Muhammad Farman

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• PhD Organic Chemistry
• Professor at Quaid-i-Azam University

A radioresistant bacterium identified as Kocuria sp.TMM 11 was isolated from Thal desert. Kocuria sp.TMM11 demonstrated resistance (57.3% survival rate) to an ultraviolet B radiations dose of 4.1 × 10³ J/m², 61.5% survival rate to hydrogen peroxide (60 mM) and 57.1% survivability to mitomycin C (6 μg/mL). An orange carotenoid pigment from strain TM...

The identification of secondary metabolites in plants is a crucial aspect of understanding their biochemical profiles and their ecological, pharmacological, and nutritional roles. Typha elephantina is a medicinally potent plant. The study aims to identify a number of bioactive compounds from Typha elephantina root extract by using GC-MS analysis. T...

Medicinal plants play an important role in human well-being, providing a source of natural remedies for a wide range of diseases and health issues. However, the true potential of these plants lies in the microbial communities associated with them, which can significantly impact the secondary metabolism of the plants and thus their therapeutic prope...

Plant bioactivities encompass the range of biological effects due to compounds derived from plants or plant-based products on living organisms. These bioactivities are typically due to the bioactive compounds of plants, such as alkaloids, flavonoids, terpenoids, polyphenols, and other secondary metabolites. These compounds can influence various phy...

Phytochemicals derived from plants have gained significant attention in recent years due to their diverse therapeutic properties. Typha elephantina is an aquatic plant having ameliorative characteristics like antioxidant, anti-inflammatory and analgesic etc. This research aims to conduct a comprehensive phytochemical investigation by Tandem mass sp...

This study aims to determine UV-B resistance and to investigate computational analysis and antioxidant potential of methoxy-flavones of Micromonospora aurantiaca TMC-15 isolated from Thal Desert, Pakistan. The cellular extract was purified through solid-phase extraction and UV–Vis spectrum analysis indicated absorption peaks at λmax 250 nm, 343 nm,...

Background: Genus Torilis (Apiaceae) known as hedge parsley, encompasses 11-13 species distributed worldwide and shows potential pharmacological uses. Its phytochemical pattern is highly diversified including many phenolic and terpenic compounds. Objective: This research-review provides new highlighting of structural organizations, structure-act...

This study aims to determine UV-B resistance and to investigate computational analysis and antioxidant potential of methoxy-flavones of Micromonospora aurantiaca TMC-15 isolated from Thal Desert, Pakistan. The cellular extract was purified through solid-phase extraction and UV–Vis spectrum analysis indicated absorption peaks at λmax 250 nm, 343 nm,...

This study aims to determine UV-B resistance and to investigate computational analysis and antioxidant potential of methoxy-flavones of Micromonospora aurantiaca TMC-15 isolated from Thal Desert, Pakistan. The cellular extract was purified through solid phase extraction and UV-Vis spectrum analysis indicated absorption peaks at λ max 250 nm, 343 nm...

Lignin is a major by-product of pulp and paper industries, and is resistant to depolymerization due to its heterogeneous structure. Degradation of lignin can be achieved by the use of potential lignin-degrading bacteria. The current study was designed to evaluate the degradation efficiency of newly isolated Bacillus altitudinis SL7 from pulp and pa...

Methylated flavones, commonly found in many plants of the Brassicaceae family, have potent antioxidant and anticancer activity with diverse therapeutic potential. However, the specific regioisomers of methylated flavones can have significantly different biochemical and potentially therapeutic properties as shown by various bioassays but analyticall...

Background Saponin metabolism shows high structural variability due to diversity of aglycones and glycosylations (Gly). Although they represent potential source of drug design, their metabolism suffers yet from a misunderstanding due to insufficient investments in analytical methods. Aim Bibliographic structural data offer a wide field for extensi...

Introduction This work provides statistical analyses of bibliographic data on pharmacologically evaluated flavonoids from different plant families. By opposition to structural elucidations benefitting from full data aspects, pharmacological evaluations are concerned with partial investigations resulting in sparse information. Methods The limited d...

Glycosylation mechanisms in saponins of Caryophyllaceae plant family were subjected to simulation by statistically exploring variability of 231 chemical structures belonging to four different aglycones: gypsogenin (Gyp), quillaic acid (QA), gypsogenic acid (GA), 16-OHgypsogenic acid (16-OH-GA). Saponins based on different aglycones were initially c...

Torilis leptophylla commonly known as bristle fruit hedge parsley is widely acknowledged for its potential to treat liver and gastrointestinal disorders. Till today no scientific evidence has been reported to support this claim. So the present investigation was carried out to get an inclusive picture of volatile phytoconstituents of Torilis leptoph...

Purpose Leukemia, one of the major cancers, affects a large proportion of people around the world. Better treatment options for leukemia are required due to large number of side effects associated with current therapeutic regimens. In the present study, we sought to determine the pathway of triggering apoptosis of leukemic cells by Ocimum basilicum...

Saponins in Caryophyllaceae were subjected to many structural elucidations for several decades leading to big datasets of molecules essentially based on four aglycones: quillaic acid (QA), gypsogenin (Gyp), gypsogenic acid (GA) and 16α-OH-gypsogenic acid (16α-OH-GA). Statistical analyses of structural variability of 231 saponins (published between...

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The current study focuses on the production of poly (lactic acid) (PLA) degrading enzyme from Sphingobacterium sp. strain S2 under optimized conditions. The important variables influencing lipase production were identified by Plackett–Burman Design (PBD) and Central Composite Design (CCD). The results demonstrated NH4Cl as significant independent v...

Martynia annua is an indigenous plant found endemic in the Indian subcontinent where it is commonly used for self-treatment of a variety of ailments and diseases. Previous studies have shown that preparations from the plant have antiseptic, anti-inflammatory, and antiepileptic effects in vitro, but the biochemical composition and active compounds r...

Martynia annua Linn. (Family: Martyniceae), is a medicinally important plant being rich in phenolics. The current study was undertaken to investigate the phenolic acids and flavonoid glycosides using HPLC-DAD-ESI-MS fingerprinting and explore their total phenolic content (TPC), total flavonoid content (TFC) and antioxidant potential. Various parts...

Thy food is thy medicine" this statement led us to explore the antimicrobial and antioxidant potential of Cucurbita pepo L. The plant belongs to family Cucurbitaceae. Cucurbits have a lot of folkloric medicinal uses. In this study, in vitro spectroscopic protocols were executed for the determination of total phenolic content, the concentration of f...

Genus Oenothera includes medicinal plants that are distributed throughout the world and are known since ancient times. Popular indications of different species of this genus include treatment of inflammations, diabetes, microbial infections, ulcers, tumors, kidney and liver problems. The plants of this genus are a botanical source for various pharm...

Objective: To evaluate the total phenolic content and compare the antioxidant activity of various solvent extracts and fractions from the aerial parts of Coronopus didymus through various assays. Methods: Total phenolic content was determined using the Folin-Ciocalteu assay and the in vitro antioxidant activity of a number of different extracts...

This chapter aims at analyzing the extraction and separation protocols documented for the saponins from the plant family Caryophyllaceae during the period 1967-2014. This family has been found to be a quite rich source of oleanane skeleton-based saponins including gypsogenic acid, gypsogenin and quillaic acid. Distribution and frequencies analyses...

Background. Olive oils (OOs) show high chemical variability due to several factors of genetic, environmental and anthropic types. Genetic and environmental factors are responsible for natural compositions and polymorphic diversification resulting in different varietal patterns and phenotypes. Anthropic factors, however, are at the origin of differe...

Ethnopharmacological relevance: Coronopus didymus Linn. (Brassicaceae) is a medicinal plant used traditionally as antipyretic, expectorant, to purify blood and for alleviating symptoms of pain, inflammations, malaria, wounds and cancer. Aim of the study: The present study was designed to isolate and identify the cytotoxic compounds responsible f...

Coronopus didymus is a medicinal plant belonging to family Brassicaceae. Volatile phytochemical constituents from various extracts of Coronopus didymus were investigated by gas chromatography-mass spectrometry to analyze the biologically active constituents of the herb. A total of 69 compounds were identified including 34 from the aerial parts and...

New series of benzophenone imines with general formula Ph2-C=NR; R = Benzyl, 4-Fluorobenzyl, Naphthyl, Phenyl, 4-Nitrophenyl were synthesized by condensation of dichlorodiphenylmethane and different aromatic primary amines (1:1) Those imines were characterized by different physiochemical and spectroscopic techniques like melting point, elemental an...

Various species in genus Hibiscus are traditionally known for their therapeutic attributes. The present study focused on the phytochemical analysis of a rather unexplored species Hibiscus caesius (H. caesius), using high-pressure liquid chromatography coupled with mass spectrometry (HPLC-MS). The analysis revealed five major compounds in the aqueou...

A series of novel 3-aryl-6-adamantylmethyl-[1,2,4] triazolo[3,4-b][1,3,4] thiadiazoles 6a-1 were synthesized by a simple method with the aim of developing novel HIV non-nucleoside reverse transcriptase inhibitors. All the synthesized compounds were structurally confirmed by spectral analyses. The structure of 6a was unambiguously verified by X-ray...

Orally administered drugs usually face the problem of low water solubility, low permeability and less retention in blood stream leading to unsatisfactory pharmacokinetic profile of drugs. Polymer conjugation has attracted increasing interest in pharmaceutical industry for delivering such low molecular weight (Mw) drugs as well as some complex compo...

The title compound, C(9)H(12)N(2)O(2), is approximately planar (r.m.s. deviation = 0.13 Å for all non-H atoms). The carbonyl O atom is involved as acceptor in three different hydrogen-bond inter-actions. One N-H⋯O and the C-H⋯O(carbonyl) contact together with a weak C-H⋯O(eth-oxy) interaction link the mol-ecules into sheets parallel to (102). These...

Analysis of plant diversity aims to understand the organization and the variability of biological populations within ecosystems. In classical analysis, individual plants are firstly identified on the basis of morphological/cytological parameters, then biodiversity is evaluated tacking into account presence/absence, abundances and densities of plant...

Since plants are immobile, they must put up with the conditions in which they find themselves. Therefore, to maximize the acquisition of the basic resources, plants have evolved elaborate mechanisms capable of detecting incoming physical, chemical and biological signals. For that, Secondary metabolites (SMs) represent a vast catalogue of plant comp...

In the title compound, C18H19FN2O, the hydrazide side chain is approximately perpendicular to the central ring [dihedral angle = 76.80 (5)°]. The F atom is disordered over two positions with occupancies of 0.818 (2) and 0.182 (2). The packing consists of chains of molecules parallel to the a axis, connected by a bifurcated N—H...(O,N) hydrogen bond...

In the title compound, C18H19FN2O, the hydrazide side chain is approximately perpendicular to the central ring [dihedral angle = 76.80 (5)°]. The F atom is disordered over two positions with occupancies of 0.818 (2) and 0.182 (2). The packing consists of chains of mol­ecules parallel to the a axis, connected by a bifurcated N—H⋯(O,N) hydrogen bond...

Extracts of Pistacia integerrima galls have been dispensed by Traditional Practitioners of Subcontinent for chest diseases as well as for aches and pains in the body. This study was planned to evaluate the possible analgesic and antiinflammatory effects of Pistacia integerrima extracts. Analgesia was determined using acetic acid induced abdominal c...

Analysis of plant diversity aims to understand the organization and the variability of biological populations within ecosystems. In classical analysis, individual plants are firstly identified on the basis of morphological/cytological parameters, then biodiversity is evaluated tacking into account presence/absence, abundances and densities of plant...

The title compound, C17H19N3O3S, crystallizes with two closely similar independent molecules related by a pseudotranslation of c/2. Each molecule consists of three approximately planar moieties centred on the N2CS group and the two ring systems. The packing involves classical H bonds of the form Namide—H...S and Nhydrazine—H...OC, together with var...

The title compound, C17H19N3O3S, crystallizes with two closely similar independent mol­ecules related by a pseudotranslation of c/2. Each mol­ecule consists of three approximately planar moieties centred on the N2CS group and the two ring systems. The packing involves classical H bonds of the form Namide—H⋯S and Nhydrazine—H⋯OC, together with vario...

Since plants are immobile, they must put up with the conditions in which they find themselves. Therefore, to maximize the acquisition of the basic resources plants have evolved elaborate mechanisms capable of detecting incoming physical, chemical and biological signals. For that, Secondary metabolites (SMs) represent a vast catalogue of plant compo...

Electron ionization mass spectra of twenty six nitrites (la-m & 2a-m) synthesized as racemates are discussed. The mass fragmentation patterns were designed with die help of EIMS. The molecular formulae were confirmed further by HREIMS in some selected cases.

Pistacia integerrima Stew ex. Brandis is an important component of commonly dispensed traditional dosage forms. We wished to determine whether polyphenolic constituents of this plant could be useful in oxidative stress and have potential to counter hyperuricemia. Radical scavenging activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and...

The quantitative assessment of plant diversity and its monitoring with time represent a key environmental issue for management and conservation of natural resources. Assessment of plant diversity could be based on chemical analyses of secondary metabolites (e.g. flavonoids, terpenoids), because of the substantial quantitative and qualitative betwee...

The title compound, C9H12N2O2, is an important intermediate for the synthesis of biologically active heterocyclic compounds. The planar hydrazide group is oriented with respect to the benzene ring at a dihedral angle of 86.66 (3)°. In the crystal structure, intermolecular N—H...O hydrogen bonds link the molecules.

The title compound, C9H12N2O2, is an important inter­mediate for the synthesis of biologically active heterocyclic compounds. The planar hydrazide group is oriented with respect to the benzene ring at a dihedral angle of 86.66 (3)°. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules.

In previous work, 14 flavonol glycosides were characterised in the leaves of Astragalus caprinus, an endemic Fabaceae, widely distributed in North West Africa. These compounds included quercetin and kaempferol derivatives, glycosylated by two, three or four sugars with an aliphatic or aromatic acyl moiety. In this paper, we describe the flavonoid p...

Two new flavonoid glycosides, kaempferol 7-alloside and 3,7-diarabinoside have been characterized from leaves of Indigofera hebepetala, together with the known glycosides, kaempferol 3-arabinoside-7-rhamnoside and 3-rhamnoside-7-arabinoside.