Mukhtar GAMBO Lawal

• Doctor of Philosophy
• Lecturer at Umaru Musa Yar'adua University

Study’s Novelty/Excerpt A review of recent advancements in artificial intelligence (AI)-based techniques, convolutional neural networks (CNNs) and deep learning, for malaria detection and quantification, is presented. The strengths and limitations of AI approaches in analyzing digital images and blood smears as well as current challenges, including...

Study’s Novelty/Excerpt This review systematically explores the anti-ulcerogenic potential of medicinal plants, emphasizing their bioactive compounds and pharmacological properties, a topic underexplored in the context of peptic ulcer management. The inclusion of 33 studies from 2010-2024 offers a comprehensive analysis of plant species like Curcum...

Objective: Inflammatory diseases are influenced by oxidative stress. Oxidatively damaged 8-oxoG in DNA is linked to inflammation. The enzyme OGG1 is responsible for repairing the damaged base in the DNA which is linked to pro-inflammatory signaling and severe inflammation. This study aims to explore the potential of targeting OGG1 as a therapeutic...

Objective: To determine the involvement and the modulatory effects of IL-33 during Plasmodium berghei ANKA (PbA) infection. Methods: PbA infection in male ICR mice was utilized as a model of malaria. Systemically circulating IL-33 levels were determined in blood plasma by enzyme-linked immunosorbent assay (ELISA). After 24 hours post-inoculation of...

Background Vascular dysfunction can lead to many health problems including hypertension and heart disease. The complexities of vascular dysfunction and vascular disorder-related diseases have prompted the search for many new biologically active compounds in the efforts of resolving the problems. Previous studies have shown that Ama-ryllidaceae alka...

There are increasing reports of substandard antimalarial drugs, and these have been a severe under-recognised public health problem especially in developing countries. For this reason, 21 samples of different brands of artemisinin-based combination therapies (ACTs) comprising of artemether/lumefantrine and artesunate/amodiaquine oral drug formulati...

Aims: To determine the prevalence of glucose-6-phosphate dehydrogenase deficiency and its variant (G6PD A-) among children diagnosed with Plasmodium falciparum malaria in Katsina state, Nigeria. Study Design: Cross-Sectional Studies. Place and Duration of Study: General Hospitals Katsina, Dutsin-ma, Daura, Baure, Malumfashi and Funtua of Katsina st...

Microbial contamination of non-sterile pharmaceutical products is a serious problem because it can result in the spoilage of the products or pose a serious health risk to the patient. Identification of microbial contaminants is pertinent with the view to help prevent putting patients at risk due to inadequate safety, to track contamination sources...

Despite the recommended methods of current good manufacturing practices (CGMP) and the efforts of the Government's regulations, there is still suspicion on the circulation of pharmaceutical products with questionable quality primarily in the developing countries. The circulation and use of substandard drugs pose a serious health risk to the patient...

Pharmaceutical oral liquid dosage forms are basically formulated as non however, must satisfy the appropriate microbiological purity criteria. pharmaceutical products are susceptible to contamination by a variety of microorganisms during manufacturing and use. In this study, sixty seven (67) samples of four (4) different pediatric oral liquid drugs...

This study characterized multi-drug resistant M. tuberculosis phenotypically by the LJ-proportion method and genotypically by GenoType MTBDR plus LPA. Out of the forty M. tuberculosis isolates tested, two (5.0%) were found to be multi-drug resistant by the LJ proportion method and one (2.5%) was MDR by LPA. None was found to be mono-resistant to an...

Certain factors bring about microbial preterm infections, including mode of delivery, socio-economic/geographic factors, gut microbial diversity etc. Consequent colonization of the gut by these microorganisms can have malevolent aftermaths. In the same vein, premature infections such as necrotizing entero colitis (NEC) and sepsis are among the cruc...

Infection with Herpes Simplex Virus type 2 (HSV-2) is a significant public health problem being the leading cause of genital ulcerative disease. This study was aimed to evaluate the seroprevalence of herpes simplex virus type 2 among healthy individuals in Katsina State, and to determine the socio demographic and risk factors associated with HSV-2...

G6PD deficiency is one of the most common human enzyme deficiencies in the world. It is particularly common in populations living in malaria-endemic areas. The aim of this study is to molecularly screen G6PD enzyme among deficient children (aged 0-5 years) with Plasmodium falciparum malaria in Katsina State, Northwestern Nigeria, and a region with...

These antibiotics are designed to target pathogenic organisms but related members of the microbiota are also affected, often leaving an imprint on the gut community long after the antibiotics have been removed . However, sometimes an imbalance in the commensal gut microbiota due to antibiotic administration can result in intestinal problems, such a...

Background: Gastroenteritis is a leading cause of childhood morbidity and mortality in developing countries. The study determines the prevalence of rotavirus and adenovirus infection and their clinical manifestations in children aged < 5 years in Katsina State, North-west zone of Nigeria. Methods: A total of 400 (322 diarrhoiec and 78 non-diarrhoie...