The placenta plays a key role in the development of pre-eclampsia. Knowledge of the histopathologic changes in the preeclamptic placenta will improve our understanding of the pathophysiology of preeclampsia, which may contribute to the development of timely interventions, prevention strategies or treatment options. Therefore, in this stu...

Objectives: Placental damage might be the primary underlying cause of the high rates of fetal adverse outcomes in cases with gestational diabetes mellitus (GDM). Histopathological changes were considered to be associated with GDM in the literature. However, there are also studies showing no changes in the placenta in some gestational diabetic women...

Objective: The primary objective of this study is to detect potential alterations in sperm cells in cases of varicocele using immunohistochemical methods. Materials and Methods: In this study, semen samples obtained with consent from infertile males aged between 25-40 years were analyzed for the presence of varicocele and other determined factors,...

Objective: This study aimed to investigate WD-repeat protein interacting with phosphoinositides-2 (WIPI-2) protein expression in the placen-tas of preeclamptic patients by immunohistochemical method. Methods: Placentas of 25 healthy normotensive women and 25 women with preeclampsia were enrolled in this study. Placental samples were fixed in zinc-f...

Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a global health problem that has claimed many lives worldwide. The disease is affecting almost all populations, but it poses a particular risk for groups such as the elderly and those with chronic diseases. Although the number of studies on clinical situations involving pregnant women an...

Aim: Acrylamide (ACR) is a water-soluble neurotoxic substance that has been widely researched in recent years. Boric acid (BA) is a component that does not have a toxic effect when taken at low concentrations and has a cystotoxic activity. Studies have reported that BA has antioxidant effects. In this study, we aimed to examine the protective effic...

Deltamethrin (DM) is an insecticide and is widely used around the world. Rosmarinic acid (RA) is found in herbs and spices in the Lamiaceae (mint) family and has antioxidant, anti-inflammatory and anti-apoptotic effects. We aimed to examine the protective efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. A total of 28 mal...

To investigate if the administration of boric acid (BA) would exert any protective effect against possible nephrotoxicity and hepatotoxicity induced by the exposure to acrylamide (ACR) in rats. In our study, we used a total of 28 rats that were divided into four equal groups. Group 1: the control group which was not treated with any procedure. Grou...

Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa without acrosomes. It is still unclear whether patients whose ejaculate contains both normal and globozoospermic cells (partial globozoospermia) suffer from a variation of the same syndrome. Affected men may experience decreased fertility and even infertility. In so...

Wound healing is a dynamic process initiated in response to injury. There are many factors that have detrimental effects on the wound healing process. Numerous studies have been conducted for improving wound healing processes. Dexpanthenol is widely used to accelerate wound healing. Sucralfate is used for the treatment of peptic ulcers. We aimed to...

İskemi, doku ve organların arteryel veya venöz kan akımının azalması nedeniyle yetersiz kanlanmasıdır. Sonuçta hücre enerji depolarının boşalması ve toksik maddelerin birikimiyle hücre ve dokuda hasar veya ölüm gerçekleşir. İskemi sonucunda dokularda hipoksi oluşur ve hipoksik doku hasarı ortaya çıkar. Reperfüzyona sekonder oluşan doku hasarında, h...

Benzene is an aromatic hydrocarbon and a colorless and odorous liquid. It is used in the production of plastics, detergents, pesticides, and other chemicals. Serious deterioration is seen in sperm production of men who are exposed to hydrocarbons such as ethylbenzene, toluene, xylene, and aromatic solvents found in paints, lacquers, adhesive-like s...

The pathogenesis of preeclampsia is still not clear, but endothelial dysfunction is believed to be one of the most encountered problems during placenta development in preeclamptic patients. Both vascular endothelial growth factor (VEGF) and its antagonist, soluble Fms-Like tyrosine kinase-1 (sFlt-1), have roles in vascular function. In this study,...

Introduction: Reperfusion surgery following testicular ischemia is a reproductive health threatening status and may result with organ dysfunction in men. The high level of reactive oxygen species (ROS) and cease of blood flow to the testis are the most important reasons of this testicular injury. Until today, numerous experimental studies reported...

Reperfusion surgery following testicular ischemia is a reproductive health threatening status and may result with organ dysfunction in men. The high level of reactive oxygen species (ROS) and cease of blood flow to the testis are the most important reasons of this testicular injury. Until today, numerous experimental studies reported that antioxida...

Varicocele is one of the main and surgically repairable causes of male infertility, which arises from dilatation and torsion of the testicular veins in the plexus pampiniformis. In this study, we examined semen samples from 40 patients diagnosed with varicocele between the ages of 15 and 30 years, according to WHO criteria (pre-operatively, and at...

Myocardial lipid accumulation due to diabetes and/or obesity plays a role in the progression of left ventricular diastolic dysfunction. Our aims were to exhibit the correlation between histopathologic stage of the liver and cardiac functions, and to evaluate the effects of metformin HCl and rosiglitazone on myocardial functions. Thirty-two male Spr...

OBJECTIVE: To examine the levator muscle in patients with congenital blepharoptosis and to investigate the relationship between those findings and age, gender, and degree of blepharoptosis. STUDY DESIGN: The levator muscles of 13 congenital ptosis patients who had undergone levator muscle resection were examined by light and electron microscopy. Du...

Infertility is described as the inability of a couple to conceive after 1 year of unprotected intercourse. Male factor is assumed to be responsible for 50% of cases of infertile couples. It is a common clinical problem, affecting approximately 13-15% of couples worldwide. In this study we aimed to investigate the effects of hypoosmotic swelling (HO...

The present study aimed to investigate the effects of the bacterial biofilm formation on the tonsil surface exposed N-acetyl-cysteine (NAC) and acetylsalicylic acid (ASA) of patients undergoing tonsillectomy by light and electron microscopy. The general process of biofilm formation comprises adhesion of free-living or planktonic bacteria to a surfa...

Objectives: Obesity is a worldwide problem, leading to cardiomyopathy. Oxidative stress and inflammation have been reported to play significant roles in developing obesity cardiomyopathy. N-acetylcysteine is a glutathione prodrug that preserves liver against steatosis via constraining the production of reactive oxygen species. Etodolac is a nonste...

Stroke is one of the major reasons of death in the United States and related to adult disability. Despite aggressive research, the treatment approaches of stroke still remains a major clinical problem. Intravenous immunoglobulin (IVIg) is a polyspecific Ig G preparation obtained from plasma of several thousand healthy people (donors). IVIg is an im...

To investigate the effects of cetuximab and bevacizumab on experimental rat model of corneal angiogenesis. The right eyes of 28 male Sprague-Dawley rats were included in silver nitrate cauterization-induced corneal angiogenesis model. They were divided into four groups: (1) silver nitrate cauterization-induced and 0.15 ml serum physiologic was give...

Ectodermal dysplasia is a group of symptoms affecting tissues and organs of ectodermal origin. In this study, conjunctival impression cytology technique which is a non-invasive method was performed in patients with ectodermal dysplasia to evaluate the effects on the conjunctiva. Six eyes of three patients with ectodermal dysplasia who were followed...

To evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8, 9 and 10. The fetuses (n:24) were divided into four groups: control, VPA,...

To evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8, 9 and 10. The fetuses (n:24) were divided into four groups: control, VPA,...

In this study, we evaluated the ultrastructural findings of testis with systemic administration of different doses of melatonin during ischemic period in a rat model of testicular torsion/detorsion (T/D). Testis ischemia-reperfusion (I/R) injury was induced by torsion of the left testis, with a 720 degrees twisting of the spermatic cord so as to pr...

In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty a...

In this study, we evaluated the ultrastructural findings of testis with systemic administration of different doses of melatonin during ischemic period in a rat model of testicular torsion/detorsion (T/D). Testis ischemia-reperfusion (I/R) injury was induced by torsion of the left testis, with a 720 degrees twisting of the spermatic cord so as to pr...

In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty a...

The aim of this study was to examine levator palpebralis superior muscle histologically in patients with congenital blepharoptosis and to investigate the relationship between these findings and age, sex and degree of blefaroptosis in this patient group.Materials and methods: Levator muscle of 13 patients with congenital ptosis, who had applied to D...

Objective: The aim of this study was to investigate the the distribution of CMA1 protein (MCC), CCL17 protein (TARC) and Integrin beta 4 (CD 104) monoclonal antibodies in normal adult human lung tissue. Material and Methods: In this study we examined the lung biopsy specimens obtained from the adult patients who underwent operations for different r...

Thromboangiitis obliterans is an inflammatory disease possibly resulting from cigarette smoking as a primary etiologic factor, perhaps as a delayed type of hypersensitivity or toxic angiitis. As little is known about the pathogenesis of the disease, we aimed to determine novel antigens that might be responsible from the local inflammatory reactions...

Thromboangiitis obliterans is an inflammatory disease possibly resulting from cigarette smoking as a primary etiologic factor, perhaps as a delayed type of hypersensitivity or toxic angiitis. As little is known about the pathogenesis of the disease, we aimed to determine novel antigens that might be responsible from the local inflammatory reactions...

This study has goals of examining whether pre-eclampsia may lead to an increase of elastic tissue fibers in blood vessel walls of placental stem villi or whether there are differences in the thickness of blood vessel walls within these villi when compared to normotensive pregnant women. Non-infarcted placental tissue samples from 28 participants wi...

Milky spots are opaque patches in the greater omentum. They were first described by von Recklinghausen (1863) in the omentum of rabbits. In man, milky spots are relatively uniform, highly vascularized accumulations of mononuclear cells. The objective of this study was to describe in human omental lymphoid tissue components with S-100. Tissue sample...

Background: Smoking is one of the most serious health care issues worldwide, as one third to one half of all people who smoke eventually use tobacco habitually. Chronic smoke exposure causes airway and lung parenchymal inflammation and the destruction of alveolar cell walls. Statins may have anti-inflammatory effects that would play a role in prev...

To investigate the effects of oral cinnamon supplementation on the nervus ischiadicus at the electron microscopical level in rats. This study was performed between 2004-2006 in Dicle University School of Medicine, Diyarbakir, Turkey in 15 adult Sprague-Dawley rats. Rats were divided into 3 groups; control (C) (n=5), diabetic without cinnamon (D) (n...

Poster presented in 10th Congress of European Association of Clinical Anatomy

We aimed to investigate the potential harmful effects of maternal valproic acid (VPA) on fetal sciatic nerve, and the protective effects of vitamin E (Vit E) and folic acid (FA) on fetal rats. Valproic acid (400mg/kg), folic acid (400mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days 8-10. All fetuses were collecte...

Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlu...

In this study we evaluated toxic effects of atorvastatin on the development of muscle necrosis in rats at the light microscopic level .Male, adult 40 Wistar- albino rat used in this study. Rats divided into 10 equal groups as one control, 9 treatment groups. All rats were sacrified after 5th 10th and 15th days of the study.And their quadriceps femo...

In this study, we aimed to investigate Clomiphene Citrate (CC) on vagen of adult Ovariectomised rats. Transmission electron microscopy and light microscopy have been used to study changes to the vaginal epithelium induced by C administered to Ovariectomised rats. The study was performed in Department of Medical Science Application and Research Cent...

It is generally agreed that the testis is under endocrine control from the pituitary, and is influenced by physiological and paracrine factors within the organ.The aim of this study is to analyze the effect of unilateral and bilateral epididectomy on the testicular tissue growth of rats.Twenty- one male old Sprague-Dawley rats (28 days old) were us...

The harlequin fetus, a severe variant of ichthyosis, occurs rarely, and these babies die within the first few days of life. Early retinoid therapy may improve the disorder and help increase survival rates. The exact cause of the sudden infant death syndrome of the suckling is not known and the incidence approximately is 0.1-0.3 %. In general, these...

In this study 34 dental bridges constructed for 30 individuals. The bridges removed at the department of Prosthetic Dentistry University of Dicle.The results revealed that the rate of bridges failure %100 . The major reasons for failure revealed by this study were periodontal disease and mucosal inflamations. The average life span for bridges was 4...

Elongation of peripheral nerve by the use of a tissue expander is helpful to repair nerve defects. This study was designed to investigate the effects of some antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure. Twenty-five Wistar rats were used in this study. Following the exposition of the sciatic nerve and p...

To present additional data on high endothelial venule (HEV) structure and immunophenotype. We used the zinc iodide-osmium tetroxide technique (ZIO), which is a metallophilic fixation and staining technique to examine HEVs at light and electron microscopic levels as this technique was previously reported to be reactive with cells in HEVs. Tonsils an...

Milky spots in the human omental tissue are known to be consisting of lymphocytes, macrophages and mast cells. Our goal was to evaluate the relationship of lymphoid cells and macrophages with vasculature and stromal components. In this study we examined the biopsy specimens obtained from the adult patients whom were operated for different purposes...

In this experimental study, I examined the advantage of the retrogradehypothermic saline solution through the inferior vena cava during aortic surgery toprevent the complications of spinal cord ischemia. This study was examined on 14kangal dogs. In the first (control) group, no preventive method was used. In thesecond (hypotermic) group, hypothermi...

Valproic acid is an anticonvulsan drug used in epilepsy. Thehistopathological changes of valproic acid on liver and the protective effectof vitamin E and also folic acid were observed. 24 adult female Wistar Albinorats were used. The first control, the second valproic acid group that wasgiven 300 mg/kg on 8.9. and 10. days of gestation, the third v...

In this study we investigated the histopathological changes of nasal mucosa after the use of topical benzalkonium-chloride solution. In the study, 28 male New Zealand white rabbits were used. The animals were divided into two groups. In the first group, 50 micro l of 0.001% benzalkonium-chloride solution was sprayed into the right nostril and 50 mi...

Ovarian mucinous tumors stem from ovarian surface epithelium and are divided into benign, borderline and malignant. It is difficult to differentiate borderline and malignant mucinous tumors. Thirty-eight cases of ovarian mucinous tumors which were diagnosed at the Pathology Department of Dicle University Medical Faculty were reviewed. Of these, 18...

Replacement of the circumflex branch of the left coronary artery is extremely rare. We conducted a retrospective study to determine the incidence of this anomaly of circumflex branch of the left coronary artery. Two such patients were identified from 850 adults undergoing cardiac catheterization procedures. The circumflex branch of the left coronar...

The dithiocarbamates are known to cause dermatitis, conjunctivitis, rhinitis, pharyngitis and bronchitis in humans. The experimental group received Propineb (obtained from Bayer) concentrations of 400 ppm in distilled water five days a week (treatment time three weeks) administered orally by gasric pit. Acute oral LD50 for male rats has been found...

Unlabelled: Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5 +/- 5...

Intravesically applied oxybutynin, rapidly absorbs into the bloodstream, additional to profound local effect. Currently morphologic effects of oxybutynin on local bladder tissue relatively well established at light microscopic level, but not ultrastructural level. Thirty New Zealand White female rabbits were catheterized daily and intravesical inst...

Zinc iodide-osmium tetroxide (ZIO) fixation/staining technique is a metallophilic technique which has been used for the examination of various tissues and cell types. We examined the ZIO (+) cell types in rat exocrine pancreas to obtain further evidence for the significance of the reaction. Among mostly non-reactive pancreatic acinar cells there we...

In rats penis development a seen two stages in prenatal life, the second stage is androgen hormone dependent chondrocyte and osteocyte differentiation period. To investigate Tamoxifane (Tx) administration on the developmental anomalies of penis. The newborn male rats were injected with 100 μg Tamoxifen subcutaneously from the day of birth to fifth...

SUMMARY In this study 34 dental bridges constructed for 30 individuals. The bridges removed at the department of Prosthetic Dentistry University of Dicle. The results revealed that the rate of bridges failure %100 . The major reasons for failure revealed by this study were periodontal disease and mucosal inflamations. The average life span for brid...

This study was planned for evaluating the eLect of collagenase which is one of the popular enzyme used in wound healing recently. Two groups of rats which consist .15 animals each were ıısed by this aim. Oıı collagenase applied group Novuxol-as ointment- consist of the enzymes asprotease and clostrodiopepsjdase..A that is obtained fflom the culture...