Muhammad Shoaib Akhtar

Muhammad Shoaib Akhtar
University of Sargodha | UOS · Department of Pharmacology

PhD (Munich-Germany)

About

121
Publications
68,668
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4,001
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Additional affiliations
August 2008 - September 2016
University of Sargodha
Position
  • Professor of Pharmacology
Description
  • Teaching and guiding research of M Phil and PhD Pharmacology students
August 2008 - present
University of Agriculture Faisalabad
Position
  • Starting from Lecturer(1967) to Professor meritorious(2002)
Description
  • Postgraduate Teaching and Research

Publications

Publications (121)
Article
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Peptic ulcer is a common disorder of the gastrointestinal system affecting people of all ages worldwide. Ethanol is one of the most common causative agents for peptic ulcer. The aim of this study was to evaluate the protective effect of two newly synthesized indole imines (389 and 393) against ethanol-induced gastric ulcer in rats. Animals were ora...
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The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. The research work was planned to study the therapeutic potential of some newly synthesized chalcones against 4-acetaminophenol induced hepatotoxicity in rats. Male albino rats (N = 30) were divided into 6 groups of 5 animals e...
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Abstract : Lactucaserriola(L. serriola), commonly known asprickly lettuce, is an annual and biennial herb. The plant is traditionally used as sedative, hypnotic, cough suppressant, expectorant, purgative, diuretic, vasorelaxant, demulcent, antiseptic and antispasmodic. Aim of present study was to evaluate protective effect of L. serriola in paracet...
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Polyherbal formulation (POL-4) is popularly used by traditional practitioners to treat diabetes in district Badin, Sindh, Pakistan. This study validates the folk claim of POL-4 in diabetes and associated dysfunctions (hyperlipidaemia, endothelial dysfunction, hypertension) using OGTT and alloxan-challenged diabetic assays. Administration of POL-4 e...
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Ziziphus oxyphylla Edgew (Z. oxyphylla) is a small shrub to a medium sized tree. The aim of the present study was to evaluate the hepatoprotective activity of Z. oxyphylla in paracetamol-induced hepatotoxic rat model. Silymarin was used as a standard drug. Methanol extract was found to be the most potent in in-vitro antioxidant studies. The methano...
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Background Delay in seeking health care by breast cancer patients is associated with advanced stage of disease at presentation and poor survival rates. This study aimed to identify the reasons for delayed presentation and their association with various sociodemographic variables. Methods A total of 200 female patients with abnormal clinical findin...
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Objective: We aimed to study the anti-inflammatory and analgesic effects for two polyherbal tablets in animal model. Methods: Suspensions of Qurs-Saffron and Quknar polyherbal formulations (p.o.) were evaluated for their anti-inflammatory (in carrageenan-induced paw edema) and analgesic activities (in formalin-induced paw licking test) in albino mi...
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The present study describes the synthesis and characterization of a series of novel Schiff bases derived from 2,4-dihydroxybenzaldehyde. The biological activities of the newly synthesized compounds were examined by investigating their antioxidant, antibacterial, antifungal, enzyme inhibition and DNA interaction potential. The potential of these com...
Article
p>The current study was planned to evaluate comparative anti-inflammatory, analgesic and anti-pyretic activities of two newly synthesized organo-antimony (v) ferrocenyl benzoate derivatives with piroxicam. Anti-microbial activity of these compounds was also screened against two microorganisms. Analgesic effect of test compounds was evaluated by for...
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The presently available therapies for type 2 diabetes have not been able to achieve normoglycemic status in a majority of the patients which may be either due to the limitations of the drug itself or its side effects. In an effort to develop potent and safe oral antidiabetic agents, 4-ethyloxychalcone, which was found to be the most potent antiglyc...
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The present investigation was carried out to evaluate the effect of aerial parts of Sonchus asper L. in normotensive, glucose and egg feed diet induced hypertensive rats. Aqueous-methanolic extract of Sonchus asper in 250, 500 and 1000 mg/kg doses was studied in normotensive and glucose induced hypertensive rats using the non-invasive technique. Th...
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Objective: Even though the rhizome of Rheum emodi (Chinese rhubarb) has been used since centuries as a traditional medicinal plant in treating a number of disease conditions, the bioactive components responsible for its hepatoprotective activity have not been identified. Therefore, we isolated, identified, and evaluated in vivo the compounds in chl...
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Introduction: Numerous herbal medicines have been recommended for the treatment of different diseases. Achyranthes aspera, Linn. (Family: Amaranthaceae), popularly known as Charchitta or Pitpapra, is commonly used by traditional healers for the treatment of fever, malaria, dysentery, asthma, arterial hypertension, pneumonia, and diabetes. The root...
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The present study was carried out to evaluate the seeds of Pennisetum glaucum for its blood pressure lowering effect in rats. Aqueous-methanolic extract of P. glaucum seeds in 250, 500 and 1000 mg/kg doses was studied in normotensive, egg-feed diet and glucose-induced hypertensive rats using non-invasive technique. The extract significantly (p <0.5...
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In present study hypoglycaemic effects of the crude powdered C. decussata and its methanolic extract (ME) in alloxan diabetic rabbits were evaluated. The hypoglycaemic effect was measured by blood glucose, insulin level, HbA1c and his to pathology of pancreas. Glucose lowering effect of the ME was studied in diabetic rabbits. The effects of extract...
Article
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Berberis orhob, otrvs Bien. ex Aitch. (B.o.) has been reported to have antihypertensive effect in different experimental models. The aim of present study was to evaluate the possible antihypertensive mechanism. Aqueous methanolic extract of B.o. roots and its various fractions namely (ethyl acetate, n-butanol or aqueous) in different concentrations...
Article
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Traditionally Thymus linearis Benth. have been used for treatment of various diseases including hypertension. The present study was conducted to evaluate the hypotensive and antihypertensive effect of aqueous methanolic extract of aerial parts of Thymus linearis Benth. in normotensive and hypertensive rats. Acute and subchronic studies were also co...
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A series of schiff base derivatives of 4-aminophenazone (4APZ-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) with different aldehydes were synthesized. The synthetic compounds were screened for their anti-inflammatory, analgesic and antipyretic activities. The characterization of synthesized compounds was carried out by 1H NMR, 13C NMR and MS....
Article
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Liver is a vital organ play major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem. The present study was carried out to evaluate the hepatoprotective role of whole plant extracts of Canscora decussata. Hepatoprotective activities of aqueous and methanolic extracts of C. decu...
Article
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The cardiac activity of Saussurea lappa roots was evaluated in isolated perfused rabbit heart by the Langendorff's technique. Heart rate, contractility and coronary flow were determined in the presence of different concentrations of methanolic extract of Saussurea lappa, digoxin and diltiazem. The extract exhibited significant (p<0.01) positive ino...
Article
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Purpose: To investigate the analgesic and anti-inflammatory activities of two herbal polymedicines - Aujaie and Surangeen to ascertain their therapeutic claims. Methods: A total of 96 rats were divided into two equal groups; one for determination of anti-inflammatory activity and the other for analgesic activity. Anti-inflammatory and analgesic act...
Article
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Purpose: To investigate the hypotensive potential of Berberis orthobotrys Bien Ex Aitch (Family: Berberidaceae) in both normotensive and hypertensive rats. Methods: Aqueous-methanol (70:30) extract of Berberis orthobotrys at doses of 25, 50, 75 and 100 mg/kg was evaluated for its effect on blood pressure and heart rate using non-invasive blood pres...
Article
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The current study was designed to evaluate the hypolipidemic and renoprotective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 an...
Article
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Aquilaria agallocha Roxb. (Thymelaeceae) heartwood is used in cardiac failure; however, its cardiotonic properties are poorly understood at a pharmacological level. This study investigated methanol extract of A. agallocha for presence of glycosides and its effects on force of contraction, heart rate and coronary flow on rabbit isolated heart. Furth...
Article
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Despite widespread use of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA) in the traditional medicine, there was a lack of scientific evidence on its efficacy and safety. The present investigation was designed to evaluate its ex vivo antioxidant and in vivo hepatoprotective properties against carbon tetrachloride toxicity in albino rats. At fir...
Article
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Unani system of medicine (Unanipathy) originated in Greece, enriched by Persians and Arabs and now became an integral part of Alternative medicinal systems of Pakistan and India. Habbe Sara (HS) is a Unani medicine prescribed for liver damage and febrile convulsions. The drug was tested for antioxidant activity, as there is growing evidence of role...
Article
Background In spite of all recent advancements, the complete cure of gastric ulcer disease has awaited, to be explored. Earlier we reported the potent anti-secretary and anti-ulcer activities of ethanol extract and a fraction of Nigella sativa, seed (NS) in indomethacin-induced gastric ulcers-models. Therefore, anti-ulcer activity of purified fract...
Article
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Methanolic extracts of 6 commercially available citrus spp. peels and tissues growing in Pakistan were investigated for their antioxidant activity by DPPH method. IC 50 for antioxidant activity ranged from 0.8-4.7 mg/ml. Total phenolic content of the citrus spp. samples (based on folin Ciocalteu method) varied from 99.4 to 229.5 mg gallic acid equi...
Article
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The study was conducted to assess the prescribing practices of GP in Islamabad. The purpose of this study is to measure the performance of health care providers related to appropriate use of drugs. These indicators basically base on clinical encounters taking place on at outpatient health facilities for the treatment of disease. For the purpose of...
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The present study was conducted to investigate the effect of the aqueous methanolic extract of Mentha longifolia, L on blood pressure of both normotensive and hypertensive (egg- feed and glucose- induced) rats. The effect of the extract on systolic, diastolic, mean blood pressures and heart rate were evaluated by using non-invasive blood pressure m...
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Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Insulin deficiency in turn leads to chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. It is the most common endocrine disorder and by the year 2010, it is estimated that more than 200 million peopl...
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The present study was designed to assess the effect of methanolic (M) extract of Canscora decussata on hematological parameters in alloxan-induced diabetic rabb-its for duration of one month. (M) extract significantly (P<0.001) increase RBCs, PCV, MCV, MCHC, Hb level, total leucocytes count (TLC), neutrophil and platelet count of the treated diabet...
Article
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Berberis lycium Royle is used in folk medicines for treating various ailments however it has not been investigated in cardiac problems at pharmacological level. Here, iono- and chronotropic effects of B. lycium root bark's aqueous extract and berberine were studied on frog-heart. Present data showed that aqueous extracts of B. lycium and berberine...
Article
Full-text available
Berberis lycium Royle is used in folk medicines for treating various ailments however it has not been investigated in cardiac problems at pharmacological level. Here, iono-and chronotropic effects of B. lycium root bark's aqueous extract and berberine were studied on frog-heart. Present data showed that aqueous extracts of B. lycium and berberine e...
Article
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Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. The rabbits (n = 70) were divided into seven grou...
Article
The dichloromethane and methanolic extracts of the plant Euphorbia granulata were investigated for their antifungal, antibacterial, phytotoxic, brine-shrimp cytotoxic, antioxidant, spasmolytic (antispasmodic) and acetylcholinestrase inhibitory activities. The dichloromethane extract showed strong inhibition against Microsporum canis (90%) and again...
Article
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Pure culture of wild type of Aspergillus niger was subjected to gamma rays mutagenesis at different dose rates (40 to 120 k.Rads). The mutant strains of Aspergillus niger were isolated and selected by random screening method. The selected mutant derived strains were compared with parent type of Aspergillus niger for enhanced production potential of...
Article
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Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. The rabbits (n = 70) were divided into seven grou...
Article
Medicinal plants have considerable widespread use as crude drugs in the primary health care of communities. Various plants have already been tested for their antimicrobial activity to discover new antimicrobial agents. In this investigation antimicrobial activities of aqueous and methanolic extracts of Heterophragma adenophyllum leaves and seeds we...
Article
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Numerous indigenous medicinal plants have been found to contain important active principles that make these plants helpful to treat diseases. The present study was conducted to evaluate hypoglycemic and weight stabilizing effects of a compound herbal formulation named Ziabeen in normal and alloxan-diabetic rabbits. Diabetes was induced by alloxan m...
Article
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The present study evaluated the anti-hyperglycemic and lipid-lowering properties of Emblica officinalis Gaertn. fruit in normal and diabetic human volunteers. The results indicated a significant decrease (P < 0.05) in fasting and 2-h post-prandial blood glucose levels on the 21st day in both normal and diabetic subjects receiving 1, 2 or 3 g E. off...
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The present study evaluated the effects of cooking on the total, soluble and insoluble oxalate contents in six different types of locally consumed vegetables and beans (spinach, carrots, beet root, white bean, red bean and soybean). The foods were cooked in water until they reached the soft consistency (12–15 min for vegetable and 2 h for beans). T...
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Prevalence of diabetes mellitus has increased all over the world particularly in the developing countries including Pakistan. A study was designed to determine the nutritive value and glycaemic responses of 5 different test and control meals including chapatti + eggs and three varieties of KFC burger (Zinger, Chicken, Sub 60) and local burgers....
Article
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A number of plants including Berberis aristata roots are considered effective as antidiabetic agents in ethnomedical practices. In this study effects of certain isolated fractions from root-bark of Berberis aristata on blood glucose levels were determined in normal and alloxan-diabetic rabbits. In normal rabbits, ethanolic fraction in 0.5, 1.0 and...
Article
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This study was carried out to assess the anthelmintic activity of Acacia nilotica bark and leave extracts in different solvents. Adult motility assay, egg hatch test and fecal egg count reduction test were carried out to evaluate the anthelmintic activity. Effect of plant extracts both of leaves and bark of A. nilotica was dose-dependent. Highest m...
Article
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Antidiabetic folkloric use of Dodonaea (D.) viscosa leaves was evaluated in normal and alloxan-diabetic rabbits. Blood glucose levels were determined after oral administration of 250 and 500 mg/kg of D. viscosa leaves and glibenclamide (5 mg/kg). These doses of the leaves significantly reduced blood glucose in normal and highly significantly in all...
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The aim of this study was to evaluate the effect of Butea monosperma (Lamk.)Taub on blood glucose and lipid profiles in normal and diabetic human volunteers. This study indicated a significant decrease (P < 0.05) in 2 h post-prandial blood glucose (mg/dl) on 21st day in the diabetic subgroups treated with 2 g (194.2 ± 27.01 vs. 172.2 ± 20.37) and 3...
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This study evaluated the chemical composition and glycemic index (GI) of eight different types of traditional Omani breads made from wheat flour. Significant (P < 0.05) differences were observed in the proximate chemical composition, dietary fibre content, and gross energy value of these breads. The moisture, crude protein, total fat, ash, crude fi...
Article
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SUMMARY Effects of oral administration of sea coconut (Lodoicea sechellarum Labill) on blood glucose and lipid profile were studied in normal and diabetic volunteers. Oral treatment with 2, 3 and 4 g of sea coconut and repaglinide (1 mg) decreased blood glucose significantly in normal and diabetic subjects. Furthermore, sea coconut decreased total...
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We evaluated the distribution of ABO and Rhesus (Rh) D blood groups in the population of Poonch district in Azad Jammu and Kashmir. The blood group phenotypes were detected by the classic slide method. The ABO blood group system in the total sample showed the same trend of prevalence as for the general Indian subcontinent (B > or = O > A > AB). The...
Article
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Hepatoprotective effects of Rheum emodi roots and their aqueous and methanolic extracts were studied against liver damage induced by paracetamol in albino rats. In addition, the effects of herbal preparation, Akseer-e- Jigar and a control drug, silymarin were also studied. Pretreatment and post-treatment hepatoprotective effects of all these drugs...
Article
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Pyrazinamide resistance emerged as a major cause of failure of anti-tubercular therapy. The risk of infection with resistant mycobacterium is increasing posing a threat to control and eradicate this disease. The main reasons of emergence of resistance included erratic drug ingestion, monotherapy, omission of one or more prescribed agents and subopt...
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Abstract Antiulcerogenic effects of extracts, volatile oils and flavonoid glycosides of Ocimum basilicum leaves were studied in normal as well as aspirin-, acetic acid- and stress-induced ulcerated rats. Also, their effects on outputs of gastric acid, pepsin and hexosamines were recorded in normal and ulcerated rats. The aqueous, methanol and water...
Article
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This paper describes comparative in vitro. and in vivo. anthelmintic activities of Vernonia anthelmintica. (L.) Willd. (Compositae) seeds and levamisole. In vitro. studies revealed higher anthelmintic effects (p ≥ 0.05) of crude methanol extract (CME) as compared with crude aqueous extract (CAE) of V. anthelmintica. seeds on live Haemonchus. contor...
Article
This paper describes in vitro and in vivo anthelmintic activities of Swertia chirata. In vitro studies revealed that at 25 mg/ml (P>/=0.05) the crude aqueous (CAE) and methanolic extracts (CME) of S. chirata whole plant showed an anthelmintic effect on live Haemonchus contortus. Moreover, in the in vivo study, the whole plant of S. chirata administ...
Article
This paper describes the anthelmintic activity of Zingiber officinale Roscoe (family Zingiberaceae) rhizome, commonly known as ginger, to justify its traditional use in veterinary medicine. Crude powder (CP) and crude aqueous extract (CAE) of dried ginger (1-3 g/kg) were administered to sheep naturally infected with mixed species of gastrointestina...
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In the present study, extracts from four folkloric medicinal plants, previously reported potential anti-ulcer; Anethum graveolens L. fruit, (AG), Cichorium intybus L. leaf, (CI), Plantago ovata L. seed husk (PO) and Polygonum viviparum , L. root, (PV), were screened for anti- Helicobacter pylori (HP) activity. Anti-HP activity of the powdered drugs...
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This study was carried out on some epidemiological aspects and vector role of ticks infesting layers in Faisalabad (Pakistan). The prevalence of tick infestation was found as 11% (88/800), 24% (192/800) and 12.7% (413/3250) on Indigenous, Babcock and White Leghorn varieties of layers, respectively. Two species of ticks namely Argas persicus (10%; 4...
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Although introduction of modern drugs to the classic anti-ulcer therapy has been revolutionized the treatment of peptic ulcer but the complete cure of the disease has yet to be discovered. In an effort to explore indigenous medicinal plants the powdered leaves of Cichorium intybus (CI) and its extracts i.e., aqueous, ethanol, were investigated for...