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Introduction
Muhammad Ibrahim currently works at the Department of Applied Chemistry, Government College University Faisalabad. Muhammad does research in Organic Chemistry, Medicinal Chemistry and Phytochemistry . Their current project is 'Investigative Study for the Treatment of Dementia with Selected Medicinal Plants of Cholistan Desert (Punjab).'
Additional affiliations
August 2012 - present
Publications
Publications (49)
The emerging concepts of sustainable textiles and controlled production strategy demands ideally zero emissions of contaminants into the aquatic environment. However, the currently in-practiced conventional processes in textiles dispose of a number of contaminants especially super toxic synthetic dyes as effluents. In recent years, nanomaterials ha...
Choline chloride (CC) application enhanced the tolerance of cluster bean ( Cyamopsis tetragonoloba L.) against salinity stress. The aim of the study was to determine the protective role of CC on plant growth, photosynthesis, and biochemical indicators of oxidative stress. The seeds of BR-99 (tolerant) and BR-2017 (sensitive) were surface sterilized...
Bisphenol A (BPA) is a man-made chemical substance that is used in our daily life for the production of many plastic wares. In this chapter, sources of BPA exposure and its effects on human being have been summarized in detail. Many in vivo and in vitro studies show that BPA is considered as a toxic, mutagenic, carcinogenic, and endocrine disruptor...
Nanotechnology, a rapidly flourishing field has emerged as cutting-edge technology in the twenty-first century indicating a promising future. Over the past decades, explosive research efforts have resulted in the development and evaluation of a plethora of nanoparticles for potential applications such as diagnosis and therapy. Hence playing a cruci...
The study aimed to characterize the antioxidant properties regarding the Sida cordifolia with special reference to its detailed biochemical analysis. The study revealed that chlorophyll A (0.9 ± 0.3 mg/g), total chlorophyll content (3.0 ± 0.7 mg/g), total carotenoid content (0.3 ± 0.1 mg/g), total soluble proteins (7.5 ± 0.1 mg/g), and total phenol...
The exogenous application of silicon (Si) is reported to enhance tolerance of plants against various environmental stresses. Therefore, the present study was carried out to examine the influence of foliar applied Si (1.5 mM) on growth, physiochemical processes and antioxidant defense system of barley plants (cvs. Jow-83 and B-12026) under different...
The pyrimidine ring is significantly distributed in nature due to its existence in deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) as nitrogenous bases. The heterocyclic aromatic compounds have become an important pharmacophore due to promising applications in medicine and nonlinear optics (NLO) fields. Keeping in view of the significance of...
Herein, first attempt has been made to utilize fluorene-based dye-sensitized solar cell (DSSCs) dye JK-201 as potential nonlinear optical (NLO) material and for the theoretical designing of novel NLO chromophores JK-D1–JK-D12. DFT/TDDFT calculations were performed to compute the effect of π-linkers and acceptors-steered modulation on electronic, ph...
In this work, we designed series of indolo[3,2,1-jk]carbazole based donor-π-acceptor organic dyes S1-S8 by modifying the π-bridge of experimentally synthesized dye IC-2 in order to evaluate their potential nonlinear optical (NLO) properties. Density functional theory (DFT) calculations with B3LYP/6-31+G(d,p) level of theory was used to shed light o...
Development of curcumin-loaded mixed polymeric micelles based on chitosan, alginate, maltodextrin, pluronic F127, pluronic P123, and tween 80, by thin-film hydration method has been investigated in Bisphenol A induced diabetics rats. Curcumin (C23H20O6) extracted from rhizomes of the "Curcuma longa" has attracted considerable attention of pharmaceu...
Biologically important triazole derived Schiff base ligand 2-[(1Z)-N-(1H-1,2,4-triazol-3-yl)- etanimidoyl]phenol (SR) is synthesized by condensation of 3-amino-1,2,4-triazole with 2-hydroxyacetophenone. The ligand forms the corresponding complexes upon reaction with salts of VO(IV), Cr(III), Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) in 2:...
This work was inspired by a previous report (M.R.S.A. Janjua, Inorg. Chem. 2012, 51, 11306−11314) in which the nonlinear-optical (NLO) response strikingly improved with double heteroaromatic rings. Herein, series of triphenylamine-dicyanovinylene based donor-π-acceptor dyes have been designed by structural tailoring of π-conjugated linkers and theo...
Traditionally, many natural medicinal plants have been used to treat a variety of diseases since ancient times and are considered a potential source of phytochemicals for the development of new drugs. One of these is curcumin, which is an easily accessible, inexpensive, and nontoxic bioactive compound. Curcumin is a very important, naturally occurr...
The genus Urtica belongs to the family Urticaceae. The plants of this genus are known as nettles or, quite often, as stinging nettles. These plants can be easily identified by the presence of stinging hairs. Urtica species have previously been used for various medicinal purposes. The history for the use of these plants for medicinal purposes starts...
The genus Datura comprises wild shrub plants that belong to the Solanaceae family. Naturally, they possess both medicinal and poisonous properties due to the presence of many biologically active phytochemical constituents. Traditionally, Datura had been used for mystic and religious purposes, as a natural drug to treat asthma, pain, gout, boils, ab...
In this study, two compounds: 4-(3-bromopropoxy)-3-methoxy phenyl methanol (1) and 4-(3-bromopropoxy)-3-methoxybenzaldehyde (2) have been isolated from Neurada procumbens for the first time. Their structures have been elucidated by EI-MS, HR-EI-MS, HR-FAB-MS, ¹H and ¹³C-NMR and XRD crystallographic techniques. These compounds have been further inve...
Algae belong to a much-diversified group of autotrophic organisms ranging from simple unicellular to complex multicellular forms. Till date at least 37,000 species of “true” algae and 4000 cyanobacteria are well recognized. They have proved to be the chief source of vitamins, minerals, proteins, and amino acids. Marine algae are used mainly as food...
Fifteen secondary metabolities containing steroid and terpenoids skeleton have been isolated from the plant
Kochia prostrata namely Kochioside A-C (1-3), Myristic acid (4), Lignoceric acid (5), Lacceric acid (6),
Octacosanoicacid (7), β-Sitosterol (8), Stigmasterol (9), Oleanolic acid (10), Betulinicacid (11), Stigmasterol3-OD-glucoside(12), Betuli...
Cadmium (Cd) toxicity causes leaf chlorosis, growth inhibition, and disruption of photosynthetic machinery. A pot experiment was conducted to evaluate the changes in growth, physiochemical attributes and expression level of the catalase (Cat2) gene in two tomato cultivars (cv. Nagina; cv. Roma) under cadmium (Cd) stress. Plants were subjected to va...
The genus Cuscuta, of the family Cuscutaceae, is present in plants and has been traditionally used medicinally against many diseases and conditions, notably depression, mental illness, headache, spleen disease, jaundice, diabetes mellitus, and hypertension. Large numbers of phytochemical constituents such as alkaloids, flavonoids, lignins, oxygen h...
Hepatitis C virus (HCV) presents a serious global health threat. Initially, the health-care community mainly focused on interferon (IFN)-based therapeutic options to eradicate HCV, but with the passage of time, these applications became unsuitable due to some serious side effects related to the use of IFN. In recent years, research conducted on dif...
The present investigation was conducted to appraise the physiochemical adjustments in contrasting maize cultivars, namely, PakAfgoi (tolerant) and EV-5098 (sensitive) subjected to heat shock. Seven-day-old seedlings were exposed to heat shock for different time intervals (1, 3, 6, 24, 48 and 72 h) and data for various physiochemical attributes dete...
The Amberboa is a medicinally important genus present in the family Asteraceae;
members of this genus are mainly distributed in Pakistan and India. It has been used in
different systems of traditional medicines for different diseases. Amberinone (1), a new
sesquiterpene lactone, has been isolated from the ethyl acetate (EtOAc) soluble fraction
of A...
Recent advances in genetic engineering and pharmaceutical biotechnology have made possible to combat life-threatening diseases with efficient delivery of therapeutic proteins. These advancements have increased the significance of therapeutic proteins in pharmaceutical market, but their therapeutic delivery to the targeted site is still a major obst...
For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to chronic conditions. However, many challenges, like emergence of drug resistance, limited the scope of activity of currently existing anti-HIV agents. Quite often se...
Recent advances in genetic engineering and pharmaceutical biotechnology have made possible to combat life-threatening diseases with efficient delivery of therapeutic proteins. These advancements have increased the significance of therapeutic proteins in pharmaceutical market, but their therapeutic delivery to the targeted site is still a major obst...
Background:
Tinospora cordifolia (T. cordifolia) is a valuable resource due to its traditional uses in the treatment of pain, fever and inflammation, but no sufficient scientific literature is available online to confirm its traditional uses in these ailments.
Objectives:
This study was carried out to validate the traditional uses of T. cordifol...
Background: Alzheimer’s disease (AD) is characterized by a progressive memory loss that leads to a profound
emotional disturbance in later stages. As no safe and effective drug is yet available for the treatment of AD,
secondary metabolites from plants may be instrumental in meeting this challenge. Keeping in view this point we
evaluated sesquiterp...
In wheat seeds, sodium nitroprusside (SNP) priming enhanced germination percentage, energy, index and rate as well as vigour index, while shortened the mean germination time compared to the control. The level of biochemical such as proteins, non-reducing sugars, superoxide dismutase, protease and peroxidase activities increased as well. Notably, SN...
New series of three bidentate N, O donor type Schiff bases (L
1
)–(L
3
) were prepared by using ethylene-1,2-diamine with 5-methyl furfural, 2-anisaldehyde, and 2-hydroxybenzaldehyde in an equimolar ratio. These ligands were further complexed with Co(II), Cu(II), Ni(II), and Zn(II) metals to produce their new metal complexes having an octahedral...
The Abutilon genus from the Malvaceae family is of medicinal importance, and members of this genus are distributed in the tropical and subtropical regions of Asia and other parts of the world. Abutilon pakistanicum Jafri & Ali is mainly found in Pakistan. It has been used by different systems of traditional medicines to treat different diseases. Pa...
Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient pharmacological-based scientific literature is not available online to authenticate its use in liver ailments. We aimed to assess the hepatoprotective effects of Malva sylvestris against paracetamol-induced hepatotoxicity in mice. The extract was concentrated...
Oxalis corniculata L. (creeping wood sorrel) is medicinally important member of family Oxalidaceae, and is distributed in the tropical and subtropical regions of the world. It has been used in different systems of traditional medications for different diseases. Corniculatin A, a new fl avonoid glucoside, was isolated from the ethyl acetate soluble...
Alzheimer's disease (AD) is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages. As no safe and effective drug is yet available for the treatment of AD, secondary metabolites from plants may be instrumental in meeting this challenge. Keeping in view this point we evaluated sesquiterpenes of medi...
Abstract
This paper describes a methodology to develop a new method for qualitative and quantitative determination
of glibenclamide (GLB) in three brands of GLB tablets. We validated the developed method for linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) according to the guidelines of the International Co...
Present study was conducted to appraise the inhibitory effects of cadmium applied at different time intervals on various growth and biochemical parameters in two maize lines, Maize-TargetedMutagenesis 1 and 2 (MTM-1 and MTM-2). Twenty-day-old seedlings were exposed to 0, 3, 6, 9, and 12 mg CdCl2 kg⁻¹ sand. Both maize lines exhibited significant per...
Amberin (1), a new sesquiterpene lactone, has been isolated from the ethyl acetate soluble fraction of Amberboa ramosa together with apigenin (2), jaseocidine (3), crysoeriol (4), and 3β, 8α-dihydroxy-11α-methyl-1αH, 5αH, 6βH, 7αH, 11βH-guai-10(14), 4 (15)-dien-6, 12-olide (5). The structures of the isolated compounds have been elucidated by 1D and...
Two new sesquiterpene lactones named amberbins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of Amberboa ramosa, together with jaseocidine (3), crysoeriol (4) and 3beta,8alpha-dihydroxy-11alpha-methyl-1alphaH,5alphaH,6betaH, 7alphaH,11betaH-guai-10(14), 4(15)-dien-6,12-olide (5). The structures of the isolated compound...
Aervins A-D (1-4), four new coumaronochromone analogues have been isolated from the CHCl(3)-soluble fraction of the MeOH extract of the whole plant of Aerva persica. Their structures were assigned based on (1)H NMR, (13)C NMR spectra, DEPT, and by 2DNMR experiments.
Eleven compounds have been isolated for the first time from Aerva persica namely. β-sitosterol (1), 4-hydroxybenzaldehyde (2), 4-hydroxybenzoic acid (3), 5,7-dimethoxycoumarin (4). 5,8-dihydroxycoumarin (5), 5,6,7- trimethoxycoumarin (6), 4-hydroxy-3,5-dimethoxybenzaldehyde (7), 3,4'-dihydroxy-3',5'-dimethoxypropiophenone (8), gallic acid (9), 5-hy...