Muhammad Ovais

Muhammad Ovais
Chinese Academy of Sciences | CAS · National Center for Nanoscience and Technology

PhD @Nano-biotech | Peptides | Biomaterials | Anti-microbials | DM to collaborate 🧪👋
Scientific researcher turned entrepreneur who loves to built innovative technologies

About

88
Publications
81,406
Reads
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3,802
Citations
Introduction
👉https://ovaisnanotech.com/ 👉https://www.linkedin.com/in/muhammad-ovais-544bb8a5/ 👉Twitter: @OVAISBiotec
Education
September 2017 - January 2022
Chinese Academy of Sciences
Field of study
  • Nano-Biotechnology
September 2015 - August 2017
Quaid-i-Azam University
Field of study
  • Biotechnology
September 2011 - September 2015
University of Peshawar
Field of study
  • Biotechnology

Publications

Publications (88)
Article
Full-text available
With the development of the latest technologies, scientists are looking to design novel strategies for the treatment and diagnosis of cancer. Advances in medicinal plant research and nanotechnology have attracted many researchers to the green synthesis of metallic nanoparticles due to its several advantages over conventional synthesis (simple, fast...
Article
Full-text available
The design, development, and biomedical applications of phytochemical-based green synthesis of biocompatible colloidal gold nanoparticles (AuNPs) are becoming an emerging field due to several advantages (safer, eco-friendly, simple, fast, energy efficient, low-cost, and less toxic) over conventional chemical synthetic procedures. Biosynthesized col...
Article
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Phytochemicals offer immense promise for sustainable development and production of nanotechnology-enabled products. In the present study, Olax nana Wall. ex Benth. (family: Olacaceae) aqueous extract was used as an effective stabilizing agent to produce biogenic silver (ON-AgNPs) and gold nanoparticles (ON-AuNPs), which were investigated for biocom...
Article
Gold nanoparticles with unique optical and photo-thermal properties have promising application in nan-otheranostics, achieving the integration of diagnosis and therapy in a single platform. Compared withnormal physiological environment, tumor tissue has a unique and complex tumor microenvironment,which plays a key role in tumor progression, metasta...
Article
Increased antibiotic resistance has become a real healthcare challenge for humanity. Several novel approaches for the formation of nanomaterials have been developed to tackle different bacterial strains and wound disinfection. Short peptide modulated metal nanomaterials have gained attention because of their biocompatibility and ability to reduce m...
Article
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The rise of bacterial resistance to current antibiotics poses a threat to humanity and reinforces the need for new-generation nanomaterials with antibacterial properties and biosafety. Several types of nanomaterials have been shown to hold great potential to combat pathogenic microorganisms. Self-assembly of peptides and proteins, a spontaneous and...
Article
Achieving a complete response to cancer treatment is a severe challenge, and has puzzled humans for a long time. Fortunately, radiotherapy (RT) gives rise to a common clinical treatment method, during which the usage of radiosensitizers is essential. Among preclinical radiosensitizers, bismuth-based nanoparticles (Bi-based NPs) are widely explored...
Article
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Viral infections have been proven a severe threat to human beings, and the pandemic of Coronavirus Disease 2019 (COVID-19) has become a societal health concern, including mental distress and morbidity. Therefore, the early diagnosis and differentiation of viral infections are the prerequisite for curbing the local and global spread of viruses. To t...
Article
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Tumor cells, owing to their relentless division, require increased nutrient supply.This is made possible by angiogenesis, that is, the formation of new blood vesselsincreases the bloodflow toward tumor cells, thereby promoting the supply ofoxygen and vital nutrients required for the proliferation of tumor cells. Decreasingthe bloodflow to the tumor...
Article
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The innovative research in genome editing domains such as CRISPR-Cas technology has enabled genetic engineers to manipulate the genomes of living organisms effectively in order to develop the next generation of therapeutic tools. This technique has started the new era of “genome surgery”. Despite these advances, the barriers of CRISPR-Cas9 techniqu...
Article
Surgical site infections are the most common and serious concern in health care settings. Currently, systemic administration of prophylactic antibiotics or local disinfection treatment is prescribed after surgical procedures. However, prolonged use of antibiotics may pose adverse side effects, bacterial resistance and hospitalization costs. Recentl...
Article
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Diverse applications of nanoparticles (NPs) have revolutionized various sectors in society. In the recent decade, particularly magnetic nanoparticles (MNPs) have gained enormous interest owing to their applications in specialized areas such as medicine, cancer theranostics, biosensing, catalysis, agriculture, and the environment. Controlled surface...
Book
Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetrat...
Article
Nanozymes are next-generation artificial enzymes having distinguished features such as cost-effective, enhanced surface area, and high stability. However, limited selectivity and moderate activity of nanozymes in the biochemical environment hindered their usage and encouraged researchers to seek alternative catalytic materials. Recently, metal-orga...
Article
Past few years have seen a paradigm shift towards ecofriendly, green and biological fabrication of metal nanoparticles (MNPs) for diverse nanomedicinal applications especially in cancer nanotheranostics. Besides, the well-known green synthesis methods of plant materials, the potential of the microbial world (bacteria, fungi, alga, etc.) in biofabri...
Article
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Polygonum hydropiper L. and related species are reported to possess neuroprotective potentials. In an attempt to validate its anti-Alzheimer’s potentials, leaf oils (Ph. Lo) were extensively evaluated in this study against several in vitro and in vivo models of Alzheimer’s disease. The Ph. Lo were tested against pathological targets of Alzheimer’s...
Chapter
Cancer is a collection of ailments that severely affect the cellular metabolism established due to anomalous signaling mechanisms including cell proliferation, angiogenesis, and metastasis. Biogenic nanoparticles due to their efficacy, cost-effectiveness, and green nature provide an alternate paradigm to cancer theranostics. In this chapter we will...
Chapter
Cancer is the most threatening disease for humans worldwide. While conventional treatment modalities have limitations and result in adverse side effects, nanotechnology offers a new avenue in the development of cancer nanomedicine. Herein, we discuss the state-of-the-art principles in the design and discovery of nanomaterials for clinical use in th...
Chapter
Inorganic nanomaterials are emerging as widely applicable and solving complex modern world problems. Herein, this chapter introduces the use of microorganisms, especially their enzymes, for the synthesis of eco-friendly and cost-effective NPs. The use of enzyme in the synthetic process lets researcher controls the size, shape, growth, and reaction...
Article
Full-text available
Associations of GSTM1, GSTT1 and CYP1A1 gene variants with risk of developing Non-Hodgkin lymphoma were evaluated in this case-control study involving183 NHL cases along with 151 population-based healthy controls of Pashtun ethnicity from Khyber Pakhtunkhwa province of Pakistan. Socio-demographic data were obtained and blood samples were collected...
Article
Full-text available
In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization (WHO). As of now, many vaccines and medicines are in the approval process or at different stages of preclinical investigations to coup with the COVID-19. Coronavirus has a spike protein, which tends to...
Article
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Enzyme catalysis is an emerging technique that has been employed to identify the protein of interest in a complex cellular environment. In present article, we have utilized optical techniques for the identification of enzyme mediated catalysis of fusion protein to study the short chain amino acid epitope in both aqueous solution and cellular enviro...
Article
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Tailoring personalized cancer nanomedicines demands detailed understanding of the tumor microenvironment. In recent years, smart upconversion nanoparticles with the ability to exploit the unique characteristics of the tumor microenvironment for precise targeting have been designed. To activate upconversion nanoparticles, various bio‐physicochemical...
Chapter
Nanobiotechnology is an emerging discipline that focuses on the synthesis, development, and efficacy of nanomaterials for diverse applications in different consumer products such as personal care, hygiene, apparel, and footwear as well as biomedical and pharmaceutical applications. Until now, significant research has been carried out on the synthes...
Article
The interplay between nanotechnology and pathogens offers a new quest to fight against human infections. Inspiring from their unique thermal, magnetic, optical, or redox potentials, numerous nanomaterials have been employed for bacterial theranostics. The last decade has seen dramatic progress in the development of various nano-antimicrobials, whic...
Article
In spite of radical advances in nanobiotechnology, the clinical translation of nanoparticle (NP)-based agents is still a major challenge due to various physiological factors that influence their interactions with biological systems. Recent decade witnessed meticulous investigation on protein corona (PC) that is the first surrounds NPs once administ...
Article
Ethnopharmacological relevance Various plant parts of Persicaria hydropiper (L.) Delarbre (Syn.: Polygonum hydropiper L., Family: Polygonaceae) are used in traditional medicine systems in as astringent, sedative, antiseptic and also for the treatment of respiratory disorders, edema and snake bites. It is also used as a spice in many Asian countries...
Article
Vibrational spectroscopy of peptides and peptide‐based self‐assembled macromolecules plays key role in early stage detection of cancerous and viral diseases. We provide here a rapid and accurate trace detection system for enzyme‐triggered peptide self‐assembly by taking a snapshot of peptide nanostructures to identify specific domains based on amin...
Chapter
The recent projections indicate that Alzheimer's disease (AD) will be highly prevalent in elderly people within few years and therefore the scientific community has joined in hands to highlight it as a major disease for generations to come. The onset of the disease is however complex and needs vigorous research in understanding the potential causes...
Chapter
Cancer is considered as a great health challenge liable for outstripped demises worldwide. Currently it is treated mainly by chemotherapy and radiotherapy. However, there is a perpetual demand for the development of novel therapeutic drugs to combat this devastating disease. In this regard nanomedicine can provide an alternative platform for its di...
Poster
Full-text available
It’s vital for the herbal practitioner’s, scientists, industry and policy makers in Pakistan to exploit the opportunity given by BRI and CPEC. They should promote their own herbal values globally and learn the practices of TCM to enhance their overall skills. This will result in a massive move towards the achievement of SDGs globally and will nurtu...
Article
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Due to Belt and Road Initiative, Traditional Chinese Medicine (TCM) a 2,000-year-old Chinese national treasure is experiencing a fresh thrive. By 2020, China aims to issue 20 TCM international standards, register 100 TCM products and build 30 overseas TCM centres in BRI (Belt and Road Initiative) countries. BRI initiative is intended to expand TCM...
Article
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Medicines are often consumed concurrently with food; sometimes to improve its absorption and efficacy. However, certain foods may modify the function of drug metabolizing enzymes or transport mechanisms that are crucial determinants of systemic drug availability. Extensive work has been reported on certain juices like grapefruit that affects the bi...
Article
Full-text available
Associations of GSTM1, GSTT1 and CYP1A1 gene variants with risk of developing nasopharyngeal cancer were evaluated in this case-control study, in which 130 cases along with 151 population-based healthy controls of Pashtun ethnicity from Khyber Pakhtunkhwa province of Pakistan were recruited. Socio-demographic data were obtained and blood samples we...
Article
The emergence of multidrug resistant (MDR) pathogens is a global threat and has created problems in providing adequate treatment of many infectious diseases. Although the conventional antimicrobial agents are quite effective against several pathogens, yet there is a need for more effective antimicrobial agents against MDR pathogens. Herbal drugs an...
Article
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Modern research revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improves cognitive capabilities, inhibits or delays the senescence process and related neurological disorders including Alzheimer's disease (AD). The flavonoids rich foods such as green tea, cocoa, blue berry and other foods appear to improve sta...
Article
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Advances in the field of nanotechnology together with an increase understanding of tumor immunology have paved the way for the development of more personalized cancer immuno‐nanomedicines. Nanovehicles, due to their specific physicochemical properties, are emerging as key translational moieties in tackling tumor‐promoting, M2‐like tumor‐associated...
Article
The inhibition of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzymes represents a potential target in the treatment of Alzheimer disease. AChE and BChE inhibition was studied by biogenic metal oxide nanoparticles (ZnO, NiO, Fe2O3, Co3O4 and PbO) synthesized using aqueous extracts of Sageretia thea (Osbeck.). The results demonstrat...
Article
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Background Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of various ailments. The current study has been aimed to validate the therapeutic potential of ethnomedicinally significant plant Atriplex lasiantha Boiss. Methods The polarity based extraction process was carried out u...
Article
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During the last decade, metal nanoparticles (MtNPs) have gained immense popularity due to their characteristic physicochemical properties, as well as containing antimicrobial, anti-cancer, catalyzing, optical, electronic and magnetic properties. Primarily, these MtNPs have been synthesized through different physical and chemical methods. However, t...
Article
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Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relation...
Chapter
Full-text available
The currently available antimicrobial drugs against pathogenic microorganisms are inadequate to cope with the challenges of the newly emerging multidrug-resistant (MDR) pathogens. Other shortcomings include their partial absorption in the blood system accompanied with gastrointestinal problems such as vomiting, nausea and diarrhea. To overcome thes...
Article
Full-text available
“many vital biological factors determines the faith and toxicological impact of NPs: NP–protein interaction, blood circulation, interaction with TME, tumor tissue penetration and internalization inside tumor cell. Furthermore, morphology, composition and surface chemistry of NPs are also the key influencers in the aforementioned biological processe...
Article
Full-text available
Alzheimer disease (AD) is characterized by cognitive inability manifested through the accumulation of β-amyloid, formation of hyper phosphorylated neurofibrillary tangles (NFT’s) and malfunctioned cholinergic system. The degeneration integrity of neuronal network can appear long after the onset of disease. Nanotechnology based interventions has ope...
Article
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Metal-based nanoparticles have gained tremendous popularity because of their interesting physical, biological, optical, and magnetic properties. These nanoparticles can be synthesized using a variety of different physical, chemical, and biological techniques. The biological means are largely preferred as it provides an environmentally benign, green...
Article
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This study aimed to perform a systematic review and metaanalysis of papers discussing the efficacy of microbial synthesized metallic nanoparticles (MNPs) against cancerous and normal cell lines by exploiting Generalized Linear (BGL) model. Data was systematically Bayesian collected from published papers of 1 January 2010 to 21 February 2017 via Coc...
Article
Full-text available
Nanotechnology has emerged as a prominent scientific discipline in the technological revolution of this millennium. The scientific community has focused on the green synthesis of metal nanoparticles as compared to physical and chemical methods due to its eco-friendly nature and high efficacy. Medicinal plants have been proven as the paramount sourc...
Article
Full-text available
The present study aims to evaluate phytochemical and pharmacological potentials of Dysphania ambrosioides (L.) Mosyakin & Clemants previously known as Chenopodium ambrosioides L. Extraction was carried out using 14 solvents with wide range of polarity to find out the best solvent system for each bioactivity. Total phenolic and flavonoids contents w...
Article
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Sorafenib is the only approved targeted agent against hepatocellular carcinoma (HCC). It has several limitations predominantly poor aqueous solubility and hepatic first-pass effect that limits its oral delivery leading to low bioavailability, large inter-subject variability, narrow therapeutic window and side effects. Tosylate is used to improve it...
Article
Full-text available
Background The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesterase, and α-glucosidase inhibitory assays. Methods The crude methanolic extract of O. nana (ON-Cr) was subjected to qualitative ph...
Chapter
Full-text available
The currently available antimicrobial drugs against pathogenic microorganisms are inadequate to cope with the challenges of the newly emerging multidrug-resistant (MDR) pathogens. Other shortcomings include their partial absorption in the blood system accompanied with gastrointestinal problems such as vomiting, nausea and diarrhea. To overcome thes...
Article
Full-text available
Objectives: The present study aimed to examine the impact of rapid virological response (RVR) and early virological response (EVR) on sustained virological response (SVR) in chronic hepatitis C genotype 3a individuals. Methods: The patients were given antiviral therapy with IFN-α-2b, 3 million units 3 times a week and 800-1,200 mg of ribavirin d...
Article
Antimicrobial resistance is a challenging task for researchers to develop new strategies. Green synthesis of AuNPs is an eco-friendly approach, which can be utilized in the microbistatic and microbicidal activities. The current study is focused on Justicia glauca (aqueous leaf extract) mediated AuNPs synthesis at room temperature by treating chloro...
Article
Full-text available
Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the compo...
Data
It contain Shallow water maze (SWM) apparatus is provided as additional/Supplementary File.
Data
It contain detail process of genotyping transgenic animals.
Data
It contain NMR and Mass spectrum of β-sitosterol.