Muhammad Hakimin Shafie

Universiti Sains Malaysia | USM · Analytical Biochemistry Research Centre (ABrC)

Emerging investigations have indicated that many plant polysaccharides may be beneficial in treating metabolic diseases. Hitherto, the therapeutic efficacies and the potential toxicity of polysaccharides extracted from Clinacanthus nutans (C. nutans) remains unexplored. This investigation studied on the in-vivo acute and sub-acute oral toxicologica...

Industrial wastewater includes large amounts of contaminants thus, the wastewater must be treated prior to disposal. Moreover, since a substantial volume of wastewater is generated, environmental considerations should include the reutilizing of reclaimed water. Since industrial wastewater consists mostly of chemicals and persistent contaminants, it...

Dysregulation of lipid homeostasis contributes to obesity and can directly lead to several critical public health concerns globally. This paper aimed to present a brief review of related properties and the use of pancreatic lipase inhibitors as the future weight loss drug discovery and development procured from a wide range of natural sources. A to...

Background Coronavirus disease 2019 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that emerged in late 2019 and has activated an ongoing international public health emergency. SARS-CoV-2 was discovered in Wuhan, China, in December 2019 and rapidly spread to other cities and countries. Currently, SARS...

The anti-hyperpigmentation effect and tyrosinase inhibitory mechanism of cinnamon polysaccharides have not been reported. The current study focused on the extraction of polysaccharides from Cinnamomum cassia bark using microwave-assisted approach and optimization of the extraction process (i.e., microwave power, irradiation time and buffer-to-sampl...

The advancement in nanotechnology, nanoparticles are reported to have applications in various fields. Their positive role in the environment, especially in plant ecosystem, is extensively studied nowadays. Among the metal nanoparticles, the silver nanoparticles (AgNPs) are receiving special attention because of their ability to increase the growth...

Cosmetic industries have expanded globally and will continue to increase as there are consumers. Nowadays, the interest starts to incline towards cosmetics formulated using plant-based ingredients. Marine plants such as seaweed possess numerous natural polysaccharides. Carrageenan is one of the compounds that can be extracted from red seaweed (Rhod...

Context: Hydrosol is a residual product from the steam or hydro distillation process of abundant types of plants. It can be separated from the essential oil mixture by the liquid-liquid extraction process. Hydrosols from a variety of plants are becoming increasingly popular in cosmetology, aromatherapy, traditional pharmacy, and food sector; thus,...

The main aim of current study is to explore the potential of deep eutectic solvent (DES) as plasticizer. The influence of different choline chloride–citric acid monohydrate (ChCl–CAM) molar ratios was investigated based on the properties of the selected biopolymer film (BF). It should be highlighted that using DES as a plasticizer had improved the...

Angiotensin-converting enzyme (ACE) inhibitors are used to control blood pressure or to prevent congestive heart failure by dilating blood vessel. These inhibitors are also applied to treat patients with kidney injury or diabetic nephropathy. Due to the side effects of the synthetic drugs, such as dizziness, hyperkalemia, angioedema, dysgeusia and...

Previous study showed that deep eutectic solvent (DES)-extracted pectin exhibited undesirable structural and functional properties. It has to be noted that most of the researchers were seeking the parameters that could increase the extraction yield and neglected the importance of the pectin structures that could ultimately affect the functional pro...

The potential of Averrhoa bilimbi pectin (ABP) as a source of biopolymer for edible film (EF) production was explored, and deep eutectic solvent (DES) (1% w/w) containing choline chloride–citric acid monohydrate at a molar ratio of 1:1 was used as the plasticizer. The EF-ABP3:1, which was produced from ABP with large branch size, showed a higher va...

The deep eutectic solvents (DESs), which were made from different molar ratios (3:1, 2:1, 1:1, 1:2, 1:3) of choline chloride and citric acid monohydrate, were used as media for the pectic polysaccharide extraction from Averrhoa bilmbi (ABP). The physico-chemical, structural, functional and antioxidant properties of ABP were subsequently determined....

The objective of the study was to synthesize deep eutectic solvents (DES) using choline chloride and citric acid monohydrate at different molar ratios (i.e. DES 3:1, 2:1, 1:1, 1:2 and 1:3) followed by physicochemical characterization. The DES produced were clear and homogenized liquids under a microscopic observation, and DES 1:1 was found to meet...

The Box-Behnken Design was applied to optimize the extraction of pectin from Averrhoa bilimbi (ABP) using deep eutectic solvents (DES). The four variables of extraction were percentage of DES (X1), extraction time (X2), temperature (X3), and molar ratio of DES components (X4). The quadratic regression equation was established as a predicted model w...

Momordica charantia bioactive polysaccharide was used as an alternative source for the production of bio-based plastics (BPs) and choline chloride/glycerol based deep eutectic solvent (DES) was added as a plasticizer. In this study, seven BPs were prepared: MCBP without plasticizer (as a control), with glycerol (as a reference), and with DES in dif...