Muhammet Emin Cam

Muhammet Emin Cam
University College London | UCL · Department of Mechanical Engineering

Assoc.Prof., Istanbul Kent University

About

86
Publications
14,200
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,230
Citations

Publications

Publications (86)
Article
Full-text available
The fabrication of polymeric micro/nanofibers is gaining attention due to their use in an array of applications including tissue engineering scaffolds, nanosensors, and fiber-reinforced composites. Despite their versatile nature, polymeric fibers are widely underutilized due to the lack of reliable, large-scale production techniques. Upon the disco...
Article
Full-text available
Forming polymeric core-sheath nanofibers is gaining prominence owing to their numerous potential applications, most notably in functional scenarios such as antiviral filtration, which is attracting significant attention due to the current COVID pandemic. This study has successfully designed and constructed a novel pressurized gyration vessel to fab...
Article
Delivery of therapeutic peptides via sublingual administration is extremely desired and 3D printed scaffolds are potential candidates as carriers to enhance insulin delivery. 3D printed sublingual sodium alginate (SA)/polyethylene glycol (PEG) composite scaffolds were produced for enhancing insulin delivery by examining the chemical, morphological,...
Article
Drug delivery systems that not only show efficacy through multiple therapeutic pathways but also facilitate patient drug use and exhibit a high bioavailability profile represent a promising strategy in the treatment of Alzheimer's disease (AD). Here, donepezil (DO)/memantine (MM)/curcumin (CUR)-loaded electrospun nanofibers (NFs) were produced for...
Article
Empagliflozin (EM) was successfully loaded in polycaprolactone/poly (L-lactic acid)/polymethyl methacrylate (PCL/PLA/PMMA) fibers. In the rat β-cell line (BRIN-BD11), the insulin expression ratio of pancreatic β-cells was stimulated at high and low glucose by culturing with tri-layer EM-loaded fiber (EMF) for 48 h. The expression ratios of glucokin...
Article
Full-text available
Recently developed nanoparticles and nanofibers present new brain‐specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)‐loaded PLGA nanoparticles (DNP) are embedded in PVA/PEG nanofibers (DNPF) produced by pressurized gyration for sublingual administration. SEM images showed produced drug‐loaded...
Article
This study describes the synthesis and characterization of a series of novel hydrazide‐hydrazone derivatives containing a 1,2,4‐triazole ring. The compounds were characterized using various spectroscopic techniques, such as FT‐IR, ¹ H‐NMR, ¹³ C‐NMR, HRMS, and elemental analysis. The antiproliferative activity of the synthesized compounds was evalua...
Article
Alzheimer’s disease (AD) is a neurodegeneration type that is biologically recognizable via β-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to 131 million by 2050. Investigations suggested the existence of a direct proportion between the likelihood of AD occurrence and vita...
Article
This link given below is given by ScienceDirect and by clicking this link before January 05, 2024 you will be taken directly to the final version of our article on ScienceDirect, which you are welcome to read or download. No sign up, registration or fees are required. https://authors.elsevier.com/c/1i5x98jV52dC5W
Article
Full-text available
The name casein is given to a family of phosphoproteins which is commonly found in milk. Until recently, this was a constituent of milk that was commonly discarded; however today, it is widely used in health supplements all over the world. In this work, a high loading (50 wt%) of casein is mixed with a solution of polycaprolactone (PCL) to produce...
Article
Ethnopharmacological relevance: Recent studies claim that Type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) overlap in several common pathological pathways which from neuronal damage to impaired memory performance. It is known that the use of Rosa canina L. (R. canina) as medicine in folk medicine dates back to ancient times and is used...
Article
Full-text available
Epilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the...
Article
Treatment options for pancreatic cancer are limited and not effective enough despite recent advances in chemotherapy. In this study, Metformin (Met)/Achillea vermicularis Trin. (AV)-loaded polylactic acid (PLA)/polycaprolactone (PCL) nanofibers (NFs) were fabricated by electrospinning and their chemical, mechanical, degradation, thermal, drug relea...
Article
Full-text available
Back Cover: In article number 2100855, Muhammet Emin Cam and co‐workers present the drugs curcumin (orange) and donepezil (green), which are used for the treatment of Alzheimer's disease, which are released from nanofibers that have three different diameters (the largest, medium, and thinnest). The percentage of burst drug release from nanofibers i...
Article
Full-text available
Nanofibers offer an alternative option for the treatment of Alzheimer's disease (AD) by addressing unmet clinical problems. In this study, anti‐AD drugs, donepezil (DO) and curcumin (CUR), are loaded in polylactic acid/polycaprolactone nanofibers (NFs). The effect of fiber diameter on drug release behavior is mainly observed and the successful load...
Cover Page
Electrospinning In article number 2100471 by Muhammet Emin Cam, Mohan Edirisinghe, and co-workers, water-soluble ternary polymer blends are electrospun. Genetic algorithm methodology is used to optimize process-control parameters; applied voltage, flow rate and working distance, to theoretically and experimentally compare the impact on nanofiber ma...
Article
Full-text available
Parkinson’s disease, the second most common neurodegenerative disease in the world, develops due to decreased dopamine levels in the basal ganglia. Levodopa, a dopamine precursor used in the treatment of Parkinson’s disease, can be used as a drug delivery system. This study presents an approach to the use of 3D-printed levodopa-loaded neural tissue...
Article
Nanocarriers are used to deliver bioactive substances in the treatment of neurodegenerative diseases such as Alzheimer's disease (AD). These nanocarriers have shown many benefits over traditional treatments due to their properties such as efficient distribution and controlled release of bioactive material to the brain and loading of various drugs s...
Article
A composite nanofiber composed of three polymers, namely polyvinyl alcohol (PVA)/ polyvinyl pyrrolidone (PVP)/ polyethylene oxide (PEO), was produced. The experiments were constructed using three Design of Experiment (DOE) techniques, Taguchi L9, Taguchi L27, and Screening method. The experiments were verified using the ANOVA method, and later a ma...
Article
Vitamin D3, vitamin K2, and Mg (10%, 1.25%, and 5%, w/w, respectively)-loaded PLA (12%, w/v) (TCP (5%, w/v))/PCL (12%, w/v) 1:1 (v/v) composite nanofibers (DKMF) were produced by electrospinning method (ES) and their osteoinductive effects were investigated in cell culture test. Neither pure nanofibers nor DKMF caused a significant cytotoxic effect...
Article
Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent,...
Article
Son yıllarda, biyomedikal uygulamalarda farklı morfolojilere sahip polimerik mikro/nano partiküller kontrollü ilaç salımı gibi birçok uygulamadaki potansiyelleri nedeniyle ilgi görmektedir. Bu çalışmada, polimer kaplı mikrobaloncuklardan nanopartiküller üretmek için T-bağlantılı mikroakışkan cihaz kullanılmıştır. Mikrobaloncukların ve nanopartiküll...
Article
The combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide, which also exhibit the strongest anti-inflammatory action among oral antidiabetic drugs, were loaded into chitosan/gelatin/polycaprolactone (PCL) by electrospinning and polyvinyl pyrrolidone (PVP)/PCL composite nanofibrous scaffolds by pressurized gyration to co...
Article
Full-text available
This novel face mask is designed to be a reusable respirator with a small and highly efficient disposable fabric filter. Respirator material requirements are reduced by 75% compared to traditional designs and allow repeated cleaning or sterilization. The probability of virus particle inhalation is reduced using novel air filtration pathways, throug...
Article
Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with...
Article
Full-text available
Satureja cuneifolia Ten. (wild savoury) belongs to the Lamiaceae family and is used to produce essential oil and aromatic water. This plant is also used as a condiment and herbal tea due to its stimulating, tonic and carminative effects. The in vitro antioxidant, anti-urease, anticholinesterase and cytotoxic activities of the different extracts fro...
Article
Acute wounds are a common health problem, with millions of people affected and decreased granulation tissue formation and vascularization, it is also a big challenge for wound care researchers to promote acute wound healing around the globe. This study aims to produce and characterize Satureja Cuneifolia plant extract (SC)-blended with Sodium Algin...
Article
Full-text available
Background/aims: Astaxanthin (ATX) is a naturally occurring carotenoid and a potent antioxidant. Various anti-inflammatory effects of ATX have been examined. We aimed to investigate the protective effect of ATX and its mechanism in a cerulein-induced acute pancreatitis rat model. Materials and methods: The rats were randomized into 2 main groups...
Article
Full-text available
In Turkey, Helichrysum genus is represented by 26 taxa belonging to 20 species in Turkish flora of which 14 ones are endemic to Turkey. The aerial parts of Helichrysum plicatum subsp. plicatum are used kidney stones, kidney and stomach ailments. The extraction procedures and solvents are important step in processing of bioactive constituents from t...
Chapter
Nowadays it became obvious that a relentless increase in Type 2 diabetes mellitus (T2DM), affecting the economically affluent countries, is gradually afflicting also the developing world. The currently used drugs in the treatment of T2DM have inefficient glucose control and carry serious side effects. In this study, nano-sized uniform particles wer...
Article
Full-text available
Objective: Novel investigations have confirmed that hyperglycemia is strictly associated with the development of cognitive impairment and dementia. Sodium-dependent glucose transporter (SGLT) inhibitors, which are oral antidiabetic drugs, are currently being investigated as the medication in Alzheimer's disease (AD). In our study, Camellia sinensis...
Article
Full-text available
Introduction: Capparis species (Capparaceae), also called caper, grow naturally in various regions of the world. Caper is a plant with medicinal and aromatic properties. Flower buds, root bark, and fruits of the plant areused in folk medicine due to their analgesic, wound healing,cell regeneration, tonic, and diuretic effects. Objective: The aim o...
Article
Full-text available
In order to provide more effective treatment strategies for the rapid healing of diabetic wounds, novel therapeutic approaches need to be developed. The therapeutic potential of peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist pioglitazone hydrochloride (PHR) in two different release kinetic scenarios, burst release and sustained relea...
Article
Full-text available
The use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In this study, the characterization and performance of electrospun Achillea lycaonica-loaded (0.125, 0.250 and 0.500, wt%) poly(lactic acid) (PLA) (8%, w...
Article
Ethnopharmacological relevance: Thymus praecox subsp. skorpilii var. skorpilii (syn. Thymus praecox subsp. jankae (Celak.) Jalas) is consumed as a Turkish folk medicine for the treatment of spasm, sore throat and shortness of breath, also having strong antioxidant activity and the leaves of the plant have been utilized for the treatment of diabetes...
Article
Full-text available
Thymus species are used as food and spices in several Mediterranean and other countries as well as for medical purposes on account of their biological properties. The extraction procedures and solvents are an important step in processing bioactive constituents from the plant materials. Therefore, the aim of this study was to evaluate in vitro antio...
Article
Full-text available
Thymus species are used as food and spices in several Mediterranean and other countries as well as for medical purposes on account of their biological properties. The extraction procedures and solvents are an important step in processing bioactive constituents from the plant materials. Therefore, the aim of this study was to evaluate in vitro antio...
Article
Full-text available
Aim: This study aimed to investigate the effects of gilaburu (Viburnum opulus L.,GB) fruit extract in a rat model of acetic acid (AA)-induced ulcerative colitis. Methods: Forty Sprague-Dawley rats of both sexes were used in this study. Starting immediately after or 1 week before the colitis induction, the rats were treated with GB (100 mg/kg/d;p.o....
Article
Full-text available
Aim: This study aimed to investigate the effects of gilaburu (Viburnum opulus L.,GB) fruit extract on burn-induced remote organ injury in rats. Methods: Under ether anesthesia, rats were exposed to 90oC (burn) or 25oC (control) water-bath for 10s to induce burn and treated either with saline (1 ml;p.o.) or GB (100 mg/kg/d;p.o.) immediately and at 2...
Conference Paper
Full-text available
Serulein ile oluşturulan sıçan akut pankreatit modelinde antioksidan astaksantin ve koenzim Q10 tedavisinin olası sinerjistik iyileştirici etkisinin incelenmesi Dilek ÖZBEYLİ1*, Esra Bihter GÜRLER2, Hülya BUZCU3, Özlem Tuğçe ÇİLİNGİR-KAYA4, Muhammet Emin ÇAM5, Burcin ALEV6, Meral YÜKSEL7, Özgür Kasımay ÇAKIR3, Berrak Çağlayan YEĞEN3 1Marmara Üniver...
Article
Full-text available
The purpose of this study was to comparatively reveal for the first time the antioxidant, anti-inflammatory effects of Phlomis pungens and Coridothymus capitatus methanol extracts obtained by using maceration extraction method. According to the results of anti-inflammatory activity, P. pungens methanolic extract demonstrated a more prominent and in...
Article
Full-text available
Background T2DM is characterized by hyperglycemia that body cells inadequately response to insulin and/or pancreatic beta-cells are partly impaired. Thymus praecox subsp. skorpilii var. skorpilii (TPS) leaves are traditionally used for the treatment of diabetes in Turkey. In our previous study, we firstly evaluated the antidiabetic effect of TPS ex...
Article
Full-text available
Background Ischemia reperfusion (I/R) injury is one of the main difficulties that arise from some surgical operations such as nephrectomy, aortic aneurysm damage. A decrease in blood flow and oxygen deficiency (ischemia phase) cause destruction of energy substrates. In spite of is essential to cell viability, reperfusion generates the formation of...
Article
Background Thymus praecox subsp. skorpilii var. skorpilii (TPS) is a medical plant having strong antioxidant activity and the leaves of the plant have been utilized for the treatment of diabetes as the decoction in Turkey. In the present study, we aimed to investigate the potential antidiabetic actions of Thymus praecox subsp. skorpilii var. skorpi...
Article
Full-text available
Some Salvia and Thymus species of Lamiaceae family come into prominence with strong antidiabetic effects. Compared to the other species, there are limited studies on antidiabetic activity of Salvia triloba (ST) and Thymus praecox subsp. skorpilii var. skorpilii (TPS). The aim of this study was to adjust the dosage and to determine the antidiabetic...

Network