Muhammad Umar Qureshi

Muhammad Umar Qureshi
North Carolina State University | NCSU · Department of Mathematics

PhD

About

25
Publications
6,044
Reads
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696
Citations
Additional affiliations
August 2008 - July 2009
National University of Computer and Emerging Sciences
Position
  • Lecturer
September 2014 - July 2019
North Carolina State University
Position
  • PostDoc Position
October 2019 - present
Kitware, Inc.
Position
  • Engineer
Education
January 2010 - February 2014
University of Glasgow
Field of study
  • Mathematical Biology
February 2004 - February 2008
Quaid-i-Azam University
Field of study
  • Mathematics
September 2001 - August 2003
Government College University, Lahore
Field of study
  • Mathematics, Statistics

Publications

Publications (25)
Article
Full-text available
Isolated post-capillary pulmonary hypertension (Ipc-PH) occurs due to left heart failure, which contributes to 1 out of every 9 deaths in the United States. In some patients, through unknown mechanisms, Ipc-PH transitions to combined pre-/post-capillary PH (Cpc-PH) and is associated with a dramatic increase in mortality. Altered mechanical forces a...
Article
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflections. CTEPH treatment aims to reduce pulmonary arterial pressure and reestablish adequate lung perfusion, yet patients with distal lesions are inoperable by standard surg...
Preprint
Full-text available
Isolated post-capillary pulmonary hypertension (Ipc-PH) occurs due to left heart failure, which contributes to 1 out of every 9 deaths in the United States. In some patients, through unknown mechanisms, Ipc-PH transitions to combined pre-/post-capillary PH (Cpc-PH), diagnosed by an increase in pulmonary vascular resistance and associated with a dra...
Preprint
Full-text available
Pulmonary hypertension (PH) is a debilitating disease that includes five main subgroups, but only one is curable: chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflections. CTEPH treatment depends on lesion location...
Article
Detection and monitoring of patients with pulmonary hypertension, defined as a mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to combine imaging data from microcomputed tomography images with hemodynamic pressure and flow waveforms from cont...
Preprint
Full-text available
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to combine imaging data from microcomputed tomography (micro-CT) images with hemodynamic pressure and flow waveforms...
Article
Full-text available
Computational fluid dynamics (CFD) models are emerging tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation have made subject-specific modelling of the cardiovascular system a feasible task, which is particularly important in the case of pulmonary hypertension, requiring a combination of inva...
Article
Pulmonary hypertension (PH), defined as an elevated mean blood pressure in the main pulmonary artery (MPA) at rest, is associated with vascular remodeling of both large and small arteries. PH has several sub‐types that are all linked to high mortality rates. In this study, we use a one‐dimensional (1D) fluid dynamics model driven by in‐vivo measure...
Article
Full-text available
This study uses a one-dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the main pulmonary artery for 7 control mice with normal pulmonary function and 5 mice with hypoxia-induced pulmonary...
Preprint
Full-text available
Computational fluid dynamics (CFD) models are emerging as mathematical tools to assist in the diagnostic assessment of cardiovascular disease. Recent advances in medical imaging and computational algorithms for analyzing said images have made subject-specific modeling of the cardiovascular system a feasible task. This is particularly important in t...
Conference Paper
Full-text available
https://app.oxfordabstracts.com/stages/123/programme-builder/submission/22703?backHref=/events/123/programme-builder/view/sort/author&view=published
Preprint
Full-text available
This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a control and hypoxia induced hypertensive mouse. We use local and global sensitivity and correlation analysis to determine parameters that can be inferred from the model a...
Article
Full-text available
This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics under normal physiological and pathological conditions. This is of medical interest as it enables tracking the...
Article
Full-text available
This study uses a 1D fluid dynamics arterial network model to predict pressure and flow dynamics in healthy and hypoxic mice. Data for this study include blood flow and pressure measurements from the main pulmonary artery of 7 healthy and 5 hypoxic mice. Representative arterial network dimensions for the 21 largest pulmonary arterial vessels are ex...
Article
Objective: Characteristic impedance (Zc) is an important component in the theory of hemodynamics. It is a commonly used metric of proximal arterial stiffness and pulse wave velocity. Calculated using simultaneously measured dynamic pressure and flow data, estimates of characteristic impedance can be obtained using methods based on frequency or tim...
Conference Paper
Full-text available
In this study, we have presented preliminary results using data and a one-dimensional fluid dynamical network model to simulate the observed pulmonary hemodynamics for healthy and hypoxic mice. The aim is to understand the effects of hypoxia induced pulmonary hypertension on the qualitative behavior of pertinent hemodynamic parameters. Some of thes...
Article
Full-text available
Individualized modeling and simulation of blood flow mechanics find applications in both animal research and patient care. Individual animal or patient models for blood vessel mechanics are based on combining measured vascular geometry with a fluid structure model coupling formulations describing dynamics of the fluid and mechanics of the wall. For...
Conference Paper
Full-text available
Modeling and simulation of blood flow dynamics in 1D arterial networks require three types of equations–Navier-Stokes equations ensuring conservation of momentum and mass and a constitutive equation relating blood pressure and area–as well as outflow boundary conditions representing flow and pressure in down-stream vasculature. While many relevant...
Article
Full-text available
Experiments using wave intensity analysis suggest that the pulmonary circulation in sheep and dogs is characterized by negative or open-end type wave reflections, that reduce the systolic pressure. Since the pulmonary physiology is similar in most mammals, including humans, we test and verify this hypothesis by using a subject specific one-dimensio...
Article
Full-text available
A novel multiscale mathematical and computational model of the pulmonary circulation is presented and used to analyse both arterial and venous pressure and flow. This work is a major advance over previous studies by Olufsen et al. (Ann Biomed Eng 28:1281-1299, 2012) which only considered the arterial circulation. For the first three generations of...
Article
The mechanism of peristaltic magnetohydrodynamic (MHD) flow based on slip and heat transfer effects is studied in an asymmetric channel. An incompressible viscous fluid fills the porous space inside the channel. Long wavelength and zero Reynolds number approximation are used in the flow modeling. Expressions of stream function, longitudinal pressur...
Article
Full-text available
This work is aimed at describing the heat transfer on the peristaltic motion in a porous space. An incompressible and magnetohydrodynamic (MHD) viscous fluid is taken in an asymmetrical channel. Expressions of dimensionless stream function and temperature are obtained analytically by employing long wavelength and low Reynolds number assumptions. Th...
Article
Full-text available
In this investigation, the peristaltic flow of a third order fluid in an asymmetric channel is considered in the presence of a slip condition. The series solution of the stream function and longitudinal pressure gradient is given under long wave length and low Reynolds number approximations. Pressure rise and frictional forces per wave length are a...

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