Moza Suleiman Al Hail

• Managing Director at Hamad Medical Corporation

While standard doses of adjuvant fluoropyrimidine-based chemotherapies are generally safe for most patients, the risk of severe adverse drug reactions (ADRs) is increased for those with dihydropyrimidine dehydrogenase deficiency (DPYD), a genetic variation that affects drug metabolism. The objective of this study was to examine the cost effectivene...

Introduction The inappropriate use of antimicrobial agents has been associated with increased healthcare costs and the spread of multidrug-resistant organisms. We aimed to estimate the economic impact of the developed antimicrobial stewardship program (ASP), after five years of implementation, versus the preliminary ASP, upon implementation, in the...

Background: Pharmacogenetic testing improves the efficacy and safety of antidepressant pharmacotherapy for moderate-severe major depressive disorder by identifying genetic variations that influence medication metabolism, and adjusting treatment regimens accordingly. This study aims to assess the cost-effectiveness of implementing a pharmacogenetic...

Background The COVID-19 outbreak had significant global healthcare implications, including the use of medications. This is specifically evident in the surge in use of some medication and a decline in the use of others. As a result, some medications end up unused, which may have subsequent health, economic, and environmental impacts. Aim To explore...

Pharmacogenetic (PGx)‐informed medication prescription is a cutting‐edge genomic application in contemporary medicine, offering the potential to overcome the conventional “trial‐and‐error” approach in drug prescription. The ability to use an individual's genetic profile to predict drug responses allows for personalized drug and dosage selection, th...

Objective Preterm babies are prone to experiencing apnea of prematurity (AOP), mostly characterised by a pause in breathing lasting a minimum of 20 seconds. Recent literature supported higher maintenance doses of caffeine, indicating benefits. This study evaluated the cost-effectiveness of high maintenance dose (HD) versus low maintenance dose (LD)...

Introduction Poisoning is a major public health issue and a leading cause of admission to the emergency department (ED). There is a paucity of data describing the epidemiology and cost of acute poisoning. Therefore, this study investigated the epidemiology, patterns, and associated costs of acute poisoning in emergency department of the largest ter...

Background Global evidence has linked unused medications and their inappropriate disposal to adverse health, economic, environmental, and ethical impacts. However, such evidence is scarce in Qatar. This study explored patients’ knowledge and attitude toward unused medications and their practices toward medication supply and disposal (KAP) in Qatar....

Objective To estimate the economic impact of the developed antimicrobial stewardship program (ASP) versus the preliminary ASP use, in the adults’ general medicine settings in Qatar. Methods Patient records were retrospectively reviewed during two periods: preliminary ASP was defined as the 12 months following ASP implementation (i.e. May 2015-Apri...

Aim To evaluate the cost-effectiveness of dapagliflozin added to standard of care (SoC) versus SoC in heart failure with reduced ejection fraction (HFrEF) and without type 2 diabetes mellitus (T2DM) patients from the Qatari healthcare perspective. Materials and Methods A lifetime Markov model was developed to evaluate the cost-effectiveness of add...

Objective This study aimed to assess the overall economic impact of clinical pharmacist interventions in the neonatal ICU (NICU) in Qatar. Methods A retrospective review of neonates’ records was performed over a 3-month duration in the NICU of Qatar to determine the total economic benefit of clinical pharmacist interventions. The total benefit of...

Purpose This study aimed to explore emergency pharmacy workforce perspectives and experiences in providing pharmaceutical care during mass gathering events (i.e., FIFA World Cup Qatar 2022™). Methods A qualitative methodology was employed using focus groups discussions. Emergency pharmacists across Hamad Medical Corporation were invited to partici...

Background Vaccine hesitancy poses a global challenge and is acknowledged to be a complex, multifactorial phenomenon. Of particular concern is hesitancy among health professionals, as this may also impact their advocacy roles. There is a lack of theory-based investigations of pharmacy professionals. Aim The study aims to determine the behaviour an...

Medication-related problems (MRPs) are prevalent throughout healthcare systems, whereby pharmacy-based interventions are pivotal to reducing occurrence. In the Middle East, including Qatar, the professional roles of pharmacists have been expanding to improve patient safety. This study aimed to characterize and analyze pharmacist-led interventions a...

We aimed to investigate the characteristics and clinical outcomes of paracetamol poisoning and paracetamol overdose in Qatar. This retrospective cohort study included patients admitted to the emergency department (ED). We included patients who presented with excessive paracetamol ingestion, between December 2018 and September 2019. The primary outc...

Background Well-designed and well-maintained drug formularies serve as a reliable resource to guide prescribing decisions; they are associated with improved medicine safety and increased efficiency, while also serving as a cost-effective tool to help manage and predict medicine expenditure. Multiple studies have investigated the inappropriate presc...

Background The likelihood of elderly patients with heart failure (HF) being readmitted to the hospital is higher if they have a higher medication regimen complexity index (MRCI) compared to those with a lower MRCI. The objective of this study was to investigate whether there is a correlation between the MRCI score and the frequency of hospital read...

Background With an increasingly strained health system budgets, healthcare services need to continually demonstrate evidence of economic benefits. This study sought to evaluate the economic impact of interventions initiated by clinical pharmacists in an adult general tertiary hospital. Methods A retrospective review of clinical pharmacist interven...

Introduction Poisoning is a major public health issue and a leading cause of admission to the emergency department (ED) worldwide. There is paucity of data describing epidemiology, outcomes, and cost of acute poisoning. Up-to-date information about poisoning pattern is imperative for accurate diagnosis and effective management. This study therefore...

We sought to investigate the economic impact of preventing adverse events in a cardiology setting in Qatar as an effect of the clinical pharmacist as an intervention. This is a retrospective study of interventions by clinical pharmacists within an adult cardiology setting in a public healthcare setting (i.e Hamad Medical Corporation). The study inc...

Purpose The aim of this study is to assess the level of preparedness of pharmacists working in the emergency department at Hamad Medical Corporation (HMC) for any emergency disasters that may take place during the FIFA World Cup Qatar 2022™ by evaluating their awareness (A), attitude (A), and readiness (R). Methods A cross-sectional quantitative o...

Background: The economic benefit of the clinical pharmacist's role in ensuring the optimum use of medicines is potentially considerable, particularly when it comes to cancer management. We sought to evaluate the overall economic impact of clinical pharmacist interventions in the main cancer setting in Qatar. Methods: The total economic benefit o...

Background The likelihood of elderly patients with heart failure (HF) being readmitted to the hospital is higher if they have a higher medication regimen complexity index (MRCI) compared to those with a lower MRCI. The objective of this study was to investigate whether there is a correlation between the MRCI score and the frequency of hospital read...

Background: Heart failure (HF) readmissions are common among elderly patients with a high medication regimen complexity index (MRCI) compared to patients with a low MRCI. This study aimed to find out if there is a link between the MRCI score and the number of times elderly HF patients have to go back to the hospital. Methods: This is a single-cent...

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gained global attention because of its high transmissibility and the devastating impact on both clinical and economic outcomes. Pharmacists are among the front-line healthcare workers who contributed widely to COVID-19 pandemic control. We aim to evaluate knowledge and at...

Background Routine utilization of evidence-based clinical practice guidelines (CPGs) is an effective strategy to optimize patient care and reduce practice variation. Healthcare professionals’ failure to adhere to CPGs introduces risks to both patients and the sustainability of healthcare systems. The integration of theory to investigate adherence p...

Introduction Linezolid is an oxazolidinone antibiotic with a reversible, non-selective monoamine oxidase inhibitory effect. Combining linezolid with serotonergic agents may increase serotonin syndrome (SS) risk. linezolid is recommended in patients with suspected or confirmed resistant gram-positive bacterial infections, especially if vancomycin ca...

Introduction: Linezolid is an oxazolidinone antibiotic with a reversible, non-selective monoamine oxidase inhibitory effect. Combining linezolid with serotonergic agents may increase serotonin syndrome (SS) risk. Secondary to its high tissue penetration, linezolid is recommended in patients with suspected or confirmed resistant gram-positive bacter...

Introduction: Linezolid is an oxazolidinone antibiotic with a reversible, non-selective monoamine oxidase inhibitory effect. Combining linezolid with serotonergic agents may increase serotonin syndrome (SS) risk. Secondary to its high tissue penetration, linezolid is recommended in patients with suspected or confirmed resistant gram-positive bacter...

Background: Clinical pharmacists play a key role in ensuring the optimum use of cancer medicines. Yet, the economic benefit of this role has never been assessed in Qatar. Aim: To evaluate the overall economic impact of clinical pharmacist interventions in the main cancer care setting in Qatar. Methods: From the public healthcare perspective, this w...

Background Studies have highlighted advancing clinical pharmacy practice in Qatar. Objective To explore pharmacists’ aspirations and readiness to implement pharmacist prescribing. Setting Hamad Medical Corporation (HMC), the main provider of secondary and tertiary care. Method A sequential explanatory mixed-methods design. Questionnaire items were...

Background Studies have highlighted advancing clinical pharmacy practice in Qatar. Objective To explore pharmacists’ aspirations and readiness to implement pharmacist prescribing. Setting Hamad Medical Corporation (HMC), the main provider of secondary and tertiary care. Method A sequential explanatory mixed-methods design. Questionnaire items were...

Objective: Exploring potential synergistic effect of darunavir/cobicistat (DRV/COBI) plus ribavirin (RBV) in COVID-19 treatment. Methods: Retrospective, observational comparison study conducted in Qatar. Adult patients with confirmed positive SARSCoV- 2 who received either DRV/COBI or DRV/COBI+RBV were included. Primary outcome was time to viral cl...

Purpose Use of ibuprofen for the patent ductus arteriosus (PDA) has become increasingly common. This study aimed to evaluate the clinical and economic impact of oral ibuprofen versus intravenous ibuprofen for PDA among preterm infants. Methods This retrospective, cohort-based pilot study examined the clinical and economic associations of oral vers...

Background: Unused medications in homes pose significant health, economic, and environmental risks. Patients are the medications end users and their knowledge, attitude, and practices (KAP) play an important role towards medication use, unuse and wastage. Thus, a valid instrument to reliably measure patients' KAP towards unused medications in homes...

Evidence‐based treatment involving multidisciplinary decision making is warranted to treat COVID‐19 in pregnancy. This case presents the management of a critically ill pregnant women infected with SARS‐CoV‐2.

Background In Qatar, the National Vision 2030 and the National Health Strategy 2018-2022 articulate the need to improve healthcare delivery by better utilisation of the skilled workforce. In this regard, pharmacy practice is rapidly advancing and several extended pharmacy services are now available in institutionalised settings. Objective This stud...

Background Medication errors are a major public health concern that negatively impact patient safety and health outcomes. Effective and efficient medication error reporting systems and practices are imperative in reducing error incidence and severity. Objective The objectives were to quantify the incidence, nature and severity of medication errors,...

Antimicrobial Resistance (AMR) is a major global concern, negatively impacting public health outcomes (1-5), patient safety (3,6-8) and poses enormous burden on economic development and security (8-16). Internationally, data suggests, at any given time, approximately one-third of the hospitalized patients and over two-thirds of critically ill patie...

Background: Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general population; however, there is scarcity of information related to pharmacological management and maternal and perinatal outcomes during...

Background As COVID-19 continues to infect women of all gestational ages; gravida in labor and the acutely ill parturient are particularly at higher risk of infection. No therapeutic agent or vaccine is approved to treat COVID-19 till date. Thus, managing COVID-19 and associated complications during pregnancy is often challenging and requires a mul...

Drug Safety in Developing Countries: Achievements and Challenges provides comprehensive information on drug safety issues in developing countries. Drug safety practice in developing countries varies substantially from country to country. This can lead to a rise in adverse reactions and a lack of reporting can exasperate the situation and lead to ne...

Background Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general population, however, there is scarcity of information related to pharmacological management, maternal and perinatal outcomes during the...

Background: An accumulation of international evidence demonstrates that pharmacist prescribing is effective, safe and well-accepted. While there is potential for such development in the Middle East, the majority of published studies are largely reported from Western countries and the perspectives of individuals in strategic positions of policy and...

This chapter introduces aspects of medication safety in the State of Qatar. It starts by presenting an overview of the geography and demographics of the population. There is then a description of key strategic national documents which guide national developments generally and health care specifically. The structure of health care within Qatar is ou...

Background There is an extensive evidence base of the effectiveness and safety of pharmacist prescribing around the globe. There is therefore potential to develop a framework to support the implementation in Qatar to achieve the National Vision 2030 of establishing a comprehensive world-class healthcare system by better utilisation of its healthcar...

Introduction: Hospital Antimicrobial Stewardship Programs (ASPs) Aim: to optimize the antimicrobial therapy by reducing inappropriate use of antibiotics, and thereby reducing antimicrobial resistance and improving patient’s clinical outcomes and quality of care. An estimated 40-60% of pregnant women worldwide receive antibiotics during pregnancy o...

Purpose The aim was to critically appraise, synthesise and present the evidence of medication errors amongst hospitalised patients in Middle Eastern countries, specifically prevalence, nature, severity and contributory factors. Methods CINAHL, Embase, Medline, Pubmed and Science Direct were searched for studies published in English from 2000 to Ma...

Background There is a need for theory informed interventions to optimise medication reporting. This study aimed to quantify and explain behavioural determinants relating to error reporting of healthcare professionals in Qatar as a basis of developing interventions to optimise the effectiveness and efficiency of error reporting. Methods A sequentia...

Background There is a lack of robust, rigorous mixed methods studies of patient safety culture generally and notably those which incorporate behavioural theories of change. The study aimed to quantify and explain key aspects of patient safety culture which were of most concern to healthcare professionals in Qatar. Methods A sequential explanatory...

Responses to each of the HSOPS composites. (DOCX)

Study questionnaire. (DOCX)

Adverse Drug Reactions (ADRs) are major global concern, adversely impacting patient safety and health outcomes. ADRs cause significant morbidity and mortality among hospitalised patients, causing greater length of hospital stay, increased healthcare costs and patient dissatisfaction to the treatments. Pharmacovigilance (PV), a process of detecting,...

Background: Medication use during pregnancy is common. Pharmacists have an important role in improving medication use during pregnancy. There is a lack of empirical evidence on pharmacists' knowledge and practice characteristics towards medication use in pregnancy. Objectives: This study aimed to determine the knowledge and practice characterist...

Background Pregnant women are routinely prescribed medicines while self-medicating with herbal natural products to treat predominantly pregnancy related conditions. The aim of this study was to assess the potential for herb-drug interactions (HDIs) in pregnant women and to explore possible herb-drug interactions and their potential clinical signifi...

We report a case of 22-year-old primigravida presented to Women’s Hospital – Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history sho...

Q

The third United Nations (UN) Sustainable Development Goal focuses on ensuring healthy lives and promoting well-being for people of all ages.[1][1] One target of this goal is to ensure access to safe, effective, quality, and affordable essential medicines and vaccines for everyone worldwide. While

Background and aim: Medication errors (MEs) are a major global issue, adversely impacting patient safety and health outcomes. Promoting patient safety through minimising MEs is therefore a key global healthcare objective. This study aims to systematically review the incidence, nature and causes of MEs in hospitalised patients in Middle Eastern coun...

Exploring medication error causality and reporting: a cross sectional survey of HMC health professionals Introduction Medication errors are a major global issue, adversely impacting patient safety and health outcomes. Promoting patient safety through minimizing medication errors is therefore a key global healthcare objective. The most widely used a...

Exploring medication error causality and reporting: a cross sectional survey of Hamad Medical Corporation health professionals Aim To quantify the views and attitudes of health professionals in Hamad Medical Corporation (HMC), Qatar, towards medication error causality and reporting. Description A recent systematic review of the literature on medica...

Background: Over the last decade academic interest in the prevalence and nature of herbal medicines use by pregnant women has increased significantly. Such data are usually collected by means of an administered questionnaire survey, however a key methodological limitation using this approach is the need to clearly define the scope of 'herbals' to...

Exemplar Antenatal CAM in Pregnancy Questionnaire. (DOC)

Table of Complementary and Alternative Therapies. Complementary and Alternative Therapies listed for the Question “Please tell us if you have used any of the following Complementary and Alternative Therapies?” (DOCX)

Table of Herbal Medicines and Products. Herbal Medicines and Products listed for the Question “Please tell us if you have used any of the following Herbal and Natural Products? (DOCX)

Introduction A medication error can be defined as “any error occurring in the medication use process” and focuses on problems with the delivery of medication to a patient [1]. Medication errors are a complex and ongoing issue that are of concern in all health care institutions [1]. Such errors range in severity but have been associated with an incr...

Introduction Medication errors are a major global issue, adversely impacting patient safety and health outcomes. Promoting patient safety through minimizing medication errors is therefore a key global healthcare objective. The most widely used and accepted definition of the term ‘medication error’ is that of the United States (US) National Coordina...

Background: There is a need to systematically develop research capacity within pharmacy practice. Hamad Medical Corporation (HMC) is the principal non-profit health care provider in Qatar. Traditionally, pharmacists in Qatar have limited training related to research and lack direct experience of research processes. Objectives: To determine the i...

Nausea and vomiting are common symptoms experienced by 50– 90% of women’s in early pregnancy. ‘Morning sickness’ is a misnomer frequently used to describe nausea and vomiting in pregnancy (NVP), although the symptoms may persist the whole day and/or night. Pregnant women experience these symptoms mainly in the first trimester between 6 and 12 weeks...

Case description: Hyperkalemia can cause altered cardiac electrical conduction resulting in death. We describe a case of a 23-year old pregnant patient who presented with severe epigastric pain and vomiting. She was severely pre- eclamptic and received initial treatment with intravenous labetalol and decision was taken to deliver. She quickly beca...

Background: There is little emphasis on pharmacy practice research in Qatar, with a lack of relevant education and training and a notable lack of exposure to processes of research. Objective: To describe views and attitudes of pharmacists in Qatar to pharmacy practice research prior to and following a 2 day introductory research workshop. Metho...

Introduciton: Neonatal sepsis is the leading cause of death in neonatal ICUs of hospitals. Because of wide use of broad spectrum antibiotics bacterial resistance pattern gets change from time to time. This study was aimed identify antibiotic susceptibility pattern of bacteria causing sepsis in neonatal intensive care unit (NICU) of Hamad Medical Co...

Tuberculosis (TB) hampered with poor patient compliance and intolerance at least partially due to adverse drug reactions (ADRs). A prospective observational and interventional healthcare teamwork study was carried out to implement a self-reporting pharmacovigilance system in TB patients through a knowledge based approach in the Pulmonology departme...

Abstract Background - Even with advancement in the care provided for patients in Neonatal Intensive Care Units (NICU) and wide spread use of antibiotics, sepsis remains an important cause of high mortality and morbidity. This study was done to determine the Incidence of bacterial isolates. Objective - We aimed to investigate bacterial pathogens cau...

The study is aimed to find out the prevalence, risk factors, maternal and fetal outcome of gestational diabetes mellitus. 222 women diagnosed with Gestational Diabetes Mellitus (GDM) for the period of 8 years from Januarys 2003 to December 2010 were taken into the study. Data on maternal and neonatal outcome, patient history and diabetic mana...