Mudhir Sabir Shekha

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Mudhir verified their affiliation via an institutional email.

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• PhD in Physiology
• Researcher at Uppsala University

Crataegus azarolous var. aronia (C. aronia) is one of the most important medicinal plants used widely in folk medicine for its cardiotonic, vasorelaxant and hypotensive effect. The present study was done to investigate the effect of the Chlorformic fraction (CF) of C. aronia on ileum, jejunum, trachea and aortic smooth muscle. CF induced a concentr...

The aim of the present study was to investigate the vasoactive effects of aqueous extract (AE) of Cartaegus azarolous (Var. aronia) and quercetin with a special emphases on their mechanisms of action on rat thoracic aorta. Muscle contraction and relaxation was recorder using PwerLab Data Acquisition System ( ADI, Model ML 870 ) connected to a compu...

Crataegus azarolous var. aronia is one of the most important medicinal plants used widely in folk medicine for its cardiotonic, vasorelaxant and hypotensive effect. Hawthorn belongs to amember of the Rosaceae family, which contains many flavonoid and procyanidine as the majorcomponents for treating various cardiovascular conditions. An extract prep...

The cerebral cortex contains huge numbers of neurons. Activity of these neurons is to some extent synchronized in regular firing rhythms ('brain waves'). Many researchers have investigated the effect of various events to the EEG signals such as meditation and classical music. EEG signals from subjects at rest, as well as in different cognitive stat...

The aim of the present study was to investigate the relaxant effects of rutin on rat thoracic aorta, ileum and trachea. Rutin (1X10-7 - 6X10-3 M) caused a concentration-dependent relaxation of aortic rings precontracted with phenylephrine (PE 10-6M) while produced non-significant relaxed effect on KCl induced contraction with Log IC50’s -3.025 and...

Background Unraveling myeloperoxidase’s (MPO) correlation with coronary artery disease (CAD) and genetic variations, this study seeks to enhance diagnostic precision and therapeutic strategies. Results CAD patients were found to be older and more male than controls. Several clinical parameters, including glucose, total bilirubin, alkaline phosphat...

Background: Coronary artery disease is caused by plaque buildup in the arteries' walls that deliver blood to the heart. The study examined the correlation between the IL-6 gene promoter 174G>C polymorphism, blood IL-6 levels, and specific physiological parameters in Kurdish people from Iraq with stable coronary artery disease (CAD). Methods: The in...

The research explored the link between Brain Natriuretic Peptides (BNP) gene promoter T-381C polymorphism, serum BNP, and lipid profiles in Kurdish people from Iraq with stable coronary artery disease (CAD). The study was conducted on 62 individuals with CAD and 31 without CAD (control group). DNA was extracted from each individual's sample using t...

The research explored the link between Brain Natriuretic Peptides (BNP) gene promoter T-381C polymorphism, serum BNP, and lipid profiles in Kurdish people from Iraq with stable coronary artery disease (CAD). The study was conducted on 62 individuals with CAD and 31 without CAD (control group). DNA was extracted from each individual's sample using t...

Objective Coronary artery disease (CAD) is a complex disorder influenced by genetic and environmental factors. This case-control study investigated the association between Sirtuin SIRT3 gene polymorphisms, serum malondialdehyde (MDA) levels, and CAD susceptibility. Methods Blood samples were collected from 70 CAD cases and 30 controls at the Cardi...

Aim: To elucidate how proinsulin synthesis and insulin was affected by metformin under conditions of nutrient overstimulation. Materials and methods: Isolated human pancreatic islets from seven donors were cultured at 5.5 mmol/L glucose and 0.5 mmol/L palmitate for 12, 24 or 72 h. Metformin (25 μmol/L) was introduced after initial 12 h with palm...

Purpose: The study aimed to examine if the polymorphism of the endothelial nitric oxide synthase (eNOS) gene variable number of tandem repeats (VNTR) and the serum NO levels are associated with CAD. Materials/methods: Case-control study, 70 CAD and 30 control subjects were enrolled. The eNOS gene polymorphism was measured by polymerase chain rea...

Introduction: There are limited published data regarding the recent incidence trends of cancer in Iraqi Kurdistan. Methods: The present study assessed the epidemiological estimates of cancer incidence, as well providing a projection of future cancer trends in the upcoming decade by analysing the population-based cancer registry between 2013 and 20...

BACKGROUND: Thalassemia syndromes and structural hemoglobin variants generate blood crisis of variable clinical symptoms, ranging from mild-to-moderate hematological disorder to severe, lifelong, transfusion-dependent anemia. The aim of current study was to uncover the prevalence of thalassemia and other hemoglobinopathies in the Erbil governorate,...

Introduction: The present study aimed to determine the alterations in the serum levels of tumor markers used to evaluate cardiac, renal and liver function, and detect the interleukin (IL)-18 rs1946518 polymorphism in breast (BC), colorectal (CRC) and prostate cancer (PCa) patients. Methods: Blood samples were collected from 65 female BC, 116 CRC...

There is limited published data on recent cancer incidence trends in Iraqi Kurdistan. Therefore, this study assesses epidemiological estimates of cancer incidence as well as the projection of future cancer trends in the upcoming decade by analysing the population-based cancer registry from 2013 to 2019 in both Erbil and Duhok governorates. A retros...

Chronic myeloid leukemia (CML) result from many reactions of heredity non-heredity factors. The null genotype for glutathione S-transferase (GSTM1 or GSTT1) is regarded a risk agent leukemia, especially on CML in various inhabitants. The current study focused on evaluating association of two polymorphic identified genes Glutathione S-Transferase Mu...

Exogenous administration of hydrogen sulfide (H2S) is emerging as an alternative anticancer treatment. H2S-releasing compounds have been shown to exert a strong anticancer effect by suppressing proliferation and/or inducing apoptosis in several cancer cell types, including colorectal carcinoma (CRC). The mechanism whereby exogenous H2S affects CRC...

Development of optical nanobiosensors is one of the important priorities especially in the field of biomedical diagnostics science and technology. The application of nanobiosensors has been accelerated with the introduction of plasmonic NPs, which overcome the most of the limitations in the case of conventional optical nanobiosensors. Since the pla...

The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical propert...

The utilization of AuNPs in therapeutic applications has been accelerated by discovering their catalytic activity consistent with the activity of natural enzymes. However, to reduce unwanted activities, it is imperative to fully understand their catalytic mechanisms to increase efficiency and safety. Therefore, along with other reports, we aimed to...

AuNPs with enzyme-like features have received strong attention in different areas, although limited data is available in literature on their biological/industrial functions. NPs especially Au counterparts have been shown to functionally mimic the activity of antioxidant enzyme. Indeed, due to low cytotoxicity and SPR characteristics of AuNPs, there...

Multiple sclerosis (MS) is a type of autoimmune disease where immune cell attacks our cells mistakenly; its severity is measured by expanded disease status scale (EDSS). The study aims the investigation of −1082 polymorphism in interleukin 10 (IL-10) as one of the etiologies that develops the disease. This is a case-control study that allele-specif...

In this study, we formulated silymarin-HSA nanoplex and assayed its ability to reduce LPS-induced toxicity in vitro and in vivo. Silymarin molecules were encapsulated into HSA nanoplex and the loading efficiency and characterization of fabricated nanoplex were performed by using HPLC, TEM, SEM, DLS, FTIR analysis, and theoretical studies. Afterward...

Herein, the interaction of CeO2 NPs with HSA was explored by fluorescence, CD, UV–vis and molecular docking studies. Afterwards, the antioxidant activity of CeO2 NPs against H2O2-induced oxidative stress in BM-MSCs were explored by MTT, ROS and apoptosis assays. Antibacterial assay was also done on two Gram-positive and Gram-negative bacterial stra...

Nickel oxide nanoparticles (NiO NPs) have received great interests in medical and biotechnological applications. However, their adverse impacts against biological systems have not been well-explored. Herein, the influence of NiO NPs on structural changes, heme degradation and aggregation of hemoglobin (Hb) was evaluated by UV-visible (Vis), circula...

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular endothelial growth factor, basic fibroblast growth factor, stromal derived factor-1α and angiopoietins. Recently, it was shown that intracellular Ca2+ signaling also drives vascu...

The method was developed to detect crystals (calcium oxalate) in plant and animal tissues and stain the bacteria by using silver nitrate solution2%. By adding the prepared solution to the bacterial fixed on the slide and leaving it for 10 minutes at room temperature, then expose the slide to ultraviolet light for 30 minutes. Also expose the slide o...

Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca 2+ release. NAADP-induced EL Ca 2+ signals may be amplified by the endoplasmic reticulum (ER) through the Ca 2+-induced Ca 2+ release mechanism (CICR). Herein, we aimed at assessing for the first time the role of EL...

The acidic vesicles of the endolysosomal (EL) system are emerging as an intracellular Ca2+ store implicated in the regulation of multiple cellular functions. The EL Ca2+ store releases Ca2+ through a variety of Ca2+-permeable channels, including Transient Receptor Potential (TRP) Mucolipin 1-3 (TRPML1-3) and two-pore channels 1-2 (TPC1-2), whereas...

This study was designed to determine effects of exercise training (Moderate and severe) and alpha tocopherol on lipid profiles and organ weights in hypercholesterolemic domestic rabbits. Hypercholesterolemia (HC) and atherosclerotic lesions were induced by feeding the male rabbits the standard chow supplemented with 1% cholesterol (atherogenic diet...

The aim of this study was to evaluate the effects of nitric oxide in barium chloride (BaCl2)-induced arrhythmia in male albino rats. 10mg/kg/hr of BaCl2 was infused intravenously through caudal vein to induce arrhythmia, to ameliorate this effect 1mg and 10mg/kg/hr of sodium nitroprusside (SNP; nitric oxide donor) were infused, respectively. The EC...

The impact of magnesium (Mg) on vascular tone is mainly due to its calcium antagonist activity resulting in smooth muscle relaxation. The present study was designed to determine the roles of nitric oxide and calcium ions in magnesium -induced vasorelaxation in rats aortic rings. In this study, the aorta contracted with NE (3x10-6M), pre-incubated w...

A peptic ulcer is one of the more severe diseases and most classic treatment protocol produce adverse drug reactions. Therefore, this study aimed to examine the therapeutic effects of two natural extracts, namely Pomegranate and Ginger, on indomethacininduced gastric ulcer in rats. Animals were divided into five groups; 1. Normal control group, 2....

A peptic ulcer is one of the more severe diseases and most classic treatment protocol produce adverse drug reactions. Therefore, this study aimed to examine the therapeutic effects of two natural extracts, namely Pomegranate and Ginger, on indomethacin-induced gastric ulcer in rats. Animals were divided into five groups; 1. Normal control group, 2....

The impact of Magnesium on vascular tone is mainly due to its calcium antagonist activity resulting in smooth muscle relaxation. The present study was designed to determine the roles of nitric oxide and calcium ions in magnesium -induced vasorelaxation in rats aortic rings through these enzyme pathways. In this study, the aorta contracted with NE (...

The aim of this study was to evaluate the effects of nitric oxide in barium chloride (BaCl 2)-induced arrhythmia in male albino rats. 10mg/kg/hr of BaCl 2 was infused intravenously through caudal vein to induce arrhythmia, to ameliorate this effect 1mg and 10mg/kg/hr of sodium nitroprusside (SNP; nitric oxide donor) were infused, respectively. The...

A B S T R A C T: Paracetamol as analgesic drugs makes hepatotoxicity and kidney damage in overdose situations. The present study investigates the protective effects of L-arginine and vitamin c against paracetamol toxicity. Thirty male rats with age of eight weeks divided into five groups: Control group with normal diet, Model animals received 500 m...

Since the mechanism of salt impairing NO-induced vascular relaxation is not fully clear, this study was designed to investigate the role of potassium (K+) channels in the vasodilatory effects of NO donor in salt loaded rats. Isolated thoracic aortic rings of adult male albino rats fed 8% NaCl containing diet for six weeks were used for isometric te...

This Paper is Under Evaluation In JJBS

Published in Journal University of Zakho, Vol. 3(A) , No.2, Pp 164-170, 2015 ISSN: 2410-7549

The vasodilator response of nitric oxide (NO), hydrogen sulfide (H 2 S) and sulfur dioxide (SO 2) were studied to determine the significance of the actions and interactions of these gasotransmitters for controlling aortic tone in rats. The isometric tension of five separate sets of experiments was recorded. Sodium nitroprusside (SNP; NO donor), sod...

Vascular endothelium plays a key role in the local regulation of vascular tone and vascular architecture. However, it is unclear whether the combination of NKCC cotransporter with endothelial mediated factor and potassium channel in rat aortic ring contributes in regulation of the vascular activity. In the current study, the potential role of endot...

Renal calculi formation is one of the most common urological disorders. Urinary stone disease is a common disease, which affects 10‑12% of the population in industrialized countries. The objective of this study was to investigate the antiurolithiatic and antioxidant activity of fenugreek on ethylene glycol-induced urolithiasis in rats. Twenty male...

Renal calculi formation is one of the most common urological disorders. Urinary stone disease is a common disease which affects 10-12% of the population in industrialized countries. The objective of the present study is to investigate the antiurolithiatic and antioxidant activity of fenugreek on ethylene glycol-induced urolithiasis in rats. Twenty...

The aim of these experiments was to determine the significance of interaction between H2S, NO and SO2 for the control of aortic relaxation. This study included four separate sets of experiments. First, when the PE-induced contraction reached the peak value, Na2S (2.4 mM), SNP (2.3 μM) and SO2 derivatives (6 mM) were added and left for 20 minutes, a...

Fenugreek is one of several herbal medicines whose seeds and leaves are used either as food or as an ingredient in folk medicine. In the existing literature, there is evidence regarding the effects of fenugreek on ethylene glycol induced kidney stone formation of rats. Regarding the other drugs, such as Cystone, the seeds of Trigonella foenum-graec...

Objective: The present study was undertaken to investigate the effect of Luteolin, chlorogenic acid, amygdalin and tannic acid on vascular smooth muscle contractility. Materials and Methods: The effect of different concentrations of some polyphenols and glycosides on contractile responses of isolated aorta, ileum and trachea to Acetylcholine, KCl...

1Biology, College of Science- Salahaddin University, 2Biology, Faculty of Science, University of Zakho, Iraq, 3Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Italy

Crataegus azarolous var. aronia is one of the most important medicinal plants widely used in folk medicine for its cardiotonic, vasorelaxant and hypotensive effects. The present work was undertaken to study the physiological effects of butanol fraction (BF) on isolated aorta and Langendorff perfused heart. In thoracic aorta, BF produced more potent...

The effect of Ginkgo biloba and α-tocopherol was investigated on white blood cells (WBCs) count, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P- LCR), in the diagnosis of liver fibrosis and thrombosis in carbon tetrachloride treated male albino rats. Rats were divided into four groups,...

Crataegus azarolous var. aronia (C. aronia) is one of the most important medicinal plants used widely in folk medicine for its cardiotonic, vasorelaxant and hypotensive effect. Since there is no traditional work carried out on the effect of various C. aronia fractions on isolated smooth muscle and Langendorff perfused heart, the present work was un...

Animal were divided into four goups. The 1st group was given standard diet and water ad libitium and considerd as controlgroup. The second group, the diet supllemented with Cd (80mg Cd/Kg diet). The third group was provided with Vitamin C (along with drinking water as a concentration of 2500 mg Vit C/L) and Cd supplemnted diet (80mg Cd/Kg diet). An...

The study was performed in the animal house of college of Science, University of Salahaddin -Erbil. The physiological effects of Rhubarb Root, Lovastatin and their combination on some haematological and biochemical value in male rats (Rattus norvegicus) were studied. Fifteen rats were randomly assigned to 5 groups, (T1) cholesterol diet, (T2) Lovas...

This research studies the effects of different variables such as sex, age, geographical distribution, consanguinity and causality on B- thalassemia. The present study conducted on 172 patients The following conclusion could be made:- Thalassemia a disease is distributed in Erbil of Kurdistan (Rural =39.54% & Urban =60.46). The morbidity of thalasse...

Atherosclerosis and cardiovascular diseases remain as a major health problem cause premature death in much of the worlds population (Chan, 1998). The origin of these diseases were related to dietary improperty Kumer, (1997) and genetic influences Thomson, (2001). The dietary imbalance is relating to cholesterol (Hexeberg, 1993).