Mudasir Mudasir

Universitas Gadjah Mada | UGM · Department of Chemistry

The evaluation of chitosan and thiamin interactions has been conducted using density functional theory (DFT) to model a slow-release system of the active ingredient thiamin from the chitosan matrix. The geometry optimization method for modeling was selected using the DFT/B3LYP method with various basis sets. Molecularly imprinted chitosan (MIC) com...

DNA extraction technology continues to evolve along with the need for a fast and simple process. The DNA extraction with magnetic nanoparticles accommodates these demands by providing a method that is safe, simple, and yet able to give good purity. The purity parameter of the extracted DNA is based on the A260/280 value. This meta-analysis aims to...

The electrocatalytic degradation method with PbO2/rGO electrode (anode) was chosen to treat Safranine-O waste because it was cheap and environmentally friendly. This research aimed to study the electrocatalytic efficiency of PbO2/rGO working electrode in Safranine-O removal. In this research, rGO and PbO2/rGO electrodes were synthesized and applied...

Hisditine-functionalized UiO-66-NH2 (UiO-66-NH2@Hst) as a novel “turn-on” fluorescent probe to detect fluoride ions has been successfully synthesized using the solvothermal method. The results showed that fluoride ion detection gave the best fluorescence response in water media and no response was observed in non-polar solvents. Detection at pH 3–1...

In this study, magnetic natural zeolite (ZTM) was prepared using the coprecipitation method and dithizone was then immobilized on its surface in less toxic medium of alkaline to yield dithizone-immobilized magnetic zeolite (ZTM-Dtz). The synthesized ZTM-Dtz was characterized by FTIR and XRD, indicating that dithizone was successfully immobilized on...

The remarkable optical properties and strong biocompatibility of carbon dots make them highly promising for applications in biochemical sensing and environmental testing. These carbon dots possess a surface that is easily modifiable. In this study, carbon dots have been successfully synthesized and modified by the addition of N and B dopants using...

The toxicity test of zinc metal in soil samples around the textile industry in Bantul on the growth of spinach (Amaranthus gangeticus) and bean sprouts (Phaseolus aureus) has been investigated in relation with the environmental assesment for the impact of industrial activities. This research was conducted to study physicochemical properties, adsorp...

The optimization of deacetylation process parameters for producing chitosan from isolated chitin shrimp shell waste was investigated using response surface methodology with central composite design (RSM-CCD). Three independent variables viz, NaOH concentration (X1), radiation power (X2), and reaction time (X3) were examined to determine their res...

Facile synthesis of reduced-graphene oxide (rGO) has been conducted in this study using the extract of Caesalpinia sappan L. as a green reducing agent. Graphite sheets were first exfoliated using an improved Hummer process to produce graphene oxide (GO). Then, the reduced-graphene oxide (rGO) was obtained by reducing GO with Caesalpinia sappan L. e...

An afford to enhance TiO2 activity under visible light as well as to utilize the iron rusty waste, has been conducted by doping Fe from the waste into TiO2. The doping was performed by sol-gel method of titania tetra isopropoxide with Fe3+ ions dissolved from the iron rust waste. In the doping, the concentration of Fe3+ was varied giving various mo...

Modification of silica purified from the Merapi volcanic ash with magnetic material of Fe3O4 and attachment of cetyl triamine bromide (CTA-Br) on the magnetic cored has been performed to provide recoverable and positive surfaced of natural adsorbent. The magnetic cored was prepared via co-precipitation and CTA-Br attachment was conducted by a facil...

The chiral separation of hydroxychloroquine, an antimalarial drug with one chiral center, has been predicted using molecular docking and was proven using the HPLC method. Docking utilized the PM3 semi-empirical method with specific grid coordinates (X = 19.977, Y = 20.069, and Z = 25.901) and a grid size of (X = 20, Y = 20, and Z = 60), employing a...

Silica from rice husks (RH) has been used as a starting ingredient in the sonication synthesis of MCM-41 (RH-MCM-41). The impregnation of Fe3+ into RH-MCM-41 pores to produce RH-MCM-41 containing Fe2O3 and Fe (denoted as Fe2O3-Fe-RH-MCM-41) was carried out by examining the effect of various Fe3+ concentrations on the weight percent of Fe-frameworks...

In this study, isotherm and kinetic adsorption of malachite green (MG) using coal fly ash (CFA) as the adsorbent was investigated. This study aimed to examine the character of CFA analyzed by Atomic Absorption Spectrophotometry (AAS), Fourier-Transformed Infra-Red (FTIR), and X-Ray Diffraction (XRD) analysis. In addition, the adsorption of MG on CF...

The kinetic and isotherm study on the adsorption of crystal violet (CV) on coal fly ash (CFA) has been studied. Before being used as an adsorbent, CFA was characterized with AAS, XRF, FT-IR, and XRD to determine the mineral components in CFA. The adsorption study of crystal violet in water with CFA includes the effects of solution pH, mass adsorben...

The hydrothermal synthesis of amikacin modified carbon dots-doped nitrogen and zinc- (N,Zn-CDs) and its capacity to detect Escherichia coli ( E. coli ) have been investigated. Amikacin is one of the aminoglycoside antibiotics utilized in this study as a ligand of N,Zn-CDs to attach to E. coli . This study also examined the effect of nitrogen (N) an...

Biosorption of Cu (II) using bacteria Pseudomonas aeruginosa FNCC-0063 was immobilized on calcium alginate (PAI). This research examined the effect of various parameters such as pH, contact time, and initial Cu (II) concentration. The biosorption mechanism of Cu (II) was studied by sequential desorption with H2O, KNO3 1 M, HNO3 0.5 M and Na2EDTA 0....

Simultaneous adsorption of Pb(II), Cd(II) and Mg(II) ions using activated coal bottom ash (Act-CBA) and dithizone-immobilized Act-CBA (Dtz-CBA) prepared in an eco-friendly medium of the alkaline solution has been done. The parameters affecting the adsorption, such as pH, contact time, initial concentration, and coexisting cations, were systematical...

Enzymatic hydrolysis is the main target to deal with ACh depletion. However, a recent study indicates that the non‐enzymatic one may contribute to the depletion. This study highlights the necessity of considering possible conformers, discrete‐continuum models, and dispersive effects for investigating the neutral (non‐enzymatic) hydrolysis of flexib...

Exfoliated graphene has been successfully synthesized using electrochemical exfoliation method followed by sonication of the graphite rod. Ammonium sulfate, sodium sulfate, ammonium oxalate, hydrogen peroxide, and ammonium persulfate were used as electrolytes. The effect of sonication time was studied for several products. The exfoliated graphene (...

The production of thiamine chitosan nanoemulsion via sonication treatment has been optimized using response surface methodology (RSM). This study examines the effect of sonication treatment on thiamine chitosan formulation and variations in time, amplitude, and surfactant concentration to distinguish optimum production conditions. Chitosan thiamine...

Design and synthesis of the poly vinyl chloride (PVC) membrane as Fe(III) ion selective electrode (ISE) sensor based on EHA ionophore as an excellent sensory molecule for monitoring Fe(III) in the sample solution had been done. Simple and efficient EHA was made by condensation of carboxylic acid HA with ethanol and sulfuric acid as catalist. PVC me...

One of the most dangerous pollutants frequently found in environment are heavy metal ions. Industrial effluents especially those rich in heavy metals are potential pollution source for aquatic environment. In this study, magnetic modification of activated natural zeolite (MZ) was prepared and then used as host for immobilization of dithizone in les...

Carbon/Alginate/Chitosan Composite (CAC) as a sorbent for solid-phase extraction of Cu(II) (pre-concentration) with atomic absorption spectrometry for analysis was successfully prepared. The sorbent was made with a mass ratio of chitosan:alginate:carbon = 1:1:1. CAC sorbents were characterized using FTIR for functional group analysis while SEM-EDX...

A fluorescent probe has been developed by synthesizing N,S co-doped carbon dots (N,S-CDs) through a microwave-assisted process for early detection of Cr(VI) in the environment. In this work, the optimization of irradiation time and ammonium persulfate mass as a source of N and S dopants were studied. The optimal conditions were then employed to syn...

AuNPs have been synthesized with reducing agents and sodium citrate covering agents using the colorimetric method. The formation of sodium citrate-covered AuNPs was confirmed using a UV-Vis spectrophotometer. The optimization of creatinine concentration of 10 mM was indicated by shifting the absorption peak from 530 to 700 nm. The results of this o...

Prediction of chiral separation of R- and S-ketorolac has been carried out using a molecular docking approach. Geometry optimization using different calculation methods suggests that Hartree-Fock (HF)/6-31G is the best method to describe the most stable ketorolac structure. Docking studies have been performed on AutoDock and Gaussian software. Mole...

A study of the molecular anchoring and inclusion complex of the R/S-ibuprofen chiral compound with α-1-acid glycoprotein (AGP) has been carried out. This study aimed to predict the chiral separation of ibuprofen using chiral column filled with AGP protein. The geometrical optimization of R/S-ibuprofen was conducted on different calculation methods...

The HPLC chiral separation of hydroxychloroquine (HCQ) using chiral α-1-acid glycoprotein (AGP) column has been predicted based on a molecular docking approach. The research begins with the geometrical optimization of the HCQ compound using the quantum calculation method of semiempirical (SE) of PM6, AM1, and PM3, and Hartree-Fock (HF) and density...

In this chapter, some inorganic materials such as coal ash, hydroxyapatite, and hydrotalcite are taken up as the adsorbents to remove pollutants in contaminated water and soil. Coal ash is a residual material that exists after all combustible material in coal has been burned. The main components of coal ash are silica (SiO2) and alumina (Al2O3) and...

First-principles calculations are commonly used to search for possible transition states in reaction kinetics studies, which are such a challenge to observe experimentally. However, computationally studying the reaction is also challenging because of, inter alia, the Basis Set Incompleteness Error (BSIE). Accordingly, we utilized density functional...

In the present study, new greener approach of dithizone immobilization on coal bottom ash as a source of silica-alumina materials in alkaline (NaOH) solution has been developed to replace previously used method utilizing more toxic solvents such as toluene, carbon tetrachloride or chloroform. Some parameters influencing the effectiveness of dithizo...

Immobilization of dithizone on activated fly ash (AFA) has been carried out in water medium and used as adsorbent for Cd (II) metal. Some parameters that influences the efficiency of Cd (II) adsorption such as solution pH, adsorbent mass, contact time and initial adsorbate concentration were optimized. The concentration of Cd (II) ion before and af...

Adsorption of Ni(II) ion onto adsorbent of dithizone-immobilized coal fly ash (IFA) has been investigated in batch experiments. The activated coal fly ash (AFA) and its dithizone modification were characterized by FT-IR and XRD. Several parameters influencing the adsorption of Ni (II) ions on both adsorbents including effect of pH, adsorbent dosage...

The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6 mm × 5 μm), mobile phase composition of acetonitr...

By optimizing rice husk silica mass and sonication time, SBA-15 was successfully synthesized in a more efficient and environmentally friendly way. The solution of Pluronic P-123 was mixed with the solution containing NaOH and various masses of rice husk silica (4–12 g), followed by sonication for a certain time (30–150 min). The mixture was filtere...

Rice husk silica has been used as a raw material for the sonochemical synthesis of MCM-48 (RH-MCM-48). Silylation on the outer surface of RH-MCM-48 using trimethylchlorosilane before removal of the template to prevent the formation of iron oxide in the outer of RH-MCM-48. The impregnation of Fe3+ into the externally silylated-RH-MCM-48 porous syste...

Objective: This study aimed to construct a virtual target to be used in structure-based virtual screening (SBVS) campaigns to discover ligands for human histamine receptor H4 (hHRH4). Methods: The virtual targets construction was initiated by hHRH4 homology modeling, followed by molecular docking of seliforant to the homolog model, and the virtual...

In this study, the activated coal bottom ash (Act-CBA) was first modified with dithizone in alkaline solution (Dtz-CBA) and then used for Pb(II) adsorption in water. The success of dithizone-immobilization on Act-CBA was confirmed by SEM-EDX (Scanning Electron Microscope-Energy Dispersive X-Ray), FTIR (Fourier-Transformed Infra Red), and XRD (X-Ray...

In this study, a superparamagnetic composite of magnetite-cetyltrimethylammonium bromide (CTAB) has been prepared by the coprecipitation method and then applied as a charge-selective adsorbent of anionic methyl orange (MO). The VSM (Vibrating Sample Magnetometer) measurement suggests the superparamagnetic property of MNPs (Magnetite Nano Particles)...

This research aims to synthesize silver nanoparticles (AgNPs) using Kirinyuh (Chromolaena odorata) leaf extract with different temperature and evaluate its activity in Vibrio sp. The synthesis was carried out by combining between silver nitrate solution and Kirinyuh leaf extract at room temperature (AgNPs 200) and hydrothermal process at 60oC (AgNP...

This study aimed to make a crosslinked chitosan/pectin membrane with glutaraldehyde under conditions of time, pH, and maximum concentration in the adsorption of methylene blue. The first step was to synthesize the chitosan-pectin polyelectrolyte complex membrane which was cross-linked with glutaraldehyde by dissolving pectin in distilled water, the...

An optical fiber biosensor has been developed for the detection of mercury ion based on inhibition of urease immobilized onto alginate–chitosan membrane, coupled with bromothymol blue (BTB) in the flow system. To get a good performance of the biosensor toward Hg(II) ion detection, the experimental parameters of the biosensor were optimized. Here, t...

Graphene is a nanomaterial with unique physical and chemical properties. The two-dimensional hexagonal sp ² structure in the honeycomb lattice has high thermal conductivity, high electricity, mechanical strength, and large surface area. The nano properties are significantly different from the bulk material. The review of the material, synthesis and...

This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chitosan was crosslinked with glutaraldehyde in variou...

Cadmium (Cd) has potential environmental risk because of its toxicity and persistence in water; therefore, it should be removed from waters. Several methods of Cd(II) removal have been proposed, and adsorption has become the choice because of its simplicity and low-cost operation. In this study, the modification of commercial bentonite (CB) with di...

In this paper, a generic QSPR (quantitative structure-property relationship) model have been developed to investigate the relation between the critical micelle concentration (cmc) and the molecular structure of 231 gemini cationic surfactants with the various hydrophilic head group. The QSPR modeling were performed using the OCHEM (Online CHEmical...

This study examined zeta potential of some encapsulation products of β-carotene in the starch-chitosan/TPP matrices. the effects of weight ratio of starch to chitosan, β-carotene loading, and tripolyphosphate (TPP) addition level on zeta potential of the microparticle products were determined. The native and hydrolyzed starches as well as low molec...

Coal bottom ash is one of coal combustion wastes which mainly contains metal oxides of alumina and silica, thus it can be potentially used as adsorbent for heavy metal removal in aquatic environment. We have developed a new approach of eco-friendy immobilization of dithizone on activated coal bottom ash (CBA-Act) in water medium to yield dithizone-...

Nuclear receptor REV-ERBβ is an overexpressed oncoprotein that has been used as a target for cancer treatment. The metal-complex nature of its ligand, iron protoporphyrin IX (Heme), enables the REV-ERBβ to be used for multiple therapeutic modalities as a photonuclease, a photosensitizer, or a fluorescence imaging agent. The replacement of iron with...

Adsorption of Ag(I) on dithizone-immobilized coal fly ash (Dtz-CFA) from PT Madukismo Factory, Yogyakarta, Indonesia has been investigated. Immobilization of dithizone on activated coal fly ash (Act-CFA) was done by stirring the mixture of two precursors in toluene medium at 50 °C for 16 h. Parameters influencing adsorption of Ag(I) such as pH of s...

Modeling of the relationship between structure and cytotoxicity has helped in the process of designing safer new drug compounds. In this study, modeling was carried out between the structures of 29 betulinic acid derivatives with their cytotoxicity. The modeling is done by using multiple linear regression (MLR) techniques. In the model, an equation...

The adsorption of methylene blue dye using biosorbents based on humic acid cross-linked cellulose has been carried out. The adsorbent HA/Cel-Epi characterized using FTIR, XRD, and SEM spectroscopy. The results of characterization using FTIR indicated that adsorbents HA/Cel-Epi had active functional groups among others ‒OH, ‒C=O, and ‒COOH. XRD resu...

Removal of Pb(II) ion using activated and dithizone-immobilized natural bentonites has been carried out. Natural bentonite was activated by immersing and stirring the bentonite in 6M HCl solution. The dithizone-immobilized natural bentonite was prepared by mixing the bentonite and dithizone in toluene at 50 °C for 6 h and the immobilized adsorbents...

This paper in final version had been published on https://www.scientific.net/KEM.884.282

A new crosslinked poly-bisphenol A diglycidyl ether (poly-BADGE) has been synthesized by the reaction of polyeugenol and bisphenol A diglycidyl ether in dioxane under alkaline conditions. The product was characterized using fouriertransform infrared spectroscopy (FTIR) and elemental analysis. FTIR analysis of poly-BADGE showed the loss of the typic...

The efficacy of the drug encapsulated in the polymeric matrix is closely related to the kinetics of drug release from the matrix, therefore the study about the kinetic release of a drug from a certain matrix is essential to be carried out. This study aims to evaluate the release of β-carotene from the starch-chitosan crosslinked by tripolyphospha...

In this study, we make QSAR models from 29 of BA derivatives’ HIV maturation inhibition activities against their 3D descriptors. The best model involve 5 descriptors as follows: 1/log EC50 = -462.275 + (69.213 × TDB6u) + (723.745 × TDB6e) + (-0.576 × FPSA-3) + (0.849 × RDF140u) + (0.302 × RDF80e) r2 training = 0.7918; Q2 test = 0.9644; r2test = 0.9...

In this study, a coprecipitation method followed by a hydrothermal treatment was used to synthesize Mg-Al-Ox (Ox = oxalate) layered double hydroxide (LDH), then used as the stationary phase in solid-phase extraction (SPE) for preconcentration of amoxicillin. Extraction was carried out at pH 7, flow rate 2 mL/minute, and LDH loading 20 mg. The mobil...

Photocatalytic removal of Cu(II) in aquatic solutions using TiO2-chitosan nanocomposite had been studied. The photocatalytic process was carried out using a batch system in a closed reactor equipped with a UV lamp. The results show that the percentage of photocatalytic removal of Cu(II) by TiO2 – chitosan nanocomposite was higher than that TiO2 bul...

Adsorbent such as pectin (Pec) and chitosan (Chi) usually produced with low physical stability, thus the material needs to be modified. In this research, the physical characteristic of adsorbent increased by grafted Chi using acetate carboxymetyl chitosan (CC). Further, CC and Pectin (Pec) were cross-linked using cross-linked agent bisphenol A digl...

This study aims to investigate the synthesis and characterization of β-carotene encapsulated in the blending matrices of starch (native and hydrolyzed starch)-chitosan/TPP (tripolyphosphate) by examining the effects of starch-to-chitosan weight ratio, β-carotene addition level, and TPP addition level on the encapsulation efficiency (EE) and loading...

In this research, the synthesis of silver nanoparticles (AgNPs) and its evaluation for antibacterial activity against Vibrio sp. were carried out using Kirinyuh (Chromolana Odorata) leaf extract as both reducing and stabilizing agent. In the synthesis process, the leaf extract and silver nitrate solution were mixed and hydrothermally treated at 60...

In this study, the combined factors of acid hydrolyzed starch-to-chitosan weight ratio (weight ratio SC), β-carotene addition level, and tripolyphosphate ion (TPP) addition level were investigated to produce minimum particles size of β-carotene microencapsulated in acid hydrolyzed starch-chitosan/TPP matrices using a precipitation method. For this...

Simultaneous adsorption of Zn(II) and Hg(II) in the presence of alkaline earth metal, Mg(II) on dithizone-immobilized bentonite has been done by batch method. The study was begun by activation of natural bentonite with HCl followed by immobilization of dithizone on bentonite surface. Some parameters influencing the adsorption such as pH, interactio...

Adsorption of Pb(II) ions onto selective adsorbent of dithizone-immobilized coal fly ash (DCFA) from Holcim, Cilacap, Indonesia has been investigated in batch experiments. Prepared coal fly ash (CFA) modified by immobilization of dithizone previously were characterized by FT-IR and XRD. Several parameters influencing the adsorption of Pb(II) ions s...

Research on the adsorption of Cd (II) ion in dithizone-immobilized natural bentonite has been carried out. The aims of this research were focused on the preparation of dithizone-immobilized natural bentonite (BA-D) as adsorbent and desorption experiment of Cd(II) ion. The BA-D was prepared by adding dithizone (dissolved in toluene) into the activat...

The adsorption of Cu (II) ions onto selective adsorbent of coal fly ash from Sugar Factory Madukismo, Yogyakarta, Indonesia modified with dithizone has been investigated in batch mode. Some parameters influencing immobilization of dithizone and adsorption of Cu (II) were optimized including an effect of pH, contact time and initial concentration of...

The glutaraldehyde (GA)-crosslinked carboxymethyl cellulose (CMC)-polyvinyl alcohol (PVA) film had been synthesized and used as a methylene blue adsorbent. The films were prepared using a solution casting technique and characterized using FTIR spectrophotometer, SEM. Adsorption studies include pH, contact time, methylene blue initial concentration....

The research of adsorption of Cu ²⁺ metal ion on dithizone-immobilized natural bentonite (DNB) had been carried out. The experiment was begun by the activation of natural bentonite with HCl 4 M and dithizone-immobilized on activated bentonite surface. This study included synthesis and characterization of dithizone-immobilized bentonite and its appl...