Muhammad Yunus Amran- M.D., Ph.D. FIPM. FINR
- Clinical Associate Professor and Lecturer at Hasanuddin University
Muhammad Yunus Amran
- M.D., Ph.D. FIPM. FINR
- Clinical Associate Professor and Lecturer at Hasanuddin University
I am a NEUROLOGIST & NEURO-INTERVENTIONIST
About
62
Publications
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87
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Introduction
Skills and Expertise
Current institution
Additional affiliations
Position
- Lecturer
Description
- I am a NEUROLOGIST & NEURO-INTERVENTIONIST. I work as Lecturer and Clinical Associate Professor at Division of Interventional Neurology and Neuroendovascular Therapy, Department of Neurology, Medical Faculty of Hasanuddin University, Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, and Hasanuddin University Teaching Hospital, Makassar, South Sulawesi, Indonesia. Jl. Perintis Kemerdekaan KM 11, Makassar, 90245, Indonesia. Phone :+62-411-585560, 582837; +62-822-9303-1819; Fax:+62-411-5828
April 2010 - March 2014
Graduate School of Medical Sciences, Kyushu University
Position
- PhD Student
April 2009 - March 2010
Faculty of Medicine, Kyushu University
Position
- Reseach Student
Education
July 2002 - June 2004
August 1998 - June 2002
August 1995 - June 1998
SMAN 1 Makassar
Field of study
Publications
Publications (62)
Aspilet dan Clopidogrel merupakan antiplatelet yang dapat digunakan tunggal maupun kombinasi, beberapa penelitian telah dilakukan dengan membandingkan efektivitas keduanya menunjukkan tidak ada perbedaan yang signifikan. Di Indonesia, belum pernah dilakukan penelitian mengenai manfaat dan efek samping penggunaan Clopidogrel tunggal maupun kombinasi...
Indonesia menduduki terbanyak di Asia yang menderita stroke. Statin dengan efek pleiotropiknya dapat menjadi neuroprotektan sehingga dapat memperbaiki kondisi klinis dan mencegah terjadinya stroke berulang, Di rumah sakit ataupun di klinik ada pasien yang mendapatkan terapi atorvastatin dan ada pula yang tidak. Penelitian ini bertujuan menganalisis...
Background:
Nasopharyngeal Angiofibroma is a rare neoplasm in the sphenopalatine foramen. This tumour is histologically benign, but clinically malignant because it can erode the bone and surrounding structures, such as the pterygopalatine fossa, paranasal sinuses, and nasal cavity. It is a highly vascular tumour, sometimes from multiple Feeding ar...
Objectives
Cerebral venous sinus thrombosis (CVST) is a rare but serious condition characterized by thrombosis in the cerebral veins and dural sinuses. This study aimed to evaluate the diagnostic accuracy and practicality of imaging modalities, emphasizing computed tomography (CT) scans for emergency use due to their speed, accessibility, and cost-...
Pendahuluan: Distal Symmetric Polyneuropathy (DSPN) atau polineuropati distal simetris adalah subtipe neuropati diabetika yang paling sering ditemukan pada pasien Diabetes Mellitus (DM). Skrining awal penting untuk mencegah komplikasi. Michigan Neuropathy Screening Instrument (MNSI) dibuat pada 1994 sebagai alternatif alat skrining neuropati diabet...
Antiseizure medications (ASMs) are frequently utilized either as ongoing supplementary treatment or as the primary therapy for epilepsy. Different ASMs either inhibit of induce isoenzymes of CYP450 system, potentially altering the pharmacokinetic characteristics of various medications, including in polytherapy of ASMs. This study investigate the in...
Cerebral venous sinus thrombosis (CVST) is a rare but serious condition involving blood clots in the cerebral venous system often linked to prothrombotic states. It can result in complications such as intracranial hemorrhage and neurological deficits. We present the case of a 16-year-old female with CVST affecting the superior sagittal sinus, who e...
Background and aim: Intracranial atherosclerosis (ICAS) is a significant contributor to global stroke incidence and is associated with a substantially higher risk of stroke recurrence compared to other stroke types. The annual recurrence rate of ischemic stroke in ICAS ranges from 10% to 50%, with a two-year recurrence rate of 38.2% in the affected...
Background and aim: Acute ischemic stroke (AIS) causes neuronal damage and activates repair mechanisms, involving key biomarkers Vascular Endothelial Growth Factor (VEGF) and Brain-Derived Neurotrophic Factor (BDNF). VEGF facilitates angiogenesis and neuroprotection but may increase vascu-lar fragility, while BDNF supports synaptic plasticity and n...
Diabetic Painful Neuropathy (DPN) is caused by the progressive loss of nerve fibers due to hyperglycemia, oxidative stress, andhomocysteinemia. Mecobalamin supplementation has shown potential in improving peripheral neuropathy symptoms by enhancing nerve conduction and alleviating neuropathic pain. However, its efficacy data remains limited. This r...
Introduction: Shift work often leads to sleep disorders, affecting workers health and cognitive functions, including attention and heart rate variability (HRV). This study investigates the effect of binaural auditory beats with beta waves on HRV and attention among shift workers with sleep disorders. Objective: To determine the impact of binaural b...
Introduction: Subclavian steal syndrome (SSS) is a hemodynamic phenomenon that occurs when a total occlusion in the subclavian artery (SA) proximal to the vertebral artery (VA) causes retrograde flow in the ipsilateral VA. Subclavian steal syndrome with total occlusion of bilateral SA is a very rare case. Case Report: A 60-year-old woman reported e...
Introduction
Spinal subdural hematoma (SSH) is a rare entity. Clinical symptoms include motor, sensory and/or autonomic dysfunction due to compression of the spinal cord. There is no standard consensus in the management of SSH. Here, we report a rare case of SSH of sudden onset following trauma, successfully treated with conservative therapy.
Aim...
Background: Stroke is the main cause of death and disability worldwide. Intracerebral hemorrhage (ICH) is a subtype that contributes to 10 to 20% of all stroke events. Meanwhile, several studies in Indonesia show that the rates of vitamin D deficiency and insufficiency are still high, at 60.6% and 33.3% respectively in young adults. Several studies...
Abstrak Stroke merupakan masalah kesehatan global di dunia karena merupakan penyebab utama kecacatan pada orang dewasa. Stroke adalah penyakit atau ganguan fungsional otak berupa kelumpuhan saraf yang diakibatkan oleh gangguan aliran darah pada salah satu bagian otak. Stroke secara global menduduki peringkat ketiga angka kematian setelah penyakit j...
Vertebral artery dissection is one of the causes of stroke and transient ischemic attack in young adults, with an incidence rate of 1.0–1.1 per 100,000 people. Vertebral artery dissection occurs due to a tear in the vertebral artery wall, which results in blood flow entering the blood vessel wall. The etiology of vertebral artery dissection is very...
Objective: This study aims to analyze the influence and effectiveness of
Repetitive Peripheral Magnetic Stimulation (rPMS) intervention on
reducing the pain scale and improving the quality of life in patients with
lower back pain (LBP) due to herniated nucleus pulposus (HNP).
Material and Method: This is experimental research with a pre-test
and po...
Syok neurogenik disebut juga syok spinal yang merupakan bentuk dari syok distributif, syok neurogenik terjadi akibat kegagalan pusat vasomotor karena hilangnya tonus pembuluh darah secara mendadak di seluruh tubuh, sehingga terjadi hipotensi dan penimbunan darah pada pembuluh tampung (capacitance vessels). Hasil dari perubahan resistensi pembuluh d...
The prevalence of adolescents who spend >5 hours per day playing games has a higher risk of developing sleep disorders. Gaming addiction can cause sleep deprivation and the inability to concentrate, which can lead to attention disorders and impulsive behavior. This study is an analytical observational study with a cross-sectional design that aims t...
Introduction Stroke is an acute disorder of cerebral perfusion or vascularization. Stroke patients commonly encounter numerous functional disorders, such as motor, psychological or behavioral disorders, where the most typical symptom is hemiparesis which greatly affects their ability to carry out daily life activities. Repetitive Transcranial Magne...
Introduction: A stroke is defined by the American Heart Association (AHA) and the American Stroke Association (ASA) as the sudden onset of neurological deficits lasting over 24 hours or resulting in death, without an apparent cause other than of vascular origin and one of the leading causes of death in developed countries. Acute stroke is diagnosed...
Pain is a health problem phenomenon that most often brings patients to see a doctor. Pain intensity is the most often domain which assessed in clinical and research settings. Loeser suggests that four elements need to be considered when evaluating patients with pain. Based on the biopsychosocial approach and the concept of pain from Loeser, a pain...
Pendahuluan: Perdarahan batang otak jarang terjadi pada kasus stroke hemoragik, sekitar 5-10% dari total perdarahan intraserebral. Perdarahan tersebut berkaitan erat dengan angka mortalitas yang sangat tinggi mencapai 90%, sehingga diperlukan perawatan neuro-intensif dalam penatalaksanaannya.
Laporan Kasus: Perempuan berusia 51 tahun dengan riwaya...
LATAR BELAKANG : Selama masa pandemi, pemerintah menetapkan Pembatasan Sosial Berskala Besar (PSBB) untuk menurunkan kasus infeksi COVID-19 sehingga intensitas kejadian LBP lebih meningkat daripada sebelum karantina yang mencerminkan efek negatif dari peraturan tersebut. Hal tersebut disebabkan karena adanya perubahan gaya hidup yang signifikan sep...
Pendahuluan: Pandemi Coronavirus Disease 2019 (COVID-19) memberikan dampak besar di dunia,
dengan mortalitas dan morbiditas yang tinggi. Salah satu gejala yang sering dikeluhkan pasien
COVID-19 adalah fatigue. Fatigue dapat menganggu aktivitas sehari-hari dan menurunkan kualitas
hidup, namun seringkali terabaikan. Belajar dari berbagai epidemi sebe...
BACKGROUND: Acute ischemic stroke (AIS) is the most common type of stroke. The endovascular treatment of AIS depends on stroke subtype, whether caused by large vessel occlusion (LVO) or not. We presented a case of AIS due to LVO that has complication in the form of symptomatic intracerebral hemorrhage (sICH) after an intra-arterial mechanical throm...
ENDOVASCULAR TREATMENT CAVERNOUS CAROTID ANEURYSM WITH PIPELINE FLEX EMBOLIZATION DEVICE: 1-YEAR FOLLOW UPABSTRACTAsymptomatic intracranial aneurysms are usually detected accidentally through neuroimaging. However, a large intracranial aneurysm (15-24mm) is more likely to manifest clinically due to its mass effect. Aneurysms in the cavernous segmen...
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is widely used in various neurological cases. rTMS is an effective method of restoration in patients with disability due to central nervous system disorder. AIM: This study aimed to determine the effect of high and low frequency of rTMS on serum brain-derived neurotropic factor (BDNF)...
Diseksi Arteri Vertebral Karotis (CVAD) merupakan salah satu penyebab stroke iskemik yang jarang dan tidak lazim. Prevalensinya sekitar 2,5% dari populasi dunia dan paling sering dialami pada usia muda sekitar empat hingga lima dekade kehidupan. Stroke dan transient ischemic attack (TIA) adalah konsekuensi yang paling ditakuti dari CVAD ini. Diseks...
Shiga toxin-producing Escherichia coli (STEC) causes hemorrhagic colitis, hemolytic uremic syndrome, and acute encephalopathies that may lead to sudden death or severe neurologic sequelae. Current treatments, including immunoglobulin G (IgG) immunoadsorption, plasma exchange, steroid pulse therapy, and the monoclonal antibody eculizumab, have limit...
ABSTRAK Pendahuluan: Kebanyakan aneurisma intrakranial yang tidak bergejala terdeteksi secara tidak sengaja melalui pemeriksaan radiologis pencitraan. Akan tetapi aneurisma intrakranial yang besar (15-24 mm) cenderung memberikan gejala klinis akibat efek massa yang ditimbulkan. Utamanya bila letaknya di carotid cavernosa, dengan manifestasi berupa...
PENDAHULUAN Aneurisma intrakranial merupakan suatu kelainan pada pembuluh darah di otak akibat adanya kelemahan pada dindingnya yang menyebabkan outpouching dinding pembuluh darah tersebut, dimana formasi aneurisma intrakranial tersebut dapat diakibatkan oleh stres hemodinamik, disfungsi endothelial dan proses inflamasi. 1-2 Aneurisma pada ABSTRACT...
Introduction: Intracranial aneurysms treatment is the biggest challenge in neurointerventional field. Dissecting intracranial saccular aneurysm with a very wide neck at the anterior medullary segment or proximal site of posterior inferior cerebellar artery (PICA) with the distal branch of PICA at the aneurysm dome is a very uncommon site for intrac...
Leptospirosis is a worldwide zoonosis. The importance of urban leptospirosis is recognized in Japan because urban rats carry pathogenic leptospires, and people acquire these pathogens through contact with surface water or soil contaminated by the urine of the infected animals. To determine the current Leptospira carriage rate in urban rats, we trap...
Haemangioblastoma, a benign vascular tumor derived from the capillary of endothelial cells, is an inherited disorder due to an autosomal dominant trait. The prevalence rates accounted for 1% to 2.5% of all intracranial tumors and 2% to 3% of all intramedullary spinal cord tumors. We report the infrequent case of a robust allegation of von Hippel-Li...
Background
Previously, we established a mouse model of encephalopathy by oral infection with the Stx2c-producing E. coli O157: H- strain E32511/HSC (E32511), resulting in damage to the blood-brain barrier (BBB) (Infect. Immun. 62:3447-3453, 1994).
Materials and Method
ICR mice were given streptomycin (SM)-containing drinking water (5 g/L) ad libit...
A large outbreak of Shiga toxin (Stx)-producing enteroaggregative Escherichia coli (EAEC) O104:H4 occurred in northern Germany. From this outbreak, at least 900 patients developed hemolytic uremic syndrome (HUS), resulting in more than 50 deaths. Thirty percent of the HUS patients showed encephalopathy. We previously established a mouse model with...
Video of the mouse showing symptoms after infection with E32511 1×1011 CFU/0.5 mL. The symptoms developed from 3 to 5 days after E32511 infection. The symptoms of tremor, paralysis of hind extremities, and spinal deformity were observed in infected, but not uninfected mice.
(MP4)
Structural features of histological changes in the spinal cord of the E32511 model. Sections of the spinal cord from control (uninfected) mice (A, D, G), AZM-untreated mice (B, E, H) and AZM-treated mice (C, F, I) stained with H&E are shown. A–C with original 100× magnification; D–F with 400× magnification and G–I with 1000× magnification. Intact m...
Clinical dose of CPFX and OFLX in the E32511 model. 10 µg/g CPFX 10 and 15 µg/g OFLX 15 had a statistically significant effect on the mice survival; however, CPFX and OFLX treatments were not very effective, with 40% and 30% survival, respectively (CPFX vs. untreated, p<0.0001; OFLX vs. untreated, p = 0.013. Log Rank and χ2 test, *p<0.05, **p<0.001...
Sequence of probes used in
in situ
hybridization.
(PDF)
(A) Sagittal sections of the whole brain of control mice hybridized with anti-sense and sense Gb3 synthase probes. (B) Sagittal sections of the whole brain of E32511-infected and LPS administered intraperitoneally mice hybridized with anti-sense β-actin probe. Scale bars: 3 mm.
(TIF)
Caspase-3 activation in mouse brain injected with Stx2. Whole brain of i.p. Stx2-injected mice. Scale bars: 3 mm. (A) Caspase-3 activation was detected in the neurons of the reticular formation of the medulla oblongata. Scale bars: 200 mm. (B) Caspase-3 activation was detected in the neurons of the anterior horn of the spinal cord. (C) The orientat...
Structural features of histological changes in the medulla oblongata of the E32511 model. Sections of brain stems (medulla oblongata) from control (uninfected) mice (A, D, G), AZM-untreated mice (B, E, H) and AZM-treated mice (C, F, I) stained with H&E are shown. A–C with original 100× magnification; D–F with 400× magnification; and G–I with 1000×...
The orientation of 3D images of the mouse spinal cord is shown in the boxed part of A in Figure S2C. Apoptotic motor neurons are indicated in the anterior horn of the spinal cord of mice infected with EHEC O 157 :H- Strain E32511 1×1011 CFU.
(MP4)
Introduction & Objectives: We developed a fatal neurological mouse model by infecting with a high dose (10^10 CFU/mouse) of Shiga toxin 2c (Stx2c)-producing E. coli O157:H- strain E32511/HSC (Streptomycin and Mitomycin resistant/SM^r MMC^r) in 1994 (Infect Immun 62:3447 3453). Furthermore, we reported that fosfomycin and kanamycin were not effectiv...
Introduction & Objectives We developed a fatal neurological mouse model by infecting with a high dose (1010 CFU/mouse) of Shiga toxin 2c (Stx2c)-producing E. coli O157:H- strain E32511/HSC (Streptomycin and Mitomycin resistant/ SMr MMCr) in 1994 (Infect Immun 62:3447 3453). Furthermore, we reported that fosfomycin and kanamycin were not effective i...
In 1994, we established a mouse model that induced central nervous system disorder by oral infection of Stx2c-producing E. coli. The mouse model was associated with damage of capillary endothelial cells. In this report, we detected glycosphingolipid globotriaosyl ceramide (Gb3) using in situ hybridization (IHD) with Gb3 synthase mRNA expression. Ba...
We developed a mouse model showing neurological manifestations and fatal acute encephalopathy in 1994 (Infect. Immun. 62:3447-3453). The mouse was infected with 1010 CFU/mouse of Shiga toxin 2c-producing E. coli (STEC) O157:H- (E32511/HSC) and simultaneously intraperitoneally injected with Mitomycin C (MMC). Furthermore, we reported that fosfomycin...
Background. We developed a fatal neurological mouse model by infecting it with a high dose (1010 CFU/mouse) of Shiga toxin 2c (Stx2c)-producing E. coli (E32511/HSC) in 1994 (Infect Immun 62:3447 3453). Furthermore, we reported that fosfomycin and kanamycin were not effective in preventing fatality in this animal model (FEMS Immunol Med Microbiol. 2...
