Mujittapha U. Sirajo

Skyline University, Nigeria · SBMS

Background: fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition of dopamine receptive sites on dopaminergic D2 Receptor (D3R). As a result of the abnormal calcium signalling associated with D2R inhibition, changes occur in the motor and memory neural axis leading to the observed behavioural...

How to cite this paper: Bankole, O.O., et al. (2015) Vitamin D 3 Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor Function in –D 2 R Tardive Dyskinesia Mice Model. Abstract Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of dopamine receptive sites on D...

Haloperidol is known to induce Parkinsonism by blocking dopamine-2 receptors (D 2 R). However, the mechanism in which Parkinsonism is induced is not well known. In this study, the mechanism of D 2 R inhibition model of Parkinsonism was proposed via neuromorphological findings observed in primary motor cortex and dorsal striatum. Sixteen female Wist...

Objectives The prolonged uses of fourth-generation antipsychotics have been implicated in inducing extrapyramidal syndromes characterized by the motor deficit. This was attributed to the loss of dopamine-2 receptor (D2R) signaling. However, ascorbic acid (SVCT2R stimulation) in the brain is proposed to modulate D2R activity. We, therefore, investig...

Over the years, there has been an increase in research on parkinsonism in basic and translational neuroscience. Parkinson’s disease (PD) is a progressive neurodegenerative disorder vehemently associated with motor function deficits and other unique features collectively called the Parkinsonian triad, which slightly differs from other movement di...

Objectives: Cassia singueana is widely used in northern Nigeria as an herb for the treatment of enamors ailments. Nevertheless the toxicity of the herb on liver architecture; the hepatic lobule and body weight is yet to be authenticated. Methods: A total of 24 male Wistar rats with an average weight of 150 g were randomly placed into four groups...

Background: The structural integrity of the hippocampus and the entorhinal cortex appears to be a prerequisite for normal acquisition of information about relational and contextual representation. Increased exposures to pyrethroids by pregnant women and children have raised concerns over their potentials as developmental neurotoxicants. Object...

Introduction: The structural integrity of the hippocampus and the entorhinal cortex appears to be a prerequisite for the normal acquisition of information about relational and contextual representation. Increased exposure to pyre�throids by pregnant women and children in Nigeria has raised concern about their potential as developmental neurotoxic...

Introduction: Developmental neurotoxicity involves the generation of reactive oxygen species which is an indicator of oxidative stress in the prenatally exposed offspring. Neuronal oxidative stress induces neuroinflammation, precedes tangle formation, and disrupts synaptic plasticity. The result of such changes may be expressed into adult�hood as...

Objective: To review motor deficits protocols and create a set of behavioural protocols that critically address the parkinsonian triad's quantification in Parkinson's disease models. Background: Over the years, there has been an increase in research on parkinsonism in basic and translational neuroscience. Parkinson's disease is a progressive neur...

Objectives The prolonged uses of fourth-generation antipsychotics have been implicated in inducing extrapyramidal syndromes characterized by the motor deficit. This was attributed to the loss of dopamine-2 receptor (D2R) signaling. However, ascorbic acid (SVCT2R stimulation) in the brain is proposed to modulate D2R activity. We, therefore, investig...

Prolonged inhibition of dopamine-2 receptor (D2R) is shown to cause degeneration of dopamine neurons leading to parkinsonism. Previously we have shown that vitamin D3 receptor stimulation improved motor-cognitive functions in dopamine-2 receptor (D2R) parkinsonian mice model. Presently, we examined the ameliorative effect of vitamin C and UV-B rays...

Prolonged inhibition of dopamine-2 receptor is shown to cause degeneration of dopamine neurons leading to Parkinsonism. Previously we have shown that Vitamin D3 receptor stimulation improved motor – cognitive functions in –D2R parkinsonian mice model. Presently, we examined the ameliorative effect of Vitamin C and UV-B rays on Nigrostriatal and...