Munetaka Haida

Munetaka Haida
Sport Medical Science Research Institute, Tokai University. · not spcifyed

MD, PhD

About

131
Publications
6,559
Reads
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1,423
Citations
Citations since 2017
4 Research Items
308 Citations
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
Additional affiliations
April 2008 - March 2016
Tokai University junior college of Nursing and Medical Technology
Position
  • Professor (Full)
April 2002 - March 2009
Tokai University
Position
  • Professor (Full)
April 2001 - March 2002
Tokai University
Position
  • Professor (Associate)

Publications

Publications (131)
Article
Objective: Passive muscle stretching is a common physical therapy for critically ill patients in the intensive care units. This study aimed to evaluate the effects of unilateral passive stretching of the gastrocnemius muscle (GM) before and after surgery on blood volume (BV) in the contralateral (non-stretched) GM in patients who are sedated after...
Article
Full-text available
Purpose: Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods: This case-controlled study enroll...
Article
We tested a hypothesis that liposome-encapsulated hemoglobin (LEH) with high oxygen (O2) affinity (h-LEH, P50O2 = 10 mm Hg) may work better than LEH with low O2 affinity (l-LEH, P50O2 = 40 mm Hg) in cerebral ischemia and reperfusion injury using positron emission tomography (PET) in primates undergoing middle cerebral artery (MCA) occlusion and rep...
Article
Objective: The objective of the present study is to conduct a retrospective analysis comparing graduate-entry program (GEP) and school-leaver-entry program (SEP) students from the perspective of scholastic achievements from admission through the national examination for medical practitioners. Methods: The number of students who repeated one or m...
Article
Liposome-encapsulated hemoglobin (LEH) with high (h-LEH, P50O2 = 10 mm Hg) or low O2 affinity (l-LEH, P50O2 = 40 mm Hg) may improve O2 delivery to sensitize tumor tissues for radiotherapy. A total of 10 mL/kg of h-LEH, l-LEH, red blood cells (RBCs), or saline was infused in mice transplanted with murine colon carcinoma with near-infrared spectrosco...
Article
Full-text available
The effects of heat-killed Lactococcus lactis JCM5805 (JCM5805) on the pathogenesis of common cold and influenza were evaluated. A randomized, placebo-controlled, double-blinded study was conducted and 396 healthy subjects (placebo group n = 205, JCM5805 group n = 191) completed the intervention. Subjects consumed placebo capsules or JCM5805 capsul...
Chapter
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation that is usually progressive. COPD patients have dyspnea, chronic cough and sputum production. In addition, patients with COPD develop systemic features such as body weight (BW) loss, especially muscle wasting, and skeletal muscle dysfunction in addition t...
Article
Artificial oxygen carriers were originally developed as a substitute for red blood cells (RBC) for transfusion. As the blood demand-supply balance becomes critical, it is reasonable to explore artificial oxygen (O2) carriers.
Article
Liposome-encapsulated hemoglobin with low O2 -affinity (l-LEH) was shown to be protective in focal brain ischemia and reperfusion (I/R) in rats and primates. We tested l-LEH in the transient whole brain ischemia in the Tokai high-avoider rat (THA), which has been selected, mated, and bred over 77 generations for a high and consistent learning abili...
Article
A 29-year-old female with systemic lupus erythematosus who developed accerelated hypertension, motor paralytic bladder and various other neurological abnormalities is described. Cystometry demonstrated flaccid atonic neuropathic bladder. Elevated protein level and albuminocytologic dissociation were recognized in her cerebral spinal fluid. Magnetic...
Article
Liposome-encapsulated hemoglobin (LEH) is protective early after brain ischemia in rats and nonhuman primates, but it remains unclear whether the protection persists and confers any benefits beyond the acute phase of brain ischemia and reperfusion. Ten monkeys underwent middle cerebral artery occlusion, received LEH (2 mL/kg, n = 5) or saline (2 mL...
Article
This study reports on brain activity induced by picture-based personality tests. Near-infrared spectroscopy is a newly developed, noninvasive technology in neuroimaging that can measure brain activity through blood volume changes. We measure the prefrontal cortex (Brodmann Area 10 [BA10]) activities of adolescents during the Rorschach (1921), the R...
Article
Full-text available
We hypothesize that liposome-encapsulated hemoglobin with high O₂ affinity (P₅₀0₂ = 12 mm Hg, h-LEH) may increase O₂ delivery to hypoxic tumors and enhance radiation therapy synergistically to suppress tumor growth. First, h-LEH (5, 10, and 20 mL/kg) was intravenously infused 30 min before radiation (20 Gy) of SCCVII tumor grown in C3H/HeN mice. Se...
Article
The effect of liposome-encapsulated hemoglobin (LEH) was tested in a rodent model of limb ischemia and reperfusion--causing local reperfusion injury and a cascade of systemic responses. Intracellular pH (pHi) and phosphocreatine (PCr)/inorganic phosphate (Pi) ratio were serially monitored using ³¹P-nuclear magnetic resonance spectroscopy with a 2-c...
Article
Full-text available
An artificial oxygen carrier, liposome-encapsulated hemoglobin (LEH), protective in a rodent stroke model, was quantitatively evaluated in monkeys. Serial positron emission tomography studies using the steady-state (15)O-gas inhalation method were performed to quantify O(2) metabolism, which was compared based on the infarction extent and immunohis...
Article
The aim of the present study using near-infrared spectroscopy (NIRS) is to evaluate the correlation of cerebral (parieto-temporal lobe) hemoglobin changes and vertiginous sensation during unilateral caloric stimulation. During the hot water (44 degrees C) stimulus, cerebral hemoglobin was increased bilaterally, but it was dominant ipsilaterally. Du...
Article
Liposome-encapsulated hemoglobin (LEH) was proven to be protective in cerebral ischemia/reperfusion injury. The present study evaluated LEH in a rat model of permanent middle cerebral artery (MCA) occlusion to clarify its effect during ischemia and reperfusion. Five minutes after thread occlusion of the MCA, rats were infused with 10 mL/kg of LEH (...
Article
Liposome-encapsulated hemoglobin (LEH) with a low oxygen affinity (l-LEH, P(50) = 45 mm Hg) was found to be protective in the rodent and primate models of ischemic stroke. This study investigated the role of LEH with a high O(2) affinity (h-LEH, P(50) = 10 mm Hg) in its protective effect on brain ischemia. The extent of cerebral infarction was dete...
Article
Cell-free hemoglobin-based oxygen carriers have well-documented safety and efficacy problems such as nitric oxide (NO) scavenging and extravasation that preclude clinical use. To counteract these effects, we developed S-nitrosylated pegylated hemoglobin (SNO-PEG-Hb, P(50) = 12 mm Hg) and tested it in a brain ischemia and reperfusion model. Neurolog...
Article
Although several studies have shown that plasma concentrations of branched-chain amino acids (BCAAs) are reduced in patients with chronic obstructive pulmonary disease (COPD), little is understood about how low concentrations of BCAAs limit exercise in such patients. The present study investigated whether plasma BCAAs are related to energy metaboli...
Article
Exercise capacity is frequently decreased in patients with chronic obstructive pulmonary disease (COPD), and muscle dysfunction is one factor in this reduction. Studies using (31)-phosphorus magnetic resonance spectroscopy ((31)P-MRS) have shown that phosphocreatine (PCr) and muscle pH (pHi) are significantly decreased in patients with COPD during...
Article
Liposome-encapsulated hemoglobin (LEH; TRM-645) is a novel oxygen (O(2)) carrier with a lower O(2) affinity (P(50)O(2)=40 mm Hg) than red blood cells. In contrast to cell-free hemoglobin, encapsulation prevents hemoglobin extravasation, whereas its subcellular size (230 nm) may improve O(2) delivery and limit the severity of cerebral infarction. Th...
Article
Simultaneous measurements of muscle energy metabolism using (31)P-magnetic resonance spectroscopy ((31)P-MRS) and the kinetics of muscular oxygen metabolism using near-infrared spectroscopy (NIRS) were conducted in polymyositis (PM) patients. The subjects were 12 PM patients (age 45 +/- 12 years) and 12 normal controls (age 41 +/- 12 years). The mu...
Article
We have studied the relationship between the ratio of activated platelets and the thickness of intima and media of the carotid artery in ischemic CVD patients in the chronic stage. Platelet activation was assessed by means of flow cytometry of whole blood using activation-dependent monoclonal antibodies (MoAb). Forty-one MRI-proven normative subjec...
Article
Full-text available
We assessed changes in skeletal muscle energy metabolism by 31P-magnetic resonance spectroscopy (31P-MRS) and oxygen supply by near-infrared spectroscopy (NIR), after exercise and after administration of glucose and a branched-chain amino acids (BCAA), in healthy volunteers and patients with liver cirrhosis. As for the patients with liver cirrhosis...
Article
Full-text available
A new method for quality control of multiple-choice tests was developed with the assumption that there are two classes of items-beneficial and nonbeneficial-to evaluate students' ability. The information function is applied to distinguish these two classes. Of 316 items on multiple-choice tests at Tokai Medical School in 1993, 224 (70.9%) were bene...
Conference Paper
A head mounted goggle type eye detection device with a liquid crystal display was developed for investigation of eye tracking functions of neurological disease patients. The system was based on the image analysis of eye movements and this method precisely detected eye movements. The head mounted display showed a visual target created by a PC in fro...
Article
In 1994, a pupillary response test using very dilute (0.01%) tropicamide, a cholinergic antagonist, evoked remarkable pupil dilation in subjects with Alzheimer's disease (AD) and has since been considered a diagnostic tool for AD. However, since this test was first reported, there have been studies suggesting it cannot provide a differential diagno...
Article
An abstract is unavailable. This article is available as HTML full text and PDF.
Article
We investigated the progression of cytotoxic brain edema induced by 6-aminonicotinamide (6-ANA), a potent antimetabolite of nicotinamide, by measuring the time courses of changes in brain tissue water state (with MRI), histology (with H&E staining), energy metabolism (with 31P-NMR), brain hemoglobin concentration (with near-infrared spectroscopy; N...
Article
An effectiveness of neurointensive care unit for the treatment of neurological diseases and an application of the information technology (IT) for this and a critical pathway were discussed. A critical pathway is useful to make a standardized treatment, to reduce the days in hospital and to obtain an informed consent. But the hospital information sy...
Article
Full-text available
Our study was undertaken to determine whether increased platelet activation occurs in patients with obstructive sleep apnea syndrome (OSAS) and whether a therapy with nasal-continuous positive airway pressure (N-CPAP) alters this activation. We measured the positive rate of activated platelets using activation-dependent monoclonal antibodies (MoAb)...
Conference Paper
We developed an eye movement analysis system using eye images during many kinds of eye movements. The system can display any kind of pattern in front of their eyes. It can analysis eye movements while subjects are on some ocular tasks. Our experimental system consists of a head mount display with a color liquid crystal display, infrared LEDs, and a...
Article
We evaluated a 63 year-old, right-handed woman by functional MRI (fMRI) in the early and the recovery stages following a cerebral infarction in the right precentral knob. An activated signal in the ipsilateral sensorimotor cortex and contralateral supplementary motor cortex during deteriorated hand grasping (left) was observed in the early stages,...
Article
Full-text available
We developed a new measurement system of pupil area with camera position adjustability using iris diameter, which size is constant regardless of automatic nervous system. The camera probe consists of a small CCD camera, infrared LEDs, and a stepping motor. The motor can adjust camera position to an optimum distance in order to get sharp eye images....
Article
The appearance of local cerebral dysfunction at remote regions from the focus in the acute stage of stroke (diaschisis) is well known, but its mechanism has not been established. We have analysed serial MR images of the infarcted brain of rats to evaluate the distribution of oedema. Forty-seven Sprague-Dawley rats were anaesthetized with halothane,...
Article
For better understanding of the behavior of water molecules in the animal brain, changes in magnetic resonance water proton relaxation processes were studied in the rat during maturation. Midbrains of male Wistar rats were removed at various time points ranging from 2 to 70 days after birth. Changes in relaxation time (water proton longitudinal rel...
Article
The effects of aging on muscle metabolism and oxygenation have not yet been elucidated. We evaluated the effects of aging on energy metabolism and oxygenation in sedentary healthy subjects by simultaneously measuring 31P-magnetic resonance spectroscopy (MRS) and near-infrared spectroscopy (NIRS). Nine young (28.1 +/- 5.0 yr) and nine older (61.4 +/...
Conference Paper
Full-text available
Pupillary response test using a cholinergic antagonist, tropicamide was focused as a diagnostic method of Alzheimer's disease (AD). Ever since the test was reported, there have been studies that non-AD individuals showed same responses to tropicamide compared to AD individuals and that the test could not be useful for the diagnosis of AD. In this s...
Article
Pleural effusions of seven lung cancer patients (mean age; 58) and seven non-cancer patients (mean age; 49) were examined and Cu(2+) was measured in ceruloplasmin and Fe(3+) in transferrin signals by electron spin resonance (ESR) method. The variations of total Fe and Cu ions, ceruloplasmin and transferrin, proteins, neutrophil cell counts, LDH and...
Article
A Guillain-Barré syndrome patient showed giant negative T waves on electrocardiography at the height of the disease, with large left ventricular hypokinesis on echocardiography and extensive defects on 123I-meta-iodobenzylguanidine myocardial scintigraphy. Gamma-globulin improved the neurological symptoms, and the above abnormalities resolved. We s...
Article
Regional differences in the redox ratio were studied in the gerbil brain. Brains were frozen using an in situ funnel-freezing method, and sliced coronally for scanning of mitochondrial redox imaging. The relative local redox ratio of nicotinamide-adenosine dinucleotide to its reduced form was calculated from fluorescence signals of intrinsic fluoro...
Article
Magnetic resonance (MR) and 11C-N-methylspiperone (11C-NMSP)/positron emission tomography (PET) imagings were repeatedly performed in a 50-year-old man with the interval form of carbon monoxide (CO) poisoning. In MR images obtained when delayed neuropsychiatric symptoms developed (two months after poisoning), the inner segments of the bilateral glo...
Article
Full-text available
A potential link between Alzheimer's disease and hypersensitive pupil dilation has been reported. Patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in the pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. We have devised a system to measure pu...
Article
A 49-year-old woman developed paraplegia 26 hours after appendectomy under epidural and general anesthesia. Systolic blood pressure fell to 85 mmHg for 25 minutes after epidural anesthesia, which was performed at the level of the L1/2 intravertebral space. Neurological examination revealed paraplegia and superficial sensory impairment below the lev...
Article
Full-text available
We previously examined the effect of alcohol on muscle energy metabolism in chronic alcoholics by using 31P-magnetic resonance spectroscopy. Measurements of intracellular pH and PCr index [PCr/(PCr + Pi)] during resting, hand grasping, and recovery in the left flexor digitorum superficialis muscle of alcoholics with neurological signs showed a mark...
Article
We previously examined the effect of alcohol on muscle energy metabolism in chronic alcoholics by using 31P‐magnetic resonance spectroscopy. Measurements of intracellular pH and PCr index [PCr/(PCr + Pi)] during resting, hand grasping, and recovery in the left flexor digitorum superficialis muscle of alcoholics with neurological signs showed a mark...
Article
We sought to determine whether nuclear magnetic resonance relaxation times of water in tissue would be useful to detect molecular damage in lung tissue within 2 weeks after irradiation. Tissue samples were obtained from the lungs of rats at various times between 1 and 14 days after exposure of a hemithorax to 20 Gy 60Co gamma irradiation. The spin-...
Article
Analysis of the intramedullary cell distribution by magnetic resonance imaging (MRI) using conventional techniques involves subjectively interpreting images and estimating the cell distribution on the basis of signal intensity characteristics. In recent years, attempts have been made to achieve more precise analysis by new techniques, including che...
Article
Analysis of the intramedullary cell distribution by magnetic resonance imaging (MRI) using conventional techniques involves subjectively interpreting images and estimating the cell distribution on the basis of signal intensity characteristics. In recent years, attempts have been made to achieve more precise analysis by new techniques, including che...
Article
To determine the transverse relaxation time (T2) of biological tissues in nuclear magnetic resonance measurements, the Carr-Purcell-Meiboom-Gill (CPMG) method has been recommended to avoid the effect of external magnetic field inhomogeneity on T2 values. However, a dependence of T2 on the interpulse delay time (IPDT) in the CPMG measurements has be...
Article
The water content of lung, brain, and muscle tissue was measured by nuclear magnetic resonance (NMR) and compared with gravimetric determinations. The NMR signal intensity of water was measured by a single 90 degree pulse and by a spin-echo sequence. The absolute water content was determined by the difference in the sample's weight before and after...
Article
Nuclear magnetic resonance transverse relaxation time (T2) was previously measured in studies of lung water. The T2 decay curves for peripheral lung tissue were found to be multiexponential with two T2 components: T2 fast (T2f) and T2 slow (T2s). This behavior was explained by the compartmentalization of water, in which the protons of water are res...
Article
脱血による血圧下降時の脳内各部位の脳循環自動調節能を, サルにおいてstable Xe-CT法を用いて比較検討した.対象は日本ザル10匹である.血圧下降前後における脳内各部位の脳血流 (CBF) を測定した.血圧下降前における各部位の脳血流は, 大脳基底核部90.8±41.2, 大脳皮質96.8±35.1, 大脳白質56.6±21.1, 小脳半球50.0±19.3ml/100g brain/min (mean±SD) であった.脱血による血圧下降時の脳血流の維持状態を, 脳内各部位の平均自動調節能指数 (MAI), すなわち正常血圧時 [平均動脈血圧 (MABP) 90mmHgから130mmHg] におけるCBFの平均値からMABP50mmHgにおけるCBFを減じた値を, 更に正常血圧時にお...
Article
Several methods have been employed in attempts to estimate atraumatically the in-vivo cerebral blood flow and metabolism. One approach is to measure brain hemoglobin oxygen-saturation level and blood volume in vivo by using near-infrared reflection or transmission spectroscopy1,2
Article
We investigated the effect of alcohol on muscle energy metabolism by using 31P magnetic resonance spectroscopy in 12 chronic alcoholics [6 with neurological signs and symptoms (such as cerebellar ataxia or diplopia) and 6 without neurological signs or symptoms], compared with five healthy subjects who also received acute alcohol loading. Intracellu...
Article
各種抗浮腫薬の虚血性脳浮腫に対する影響をMRIを用いた画像解析により検討した.SDラット26匹に頸動脈カテーテル法により右中大脳動脈閉塞を作製し, 24時間後0.5テスラのMRIを用いて軸状断T2画像を厚さ3mmの間隔で撮影した.撮影後直ちにglycerol 1.7g/kg (n=9), manllitol 3.3/kg (n=9), furosemide 17mg/kg (n=8) のうちいずれかを腹腔内に投与し, 2時間後にMRIを再撮影した.全脳高信号領域容積はglycerol, mannitol, furosemide投与前後でそれぞれ207→191mm3, 189→177mm3, 189→180mm3と減少し, 変化率は92% (p<0.Ol), 94 (p=0.07) %, 95...
Article
We conducted an electron spin resonance (ESR) study on human pleural effusions obtained from patients (n = 15) with and without cancer at 77 K. We detected two kinds of signals which are considered to be due to transition metal ions in metalloproteins such as Fe3+ in transferrin and Cu2+ in ceruloplasmin from their g values (g = 4.2 and 2.049) and...
Article
Models of pulmonary edema have been used to study the nuclear magnetic resonance (NMR) characteristics of lung water. Several investigators have measured changes in the relaxation times in the permeability type of pulmonary edema, but relatively few have measured relaxation times in the hydrostatic type of pulmonary edema. In this study we determin...
Article
We measured free water fraction of tissue water in rat lungs ! Wistar, 250-350g) which had received the following treatments: control (C), no treatment; overhydrated lung (S), 10 min after r<;ceiving 30 ml/kg of 0.45% NaCl solution i.V.; endotoxin lung(E), l H hrs after receiving 3 mg/kg of E. coli endotoxin i.V., fibrotic lung 111'), 1 yr after ir...
Article
To evaluate utilization of oxygen in skeletal muscle, we measured changes in oxygenated-, dcoxygenated- and totalhcmoïlohin/myoglobin loxy-, deoxy- and oxy+deoxy- Hb/Mb) using near-infrared spectroscopy (NIKS'. OM-10ÜA, Shimazu, Japan) in the right vastus laterahs muscle during incremental bicycle exi-rcisi>i:iO W/mini. Kinetics of 11-2 uptake (V(>...
Article
Myelopathy is a rare central nervous system manifestation in systemic lupus erythematosus (SLE). We present a case of SLE, who developed motor paralytic bladder and various other neurological abnormalities. A 29-year-old female with SLE was admitted to our hospital because of complete dysuria without any troubles on defecation. Accelerated hyperten...
Article
Full-text available
We investigated the relationship between nutritional status and muscle energy metabolism during exercise in 18 male patients with chronic obstructive pulmonary disease (COPD) and 15 male control subjects using 31P nuclear magnetic resonance spectroscopy (31P-MRS). The patients and control subjects were further categorized as in either a well-nouris...
Article
We measured the nuclear magnetic resonance (NMR) relaxation times TI and T2 of water in an albumin solution and compared them with values calculated using dielectric relaxation parameters obtained by time domain reflectometry (TDR) and translational diffusion coefficients obtained by NMR. The calculated NMR relaxation times reproduced well the obse...
Article
We investigated the nuclear magnetic resonance (NMR) relaxation times, T1 and T2, for lung cancer tissue, and other samples of lung tissue obtained from surgical specimens. The samples were nine squamous cell carcinoma, five necrotic squamous cell carcinoma, 15 adenocarcinoma, two benign mesothelioma, and 13 fibrotic lungs. The relaxation times wer...
Article
The magnetoelectricity of the boracite Cr3B7O13Cl has been studied by quasistatic and dynamic magnetoelectric (ME)H measurements on (001)cub platelets with a ferroelastic/ferroelectric single domain state, obtained by poling with an electric field of E = 45 kV·cm, applied upon cooling through the 42ml′ ⇒ mm21′ phase transition at 160 K. The magneto...
Article
Using a time-resolved technique, we have studied two methods of quantifying the concentration of a light absorber localized in a scattering medium. Because some of the transmitted photons pass through the absorber region many times because of complicated photon propagation in the scattering medium, we used the following methods. First, early-arrivi...