Muhammad Nouman Ahmed

Muhammad Nouman Ahmed
University of Helsinki | HY · Department of Food and Environmental Sciences

M. Sc.

About

4
Publications
508
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39
Citations
Introduction
Muhammad Nouman Ahmed currently works as PhD researcher at the Department of Microbiology, University of Helsinki. Muhammad does research in Microbiology, Bioinformatics, Biotechnology and Medicinal Chemistry. Now my PhD project revolves around the identification and characterization of selective inhibitors of human trypsin isoforms from cyanobacteria to prevent the metastasis.
Additional affiliations
December 2017 - present
University of Helsinki
Position
  • PhD Student
September 2015 - December 2016
University of Helsinki
Position
  • Assistant Researcher
Description
  • Working on my master's thesis.
Education
August 2014 - March 2017
University of Helsinki
Field of study
  • Biotechnology
August 2009 - November 2013
Forman Christian College
Field of study
  • Biotechnology

Publications

Publications (4)
Article
Full-text available
Low-molecular weight natural products display vast structural diversity and have played a key role in the development of novel therapeutics. Here we report the discovery of novel members of the aeruginosin family of natural products, which we named varlaxins. The chemical structures of varlaxins 1046A and 1022A were determined using a combination o...
Article
Full-text available
Serine proteases regulate many physiological processes and play a key role in a variety of cancers. Aeruginosins are a family of natural products produced by cyanobacteria that exhibit pronounced structural diversity and potent serine protease inhibition. Here, we sequenced the complete genome of Nodularia sphaerocarpa UHCC 0038 and identified the...
Article
Trypsin-3 is a highly active protease that has recently been identified as a potential therapeutic target for the reduction of tumor growth and metastasis in prostate, breast and pancreatic cancers. Current trypsin inhibitors typically inhibit a broad range of different trypsin-like enzymes. Thus, novel approaches to identify trypsin-3 selective in...
Article
Natural products and their semi-synthetic derivatives are an important source of drugs for the pharmaceutical industry. Bacteria are prolific producers of natural products and encode a vast diversity of natural product biosynthetic gene clusters. However, much of this diversity is inaccessible to natural product discovery. Here we use a combination...

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Projects

Project (1)
Project
To identify and characterize novel and potent trypsin inhibitors form cyanobacteria