Moudachirou Ibikounlé

Moudachirou Ibikounlé
University of Abomey-Calavi | UAC · Centre de Recherche pour la lutte contre les Maladies Infectieuses Tropicales (CReMIT)

Professor

About

91
Publications
23,260
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Introduction
Epidemiology, Control and Elimination of NTD: Lymphatic Filariasis, schistosomiasis and STH Vector control. Currently site PI for Deworm3 project led by Judd WALSON from UW, Seattle, USA and funded by BMGF,

Publications

Publications (91)
Article
Full-text available
Objectives Current guidelines for the control of soil-transmitted helminths (STH) recommend deworming children and other high-risk groups, primarily using school-based deworming (SBD) programmes. However, targeting individuals of all ages through community-wide mass drug administration (cMDA) may interrupt STH transmission in some settings. We comp...
Article
Full-text available
Background Recent evidence suggests that community-wide mass drug administration (MDA) may interrupt the transmission of soil-transmitted helminths (STH), a group of intestinal worms that infect 1.5 billion individuals globally. Although current operational guidelines provide best practices for effective MDA delivery, they do not describe which act...
Article
Full-text available
Objectives Current soil-transmitted helminth (STH) morbidity control guidelines primarily target deworming of preschool and school-age children. Emerging evidence suggests that community-wide mass drug administration (cMDA) may interrupt STH transmission. However, the success of such programmes depends on achieving high treatment coverage and uptak...
Preprint
Background Soil Transmitted Helminths (STH) infect over 1.5 billion people globally and are associated with anemia and stunting, resulting in an annual toll of 1.9 million Disability-Adjusted Life Years (DALYs). School-based deworming (SBD), via mass drug administration (MDA) campaigns with albendazole or mebendazole, has been recommended by the Wo...
Article
Full-text available
Background Despite several years of school-based MDA implementation, STH infections remain an important public health problem in Benin, with a country-wide prevalence of 20% in 2015. The DeWorm3 study is designed to assess the feasibility of using community-based MDA with albendazole to interrupt the transmission of STH, through a series of cluster...
Article
Full-text available
Background Current soil-transmitted helminth (STH) control programs target pre-school and school-age children with mass drug administration (MDA) of deworming medications, reducing morbidity without interrupting ongoing transmission. However, evidence suggests that STH elimination may be possible if MDA is delivered to all community members. Such a...
Article
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Cercarial emission of schistosomes is a determinant in the transmission to the definitive host and constitutes a good marker to identify which definitive host is responsible for transmission, mainly in introgressive hybridization situations. Our goal was to test the hypothesis that micro-mammals play a role in Schistosoma haematobium, S. bovis, and...
Article
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Background An estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635...
Article
Background Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/−G genes in malaria. We evaluated the entire HLA-E/-F/−G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods 154 unrelated children were followed-up for six months and evaluated for the presence and number of malar...
Article
Full-text available
Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi and Benin. In this article, we describe an approach which uses a combination of statistical and mathematical me...
Article
Full-text available
Global efforts to control morbidity associated with soil-transmitted helminth infections (STH) have focused largely on the targeted treatment of high-risk groups, including children and pregnant women. However, it is not clear when such programs can be discontinued and there are concerns about the sustainability of current STH control programs. The...
Article
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Human Leucocyte antigen‐C (HLA‐C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA‐C has a dual function since it also interacts with KIR receptors expressed in NK and T cells, modulating their activity. The structure and diversity of the HLA‐C regulatory regions, as well as th...
Preprint
Full-text available
Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi and Benin. In this paper, we describe an approach which uses a combination of statistical and mathematical meth...
Preprint
Full-text available
Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi and Benin. In this paper, we describe an approach which uses a combination of statistical and mathematical meth...
Article
Full-text available
We developed an electronic treatment register for the DeWorm3 Project, a cluster-randomised, controlled trial in Benin, India, and Malawi testing the feasibility of interrupting transmission of soil-transmitted helminths through community-wide mass drug administration. The electronic treatment register was designed in xlsform, deployed via the Surv...
Article
Full-text available
Schistosomiasis remains a parasitic infection which poses serious public health consequences around the world, particularly on the African continent where cases of introgression/hybridization between human and cattle schistosomiasis are being discovered on a more frequent basis in humans, specifically between Schistosoma haematobium and S. bovis. T...
Article
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The World Health Organization’s Neglected Tropical Disease Roadmap has accelerated progress towards eliminating select neglected tropical diseases (NTDs). This momentum has catalyzed research to determine the feasibility of interrupting transmission of soil-transmitted helminths (STH) using community-wide mass drug administration (MDA). This study...
Article
Aims: Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. Methods and results: 268 children...
Article
Full-text available
Background Lymphatic filariasis (LF) is still a public health burden in many developing countries. In Benin, a West African country, at least 6.6 million people are at risk for LF. With the goal of eliminating LF by 2020, mass drug administration (MDA) has been scaled-up during the last decade. Currently, 23 districts are believed to have eliminate...
Article
Background: A national mapping of human schistosomiasis was conducted in Benin to provide the baseline epidemiological data required to implement the national strategy for schistosomiasis control and elimination to achieve the WHO’s goal of reaching at least 75% of school-age children in endemic areas by 2020. Methods: Parasitological surveys were...
Article
Full-text available
The present study provides an outset of information on parasites infection in Oreochromis niloticus from fish farm and a tributary of the Ouémé River in the Benin southern region. The work was carried out between August and December 2015. A total of 171 specimens of different sizes and body weight were examined for the occurrence of external and in...
Article
Full-text available
Background: The Plasmodium falciparum transmission occurs mainly at night. Anopheles mosquitoes that transmit P. falciparum are those that have taken blood feed and laid eggs several times. Unfortunately, the biting behavior of these mosquitoes is little known. This study aims to assess the impact of the biting behavior of multiparous vectors on ma...
Poster
Full-text available
Schistosomiasis is one of the most widespread neglected tropical diseases (NTD) in the world and is considered a poverty-related disease. Benin conducted mapping of schistosomiasis infections from 2013 to 2015, in all districts. This mapping aimed to provide basic epidemiological data essential for implementation of the national strategy for schist...
Article
Full-text available
The study focused on the characterization and quantification of the effects of coccidiosis on intensive rearing of Clarias gariepinus production. The first phase of works, performed on 117 specimens of C. gariepinus consisted of the collection of oocysts of Coccidia which served as inoculum. The experimental phase was conducted on 81 juvenile of C....
Article
Indoplanorbis exustus is a freshwater snail known as the intermediate host of various trematode parasites, including different species of the genus Schistosoma. Although its genetic diversity is well described in Asia, the phylogenetic diversity of strains from Africa and Guadeloupe (French West Indies) and their relationship to Asian and South‐Eas...
Article
Full-text available
Background National mapping of soil-transmitted helminth infections (STH) was conducted for the first time in all of the 77 districts of Benin (West Africa) from 2013 to 2015. This mapping aimed to provide basic epidemiological data essential for the implementation of the national strategy against the neglected tropical diseases (NTDs) in the conte...
Data
Geographical positions of the surveyed schools during the mapping in 77 districts in Benin. UTM: Universal Transverse Mercator. (DOCX)
Data
Prevalence of three STH infections by sex. (DOCX)
Article
Full-text available
Hybrid trials that include both clinical and implementation science outcomes are increasingly relevant for public health researchers that aim to rapidly translate study findings into evidence-based practice. The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH),...
Article
Full-text available
Current control strategies for soil-transmitted helminths (STH) emphasize morbidity control through mass drug administration (MDA) targeting preschool- and school-age children, women of childbearing age and adults in certain high-risk occupations such as agricultural laborers or miners. This strategy is effective at reducing morbidity in those trea...
Article
Full-text available
Hybrid trials that include both clinical and implementation science outcomes are increasingly relevant for public health researchers that aim to rapidly translate study findings into evidence-based practice. The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH),...
Article
HLA-G/E/F genes exhibit immunomodulatory properties and are expressed in placenta. Little attention has been devoted to the study of these genes in sub-Saharan African populations, which are yet the most diverse. To fill this gap, we evaluated the complete gene variability, approximately 5.1 kb for HLA-G (n = 149), 7.7 kb for HLAE (n = 150) and 6.2...
Article
Full-text available
Lagoon areas maintain ideal water conditions for mosquito breeding habitats and are thus environments with high risk of malaria transmission. In Benin, several administrative units, among which the Sô-Ava District, are located in lagoon areas. We conducted entomological surveys in this lagoon district from July 2014 to June 2015, in order to update...
Article
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Notwithstanding the nutritional, economic and fisheries importance of Chrysichthys nigrodigitatus, and its relatively high abundance and propagation in Lake Ahozon (South Benin), nothing is known about the well-being of the species in this water body. Thus, this study investigated length and weight frequency distributions, length-weight relationshi...
Article
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Lymphatic filariasis (LF) is a parasitic disease that is endemic throughout sub-Saharan Africa, infecting approximately 40 million people. The aim of this study was to determine effect of Ivermectine and Albendazole on microfilaraemia in 10 communes that have completed 5 rounds of MDA in Benin. The study was both retrospective and prospective. The...
Article
Background: Schistosomiasis (SCH) and soil-transmitted helminthiasis (STH) are widely distributed in the Democratic Republic of the Congo (DRC) and constitute a serious public health problem. As recommended by the World Health Organization (WHO), before launching mass chemotherapy to control these diseases, parasitological surveys were conducted i...
Conference Paper
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La faune aquatique souterraine du Bénin peut être considérée comme totalement inconnue à l'heure actuelle. Or, il apparaît de plus en plus que les eaux souterraines, en général, constituent un écosystème majeur en termes de diversité biologique, d'endémisme et d'espèces reliques. Pour cette raison, la stygofaune du Bénin a fait l'objet d'une prospe...
Article
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In 2013, Benin developed strategies to control neglected tropical diseases and one of the first step was the disease mapping of the entire country in order to identify endemic districts of schistosomiasis and soil transmitted helminths (STH). This study was carried out in 30 of the 77 districts of Benin. Of these 30 districts 22 were previously tre...
Data
Gender base comparison of schistosomiasis and Hookworm infection in the district surveyed. N: Total number sampled; OR: odds ratio; 95%CI [OR]: 95% Confidence interval for odds ratio; p(fisher): p-value of Fischer exact test for odds ratio; S.h: Schistosoma haematobium; S.m: Schistosoma mansoni (PDF)
Data
Geographical position of the departments and all 150 schools survey during schistosomiasis and soil transmitted helminths mapping in 30 districts in Benin. UTM: Universal Transverse Mercator. (PDF)
Data
Other parasites identified during schistosomiasis and soil transmitted helminths mapping in 30 districts in Benin. N: number of positive samples out the total (250) examined in each commune; 95%CI: 95% confidence interval for prevalence. (PDF)
Article
This study performed in South-Eastern Benin aims to correlate the regional subterranean aquatic fauna, still poorly unknown, with the main physico-chemical characteristics of well-water used by human populations. Two kinds of descriptors are used. Physico-chemical analyses of water and faunistic sampling were consequently performed for one year at...
Article
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The groundwater genus Pseudoniphargus (Crustacea Amphipoda) which is diversified in northwestern Africa is reported for the first time from South of the Sahara, in western Africa. It is new to Benin and it is the first representative of groundwater amphipods in this country. The occurrence of the genus in Benin significantly extends its distributio...
Article
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This study concerns the first urinary schistosomiasis case observed in Corsica (France, Europe) occurring in a 12-year-old German boy. The aim was to identify the relationship between this Schistosoma haematobium infection and other schistosomes of the Schistosoma group with terminal-spined ova. Morphological and molecular analyses were conducted o...
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