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Introduction
Lawrence Mugisha is an Associate Professor, College of Veterinary Medicine, Animal Resources & Biosecurity (COVAB), Makerere University; Adjunct Professor, College of Veterinary Medicine (CVM), University of Minnesota and Mississippi State University. His a Team Leader for EcoHealth Research Group under Conservation & Ecosystem Health Alliance (CEHA). He has over 16 years of experience in zoonotic disease research at human, livestock and wildlife interface, Uganda (One Health Approach)
Mugisha Lawrence current research projects Include: 'Epidemiology of Leptospirosis in the Ugandan Albertine Rift: Unraveling a 'One Health' Malady.': Tick Microbiome and Pathogens in thier cattle host and Drivers of Antimicrobial Resistance (AMR) in humans, Livestock and Environment.
Additional affiliations
June 2007 - September 2012
Publications
Publications (33)
Diagnosing the causative agent of febrile illness in resource-limited countries is a challenge in part due to lack of adequate diagnostic infrastructure to confirm cause of infection. Most febrile illnesses (>60%) are non-malarial, with a significant proportion being zoonotic and likely from animal origins. To better characterize the pathways for z...
As the phylogenetic organization of mammalian polyomaviruses is complex and currently incompletely resolved, we aimed at a deeper insight into their evolution by identifying polyomaviruses in host orders and families that have either rarely or not been studied. Sixteen unknown and two known polyomaviruses were identified in animals that belong to 5...
STROBE checklist.
(DOC)
Alignment of the primary sequence of large T antigens and their functional motifs from novel NHP polyomaviruses. The LTag proteins of all novel NHP polyomaviruses (with complete genomes amplified and sequenced) were aligned with the LTAg of SV40. Functional motifs are highlighted with different colors. The color code is shown below the alignment.
(...
Bayesian chronogram deduced from the analysis of a 90 amino acid alignment of VP2 sequences. Polyomaviruses were identified in humans (red), apes (blue), other primates (green), and other mammals and birds (black). Novel polyomaviruses identified in this study are marked with a star. Viruses from which VP1 was used in serological assays are highlig...
Large T antigen-binding sites in NCCRs of novel NHP polyomaviruses. Sites are boxed.
(TIF)
Location of functional motifs in large T antigen. LTag is represented by an open bar.
(TIF)
Amino acid sequence identity between the host range domain of SV40 large T antigen and the C-terminal region of CeryPyV1 large T antigen. Identical amino acids are highlighted in yellow.
(TIF)
Bayesian chronogram deduced from the analysis of a 443 amino acid alignment of large T sequences. Polyomaviruses were identified in humans (red), apes (blue), other primates (green), and other mammals and birds (black). Novel polyomaviruses identified in this study are marked with a star. Viruses from which VP1 was used in serological assays are hi...
Age-stratified reactivity of human sera to VP1 proteins of chimpanzees and human polyomaviruses. Antibody reactivity against 2 human polyomaviruses (HPyV9 and JCPyV) and 4 chimpanzee polyomaviruses (ChPyV, PtrovPyV3, PtrovPyV4 and PtrosPyV2) of sera from German (n = 111) and of plasma samples from Ivorian subjects (n = 115). Samples were analysed f...
Sequence homology between NCCRs. The NCCRs of (a) MfasPyV1 and PtrovPyV5 and (b) PtrosPyV2 and PtrovPyV5 were aligned. Identical nucleic acids are marked by vertical lines, gaps by hyphens.
(TIF)
Multiple seroreactivities against chimpanzee polyomaviruses in humans. German sera (A) and Ivorian plasma samples (B) were tested for seroreactivity against ChPyV, PtrovPyV3, PtrovPyV4 and PtrovPyV10. The graph displays percentages of single and multiple reactivities.
(TIF)
Primers used for amplification of nonhuman primate polyomaviruses.
(DOC)
Genomes and encoded proteins of the novel nonhuman primate polyomaviruses.
(DOC)
Motifs in large T antigens of novel NHP polyomaviruse.
(DOCX)
Putative functional motifs in the large T-antigens of the novel NHP polyomaviruses.
(DOCX)
Correlation of seroreactivities against VP1 antigens of polyomaviruses.
(DOC)
Primate species and tissues tested with generic polyomavirus PCR.
(DOC)
LT-ag binding motifs in NCCR of novel NHP polyomaviruses.
(DOCX)
H. pylori sequences used in Mantel regressions.
(XLS)
Mitochondrial DNA haplotypes, number of H. pylori cultures and unique H. pylori haplotypes per individual.
(XLS)
Primers designed from a whole genome alignment and used to amplify and sequence the 7 homologous housekeeping gene (MLST) fragments in Helicobacter cetorum.
(XLS)
Source of human mitochondrial DNA sequences used in Mantel regressions.
(XLS)
Treefinder script to generate confidence limits from the spread of posterior IMa
t values.
(TXT)
Maximum Likelihood consensus tree based on the concatenated sequences of all 15 regions, with bootstrap values for 2000 replicates.
(TIF)
Minor allele frequency distribution for eastern chimpanzees before (a) and after (b) reamplification with a new set of primers.
(TIF)
Simulated values of various summary statistics under the standard neutral model matched for S and the number of chromosomes. Also listed is the observed value for each summary statistic.
(DOC)
For each region, the number of sites for which (1) chimpanzees are polymorphic and bonobos are fixed for the derived state; (2) bonobos are polymorphic and chimpanzees are fixed for the derived state; (3) both bonobos and chimpanzees are polymorphic; (4) chimpanzees are fixed for the derived state and bonobos are fixed for the ancestral state; and...
Location of the selected regions in the human genome.
(DOC)
Origin of the blood samples that yielded Plasmodium sequences (name in bold and GenBank Accession number in parentheses).
(0.09 MB PDF)
Phylogenetic tree of Plasmodium based on a cytochrome b fragment. NJ tree on 520 bp of cytochrome b using Tamura 3 parameter model, 1000 bootstrap pseudo-replications. Haplotypes represented in bold are as follows: Plasmodium species that infect humans (black), the haplotypes we present in the manuscript (blue), the haplotype proposed as P. gaboni...
