
Mourad AribiAbou Bakr Belkaid University of Tlemcen · Biology Department - Immunology Team
Mourad Aribi
PhD, Dr. Hab., HDR, Professor of Immunology
Modulation of cell-mediated and inflammatory immune responses in autoimmune diseases, cancer, and infectious diseases.
About
89
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Introduction
Dr. Mourad Aribi, PhD, Dr. Hab., is a professor of Immunology at the University of Tlemcen (Algeria). He is also the founder and director of the Laboratory of Applied Molecular Biology and Immunology. His creativity allowed him to construct for the first time Bachelor's, Master’s and PhD training programs in immunology at his university, welcoming students and young researchers from different regions and countries.
Additional affiliations
Publications
Publications (89)
Background:
Dietary selenium is of fundamental importance to maintain optimal immune function and enhance immunity during infection. To this end, we examined the effect of selenium on macrophage bactericidal activities against Staphylococcus aureus.
Methods:
Assays were performed in golden Syrian hamsters and peritoneal macrophages cultured with...
Background:
The bioactive form of vitamin D3, i.e.1,25-dihydroxyvitamin D3 (1,25(OH)2D3) vitamin D has been shown to modulate monocytes/macrophages physiology and their response against bacterial infections. Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterial pathogen that can most frequently be fatal in immunocompromised infected...
Background:
Red blood cells (RBCs) can have a modulatory effect on immune cells; so changes in their dynamism could considerably influence their physiology, and consequently the immune activities of neighbouring cells, like natural killer (NK) cells. Herein, we studied the effect of both RBCs and lack of cell movement on the proliferation, surviva...
Background:
Vitamin C (ascorbic acid, AscH2) has been shown to enhance immunity. Here, we studied its immunomodulatory effect on human endothelial cells (ECs) during S. aureus infection.
Materials and methods:
The ex vivo effects of AscH2 were performed on primary human umbilical vein endothelial cells (HUVECs) infected or not with S. aureus.
R...
New Topics in Vaccine Development explores the latest advancements and future directions in vaccinology across 11 chapters, each addressing a different and specific facet. This book is an essential resource for clinicians, researchers, scientists, and students in immunology aiming to deepen their understanding of this crucial field.
Vaccinology, the scientific discipline focused on vaccines, has evolved from combating infectious diseases to addressing a wide array of a broad spectrum of health concerns, including autoimmune disorders, neurodegenerative diseases, and allergies, with promising therapeutic vaccines for cancer utilizing tumor-infiltrating lymphocytes (TILs) and ad...
Staphylococcus aureus (S. aureus), often perceived as an extracellular pathogenic agent, exhibits a remarkable ability to penetrate host cells, including endothelial, epithelial, and osteoblastic cells, significantly contributing to the pathogenesis of infections. A significant pathway for this invasion appears to involve the bacterium's binding to...
The book Probing Selected Autoimmune Diseases for Focused Perspectives provides an in-depth exploration of complex autoimmune disease landscapes, encompassing conditions such as myasthenia gravis, hepatosplenomegaly, autoimmune rheumatic diseases, Buerger's disease, and autoimmune thyroid diseases. Structured into six informative chapters, it initi...
The advent of next-generation sequencing (NGS) technologies has greatly expanded our understanding of both the clinical spectra and genetic landscape of inborn errors of immunity (IEIs). Endogamous populations may be enriched for unique, ancestry-specific disease-causing variants, a consideration that significantly impacts molecular testing and ana...
This page is a summary of: Dietary vitamin D intake and sun exposure are not associated with type 1 diabetic schoolchildren and adolescents: A first report in Algeria, Mediterranean Journal of Nutrition and Metabolism, July 2023, IOS Press, DOI: 10.3233/mnm-230012.
BACKGROUND: A large number of children and adolescents worldwide suffer from physiological vitamin D (VD) deficiency, which has been associated with sun exposure and, consequently, the risk of developing various autoimmune diseases, including type 1 diabetes (T1D). However, the association of the disease with VD intake and sun exposure has yet to b...
The advent of next-generation sequencing (NGS) technologies has greatly expanded our understanding of both the clinical spectra and genetic landscape of inborn errors of immunity (IEIs). As history has shown and recent large-scale studies of monogenic risk for severe COVID have confirmed, endogamous populations may be enriched for unique, ancestry-...
Aim:
The study aims to show that sodium selenite (SS) would have an immunomodulatory effect on the functional activity of proinflammatory macrophages (Mφs) during their extended extracellular activation at the onset of human type 1 diabetes (T1D).
Background:
Exacerbated activation of proinflammatory "M1" macrophages (Mϕs) can promote chronic lo...
Background
A great number of children and adolescents worldwide suffer from physiological Vitamin D (VD) deficiency, which has been associated to the sun exposure and, consequently, to the risk of the development of various autoimmune diseases, including type 1 diabetes (T1D). However, the association of the disease with VD intake and sun exposure...
Objectives
We examined the influence of the ex vivo combination therapy of metformin (Met, 1,1-dimethylbiguanide hydrochloride) with sodium selenite (Ss, Na ² SeO ³ ) on the changes in the production of nitric oxide (NO) and selected cytokines by circulating monocytes (MOs) during T-cell acute lymphoblastic leukemia (T-ALL).
Methods
Assays were pe...
Neonatal sepsis constitutes a highly relevant public health challenge and is the most common cause of infant morbidity and mortality worldwide. Recent studies have demonstrated that during infection epigenetic changes may occur leading to reprogramming of gene expression. Post-transcriptional regulation by short non-coding RNAs (e.g., microRNAs) ha...
An amendment to this paper has been published and can be accessed via the original article.
Background
Immune activities of monocytes (MOs) can be altered within the microenvironment of solid malignancies, including breast cancer. Metformin (1,1-dimethylbiguanide hydrochloride, MET), has been shown to decrease tumor cell proliferation, but its effects have yet to be explored with respect to MOs (monocytes) activity during their crosstalk...
Background:
Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult, where haemoculture is the gold standard for detecting bacterial sepsis in blood culture. It is also very difficult to study bec...
Introduction
La sclérose en plaques (SEP) est une maladie neurodegenerative auto immune et inflammatoire. Aucune étude ne s’est intéressée à évaluer les acides aminés (AA) au cours de la SEP, alors que leurs rôles dans l’immunité est bien élucidé.
Objectifs
Déterminer le profil plasmatique des AA au cours de la SEP.
Patients et méthodes
C’est une...
Background: Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult, where haemoculture is the gold standard for detecting bacterial sepsis in blood culture. It is also very difficult to study beca...
Background: Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult, where haemoculture is the gold standard for detecting bacterial sepsis in blood culture. It is also very difficult to study beca...
Background: Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult, where haemoculture is the gold standard for detecting bacterial sepsis in blood culture. It is also very difficult to study beca...
Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell...
PLENARY CONFERENCES │
- Skin and oral cavity. Prof. Omar Boudghene Stambouli
- Screening and diagnosis approach of oral mucosal lesions. Prof. Badr-Eddine Sari
- Seroprevalence of Neutralizing Antibodies against Adenovirus type 5 and 26 and 35 in Healthy and HIV Infected Adults and Childrenin Burkina Faso and Republic of Chad: Impact on the use of...
Background
Immune activities of monocytes (MOs) can be altered within the microenvironment of solid malignancies, including breast cancer. Metformin (1,1-dimethylbiguanide hydrochloride, MET), has been shown to decrease tumor cell proliferation, but its effects have yet to be explored with respect to the crosstalk between monocytes and breast cance...
The generation of antigen receptor diversity, and thus of the B-cell repertoire, is the result of very complex immunogenetic mechanisms. So, this chapter gives a brief overview on immunoglobulin (IG) gene organization and gene rearrangements , as well as the main mechanisms of immunoglobulin repertoire development.
Background
Monocytes are the main blood innate mononuclear phagocyte and one of the most important effector cells expressing Fcγ receptor, which is critical for the interaction with Fc domain of antibodies.
Objective
To evaluate the effect of Rituximab (RTX, a chimeric human anti-CD20 monoclonal antibody) on the functional activities of Monocytes...
Objectives: We evaluated the effects of metformin (Met, 1,1‐dimethylbiguanide hydrochloride) combined or not with sodium selenite (Ss, Na2SeO3) on the functional activities of LPS-activated GM-CSF monocyte-derived macrophages (GM-MDM).
Materials and methods: Human GM-MDMs from three healthy donors were treated with Met or Ss alone, or with the comb...
Normal T-cell differentiation requires a complex regulatory network which supports a series of maturation steps, including lineage commitment, T-cell receptor (TCR) gene rearrangement, and thymic positive and negative selection. However, the underlying molecular mechanisms are difficult to assess due to limited T-cell models. Here we explore the us...
In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n Z 45) and older (n Z 40) obese men and compared to those in young (n Z 65) and older (n Z 55) normal weight controls. The purpose was to determine whether obesity exacerbates or not lipid, lipoprotein abnormalities and oxidative stress...
Motivation
While Python has become very popular in bioinformatics, a limited number of libraries exist for fast manipulation of gene coordinates in Ensembl GTF format.
Results
We have developed the GTF toolkit Python package (pygtftk), which aims at providing easy and powerful manipulation of gene coordinates in GTF format. For optimal performance...
Several studies have demonstrated that LncRNAs can play major roles in cancer development. The creation of a catalog of LncRNAs expressed in T cell acute lymphoblastic leukemia (T-ALL) is thus of particular importance. However, this task is challenging as LncRNA expression is highly restricted in time and space manner and thus may greatly differ be...
Antitumor activity of classically activated macrophage (Mϕ) may be impaired within the tumors, spleen, and bone marrow. Thus, it is possible to boost its antitumor activity after its pulsing with necrotic tumor cell lysates combined with an adjuvant. We set out to determine the potential adjuvant effects of thymoquinone (TQ; 2-isopropyl-5-methyl-1,...
The search for the bactericidal activity of macrophage (Mϕ) is crucial not only during infection, but also to explore its functional activities in normal and pathological conditions, such as autoimmune and inflammatory disorders, allergic inflammation, and cancer. There are several methods exploring the phagocytic and bactericidal activities of Mϕ....
The book Natural Killer Cells is the result of a collective work that addresses in a clear and comprehensive way for readers and through as many sensuous details as possible, the most and various fundamental aspects of natural killer cells, as well as their clinical applications in cancer immunotherapy. This book will serve as an invaluable resourc...
We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-mucosal venous malformations (VMCM). Eligible patients from twelve families and thirty healthy controls were recruited respectively at the...
Background:
Both CD4(+) T cells and macrophages are mainly involved in the autoimmune-mediated β-cells destruction in type 1 diabetes (T1D). The aim of this study was to examine the effect of HDL on functional activities of macrophage and its ability to regulate the production of cytokines in autologous mixed macrophage/CD4(+) T cells at the recen...
The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, auto...
Induction of antitumor immunity by vaccination is one of the major current immunotherapy strategies. We present a mathematical model of the competition between immune cells and mammary carcinogenesis under the effect of Triplex vaccine. The model describes both humoral and cell-mediated immune responses against cancer cells. The control of the canc...
Background:
Type 1 diabetes (T1D) is associated with an imbalance between inflammation and repair. Recently, the biologically active form of vitamin D3, i.e. 1,25(OH)2D3, has been reported to have potent immunomodulatory effects on both innate and adaptive immune cells, as well as on the production of their specific cytokines.
Methods:
We examin...
Obesity is a major public health problem. An in-depth knowledge of the molecular mechanisms of oro-sensory detection of dietary lipids may help fight it. Humans and rodents can detect fatty acids via lipido-receptors, such as CD36 and GPR120. We studied the implication of the MAPK pathways, in particular, ERK1/2, in the gustatory detection of fatty...
IIIème workshop du laboratoire BIOMOLIM - Immunoinformatique -
Analyse du transcriptome par approches haut-débit
Objective
The aim of this study was to highlight the clinical association of baseline levels of conjugated dienes in low-density lipoprotein (LDL-BCD) and nitric oxide (NO) with immunoglobulins (Igs) and T helper (Th)1/Th2 ratio in patients with newly diagnosed B-cell non-Hodgkin lymphoma (NHL).
Patients and methods
Thirty-two newly diagnosed pati...
. The aim of this study was to investigate the relationship between the circulating IL-6 and leptin levels with taste alteration in young obese patients.
Methods
. A retrospective case-control study was conducted in thirty obese patients and thirty age- and sex-matched healthy controls.
Results
. Circulating levels of IL-6 and leptin were significa...
the First International Congress of Immunology and Molecular Immunopathology (CIMIP2014) <http://cimip2014.univ-tlemcen.dz/>
The effect of pesticides on nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), including its level and relationship with the T helper 1 (Th1)/Th2 ratio, in patients suffering from non-Hodgkin lymphoma (NHL) was investigated. One hundred newly diagnosed patients with aggressive NHL (53 men, 47 women) and 40 healthy age-, sex-, and body ma...
Background and aims To assess the levels of lipid peroxidation and circulating levels of nitric oxide (NO), lipoproteins and immunoglobulins in type 1 diabetes children.
Methods Thirty (30) type 1 diabetic patients newly diagnosed and 30 healthy control subjects, comparable for age (less than 15 years), sex and body mass index (BMI) were recruited...
Background and aims To investigate whether the anomalies affecting the antioxidant defenses could start at birth and to check the decrease in antioxidant defenses in macrosomic newborns.
Methods Thirty macrosomic and 30 sex-matched control newborns were recruited for a retrospective case-control study at the Maternity of Tlemcen University Hospital...
Background and aims Type 1 diabetes (T1D) is an autoimmune disease that results from the progressive and selective destruction of pancreatic beta cells. Trace elements have a key role as well as in adaptive immunity in inflammatory processes. The aim of this study was to measure circulating levels of Zinc (Zn), Copper (Cu), and protein fractions in...
The artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease.
We present a mathematical model of the competition between immune system cells and mammary carcinogenesis under the effect of a vaccine (Triplex).
The model describes both the humoral and cellular response of the imm...
Multiple myeloma ( MM ) is an incurable disease until today, its prognosis remains formidable and the only significant improvement is the use of intensive treatment with stem cell support. To evaluate the diet and determine the frequency of monoclonal antibodies and circulating levels of CRP, complement C3 and gamma globulin in patients with MM und...
Background. Venous malformations (VM) result from an error in vascular morphogenesis. The first gene suspected in their development is the TEK gene (tyrosine kinase, endothelial). Mutations of this gene have been identified in several Belgian families with a dominant form of the disease. Therefore, we investigated whether mutations in this TEK gene...
Behcet's disease (BD) is a multisystem inflammatory disease, characterized by recurrent, oral and genital ulceration, skin lesions and uveitis. Several publications in the last decades showed the complex role of genetic factors; recent studies have revealed that SNPs of the IL10 gene promoter are associated with BD in various populations.
Objective: We have conducted the first study of the association of interleukin (IL)-10, tumor necrosis factor alpha (TNF-α), and IL23R-IL12RB2 region single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in Western Algeria.
Methods: A total of 51 BD patients and 96 unrelated controls from West region of Algeria were genotyped by direct...
Background: Non-Hodgkin lymphoma (NHL) is the seventh most common cancer in the world. They are malignancies that develop from lymphoid cells. Selenium can modulate the expression of multiple cellular signaling pathways leading to decreased inflammatory gene expression.
Objectives: To determine the relationship between selenium intake and inflammat...
Background To investigate whether the anomalies affecting the antioxidant defenses could start at birth and to check the decrease in antioxidant defenses in macrosomic newborns.
Material and Methods Thirty macrosomic and 30 sex-matched control newborns were recruited for a retrospective case-control study at the Maghnia Maternity Hospital of Tlemce...
Non-antigen-specific tolerance-based clinical trials for type 1 diabetes.AAT: alpha 1-antitrypsin (Aralast NP); Alemtuzumab: anti-CD52 monoclonal antibody (Campath 1H®); ATG: anti-thymocyte globulin; Auto ODN DC: autologous dendritic cells treated ex vivo with the mixture of the antisense oligodeoxynucleotides; Auto UCB: autologous umbilical cord b...
This study aimed to investigate whether the anomalies affecting the antioxidant and humoral immune defenses could start at birth and to check whether the decrease in antioxidant defenses may precede the immune abnormalities in macrosomic newborns.
Thirty macrosomic and 30 sex-matched control newborns were recruited for a retrospective case-control...
In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls. The purpose was to determine whether obesity exacerbates or not lipid, lipoprotein abnormalities and oxidative stress...
Background: The casein is the main protein that appears to be involved in childhood diseases caused by the consumption of adapted infant-milk formula (IMF).Objective: To measure the effect of casein of one of the most adapted IMF marketed in Algeria, on the proliferation of lymphocytes, granulocytes and cells MID and on the change in lipid profile....
To show that lipid and lipoprotein levels and cell sodium and potassium content and transport could change depending on the degree of hypertension.
Forty-three hypertensive patients and 20 healthy subjects were recruited at the Cardiology and Biochemistry Departments of Tlemcen University Hospital Centre (Northwest of Algeria).
Levels of CHOL, TG,...
Support for non-Hodgkin's lymphoma (NHL) with large cells that is refractory or relapsed after first-line chemotherapy poses a greater therapeutic problem with bone marrow transplant therapy or when old age is a contra-indication for high-dose chemotherapy, especially among developing countries such as Algeria.
To show that the regimen, including g...
Background: Myoepitheliomas are rare tumors and infrequently develop in the skin. These tumors are often recurrent and difficult to diagnose and therefore require immunohistochemical staining. Case Report: The case of a 45-year-old male patient presenting to the Otorhinolaryngology Department of Tlemcen University Medical Center in northwest Algeri...
Type 1 diabetes (T1D) is an autoimmune disease resulting from pancreatic beta-cells destruction, often appearing on a genetic ground susceptibility under the influence of one or more environmental factors. Multiplex families studies, using genetic markers allowed the identification of various genes, including HLA, insulin, SUMO-4 and CTLA-4 all bei...
Background: Vascular malformation is extremely rare, yet has a profound impact on quality of life, aesthetic and functional disorders. Aim: To show that endogamy and consanguinity may represent risk factors for labial venous malforma-tion (LVM) development. Materials and Methodology: Among the 18093 scrutinized families on a 20 years back period fr...
The auto-immune response leading to type 1 diabetes (T1D) is closely associated with the overproduction of T helper-1 (Th1) cytokines which activate macrophage production of inflammatory mediators such as interleukin (IL)-1beta. The principal aim of this study was to elucidate whether IL-1beta is associated with the development of the inflammatory...
The main genomic region controlling the predisposition to type 1 diabetes is the Human Leukocyte Antigens (HLA) class II of the major histocompatibility complex. Association with different HLA types depends also on the studied populations. In our investigation, we tried to measure the phenotypic HLA class II association frequencies of DR3 and/or DR...
In the pyramidal cell layer of the CA1 region of the hippocampus in the urethane-anesthetized adult rat, there is an initial alkalinization followed by an acidification in response to synchronized seizure activity induced by stimulus trains. In this study, the role of astrocytes in these extracellular pH changes during neuronal activity was examine...