• Home
  • Mukharram Bikbov
Mukharram Bikbov

Mukharram Bikbov

Professor
Ufa Eye Research Institute , Director

About

214
Publications
57,325
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
9,503
Citations

Publications

Publications (214)
Article
Full-text available
Abstract Information about prevalence and associated factors of non-alcoholic fatty liver disease (NAFLD) has been scarce for the Russian, Eastern European and Central Asian world region. We assessed prevalence and associated factors of NAFLD in two population-based studies (Ural Eye and Medical Study (UEMS), Ural Very Old Study (UVOS)), which were...
Article
Full-text available
Objective: To assess the prevalence of vision impairment, hearing impairment and dual sensory impairment (DSI) as combination of vision and hearing impairment, in association with cognitive dysfunction in a population aged 85+ years. Methods: The cross-sectional population-based Ural Very Old Study, conducted in rural and urban Bashkortostan, Ru...
Article
Purpose. Тo study the prevalence of cataract surgery, its effectiveness and factors that reduce visual results in a population of the population of the Republic of Bashkortostan. Material and methods. The Ural Eye and Medical Study population study, based on the Ufa Research Institute of Eye Diseases, was attended by 5885 people aged 40 years and o...
Article
Intrоduction. Various biometric indicators of the eyeball in certain categories of the population continue to be the subject of research and discussion among specialists. At the same time, the information provided by different authors regarding the normal values of the length of the axial length of the eye is quite contradictory, while the norm ind...
Article
Full-text available
Purpose: To examine prevalence and associated factors of the metabolic syndrome (MS) in populations in Russia. Methods: Two population-based studies (Ural Eye and Medical Study (UEMS), Ural Very Old Study (UVOS)) were conducted in rural and urban regions in Bashkortostan/Russia and included participants aged 40+ years and 85+ years, respectively. R...
Article
Full-text available
Background To assess central corneal thickness (CCT) and its associations in a Russian population. Methods The population-based Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals. As part of an ophthalmological and general examination, CCT was measured by Scheimflug imaging. Results The study included 5792 (98.2%) p...
Article
Purpose: To assess the macular pigment optical density (MPOD) and its associations with ocular and systemic parameters and diseases. Methods: The population-based study Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals. As part of ophthalmological and systemic examinations, MPOD was measured by reflectometry. Res...
Article
The density of macular pigment in the central retina is the total concentration of lutein, zeaxanthin and meso-zeaxanthin. Normally, the average value of the optical density of macular pigment can vary significantly as it depends on the person's lifestyle, the total amount of pigment in the body, nutrition, gender, age, as well as concomitant disea...
Article
Purpose. To carry out a comparative analysis of the intraoperative period of vitrectomy against the background preliminary intravitreal injection inhibitor of angiogenesis performed at different times in patients with proliferative diabetic retinopathy. Material and methods. The study included 134 patients (134 eyes) with proliferative diabetic ret...
Article
Background . Pterygium is ubiquitous and multifactorial; today, information on the prevalence of pterygium, risk factors, the relationship of its development with concomitant pathology and the type of life activity of patients in various regions of Russia is limited. All of the above led to the conduct of this epidemiological study in the Republic...
Article
The article presents an overview of modern publications on epidemiology, risk factors, and the main links of the etiology and pathogenesis of age-related macular degeneration (AMD). The nonexudative or “dry” form of age-related macular degeneration is a multifactorial progressive pathological process caused by hereditary predisposition, general and...
Article
Purpose: To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods: The Population-based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red-free fundus images and optical coherence tomog...
Preprint
Background: In 2021, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) validated a new equation for estimated glomerular filtration rate (eGFR) without race as an explanatory variable. Because the prevalence of chronic kidney disease (CKD) in Asians is known to differ from other ethnicities, this manuscript compares prevalence of CKD...
Article
Adherence to treatment is one of the major challenges posed by modern medicine. Today, cataract is the leading cause of reversible blindness and visual disability. The study was aimed to assess adherence to timely surgical treatment in individuals with cataract. The data of the cross-sectional, population-based Ural Eye and Medical Study were asses...
Article
Keratoconus is a progressive bilateral corneal ectasia, accompanied by loss of vision due to high irregular astigmatism, which is the leading indication for corneal transplantation. The review presents a variety of surgical corneal transplantation techniques for keratoconus available today and discussed their advantages and disadvantages.
Article
Purpose To develop and evaluate deep learning models to perform automated diagnosis and quantitative classification of age-related cataract, including all three anatomical types, from anterior segment photographs. Design Application of deep learning models to Age-Related Eye Disease Study (AREDS) dataset. Participants 18,999 photographs (6,333 tr...
Article
Full-text available
Background We undertook a Grand Challenges in Global Eye Health prioritisation exercise to identify the key issues that must be addressed to improve eye health in the context of an ageing population, to eliminate persistent inequities in health-care access, and to mitigate widespread resource limitations. Methods Drawing on methods used in previou...
Article
Residual astigmatism or ametropia are relatively common after phacoemulsification. This entity is accounted for by inaccurate intraocular lens (IOL) power calculation or improper preoperative examination. As a result, target refraction is not achieved. Spectacle correction of astigmatism in pseudophakia has several drawbacks and is often poorly tol...
Article
Background: Today, cataract is one of the main causes of reversible blindness and visual disability. In health care, monitoring of cataract surgery rates is fundamental to achieving universal health coverage. Objective: To assess the prevalence of visual impairment and blindness, cataract surgical coverage and prevalence, and the factors preventing...
Article
This article reviews information on possible adverse events occurring in the organ of vision - in particular, the retina - after using systemic drugs, discusses the drugs that lead to drug-induced retinopathy most often, and describes histomorphological changes and modern understanding of the pathogenesis of damage to retinal structures.
Article
Keratoconus (KC) is a progressive degenerative corneal disease, leads to the aberration of biomechanical and optical properties and thinning of the cornea, causes astigmatism and decreases visual acuity. Materials and methods. 33 patients (35 eyes) with stages II–III of non-progressive keratoconus and concomitant cataracts of various stages of matu...
Article
Objectives: to evaluate the effectiveness of photosensitizer solutions in the experiment in different modifications of standard UV corneal crosslinking. Materials and Methods. Experiments were performed on 32 enucleated porcine eyes ex vivo and 12 rabbits (24 eyes) in vivo, divided into 4 groups depending on instillations of the photosensitizer sol...
Article
Full-text available
Aim: To assess prevalence and associated factors of diabetic retinopathy (DR) in a Russian population. Methods: Out of 7328 eligible individuals, the population-based cross-sectional Ural Eye and Medical Study included 5899 (80.5%) individuals aged 40+ years, who underwent a detailed medical and ophthalmological examination. Using ocular fundus...
Article
M.M. Bikbov, O.I. Orenburkina, A.E. Babushkin, A.A. Fakhretdinova Ufa Research Institute of Eye Diseases, Ufa, Russian Federation Eye disorders have a special place in diabetes since visual impairment has a significant effect on the quality of life. Therefore, determining risk factors and prognostic criteria for disease course are essential for d...
Article
In the presented mainly experimental work, the regularities and mechanisms of ultrastructural transformation and changes in corneal metabolism under ultraviolet exposure are established. High-quality saturation of the stroma with riboflavin is necessary to perform safe and effective UV crosslinking of the cornea, which can be achieved mainly due to...
Article
Diabetic retinopathy is one of the socially significant problems in world ophthalmology due to a significant decrease in visual functions and patient disability. This article presents recent clinical studies on the treatment with angiogenesis inhibitors of nonproliferative and proliferative diabetic retinopathy with and without diabetic macular ede...
Article
Blepharoptosis is currently a serious pathology, the treatment of which does not always bring a satisfactory result. The article provides a review of the literature, describes the methods of surgical treatment of this ophthalmopathology. Each method is distinguished by indications, outcomes, efficiency. The method of surgical intervention depends o...
Article
Full-text available
Background To assess potential associations between the ankle-brachial blood pressure index (ABI) and ocular disorders. Methods In the population-based cross-sectional Russian Ural Eye and Medical Study including 5,899 (80.5%) out of 7328 eligible participants aged 40+ years, the participants underwent a series of ocular and medical examinations i...
Article
Full-text available
Purpose To evaluate ethnic variations, ocular and systemic determinants of retinal nerve fibre layer (RNFL) thickness and neuroretinal rim area among Asians, using a large consortium of population-based eye studies. Design Cross-sectional pooled-analysis. Participants 22436 participants (22436 eyes) from 10 population-based studies (China, Hong K...
Article
Full-text available
Background Keratoconus is a chronic degenerative disorder of the cornea characterized by thinning and cone-shaped protrusions. Although genetic factors play a key role in keratoconus development, the etiology is still under investigation. The occurrence of single-nucleotide polymorphisms (SNPs) associated with keratoconus in Russian patients is poo...
Article
Purpose. To study the results of femtosecond laser-assisted cataract surgery (FLACS) using RayOne diffractive trifocal IOLs in comparison with bifocal lenses. Material and methods. The patients were divided into 2 groups: the first group included 32 patients (46 eyes) who were implanted with a bifocal refractive IOL M-flex 630 F with +3 dptr addida...
Article
The article presents the literature review on the history and development of endothelial keratoplasty, which is one of the options for corneal transplantation. It includes different surgical techniques (posterior lamellar keratoplasty, with removal of the a circular section of the Descemet's membrane, deep lamellar endothelial keratoplasty, posteri...
Article
Purpose. To improve the technology of combined vitreoretinal intervention, including preliminary intravitreal injection of angiogenesis inhibitors followed by vitrectomy and a differentiated approach to internal limiting membrane peeling in patients with proliferative diabetic retinopathy (PDR). Material and methods. The research based on analysis...
Article
Full-text available
Abstract To assess the distribution of axial length as surrogate for myopia and its determinants in an old population, we performed the Ural Very Old Study as a population-based cohort study. Out of 1882 eligible individuals aged 85 + years, the Ural Very Old Study performed in an urban and rural region in Bashkortostan/Russia included 1526 (81.1%)...
Article
Obesity and chronic kidney disease (CKD) are major public health problems worldwide. However, the association between body mass index (BMI) and CKD is inconclusive in Asians. In this meta-analysis, eight population-based studies, from China, India, Russia (Asian), Singapore and South Korea, provided individual-level data (n=50037). CKD was defined...
Article
Full-text available
Importance Visual performance is important for quality of life. However, vision impairment among adults 85 years and older has not been intensively examined. Objective To assess the prevalence of mild vision impairment (VI), moderate to severe vision impairment, and blindness and the factors associated with these conditions among a population 85 y...
Article
Full-text available
Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30...
Article
Purpose: To assess the safety of intravitreally applied epidermal growth factor (EGF). Methods: The clinical interventional, prospective, single-centre, case series study included patients with age-related macular degeneration-related geographic atrophy (GA), in whom the eye with the worse best-corrected visual acuity (BCVA) underwent a single,...
Article
Full-text available
Purpose To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a very old population. Methods The Ural Very Old Study (UVOS), a population-based cohort study performed in rural and urban Bashkortostan/Russia, included 1526 (81.1%) out of 1882 eligible individuals aged 85+ years. The participants underwent a deta...
Article
Full-text available
Introduction To examine the compatibility of intravitreally injected epidermal growth factor (EGF) and amphiregulin as EGF family member. Methods Four rabbits (age: 4 months; body weight: 2.5 kg) received three intravitreal injections of EGF (100 ng) uniocularly in monthly intervals and underwent ocular photography, tonometry, biometry, and optica...
Article
Purpose. To study the effectiveness of the use of intravitreal anti-VEGF therapy for macular edema in patients with diabetes. Material and methods. The study involved 42 patients (42 eyes) with macular edema, against the background of compensated type 2 diabetes mellitus. All patients received 5 loading doses of aflibercept with an interval of 1 mo...
Article
Purpose. To study the effectiveness of the developed partially fistulizing glaucoma surgery in the treatment of primary open-angle glaucoma (POAG) in combination with complicated cataract. Material and methods. 28 patients (28 eyes) were examined, including 13 patients (13 eyes) with I–III stages of POAG, operated according to the method of glaucom...
Article
BACKGROUND: Macular holes are among the common causes of irreversible visual impairment. At an early stage macular holes may be asymptomatic which is a pressing problem in the diagnosis of this pathology. AIM: This work analyzes the prevalence of non-full-thickness and full-thickness macular holes in the population of the Republic of Bashkortostan,...
Article
Full-text available
Background By 2050, almost 5 billion people globally are projected to have myopia, of whom 20% are likely to have high myopia with clinically significant risk of sight-threatening complications such as myopic macular degeneration. These are diagnoses that typically require specialist assessment or measurement with multiple unconnected pieces of equ...
Article
Objective: To provide updated estimates on the global prevalence and number of people with diabetic retinopathy (DR) through 2045. Clinical relevance: The International diabetes federation (IDF) estimated the global population with diabetes mellitus (DM) to be 463 million in 2019 and 700 million in 2045. DR remains a common complication of DM an...
Article
Purpose. To substantiate the efficacy and safety of scleral collagen cross-linking with riboflavin and ultraviolet radiation. Material and methods. The study was conducted on cadaver porcine eyes and rabbit eyes. Results. It has been experimentally proven that crosslinking with riboflavin / ultraviolet A leads to an increase in the biomechanical st...
Article
Purpose. To study morphological changes in the cornea by confocal microscopy of simultaneous MyoRing implantation with corneal crosslinking in patients with keratoconus. Material and methods. The clinical study included 15 patients (16 eyes) with progressive keratoconus. All patients underwent a combination treatment: implantation of MyoRing intras...
Article
Currently, the percentage of old people is growing from year to year in developed countries their share ranges from 10 to 15% of the entire population. In connection with such trends the issue of old age should be given special attention. Purpose. Identify the main risk factors and assess the incidence of ophthalmopathology among the elderly. Mater...
Article
Full-text available
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
Article
Full-text available
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
Article
Full-text available
Background/aims Obesity is a well-known risk factor for diabetes, but its association with diabetic retinopathy (DR) is inconclusive, in particular in Asians. We aimed to assess whether body mass index (BMI) is associated with the presence and severity of DR in Asian populations with diabetes. Methods Pooled analysis of individual-level cross-sect...
Article
Full-text available
Summary Background Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World...
Article
Purpose: To conduct a comparative assessment of the effectiveness of an intravitreal dexamethasone implant as a starting monotherapy and when switching from anti-VEGF therapy for macular edema in patients with diabetes mellitus. Material and methods: The study involved 112 patients (112 eyes) with diabetic macular edema. The 1st group of the stu...
Article
Full-text available
Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disea...
Article
Full-text available
Summary Background To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision loss burden, presenting estimates for 2020, temporal change over three decades between 1990–2020, and forecasts for 2050....
Article
Full-text available
To assess the prevalence and associated factors of glaucoma in a Russian population. The population-based Ural Eye and Medical Study included 5899 (mean age 59.0 ± 10.7 years; range 40–94 years). Glaucomatous optic neuropathy was diagnosed using International Society of Geographical and Epidemiological Ophthalmology (ISGEO) criteria. Among 5545 par...
Article
Full-text available
Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled ana...
Article
Full-text available
To assess the prevalence of cataract and cataract surgery in a population from Russia, we conducted the population-based Ural Eye and Medical Study with 5899 participants (80.5% out of 7328 eligible individuals), with an age of 40 + years as the eligibility criterion. In the phakic population, the prevalence of nuclear, cortical, subcapsular catara...
Article
Aims To determine the prevalence and predictors of myopic macular degeneration (MMD) in a consortium of Asian studies. Methods Individual-level data from 19 885 participants from four population-based studies, and 1379 highly myopic participants (defined as axial length (AL) >26.0 mm) from three clinic-based/school-based studies of the Asian Eye E...
Article
Full-text available
To assess prevalence of mild vision impairment (MVI; best corrected visual acuity (BCVA) < 6/12 to 6/18 in the better eye), moderate-to-severe vision impairment (MSVI; BCVA < 6/18 but ≥ 3/60) and blindness (BCVA < 3/60) in a local population in Russia, we conducted the population-based Ural Eye and Medical Study. Out of 7,328 eligible individuals a...
Article
Purpose. To evaluate the effectiveness of intravitreal injection of biodegradable intravitreal implant containing dexamethasone (Ozurdex) in patients with resistant diabetic macular edema (DME).Material and methods. The study was conducted of 24 patients with diabetic macular edema resistant to therapy with angiogenesis inhibitors (3-5 intravitreal...