Muhammad Faisal Nadeem

Muhammad Faisal Nadeem
University of Veterinary and Animal Sciences | UVAS · Institute of Pharmaceutical Sciences

Doctor of Philosophy

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25
Publications
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192
Citations

Publications

Publications (25)
Article
Full-text available
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 International license(https://creativecommons.org/licenses/by-nc/4.0/). Noncommercial uses of the work are permitted, provided the original work is properly cited. A B S T R A C T Background: Oral anticancer drugs (OACDs) have been used since the 1950s and are expected to...
Article
Until now, no specific and effective treatment exists for coronavirus disease 2019 (COVID-19). Since honey and Nigella sativa (HNS) have established antiviral, antibacterial, antiinflammatory, antioxidant, and immunomodulatory properties, we tested their efficacy for this disease in a multicenter, placebo-controlled, and randomized clinical trial a...
Article
Full-text available
Aim: To analyze the adequacy and wellbeing of ondansetron versus less costly metoclopramide in the treatment of kids with tenacious heaving with intense gastroenteritis. Materials and Methods: A twofold visually challenged preliminary involving continuous accepted patients aged 1 to 14 years was directed in a metropolitan clinic environment from Yo...
Article
Full-text available
This study was designed to seek the phytochemical analysis, antioxidant, enzyme inhibition, and toxicity potentials of methanol and dichloromethane (DCM) extracts of aerial and root parts of Crotalaria burhia. Total bioactive content, high-performance liquid chromatography-photodiode array detector (HPLC-PDA) polyphenolic quantification, and ultra-...
Article
Full-text available
Background Coronavirus disease 2019 (COVID-19) caused by the novel coronavirus-infected millions globally. Despite a wide range of advised options for the treatment of COVID-19, a single strategy to tackle this pandemic remains elusive, thus far. That is why we are conducting a clinical trial to find out the efficacy of iodine complex to clear a vi...
Article
Full-text available
Objectives The objective of the study is to measure the efficacy of ionic-iodine polymer complex [1] for clinical and radiological improvement in coronavirus disease 2019 (COVID-19) patients. Trial design The trial will be closed label, randomized and placebo-controlled with a 1:1:1:1 allocation ratio and superiority framework. Participants All P...
Article
Full-text available
Objectives The study objective is to quantify the effectiveness of ivermectin (subcutaneous/oral IVM) in the presence or absence of zinc (Zn) for clinical and radiological improvement in coronavirus disease 2019 (COVID-19) patients with moderate severity. Trial design This quadruple-blinded, placebo-controlled randomized clinical trial will be a m...
Article
Full-text available
Sphaeranthus indicus L. is a medicinal herb having widespread traditional uses for treating common ailments. The present research work aims to explore the in-depth phytochemical composition and in vitro reactivity of six different polarity solvents (methanol, n-hexane, benzene, chloroform, ethyl acetate, and n-butanol) extracts/fractions of S. indi...
Article
Most recently, the World Health Organization (WHO) and the International Pharmaceutical Federation FIP) have published a guidance and a survey report, respectively, in view of the emerging evidence-based potential of digital technologies, especially artificial intelligence (AI), in enhancing the delivery of quality health care and medicine, increas...
Article
Seamless integration of artificial intelligence (AI) technology, especially FDA-approved AI tools, in community pharmacies can build increasingly effective and easy care pathways, thereby minimizing burden on healthcare system, and ensuring compliance to preventive measure through limiting hospital visits. In this regard, the WHO needs to enlist an...
Article
Full-text available
Since the emergence of COVID-19 pandemic in China in late 2019, scientists are striving hard to explore non-toxic, viable anti-SARS-CoV-2 compounds or medicines. We determined In vitro anti-SARS-CoV-2 activity of oral formulations (syrup and capsule)of an Iodine-complex (Renessans). First, cell cytotoxicity of Renessans on the Vero cells was determ...
Preprint
Full-text available
BACKGROUND No definitive treatment exists for Coronavirus Disease 2019 (COVID-19). Honey and Nigella sativa (HNS) have established antiviral, antibacterial, anti-inflammatory and immunomodulatory properties. Hence, we investigated efficacy of HNS against COVID-19. wide METHODS We conducted a multicenter, placebo-controlled, randomized clinical tri...
Article
Full-text available
The HIV-1 Gag protein playing a key role in HIV-1 viral assembly has recently been shown to interact through its nucleocapsid domain with the ribosomal protein L7 (RPL7) that acts as a cellular co-factor promoting Gag's nucleic acid (NA) chaperone activity. To further understand how the two proteins act together, we examined their mechanism individ...
Article
Correctional facilities are the entities that retain offenders of the law that have been convicted for a long period by the courts. Incarceration is associated with poor health and inmates, particularly those in low-income and middle-income countries (LMICs), are highly susceptible to communicable and non-communicable diseases.1 In 1995, the Americ...
Preprint
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Iodine has strong antimicrobial properties and has been used in topical applications as antiseptic. Its systemic use in form of iodine complexes derived from dried seaweed extract is beneficial in treating various disorders. Hepatitis C Virus (HCV) chronic infection is present in 6-10% of the Pakistani population and is a major healthcare burden th...
Preprint
Full-text available
Since the emergence of CoVID-19 pandemic in China in late 2019, scientists are striving hard to explore non-toxic, viable anti-SARS-CoV-2 compounds or medicines. We determined In Vitro anti-SARS-CoV-2 activity of oral formulations (syrup and capsule) of an Iodine-complex (Renessance). A monolayer of vero cells were exposed to SARS-CoV-2 in the pres...
Preprint
Full-text available
Background Micronutrients are essential for the body to produce enzymes, hormones and other substances essential for proper growth and development. Iodine, potassium iodide and ascorbic acid are ones of the most important in global public health terms. However, their lack represents a major threat to the human and animal health. Methodology Antivi...
Preprint
Full-text available
In late December 2019, a disease known as Coronavirus Disease (COVID-19), later known to be caused by a novel coronavirus, SARS-CoV-2, was first reported from Wuhan, China. This highly contagious disease has become a pandemic. The hospitalized patients are being treated mainly for a typical viral pneumonia with supplemental oxygen therapy and mecha...
Article
Full-text available
Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of Alzheimer's disease (AD). Traditional accounts of indigenous plant Jatopha gossypyfolia suggest presence of important medicinal activities including improvement of...
Article
Full-text available
Purpose: To evaluate α-glucosidase and α-chymotrypsin enzyme inhibitory activity of Jatropha gossypifolia as a probable remedy for the management of diabetes and ulcer. Methods: Different extracts and fractions of the root, leaf and stem bark of the plant were screened for their α-glucosidase and α-chymotrypsin inhibitory activity using standard in...

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