Muhammad Fauzan Lubis

• Master of Pharmacy
• Lecturer at University of North Sumatra

The rising incidence of multidrug-resistant (MDR) Acinetobacter baumannii infections underscores the urgent need for novel antimicrobial strategies. The aim of this study was to investigate the synergistic effects between a polyphenol-rich extract from Phyllanthus emblica fruit and tetracycline against MDR A. baumannii strains. The extraction proce...

Free radicals are called atoms or molecules with no electron pairs and intermediate results of organic reactions with a homolysis process resulting from a covalent combination. Antioxidants are used to protect cells from damage due to the presence of free radical molecules. Nelumbo nucifera Gaertn is a type of aquatic plant that comes from India an...

Zanthoxylum acanthopodium DC., a unique spice plant from North Sumatra, is rich in beneficial secondary metabolites, particularly phenolic compounds. This study utilized the microwave-assisted extraction method to enhance the extraction of these bioactive compounds. The goal was to determine the optimal extraction conditions, including solvent conc...

Myristica fragrans Houtt leaves contain secondary metabolites such as flavonoids, terpenoids and alkaloids, which have antibacterial properties. At the nanoscale, the particles have a bigger surface contact area, resulting in increased amounts and solubility of the active chemical. This leads to a stronger antibacterial activity. This study aims to...

Background: The Karo ethnic group in Berastagi, North Sumatra, Indonesia, relies on traditional remedies like Karo oil for various health purposes. However, scientific documentation of its medicinal properties is lacking. This study aimed to document its traditional use, medicinal plants, and community-based development efforts. Methods: Semi-struc...

The medicinal plant Portulaca oleraceae has a long history of usage in traditional medicine. Plant extracts have several interesting pharmacological effects but have some drawbacks that can be addressed via capsulation with chitosan. This work set out to do just that tally up the antioxidant effects of a polyphenol-rich P. olerace extract and see h...

Objective: This study aims to develop a spectrophotometric method with the Ratio Difference method using ethanol pro analysis solvent to obtain the results of Dextromethorphan Hydrobromide (HBr) levels of Guaifenesin and Diphenhydramine Hydrochloride (HCl) in tablets. Methods: The Ratio Difference Sprctrophotography method involves dividing the mix...

Objective: This study aims to develop a spectrophotometric method with the successive ratio derivative spectra method using ethanol pro analysis solvent to obtain the results of the levels of Dextromethorphan (DEX) Hydrobromide (HBr), Guaifenesin (GUA) and, Diphenhydramine (DIF) Hydrochloric Acid (HCl) in tablet dosage form. Methods: This method is...

Objective: To demonstrate the efficacy and benefits of aporphine alkaloids from Nelumbo nucifera Gaertn. as anti-breast cancer agents. Methods: In this study, a combination of network pharmacology and molecular docking was used to investigate the pharmacological actions and underlying mechanisms of action of nuciferine, nor-nuciferine, and roemerin...

The optimization of microwave-assisted extraction (MAE) was conducted using response surface methods to improve the extraction of flavonoids from Piper crocatum Ruiz and Pav leaf. The optimization process included a Box–Behnken experimental design (BBD), which involved three variables at three levels. The present study aimed to evaluate the impact...

Currently, antibacterial materials are attracting considerable attention across various fields. In this study, curcumin (Cur) was prepared with nanocrystal cellulose (NCC) into the polyvinyl alcohol (PVA) matrix to improve the functional properties of a pure Cur-NCC-PVA film. The NCC was obtained from Ananas comosus leaves and characterized by Four...

Lemon candy is a candy that has a combination of sweet and sour taste. In making lemon candy using several ingredients. One of them is using natural ingredients. Plants that can be used as ingredients for making candy are lemon juice and sugarcane juice. This community service activity involved class XI HKBP Sidorame Private High School students wh...

Bath salt or better known as bath salt is a product that has recently been growing rapidly. Herbal bath salt itself is still not widely developed by the community. Herbal bath salts can be made from ginger powder and lemon peel which has a distinctive fragrance that can be relaxing for anyone who uses it. This community service activity involved cl...

Paradigma kesehatan di Indonesia lebih menitikberatkan pada pengobatan (kuratif) sehingga menyebabkan pola pikir yang berkembang di masyarakat adalah bagaimana cara mengobati apabila terkena penyakit. Oleh karena itu, diperlukan sebuah paradigma baru yang biasa dikenal dengan paradigma sehat yakni paradigma kesehatan yang mengutamakan upaya promoti...

Individuals diagnosed with cancer often turn to the use of herbal remedies with the intention of treating and ameliorating the condition, impeding the progression of metastasis, enhancing immune function, mitigating stress, and inducing relaxation. Recently, medicinal plants were combined with conventional chemotherapy to decrease the side effects...

Kabupaten Batu Bara adalah salah satu kabupaten di provinsi Sumatera Utara, Indonesia. Desa Guntung merupakan salah satu daerah di kabupaten tersebut dengan daun nipah sebagai bahan alam yang banyak di desa tersebut dan digunakan sebagai bahan baku pembuatan atap rumah atau sebagai kertas rokok. Pengabdian kepada masyarakat ini bertujuan untuk meni...

Andaliman (Z. acanthopodium DC) is a kind of flowering plant that belongs to the Rutaceae family. The habitats are found in southwestern China (Guangxi, Guizhou, Sichuan, Tibet, and Yunnan), Bangladesh, Bhutan, northern India, and northeastern India (Arunachal Pradesh, Assam, Manipur, Meghalaya, Nagaland, Sikkim, Uttar Pradesh, and West Bengal), Ne...

Karenda leaves contain flavonoids, steroids or triterpenoids, saponins, and tannins that act as antimicrobial compounds. The aim of the study was to determine the antibacterial activity of the ethanol extract of Karenda leaves against several acne-causing bacteria. The research method involved characterizing the simplicia of karenda leaves and extr...

The cytotoxic activitiy of silver nanoparticles bio-functionalized by Nelumbo nucifera leaf extracts were examined in the current work. The nanoparticle (AgNPs) was characterized by scanning electron microscopy, UV–visible spectroscopy, and a particle size analyzer. Cytotoxic activity of silver nanoparticles against T47D and 4T1 cells using the MTT...

Infectious disease is the biggest problem in the world. The problem with this infection is related to antibiotic resistance if its use is not consistent. Utilization of kemangi leaves, which are always used as fresh vegetables, has potential as an antibacterial in inhibiting the growth of Escherichia coli and Pseudomonas aeruginosa bacteria. This s...

Liver cancer is a type of malignant cancer that causes many deaths in the world. Efforts to find natural ingredients that can be used to treat liver cancer are very important. This study investigated the anticancer activity of ethanol extract of Duku (Lansium domesticum) leaves (LDE) through the cytotoxic activity, cell cycle inhibition mechanism a...

The avocado (Persea americana Mill.) is a fruit that is often found. This versatile fruit has many benefits for humans. The benefits of avocado are as anti-hyperlipidemic, analgesic, anti-inflammatory, anticonvulsant, hypoglycemic, hypercholesterolemic, wound healing and prevent cancer. The aims of this study was to make avocado seed methanol extra...

BACKGROUND: Vernonia amygdalina is a native plant from Africa which is widely distributed to Asia, especially in Indonesia. Parts of V. amygdalina such as roots, leaves, and bark are used by the community as traditional medicines such as antidiabetic, antibacterial, and anticancer. AIM: This study aims to show the effect of solvents in the V. amygd...

According to some studies, two-thirds of the world's plant species have therapeutic worth. Saurauia vulcanii (Korth.) is one of them. This is something that can be found in Indonesia. Traditionally, this herb was known as pirdot and was used to cure diabetes. This article examines the scientific activities of pirdot leaves as well as their safety f...

Background: Alveolar osteitis is a well-known complication that occurs following a tooth extraction when the clot within the socket breaks down too early, causing increased localised inflammation and extreme pain. Alveolar osteitis delays the wound healing process of the socket. The polyphenols in the cocoa bean (Theobroma cacao L.) can stimulate t...

BACKGROUND: Lansium domesticum Corr. is a plant that is easily found in Indonesia. People use the fruit to be sold because it has a good taste. Some people use other parts of the plant as medicine. This plant has great potential to be developed as a standardized traditional medicine. AIM: This article review aims to collect information on secondary...

Murraya koenigii (MK) plants are a type of plant whose bioactive compounds have been widely used in various countries as traditional medicines with metabolites containing alkaloids, flavonoids, tannins, steroids/triterpenoids and anthraquinones. The purpose of this study was to determine of acute toxicity effect and to test the antifungal effects o...

Pancreatic cancer is one of the most feared types of cancer because of the high number of deaths from this disease. High cases of death are reported due to the ineffectiveness of the early detection process of this type of cancer and the low effectiveness of treatment. This review reports a natural product that has the potential to be used as an an...

Pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan mengenai pembuatan Virgin Coconut Oil secara sederhana dan memberikan pengetahuan bahwa Virgin Coconut Oil dalam meningkatkan imunitas tubuh sehingga dapat menangani atau mencegah semakin berkembangnya pasien positif Covid-19. Melalui kegiatan pengabdian kepada masyarakat yang...

Vernonia amygdalina Delile. Leaves contain cardiac glycosides, which are potential cardiotonic and anticancer. This study evaluated the activity of vernonioside D, and E inhibits the epidermal growth factor receptor (EGFR). The study of the mammalian target of rapamycin (mTOR) confirmed the activity of these glycosides. In silico docking using Auto...

Objective: This study aims to determined phytochemical compounds of simplex and n-hexane extract (nHE) of Vernonia amygdalina Delile Leaves and cell cycle arrest activity against PANC-1 cells. Methods: The leaves of Vernonia amygdalina Delile were dried and extracted with n-hexane, followed by evaporation and freeze-drying. Phytochemicals screening...