Muhammad Mosaraf Hossain

University of Chittagong · Department of Biochemistry and Molecular Biology

CTC detection in different subtypes of early breast cancer

e12529 Background: Breast cancer is a highly heterogeneous pathophysiology characterized by poor outcomes. Due to the increasing incidence and disease progression rates and undefined relapse periods, reliable disease monitoring is a challenge and has remained an unmet need. Advancements in liquid biopsy have significantly enhanced our understanding...

The manifestation of COVID-19 severity and mortality has been associated with dysregulation of the immune response, often influenced by racial disparities and conferred by changes in hematological and immunological parameters. The biological and hematological parameters as well as the cytokine profiles have been investigated in a cohort of 61 COVID...

Objectives Tumour necrosis factor (TNF)-α, an adipocytokine, is closely linked to impaired glucose tolerance (IGT) and insulin resistance (IR) in type 2 diabetes (T2D) subjects. The relationship between the polymorphisms in the TNF-α gene and IR in Bangladeshi prediabetes and T2D subjects has not yet been fully identified. This study aims to reveal...

e18011 Background: Tobacco consumption accounts for 1.6 million deaths annually in the South East Asia Region (SEAR). Notably, amongst 10-20% of the global population consuming the betel quid and tobacco, about 81% concentration is in SEAR regions, including India and Bangladesh. The prevalence of HNSCC in these regions is rising alarmingly. For ex...

Recent evidence has shown that the miR-17–92 cluster can function either as oncogene or tumor suppressor in human cancers. The function of miR-17–92 in subtypes of breast cancer remains largely unknown. The expression of miR-17–92 is elevated in triple negative breast cancer (TNBC) but reduced in estrogen receptor (ER)-positive breast cancer (ERPBC...

Recent evidence has shown that the miR-17–92 cluster can function either as oncogene or tumor suppressor in human cancers. The function of miR-17–92 in subtypes of breast cancer remains largely unknown. The expression of miR-17–92 is elevated in triple negative breast cancer (TNBC) but reduced in estrogen receptor (ER)-positive breast cancer (ERPBC...

Overexpression of epithelial cell adhesion molecule (EpCAM) has been associated with chemotherapeutic resistance, leads to aggressive tumor behavior, and results in an adverse clinical outcome. The molecular mechanism by which EpCAM enrichment is linked to therapeutic resistance via Nrf2, a key regulator of antioxidant genes is unknown. We have inv...

Overexpression of epithelial cell adhesion molecule (EpCAM) has been associated with chemotherapeutic resistance, leads to aggressive tumor behavior, and results in an adverse clinical outcome. The molecular mechanism by which EpCAM enrichment is linked to therapeutic resistance via Nrf2, a key regulator of antioxidant genes is unknown. We have inv...

Overexpression of epithelial cell adhesion molecule (EpCAM) has been associated with chemotherapeutic resistance, leads to aggressive tumor behavior, and results in an adverse clinical outcome. The molecular mechanism by which EpCAM enrichment is linked to therapeutic resistance via Nrf2, a key regulator of antioxidant genes is unknown. We have inv...

Background: The miR-17-92 is an oncogenic miRNA cluster that generate six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1. Accumulating evidences indicate the oncogenic role of the miR-17-92 cluster in human cancers. Amplification of 13q31-q32, which is the locus of the miR-17-92 cluster, have been reported in haematopoiet...

Nuclear receptor coactivators (NCOAs) function as coactivators for nuclear receptors as well as several other transcription factors and potentiate their transcriptional activity. NCOAs play an important role in biology of hormonedependent and -independent cancers. MCB-613 is a recently described, small molecule stimulator of NCOAs and anti-neoplast...

Publication Number: P5-07-14 Title: miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer Muhammad Mosaraf Hossain 1 , Vahid Arabkari 1 , David Barua 1 , Ananya Gupta 2 , Md Nahidul Islam 3 and Sanjeev Gupta 1 . 1 Lambe Instititite for Translational Research, National University of Ireland...

Sorafenib is a multikinase inhibitor that acts by inhibiting tumour growth and disrupting tumour microvasculature through anti-proliferative, anti-angiogenic, and pro-apoptotic effects. However, development of resistance to sorafenib often prevents its long-term efficacy. No validated biomarkers currently exist for appropriately selecting patients...

XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about the effectors of XBP1 in this context. Here we show that NCOA3 is a transcriptional target of XBP1. We observed increased express...

Sexual dysfunction is a common, underappreciated complication of diabetes. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunction (ED). All three forms of male dysfunction can cause significant bother for diabetic patients and can affect their quality of life. Diabetic patient...

The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted activation of three ER stress sensors, namely IRE1, PERK and ATF6. Global approaches in several cellular contexts have revealed that...

This study was undertaken for the assessment of chronic energy deficiency (CED) of farmers based on BMI, food intake pattern, oxygen consumption, clinical, biochemical parameters. Study subjects were divided into Normal, CED1, and CED2& CED3 according to WHO criteria. Functional characterization was done by working days per week and by estimating o...

This study was undertaken for the assessment of chronic energy deficiency (CED) of farmers based on BMI, food intake pattern, oxygen consumption, clinical, biochemical parameters. Study subjects were divided into Normal, CED1, and CED2& CED3 according to WHO criteria. Functional characterization was done by working days per week and by estimating o...

Objectives: Serum free insulin like growth factors-1 (IGF-1) and insulin like growth factor binding protein-1 (IGFBP-1) may have an association with insulin resistance and B-cell secretory dysfunction. Present study is undertaken to explore the independent association of IGF-1 and IGFBP-1with two basic defects in type 2 diabetic patients in a Bangl...

A total of 2.4 million men and women are employed in Garment industries of Bangladesh. Among them a remarkable number is lean and thin due to anemia. Contributing factors which may cause anemia are inadequate and inappropriate diet and poor absorption of iron by the body, poor nutrition and dietary knowledge and practices, poor hygiene and sanitati...

Objective: This prospective cross-sectional study was conducted to find out the health seeking behavior of stroke patients and their associates as well as to identify the barriers of service intervention. Methodology: The study was done at Occupational Therapy Department of Centre for the Rehabilitation of the Paralyzed (CRP), Dhaka, Bangladesh. A...

Objective: Epidemiological evidence suggests that levels of inflammatory markers, such as tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), can predict the development of diabetes but the association of these inflammatory markers with the basic pathology of type 2 diabetes is unclear. In the present study we investigated the association of...

Objective: Epidemiological evidence suggests that levels of inflammatory markers, such as tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), can predict the development of diabetes but the association of these inflammatory markers with the basic pathology of type 2 diabetes is unclear. In the present study we investigated the association of...

Aim and Background: Free IGF-1 and IGFBP-1 are associated with obesity which is one of the major features of insulin resistance. But very few studies exist on free IGF-1 and IGFBP-1 in IGT subjects. The present study was undertaken to investigate the association of free IGF-1 and IGFBP-1 with insulin sensitivity in IGT subjects. Subjects and Method...

Background: TNF-α and IL-6 have been shown to be associated with insulin resistance in T2 DM subjects. However, their causal role in the development of diabetes is still unsettled. Subjects and methods: In the present study 106 prediabetic subjects (17 IFG, 60 IGT, 29 IFG-IGT) were studied along with age- and BMI-matched 56 healthy controls. Insuli...

The economic burden resulting from Diabetic Nephropathy (DN) consumes a major portion of resources allocated for health-care services. Cost-effectiveness of various interventions on DN and its complications have relatively been well explored in developed countries, but these are almost absent in developing countries. The present study was undertake...

Background: The metabolic syndrome is a cluster of medical disorder that increases the risk of developing cardiovascular disease and diabetes. Aims and objective: Objective of the study was to determine the metabolic syndrome in prediabetic subjects to know whether this syndrome, which is common in diabetic subjects, appears in earlier stage of the...