Muhammad Ilias

Muhammad Ilias
University of Mississippi | UM · National Center for Natural Products Research

Ph. D.

About

170
Publications
33,479
Reads
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3,198
Citations
Introduction
Isolation and structure elucidation of bio-active compounds from higher plants with special emphasis on antimicrobial, antimalarial, anticancer, immunostimulant and neuro-protective/ psychoactive agents. Isolation of marker compounds from high value dietary supplements and developing validated large-scale isolation methods. Developing new Environment-friendly isolation technology and device for the application of Centrifugal Preparative Chromatography using various types of binder- free sorbents, especially reversed- phase (C18) silica gel.
Additional affiliations
November 1998 - August 2020
University of Mississippi
Position
  • Professor
Description
  • Research faculty working and developing antiinfective, anticancer and neurodegenative natural product drug discovery program
January 1989 - December 1998
King Saud University
Position
  • Researcher
Description
  • Isolation, structure elucidation and bio -activity of Saudi Arabian medicinal plants. Supervisor of Medicinal, Aromatic and Poisonous Plant Research Center’s lab.
November 1979 - May 1987
University of Dhaka
Position
  • Professor (Assistant)
Description
  • Taught pharmacognosy and medicinal chemistry to undergraduate and graduate classes.

Publications

Publications (170)
Article
Full-text available
Nelumbo nucifera (sacred lotus), locally known as Poddo, has been used as food and traditional remedy in Ayurvedic system in India and Traditional Chinese Medicine for a wide range of diseases. During past two decades, there are numerous scientific studies and general reviews have been published on its phytochemistry and pharmacology. However, in t...
Article
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A new 3,8''-flavanone-flavonol dimer gnidiflavanone-flavonol (1) and 10 known compounds (2-11), including four rare primula-type flavones 2-5, were isolated from the roots of Gnidia apiculata. Compounds 2-5 and 7 were reported for the first time from the plant family Thymelaeceae. Structures of the isolated compounds were established by spectroscop...
Article
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Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review...
Article
Full-text available
Medicinal plants have been traditionally used to treat cancer in Ethiopia. However, very few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro-ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol extracts of 22 plants...
Article
Bioactivity guided isolation of an ethanol extract of the root of Psoromanthus schottii (Family Fabaceae) afforded a new prenylated isoflavone, named schottiin (5,7,5’-trihydroxy-4’-O-methyl-6’-(3,3-dimethylallyl)-isoflavone) (1), together with four other isoflavones, including fremontone (2), 5,7,4’,5’-tetrahydroxy-2’-(3,3-dimethylallyl)-isoflavon...
Article
Full-text available
To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or s...
Article
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The anticancer activities of Rubia cordifolia and its constituents have been reported earlier, but their influence on the crosstalk of complex cancer-related signaling metabolic pathways (i.e., transcription factors; TF) has not yet been fully investigated. In this study, R. cordifolia root extract was subjected to the cancer signaling assay based...
Article
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Two new epimeric bibenzylated monoterpenes machaerifurogerol (1a) and 5-epi-machaerifurogerol (1b), and four known isoflavonoids (+)-vestitol (2), 7-O-methylvestitol (3), (+)-medicarpin (4), and 3,8-dihydroxy-9-methoxypterocarpan (5) were isolated from Machaerium Pers. This plant was previously assigned as Machaerium multiflorum Spruce, from which...
Article
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A set of structurally related O-methylated flavonoid natural products isolated from Senecio roseiflorus (1), Polygonum senegalense (2 and 3), Bhaphia macrocalyx (4), Gardenia ternifolia (5), and Psiadia punctulata (6) plant species were characterized for their interaction with human monoamine oxidases (MAO-A and -B) in vitro. Compounds 1, 2, and 5...
Article
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methyl...
Research
Full-text available
Provides an overview on the active phytochemical constituents of twenty-seven medicinal plants that are traditionally used to manage cancer in Ethiopia.
Article
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This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species th...
Article
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In an attempt to synthesize carvotacetone analogues, new 3-O-benzyl-carvotacetone (10) and previously reported 3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (11) were synthesized from piperitone (7). In this work, we describe the synthesis of 10 and other analogues from 7. Luche reduction of 7 to cis-piperitol (8), followed by benzylation yielded 3...
Article
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The investigation of the constituents that were isolated from Turnera diffusa (damiana) for their inhibitory activities against recombinant human monoamine oxidases (MAO-A and MAO-B) in vitro identified acacetin 7-methyl ether as a potent selective inhibitor of MAO-B (IC50 = 198 nM). Acacetin 7-methyl ether (also known as 5-hydroxy-4′, 7-dimethoxyf...
Article
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Although 4-O-Methylhonokiol (MH) effects on neuronal and immune cells have been established, it is still unclear whether MH can cause a change in the structure and function of the cardiovascular system. The overarching goal of this study was to evaluate the effects of MH, isolated from Magnolia grandiflora, on the development of the heart and vascu...
Article
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Stevia rebaudiana and its diterpene glycosides are one of the main focuses of food companies interested in developing novel zero calorie sugar substitutes since the recognition of steviol glycosides as Generally Recognized as Safe (GRAS) by the United States Food and Drug Administration. Rebaudioside A, one of the major steviol glycosides of the le...
Article
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In this study, 2,3-dihydro-1H-indolizinium alkaloid-prosopilosidine (PPD), that was isolated from Prosopis glandulosa, was evaluated against C. neoformans in a murine model of cryptococcosis. In vitro and in vivo toxicity of indolizidines were also evaluated. Mice were infected via the tail vein with live C. neoformans. Twenty-four hours post-infec...
Article
A bioassay-guided fractionation yielded five new polycyclic phloroglucines derivatives, namely, gundlachiione A (1), gundlachiione B (2), gundlachiione C (3), gundlachiione D (4) and gundlachiione E (5) from the fruits of Clusia gundlachii, collected in Puerto Rico, USA. Their structures were determined by full spectroscopic data, including 2D NMR...
Article
Full-text available
Infections caused by Mycoplasma species belonging to the ‘mycoides cluster’ negatively affect the agricultural sector through losses in livestock productivity. These Mycoplasma strains are resistant to many conventional antibiotics due to the total lack of cell wall. Therefore, there is an urgent need to develop new antimicrobial agents from altern...
Article
A simple, rapid, and sensitive UHPLC-UV-MS method was developed for the quantitative determination of betaine (1), choline (2), acetylcholine (3), and 20-hydroxyecdysone (4) from various species of Atriplex. The baseline separation of the four analytes was achieved on a reversed phase C18 column within nine minutes. The mobile phase was composed of...
Article
The pond-raised channel catfish (Ictalurus punctatus) industry in the United States of America can incur losses of over a $100 million annually due to bacterial diseases including columnaris disease caused by Flavobacterium columnare. One management approach available to catfish producers is the use of medicatedfeed containing antibiotics. However,...
Chapter
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Malaria remains one of the major infectious diseases with high morbidity and mortality in developing and under-developed countries of the world. Although readily curable, the development of resistance by the malaria parasite especially Plasmodium falciparum, to existing antimalarials necessitates the need for continuous search for new antimalarial...
Article
Two new flavonoids, rac-6-formyl-5,7-dihydroxyflavanone (1) and 2',6'-dihydroxy-4'-methoxy-3'-methylchalcone (2), together with five known derivatives, rac-8-formyl-5,7-dihydroxyflavanone (3), 4',6'-dihydroxy-2'-methoxy-3'-methyldihydrochalcone (4), rac-7-hydroxy-5-methoxy-6-methylflavanone (5), 3'-formyl-2',4',6'-trihydroxy-5'-methyldihydrochalcon...
Article
Full-text available
BackgroundA diverse library of pre-fractionated plant extracts, generated by an automated high-throughput system, was tested using an in vitro anti-malarial screening platform to identify known or new natural products for lead development. The platform identifies hits on the basis of in vitro growth inhibition of Plasmodium falciparum and counter-s...
Article
Eschscholzia californica, a native US plant, is traditionally used as a sedative, analgesic, and anxiolytic herb. With the rapid rise in the use of herbal supplements together with over-the-counter and prescription drugs, the risk for potential herb-drug interactions is also increasing. Most of the clinically relevant pharmacokinetic drug interacti...
Article
Salvia officinalis and Zingiber officinale commonly known as sage and ginger, respectively, are two of the historically known cultivated plants and indigenous medicine since millennia. In 1985, the German Commission E approved the use of sage internally and externally for a number of medical concerns included dyspepsia and inflammation. In 1995, th...
Conference Paper
Visceral leishmaniasis, caused by protozoan parasite Leishmania donovani, is fatal if left untreated. Extreme toxicity, increasing resistance of the parasite to currently available drugs and absence of a suitable vaccine necessitate the discovery of new anti-leishmanial drugs. The Na+-K+-ATPases and related anti-porter functions may be necessary fo...
Article
Nelumbo nucifera Geartn., known as sacred lotus, has been used traditionally in South East Asia as a traditional medicine for various CNS disorders including stress, fever, depression, insomnia, and cognitive conditions. To investigate the in vitro cannabinoid and opioid receptor binding affinities, and in vivo behavioral actions of Nelumbo flower...
Article
Eschscholzia californica, a North American plant, is traditionally used for depression, neurasthenia, and various psychiatric conditions. With the rapid rise in the use of herbal supplements in combination with conventional drugs, the risk for potential herb-drug interactions is also increasing. Most of the clinically relevant pharmacokinetic drug...
Article
Neuritogenesis or neuritic outgrowth is a fundamental cellular differentiation process for formation of new neurons. Recent reports have indicated importance of this process in neuroregeneration and repair of damaged neurons. Neurotrophic and Neuritogenic substances, which repair damaged neurons through stimulation of neuritic outgrowth, may be imp...
Conference Paper
Nelumbo nucifera Geartn. (lotus), is a perennial aquatic plant native to South-East Asia. Both white and pink flowers are reported to have a calming effect when smoked or made into a tea. Bioassay-guided isolation and identification of from EtOH extracts revealed eight benzyltetrahydroisoquinoline alkaloids, nuciferine (1), N-nor-nuciferine (2), as...
Conference Paper
Atriplex canescens (Pursh) Nutt., is an evergreen, scurfy shrub endemic to the central and western regions of the North America. Native Americans have been used it in folkloric medicine for controlling pain, ant bites and other ailments. From the EtOH extract of A. canescens leaves three key dietary ingredients, namely betaine (1), choline (2), and...
Conference Paper
Purpose- Visceral leishmaniasis, caused by a protozoan parasite Leishmania donovani, is a major global health problem. Toxicity and suboptimal efficacy of current antileishmanial drugs demand discovery of new antileishmanial drugs with better therapeutic profiles. Random screening of a library of plant-fractions identified several fractions with ca...
Article
Full-text available
The root extract of Thespesia garckeana yielded three known oxidatively coupled sesquiterpenoids, namely (-)-gossypol (1) and two of its derivatives (-)-6-methoxygossypol (2) and (+)-6,6'-dimethoxygossypol (3), and the stem bark afforded (E)-docosy1-3-(3,4-dihydroxyphenyl) acrylate (4), stigmasterol (5) and betulinic acid (6). The structures of the...
Conference Paper
Eschscholtzia californica Cham. (California poppy; Papavaraceae), is a native plant of the Pacific regions, including California and Oregon in the USA and Baja California in Mexico. California poppy is a traditional medicinal plant of the Native Americans and early settlers of California. The plant has been described as a marijuana substitute as it...
Article
Full-text available
The root extract of Thespesia garckeana yielded three known oxidatively coupled sesquiterpenoids, namely (-)-gossypol (1) and two of its derivatives (-)-6-methoxygossypol (2) and (+)-6,6′-dimethoxygossypol (3), and the stem bark afforded (E)-docosyl-3-(3,4-dihydroxyphenyl) acrylate (4), stigmasterol (5) and betulinic acid (6). The structures of the...
Article
Full-text available
Flueggea virosa (Roxb. ex Willd.) Royle (Phyllanthaceae), also known as Chinese waterberry, is a shrub up to 4 m high growing wild in tropical Africa, Middle East, tropical Asia, Japan, Australia, and Polynesia and can also be grown domestically. It has many recorded uses in Chinese herbal medicine. The plant has been used for the treatment of feve...
Article
Three novel compounds; two polymethoxylated flavonoids, 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (1), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (2), and a clerodane diterpenoid; 8-acetoxyisochiliolide lactone (3) were characterized from the leaf exudates of Microglossa pyrifolia. In addition, three known polymethoxylated flavonoids inclu...
Conference Paper
Human African Trypanosomiasis (HAT) or sleeping sickness is caused due to infection with Trypanosoma brucei. Current drugs for treatment of HAT suffer from severe toxicities and require intramuscular or intravenous administrations. Situation is further aggravated due to emergence of drug resistance. There is an urgent need of new drugs effective or...
Article
Full-text available
Propolis is the resinous material that bees gather from leaf buds, flowers and vegetables. Propolis extracts contain constituents with a broad spectra of pharmacological properties and are important ingredients of popular dietary supplements. Propolis extracts were evaluated in vitro for inhibition of recombinant human monoamine oxidase (MAO)-A and...
Article
Neurodegenerative diseases including Parkinson's (PD), Alzheimer's (AD), Huntington's (HD) and Amyotrophic Lateral Sclerosis (ALS) occur as a result of progressive loss of structure or function of neurons, including death of neurons. Neurotrophic actions and neuroprotection leading to neuroplasticity and neurite outgrowth are important markers for...
Article
Full-text available
A new technology for the preparation of ChromatorotorTM (WO 2013/036803 A8) with a choice of chromatographic phases for Centrifugal Preparative Thin-layer Chromatography (CPTLC) or Rotational Planar Chromatography (RPC) opened a new window for fast, reliable, and economic separations of various classes of natural products. In order to prepare Chrom...
Article
Bioassay-guided fractionation of the CHCl3 soluble fraction the native plant Ivesia gordonii led to the isolation of a new dimeric acylphloroglucinol, 3,3′-diisobutyryl-2,6′-dimethoxy-4,6,2′4′-tetrahydroxy-5,5′dimethyl- diphenyl methane (ivesinol) (1), together with a known monomeric acylphloroglucinol, 1,5-dihydroxy-2-(2′-methylpropionyl)-3-methox...
Article
Visceral leishmaniasis, caused by Leishmania donovani, is a prominent disease in certain tropical regions of the world. The toxicity and resistance for currently available drugs, with severely depleted drug discovery pipeline, necessitate discovery of new antileishmanial drugs. Natural products still remain an unmatched source of drugs with novel c...
Article
Bioassay-guided fractionation of the chloroform soluble fraction of stem, leaf, and flower extracts of the American plant Ivesia gordonii led to the isolation of a new dimeric acylphloroglucinol, 3,3'-diisobutyryl-2,6'-dimethoxy-4,6,2',4'-tetrahydroxy-5,5'dimethyldiphenyl methane (1), to which we have assigned the trivial name ofivesinol (1), toget...
Article
Bioassay-guided fractionation of the chloroform soluble fraction of stem, leaf, and flower extracts of the American plant Ivesia gordonii led to the isolation of a new dimeric acylphloroglucinol, 3,3′-diisobutyryl-2,6′-dimethoxy-4,6,2′,4′-tetrahydroxy-5,5′dimethyldiphenyl methane (1), to which we have assigned the trivial name of ivesinol (1), toge...
Conference Paper
Visceral leishmaniasis, caused due to infection of Leishmania donovani, is a prominent disease in certain tropical regions of the world. Toxicity and suboptimal efficacy of current antileishmanial drugs necessitate the discovery of new antileishmanial drugs with better efficacy and safety profiles. Natural products remain an unmatched source of dru...
Article
Bioassay-guided fractionation of the leaves of Eugenia rigida yielded three stilbenes, (Z)-3,4,3',5'-tetramethoxystilbene (1), (E)-3,4,3',5'-tetramethoxystilbene (2), and (E)-3,5,4'-trimethoxystilbene (3). The sterically hindered Z-stereoisomer 1, a new natural product, was prepared by time-dependent photoisomerization of the E- isomer (2) under UV...
Article
Polyalthia longifolia is an evergreen tree used in Indian System of Medicine as traditional febrifuge and tonic. Various biological activities, including antibacterial, antifungal and cytotoxic activities, were reported for this plant. In this study, three clerodane diterpenes were isolated by bioassay-guided fractionation and identified as (-) kol...
Article
Full-text available
Phytochemical investigation of the ethyl acetate-soluble fraction of stem bark extract of an African medicinal plant Terminalia brownii led to the isolation of a new oleanane-type triterpenoid, along with seven known triterpenoids, seven ellagic acid derivatives, and 3-O-β-D-glucopyranosyl-β-sitosterol. The new compound was identified using spectro...
Article
Bioassay-guided fractionation of the leaves of Eugenia rigida yielded three stilbenes, (Z)-3,4,3',5'-tetramethoxystilbene (1), (E)-3,4,3',5'-tetramethoxystilbene (2), and (E)-3,5,4'-trimethoxystilbene (3). Their structures were determined using 1D- and 2D-NMR spectroscopy and HRESIMS. The sterically hindered Z-stereoisomer 1, a new natural product,...
Article
Neuritogenesis or neuritic outgrowth is a fundamental cellular differentiation process for formation of new neurons. Recent reports have indicated importance of this process in neuroregeneration and repair of damaged neurons. Neurotrophic and neuritogenic substances, which repair damaged neurons through stimulation of neuritic outgrowth, may be imp...