Mounica Y Rao

Mounica Y Rao
Children's Hospital Los Angeles | CHLA · Department of Pediatrics

Doctor of Medicine

About

16
Publications
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184
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Publications

Publications (16)
Article
Full-text available
P2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS-primed macrophages. The role of potassium and calcium in inflammasome regulation is not well understood, largely due to limitations in existing methods for interrogating potassium in real...
Article
Full-text available
The inflammasome is a caspase-1-activating complex that is implicated in a growing number of acute and chronic pathologies. Interest has increased in identifying small molecular inhibitors of inflammasome signaling because of its role in clinically relevant diseases. It was recently reported that the protein tyrosine kinase, Syk, regulates pathogen...
Article
Purpose (1) To characterise changes in dead space fraction during the first 120 post-operative hours in neonates undergoing stage 1 palliation for hypoplastic left heart syndrome, including hybrid procedure; (2) to document whether dead space fraction varied by shunt type (Blalock–Taussig shunt and Sano) and hybrid procedure; and (3) to determine t...
Article
Full-text available
BACKGROUND: Bacillus Calmette-Guerin (BCG) is the recommended therapy for high and intermediate risk non-muscle invasive bladder cancer (NMIBC), but treatment failure is common. While a radical cystectomy is recommended after BCG failure, some patients desire bladder preservation and others are poor surgical candidates. Salvage chemotherapy treatme...
Article
We compared cardiac findings in patients with multisystem inflammatory syndrome in children and Kawasaki disease in the first 6 months of the 2020 coronavirus disease pandemic to patients with Kawasaki disease during 2016-2019. We saw a high rate of coronary aneurysms in 2020, with a similar rate of coronary involvement but greater volume and incid...
Preprint
This is the first report specifically describing outcomes of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation. One hundred forty-four cardiac catheterizations were identified that met inclusion criteria at our institution from 11/2014-10/2019. The median age and weight of the patients were 6.3 [0.01-20...
Article
Introduction: Rescue intravesical therapies for BCG failure non-muscle invasive bladder cancer (NMIBC) patients remain a critical focus of ongoing research. Sequential intravesical gemcitabine and docetaxel (Gem/Doce) has shown safety and efficacy in 2 retrospective, single institution cohorts. This doublet has since been adopted as an intravesica...
Article
Full-text available
Background: The objective of this work was to examine current oxygenation index (OI) data and outcomes using electronic medical record data to identify a specific OI value associated with mortality. Methods: This study was a retrospective electronic medical record data review from the pediatric ICU of Phoenix Children's Hospital, with data minin...

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Sensitive regulation of ion gradients is necessary to mediate rapid activation of the inflammasome for innate immune response, while also preventing aberrant activation and disease. The role of potassium and calcium gradients in the regulation of inflammasome signaling has been an area of great interest to groups studying all aspects of inflammasome biology and its relevance to disease. Here, we developed and applied tools to interrogate the specific roles of potassium and calcium in real-time in living cells stimulated to undergo inflammasome activation.