Mubashir Masoodi

Mubashir Masoodi
University of Kashmir · Department of Pharmaceutical Science

PhD, Pdf (USA)

About

93
Publications
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Introduction
Bioactive guided isolation and characterization of compounds possessing significant pharmacological activity from medicinal plants by different chromatogrphic techniques. Screening of bioactive compounds as well as active fractions for different in-vitro and in vivo biological activities.
Additional affiliations
September 2013 - September 2014
Mississippi
Position
  • Researcher

Publications

Publications (93)
Article
Background: Alzheimer's disease (AD), the primary cause of dementia, escalating worldwide, has no proper diagnosis or effective treatment. Neuronal cell death and impairment of cognitive abilities, possibly triggered by several brain mechanisms, are the most significant characteristic of this disorder. Methods: A multitude of pharmacological targe...
Article
Nanoparticles have had significant scientific activity mainly in the field of drug distribution due to their use as a carrier for minute and large-sized molecules over the last few decades. In the present review, we discussed some of the various features of nanoparticle synthesis, classification, the impact of the own features and their use in the...
Chapter
Arthritis and related disorders like rheumatoid arthritis (RA) and osteoarthritis are complex, multifactorial inflammatory diseases that result in joint destruction and functional disability if not treated adequately. Natural products with folklore use have been widely used as a therapeutic source. Nigella sativa (family Ranunculaceae), commonly kn...
Chapter
Syzygium aromaticum (Family Myrtaceae), commonly acknowledged as clove, is one of the most valuable spices in the world trade market with global distribution, though Indonesia has maintained its top position as a producer. Clove has sustained its value in the past, dating back to 1700 BC, as is evident from clove found in a ceramic vessel in Syria...
Article
Transition metal-free approaches for oxidative functionalization reactions have gained considerable importance over the past few decades. The recent updates on the use of TBAI (tetrabutylammoniumiodide) and TBHP (tert-butylhydroperoxide) as an efficient catalytic system for oxidative functionalization reactions on Csp³, Csp², and Csp carbon have be...
Chapter
Throughout human history, medicinal plants are used in traditional medicine systems and are considered a potential source of healthy life. Curry leaf belongs to the family Rutaceae obtained from Murraya koenigii, which has been used widely as a spice, flavouring agent, and as herbal medicine since ancient times in the ayurvedic medicine system. Cur...
Article
Background Traditionally, Portulaca oleracea Linn for treating abscesses, dysentery, and also for the treatment of liver diseases. Recent studies have reported its efficacy as neuroprotective, analgesic and anti-inflammatory, a bronchodilator, anticancer, antioxidant, wound healing, besides other important pharmacological actions. Aim and Objectiv...
Article
Background Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that typically causes death within 3-5 years after diagnosis. Regardless of the substantial scientific knowledge accrued from more than a century ago, truly effective therapeutic strategies remain distant. Various conventional drugs are being used but are having several...
Article
Depression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the m...
Article
Background Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments. Solid dispersion (SD) has emerged as one of the most effective formulation approaches to enhance the dissolution of poorly water-soluble herbal drugs. Formulation of solid dispers...
Chapter
Cancer, a multifactorial disease, is recognized as one of the primary reasons of mortality around the globe. In 2019 1,762,450 cancer cases with death rates of 606,880 were reported only in the United States. Despite the various advancements in the field of modern medicine, cancer treatment remains a challenging task. Treatment of cancer usually in...
Article
Heterocyclic are a class of compounds that are intricately entwined into life processes. Almost more than 90% of marketed drugs carry heterocycles. Synthetic chemistry, in turn, allocates a cornucopia of heterocycles. Among the heterocycles, indole, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring...
Article
Background Prunella vulgaris, family Lamiaceae also known as self-heal, has been traditionally used as an expectorant, anti-inflammatory, anti-pyretic, and anti-rheumatic. Due to widespread distribution of the plant, Vulgaris is also called ‘vulgar’ in Latin adjective meaning common. Objective The objective of this review was to describe the relev...
Article
Full-text available
Introduction: Oleanolic acid, a pentacyclic triterpenic acid, is widely distributed in medicinal plants and is the most commonly studied triterpene for various biological activities, including anti-allergic, anti-cancer, and anti-inflammatory. Methods: The present study was carried out to synthesize arylidene derivatives of oleanolic acid at the...
Chapter
Honey has been and is being used for medical, pharmaceutical, and domestic needs. Besides, it is used as a conventional medicine and has various pharmacological properties. A variety of polyphenolic compounds are stated in honey and among them important polyphenols are Caffeic acid (CA), Quercetin (QU), Chrysin (CR), Kaempferol (KF), Apigenin (AP),...
Article
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Neurodegenerative disorders are commonly erratic influenced by various factors including lifestyle, environmental, and genetic factors. In recent observations, it has been hypothesized that exposure to various environmental factors enhances the risk of Alzheimer’s disease (AD). The exact etiology of Alzheimer’s disease is still unclear; however, th...
Article
Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further...
Article
Full-text available
Background: Inflammation involves a dynamic network that is highly regulated by signals that initiate the inflammation process as well as signals that downregulate it. However, an imbalance between the two leads to tissue damage. Throughout the world, inflammatory disease becomes common in the aging society. The drugs which are used clinically suf...
Article
Background Propolis is a resinous substance produced by bees. Propolis extracts have been used for anti-inflammatory and antimicrobial activities. The use of propolis dietary supplements has been increasing in the United States and the rest of the world. Objective A simple, economic, and valid analytical method is needed for quality assessment of...
Article
Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, and oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. Therefore, to develop new drugs with protective action against the disease, research is turning to the iden...
Chapter
Herbal medicines have been used around the globe since times immemorial. Nanophytomedicine is an emerging domain of medicine which helps to encapsulate the active phytoconstituents from medicinal plants and treat various diseases such as cancer and diabetes. So it is very crucial to identify the potential active phytoconstituents and encapsulate th...
Article
Full-text available
Background: Prunella vulgaris, commonly known as self-heal, has been extensively used in the traditional system of medicines. The plant has been found to contain a number of bioactive molecules including those having radical scavenging property which indicates its potential for the treatment of those diseases which are induced by free radical dama...
Article
Introduction Capsella bursa-pastoris(L.) Medic is a traditional herb of the genus Capsella with long-standing Pakistan, India, Iraq, Cyprus, Turkey, Iran, Azarbayjan, Europe, Saudi Arabia, China and many other regions of Asian countries ethnomedical records. Preliminary studies from the animal model have provided valuable scientific evidence for its...
Article
Full-text available
Prunella vulgaris L. also known as self-heal has been extensively used for treating various ailments in traditional system of medicine which indicates that the plant is an important source of various bioactive constituents. Current study was performed to carry out qualitative and quantitative phytochemical evaluation and anti-inflammatory activity...
Article
Background Liver injury induced by drugs has become a basic reason for acute liver disease and therefore posed a potential regulatory and clinical challenge over the past few decades and has received greater attention. It also remains the most common cause of failure of drugs during clinical trials. In 50% of all acute liver failure cases, drug-ind...
Article
Full-text available
Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpen...
Article
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A staggering 80% of the population in developing countries relies on herbal medicine for treatment of various diseases and disorders. Among them, Achillea millifolium from Asteraceae family is one medicinally important plant called as “yarrow” and has been used in folklore medicine for ailments such as skin inflammations, spasmodic and gastrointest...
Article
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The aim of this study was to evaluate the methanolic extracts of Nymphaea mexicana Zucc. Flowers (NMF) and Indigofera heterantha Roots (IHR) for cholinesterase inhibitory potential. The study provided evidence for both the extracts to be potential cholinesterase inhibitors with NMF having maximum cholinesterase inhibitory potential than IHR. The in...
Article
Background Polyphenolics, a group of natural substances with a wide distribution in plant kingdom present a great diversity of biological activities such as anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, modulation of enzyme activity, prevention of CHD, etc. The objective of this review was to describe the relevant aspects of...
Conference Paper
Full-text available
Peripheral neuropathy is a disorder resulting from damaged or destroyed peripheral nerves, that disrupts nerves' normal functioning. The injuries, illnesses, infections, auto-immune diseases, medications, inheritance, and poor nutrition are some of the reasons for the condition. Our focus is to have a brief review on the contribution of nutritional...
Article
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The study was intended to investigate the presence of phytoconstituents in the bulbs of Narcicuss tazetta, flowers of the plant Nymphaea mexicana, and roots of Indigofera heterantha. The present study provides evidence that methanolic extracts of Narcicuss tazetta, Nymphaea mexicana and Indigofera heterantha contain important compounds with marked...
Article
Full-text available
Background: The current study was carried out to evaluate the phytochemical, antioxidant, and In-vitro antidiarrheal properties of Euphorbia hirta Methods: Extracts were obtained using cold extraction, hot extraction and autoclave extraction methods using Methanol, Chloroform, Petroleum ether and distilled water as solvents. Crude extracts were scr...
Article
Liver diseases pose a serious threat to human health and the conventional drugs available for the treatment of this life threatening condition often causes inadequate results. Propolis has been used from centuries traditionally for their hepatoprotective effect. We wanted to assess the liver protective activity of Propolis. The aim of the present s...
Chapter
Artemisia absinthium Linn. (wormwood) is a species of Artemisia of family Asteraceae. It is an important perennial shrubby plant native to temperate regions of Asia, Europe, and Northern Africa, also found in the United States and Canada. It is grown as an ornamental plant and is used in some alcoholic drinks and also as an ingredient of spirit abs...
Article
Background Great Mullein; Verbascum thapsus has been traditionally used as an analgesic, anti-inflammatory, antiseptic, spasmolytic, astringent, diuretic, emollient, expectorant piles, bruises and frostbites in Greece, Western United States, Rome, India, Turkey, Italy, and Pakistan. Objective The aim of the present review is to summarize ethnophar...
Article
Full-text available
Diabetes is considered as the most common metabolic disease affecting millions of people all around the world. Use of natural herbal medicines can be effective in treating diabetes. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) a polyphenolic alkanone extracted from ginger has a broad spectrum of pharmacological properties and thus can be us...
Conference Paper
The flowers of Hibiscus rosa-sinenis are known for its medicinal properties ranging from Anidiabetic,Anticancer,Antimicrobial.In the present study various extracts of flower were made using soxlet apparatus for evaluating the antimicrobial activity by disc diffusion method against E.Coli,S.Typhi. Phytochemistry of Hibiscus rosa-sinenis after thorou...
Poster
Northern India is home to thousands of plant species and sadly, only a little percentage of them have been explored for medicinal properties. This is mostly because the metabolites present in these plants have not been scientifically investigated, mainly because of the prolonged and cumbersome nature of such analysis. Furthermore, the effect of the...
Conference Paper
Full-text available
Current therapies for type-2 diabetes mellitus have mainly centred on elevating plasma insulin levels (direct insulin administration or oral agents that promote insulin secretion), improving insulin sensitivity of tissues, and eventually reducing the rate of carbohydrate absorption from the gastrointestinal tract. The established drugs [sulfonylure...
Article
The flowers of Hibiscus rosa-sinenis are known for its medicinal properties ranging from Anidiabetic,Anticancer,Antimicrobial.In the present study various extracts of flower were made using soxlet apparatus for evaluating the antimicrobial activity by disc diffusion method against E.Coli,S.Typhi. Phytochemistry of Hibiscus rosa-sinenis after thorou...
Article
Full-text available
Inula racemosa Hook. F (Asteraceae) commonly known as Pushkaramula is a well documented Indian medicinal plant. Pushkarmula is one of the herbs mentioned in all Ayurvedic scriptures. It possesses various synonyms like kasari-an enemy of cough, sulahara-pain killer, sughandhika-fragrant etc. The great sage Charaka has categorized it as hikkanigrahan...
Article
Full-text available
Colon cancer is a world-wide health problem and one of the most dangerous type of cancer, affecting both men and women. Naringenin (4, 5, 7-trihydroxyflavanone) is one of the major flavone glycoside present in citrus fruits. Naringenin has long been used in Chinese's traditional medicine because of its exceptional pharmacological properties and non...
Article
Full-text available
Obesity is one of the most prevalent health problems recorded worldwide affecting all age groups contributing to a variety of disorders, notably affecting cardiovascular and endocrinological systems. According to WHO, in 2014 about 13% of World's Adult population (11% Males & 15% Females) were obese. The highest proportion living in the USA followe...
Article
Northern India is home to thousands of plant species but sadly, only a little percentage of them have been explored for medicinal properties. This is mostly because the metabolites present in these plants have not been scientifically investigated, mainly because of the prolonged and cumbersome nature of such analysis. Furthermore, the effect of the...
Article
Full-text available
Background: Hyperlipidemia and underlying high cholesterol has been reported among the top five leading cause of global mortality. Many drugs and extracts from plant origin and specifically from Indian plants have been reported and used for hyperlipidemia alleviation. Objective: The present study was aimed to evaluate antioxidant and anti-hyperlipi...
Article
Full-text available
Background: Hypertension is one of the most common cardiovascular diseases in the world, and often, the treatment is limited by huge side effects due to allopathic medicine regimens. Objective: The purpose of this study was to investigate the antihypertensive properties and effects on biochemical parameters of Heterophragma adenophyllum Wall. ex G....
Conference Paper
Full-text available
Diabetes is a common metabolic disease characterized by abnormally high plasma glucose levels, leading to major complications, such as diabetic neuropathy, retinopathy, and cardiovascular diseases. Although the drug treatment for type 2 diabetes mellitus has been improved to some extent during the last decade, drug resistance is still a big concern...
Conference Paper
Screening of medicinal plants is one of the alternative and valid approaches in the drug development for treatment of various diseases like diabetes, because they contain diverse phytoconstituents which may give new drug leads which may be effective and safe against diabetes. Currently, there is growing interest in drug development from plants and...
Article
Full-text available
p> Objective: Eremurus himalaicus Baker , an edible herb of North Western Himalayas, has not been scientifically assessed for hepatoprotective potential. The ethyl acetate extract (EHE), methanolic extract (EHM) and aqueous extract (EHA) of Eremurus himalaicus were therefore evaluated for potential hepatoprotective activity in Wistar strain albino...
Article
Full-text available
Introduction: A number of plants of Kashmir valley are unexplored and Eremurus himalaicus is one amongst them. Eremurus himalaicus is an edible herb of North Western Himalayas which is yet to be evaluated for possession of antioxidant and antimicrobial activities. Method: The antioxidant potential of the plant extracts (Ethyl acetate, EHE; Methanol...
Article
Bee propolis is a resinous, gummy and balsamic material collected from flora by honey bees (Apis mellifera L. belongs to Apidae family). Bee propolis is official in the United States Pharmacopeia and natural health product monograph Canada (USP. 2009), (Health Canada 2009). The main phytoconstituents reported to have been isolated from the bee prop...
Article
Full-text available
Abstract Phytochemical investigation of the whole plant of Marrubium vulgare L. (Lamiaceae) resulted in isolation and characterization of two new labdane diterpenoids, 12(S)-hydroxymarrubiin and 3-deoxo-15-methoxyvelutine C and 11 known compounds, marrubiin, peregrinin, thessaline D, marrubinone B, deacetylvitexilactone, verbascoside, leucosceptosi...
Book
Full-text available
Meloxicam (4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3carboxamide-1,1 -dioxide) is an NSAID used in the management of rheumatic disease, which is distinguished by the fact that it is well tolerated by the stomach at the doses necessary for therapy. The anti-inflammatory and pain-relieving properties of Meloxicam make this act...
Article
Full-text available
Cisplatin (cis-diamminedichloroplatinum (II) (CDDP)) is a commonly used chemotherapeutic drug for the treatment of numerous forms of cancer, but it has marked adverse effects, namely nephrotoxicity, hepatotoxicity, ototoxicity, neurotoxicity, diarrhoea etc. CDDP-induced emesis and diarrhoea are also noticeable toxicities that may be due to intestin...
Article
Full-text available
Introduction: Propolis from Kashmir has not been explored as far as its phytochemistry and pharmacological activities are concerned. This piece of work is the first approach to explore it for various activities. Methods: Total phenolics, flavonoids contents and in vitro antioxidant assay such DPPH, H2O2 scavenging assay, ferrous metal ion chelating...
Article
Kashmir, an elevated region in the North of India, is blessed with with huge potential for medicinal plants. Marrubium vulgare L. commonly known as 'horehound' or 'paharigandana' is well known for curing different ailments. Analgesic, anticancer, antiodematogenic, hypoglycaemic and many other biological activities have been associated with this pla...
Article
Full-text available
The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). The plant was extensively exam...
Article
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The study was carried out to evaluate the phytochemical constituents and antioxidant potential of methanolic root extract of Mentha arvensis L. from Kashmir region. The antioxidant activity of methanol extract of Mentha arvensis L. was evaluated by using 1, 1-diphenyl, 2-picrylhydrazyl (DPPH) scavenging, reducing power, metal chelating, nitrous oxi...
Article
Euphorbia hirta is a very popular herb amongst practitioners of traditional herbal medicine for its hypotensive, tonic, antipyretic, antiinflammatory, hypoglycemic and sedative activities. Moreover it is also used in different systems of medicine in the treatment of diarrhoea, bronchitis, skin diseases, fever, analgesic, gastrointestinal disorde...
Article
Full-text available
A simple, precise and accurate isocratic RP-HPLC method was developed and validated for determination of Meloxicam in bulk drug and tablets. Isocratic RP-HPLC separation was achieved on a LiChrospher RP-18 column (250 x 4.6 mm id, 5 micron particle size) using the mobile phase 'A' 0.1 M dipotassium hydrogen phosphate pH 4.0 with orthophosphoric aci...
Article
Paeonia emodi (Peony) is a well known Himalayan medicinal plant used in the treatment of hypertension, palpitations, asthma, uterine diseases, colic, bilious obstructions and has also been used as an anticoagulant. Many of these ethnomedicinal properties have been experimentally proven in different animal models. The present work reviews the ethnop...
Article
Full-text available
Objective In the present study an attempt has been made to study the antihepatotoxic activity of active compounds in this plant through in silico methods.Methods We have taken 12 compounds form this plant. All the compounds were further subjected to molecular propertied prediction and drug likeness by Molinspiration and found in compliance with Lip...
Article
Rhubarb (Rheum emodi, family Polygonaceae) has been traditionally used as diuretic, liver stimulant, purgative/cathartic, stomachic, anticholesterolaemic, antitumour, antiseptic and tonic. A number of anthraquinone derivatives including emodin, aloe-emodin, physcion, chrysophanol, rhein, emodin glycoside and chrysophanol glycoside occur as the main...
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Portulaca is a genus of succulent herbs distributed in the warmer parts of the world. Four species are found wild in India and two exotics have become naturalized. P. oleracea, commonly known as Purslane is an herbaceous weed. In traditional system it has been claimed to cure diarrhoea, dysentery, leprosy, ulcers, asthma, piles; reduce small tumors...