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Publications (36)
1,2,3-Thiadiazole, 1,2,3-selenadiazole, and semicarbazones that are prepared from ketones are promising moieties for lead compound development. New 1,2,3-thiadiazole (2c-4c) and 1,2,3-selenadiazole derivatives (2d–4d) were prepared from the corresponding semicarbazones (2b-4b). The semicarbazones (2b-4b) were prepared from the corresponding ketones...
Reactions of (dppe)NiCl2 (dppe = 1,2-bis(diphenylphosphino)ethane) with chlorido-substituted phenyl thiolates (RClS⁻) produced the corresponding nickel thiolate complexes (dppe)Ni(SRCl)2 (RCl = 3,5-C6H3Cl2 (1), C6Cl5 (2)) in high isolated yields. Complexes 1 and 2 were characterized by spectroscopic techniques such as (UV–Vis, IR, ¹H-, ³¹P{¹H}-, ¹³...
Thiadiazole compounds and their derivatives cause many structural, physiological and developmental changes as well as metabolic pathways associated with carbon and nitrogen metabolism and the redox state inside plant tissues. In this study, physiological and biochemical effects of 0, 5, 25 and 50 μg/L of synthetic 1,2,3-Thiadiazole [1,3-Bis[4-(1,2,...
New 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives, (4-[4-((4-bromobenzyl)oxy)-phenyl]-1,2,3-thiadiazole (5a), 4-[4-((4-chlorobenzyl)oxy)-phenyl]-1,2,3-thiadiazole (5b)), (4-[4-((4-bromobenzyl)oxy)-phenyl]-1,2,3-selenadiazole (6a), and 4-[4-((4-chlorobenzyl)oxy)-phenyl]-1,2,3-selenadiazole (6b)), were prepared and screened in vitro for their...
Glyoxalase-I (Glo-I) enzyme was established to be a valid target for anticancer drug design. It performs the essential detoxification step of harmful byproducts, especially methylglyoxal. A robust computer-aided drug design approach was used to design and validate a series of compounds with selenium or sulfur based heterorings. A series of in-house...
Jordan occupies the eighth place in oil shale reserve in the world. Prospective efforts are directed toward the production of fuel from shale. Analysis of oil shale samples will help in planning for energy strategies. Oil shale samples were collected from Wadi Ash Shallala at Yarmouk Basin. X-ray fluorescence spectrometer and X-ray diffraction show...
Several applications of chalcones and their derivatives encouraged researchers to increase their synthesis as an alternative for the treatment of pathogenic bacterial and fungal infections. In the present study, chalcone derivatives were synthesized through cross aldol condensation reaction between 4-(N,N-dimethylamino)benzaldehyde and multiarm aro...
Jordan occupies the eighth in oil shale reserve in the world. Prospective efforts are directed toward the production of fuel from shale. Analysis of oil shale samples will help in planning for energy strategies. Oil shale samples were collected from Wadi Ash Shallala at Yarmouk Basin. X-ray fluorescence spectrometer and X-ray diffraction showed tha...
A new series of 9-substituted-4,10-dimethylpyrano[2,3-f]cinnolin-2-ones (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l, 5m) were synthesized via intramolecular cyclization of the respective acyl amidrazone derivatives (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m), catalyzed by polyphosphoric acid. Compounds (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h,...
A new series of 9‐substituted‐4,10‐dimethylpyrano[2,3‐f]cinnolin‐2‐ones (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l, 5m) were synthesized via intramolecular cyclization of the respective acyl amidrazone derivatives (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m), catalyzed by polyphosphoric acid. Compounds (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h,...
Three derivatives of substituted 1,2,3-thia- or 1,2,3-selenadiazole (4a–c) were prepared and characterized by different chemical techniques. These compounds were evaluated for their antimicrobial and antitumor activities. Compounds 4a (propenoxide derivative), 4b (carbaldehyde derivative), and 4c (benzene derivative) were active against the yeast-l...
In this study, we investigated the physiological effects of three synthetic 1,2,3-thiadiazole compounds (compound I: 4-[1,2,3]-Thiadiazole-4-yl-phenol, compound II: 1,3-Bis[4-(1,2,3-thiadiazol-4-yl)phenoxy]propane, compound III: 4-(4-{2,3,4,5,6-Penta[4-(1,2,3-thiadiazole-4-yl)phenoxymethyl]benzyloxy}phenyl)-1,2,3-thiadiazole) treatments on plants v...
The chemical composition and antimicrobial activity of essential oils from the shoots of S. alba L. and S. arvensis L. (Brassicaceae) were examined. The essential oils of both plants had a pale yellowish color with a characteristic sulfury odor. GC/MS analysis of the essential oils revealed a complex mixture of compounds including aldehydes, nitril...
Five ruthenium complexes of the general type trans-[RuII(btd)(Azo)Cl2] ({Azo = PhN=NC(COMe) = NC6HY, where Y = H (a), Me (b), OMe (c), Cl (d) or Br (e)} and btd = 4,4′-bi-1,2,3-thiadiazole) have been prepared by the reaction of RuCl3 with the ligands in the presence of LiCl. These complexes have been characterized by spectroscopic (IR, UV–Vis, and...
The compounds of the present study are synthesized of disaccharides where
the link between the two carbohydrate groups via a 1,2,3,-triazole or triazoline groups one
type of sugars is unsaturated sugar which contained carbon carbon double bond inside the
ring , like 3,4,6 – tri acetyl glucal and 1,3,4,6,-tetra benzoyl fructal.Addition of seven
azid...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
1,2,3-Thiadiazoles with polymerizable functionalities in the 4-position were synthesized as potential negative photoresists. The polymerization to soluble, film-forming materials must leave the heterocyclic rings intact, because they are needed for photocrosslinking reactions to give insoluble materials. 1,2,3-Thiadiazoles 1 cycloeliminate N(2) on...
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New multiarm aromatic chalcone derivatives 2a , 2b , 2c , 2d were prepared through cross‐aldol condensation reaction between multiarm aromatic ketones 1a , 1b , 1c , 1d and 4‐(dimethyl amino)benzaldehyde in basic medium. The multiarm aromatic chalcones 2a and 2c were able to undergo cyclization reactions when treated with hydrazine...
The commercially available aromatic polyketones 1a-d were utilized for the synthesis of the multi-arm1,2,3-selenadiazole derivatives 3a-d. The preparation starts with the reaction between compounds 1a-d and p-toluenesulfonyl hydrazide to give the corresponding tosylhydrazones 2a-d. Subsequent reaction with selenium dioxide leads to regiospecific ri...
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The diketones 2a‐d with different alkyl chain length are used for the synthesis of di‐1,2,3‐thia or selenadiazole derivatives 4a‐d and 5a‐d . The diketones 2a‐d where prepared by a unique method through the reaction between the corresponding dibromoalkanes 1a‐d and ethyl acetoacetate, which are transformed into the corresponding sem...
New dendrimers 1c-4c with multi-arm 1,2,3-thiadiazole systems 1a-4a have been prepared and characterized. Alkaline cleavage of 1a-4a led to the corresponding alkynethiolate 1b-4b, which were trapped by electrophiles such as Fréchet's[G-3]-Br to furnish the third-generation dendrimers. The advantage of the use of 1a-4a as nucleophilic core reagents...
The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydroc...
The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydroc...
The many fold aromatic ketones 2a-d are versatile compounds for the synthesis of the many fold 1,2,3-selenadiazole aromatic derivatives 5a-d. The preparation starts with the reaction between the many fold bromomethylene benzene derivatives 1a-d and 4-hydroxyacetophenone, which are transformed through the reaction with semicarbazide hydrochloride or...
New 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives, 14-23, were prepared from the ketones 1-5 via the corresponding semicarbazones or hydrazones 6-12. The Hurd-Mori and Lalezari methods were used, respectively, for the preparation of these 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives. The intermediate 13 was also trapped, separated...
The identification of a new anthocyanin species, cyanidin-3-O-arabinosylglucoside is presented. The compound is chemically extracted from the flowers of pheasant's eye petals (Adonis aestivalis L.) followed by chromatographic, HPLC and preparative HPLC separation. Chemical structures of the aglycon, cyanidin part and the sugar moieties, glucose-ara...
The lesions in rumens of goats with soft foreign bodies (SFB), namely plastics, and its prevalence in Jordan are investigated. In cases where hard masses of plastics were seen, congestion, erosions, focally denuded areas and focal thickening of nodular- and proliferative-type were seen in the mucosal wall of the rumen. Shortening and stunting of th...
Benzene derivatives 2a–c with 6, 4, and 3 side chains bearing terminal 1,2,3-thiadiazole rings, respectively, have been prepared. Alkaline cleavage of 2a–c led to the corresponding alkynethiolates 6a–c, which were trapped by electrophiles such as benzyl bromide or iodomethane. The method provides an alternative to the thermal or photochemical cleav...
A series of compounds 3a-d,i-n with two or three 1,2,3-thiadiazole rings, useful for photocrosslinking processes, was prepared from the di- or triketones 1a-d,i-n via the corresponding hydrazones 2a-d,i-n by applying the Hurd-Mori method. A special synthetic sequence, 1e, 2e, 3e, 3f/3g, was elaborated for the olefinic system 3h.
The phosphonium salts 4 are versatile reagents for the synthesis of 1,2,3-thiadiazoles 6 with unsaturated side chains. The preparation Starts with the a-chloroketones 1 which are transformed in a stepwise process to the phosphonium salts 2 and 3. The reaction with SOCl2 leads to a regioselective ring closure 3→4. Subsequent Wittig reactions yield t...
Thesis (doctoral)--Johannes Gutenberg-Universität in Mainz, 1998.
