Mostafa I Waly

Mostafa I Waly
Sultan Qaboos University | SQU · Department of Food Sciences and Nutrition

Professor
Biochemistry, Clinical Nutrition, and Medical Sciences.

About

330
Publications
237,656
Reads
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Introduction
My research expertise is in the field of Biochemistry, Human Nutrition, and Medical Sciences. The theme of my current research is to study the protective role of dietary bioactive agents and natural plants extracts against oxidative stress-mediated carcinogenesis using in vivo and in vitro experimental models. I’m also interested in identifying the metabolic role of B vitamins (Folate, B6, and B12) and hyperhomocysteinemia in the parthenogenesis of chronic diseases.
Education
June 1999 - September 2003
Northeastern University
Field of study
  • Health Sciences
January 1993 - January 1997
High Institute of Public Health
Field of study
  • Human Nutrition
June 1988 - June 1992
Faculty of Science
Field of study
  • Biochemistry

Publications

Publications (330)
Article
Objectives The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods The eel mucus was collected fleshly and topical gel with carbopol...
Article
Al-Ce alloys are currently receiving attention due to their high-temperature properties. Ultrasonic treatment (UST) is a liquid metal processing method, through which the structure of light alloys is modified. In the present study, Al-10 wt.% Ce alloy is prepared by melting and solidification under ultrasonic vibrations. UST temperatures (645-665 °C)...
Article
Full-text available
The COVID-19 pandemic has revealed the Eastern Mediterranean Region's food system's fragility posing severe challenges to maintaining healthy sustainable lifestyle. The aim of this cross-sectional study (N = 13,527 household's family members, mean age: 30.3 ±11.6, 80% women) is to examine the impact of the COVID-19 pandemic on food consumption patt...
Article
Full-text available
The COVID-19 pandemic has revealed the Eastern Mediterranean Region's food system's fragility posing severe challenges to maintaining healthy sustainable lifestyle. The aim of this cross-sectional study (N = 13,527 household's family members, mean age: 30.3 ±11.6, 80% women) is to examine the impact of the COVID-19 pandemic on food consumption patt...
Chapter
Full-text available
The significance of elevated blood homocysteine (Hcy) in clinical practice is a serious subject for researchers and is considered as a marker of certain diseases [1]. Hcy, is a sulfur containing, non-proteinogenic amino acid required for the growth of cells and tissues [2, 3]. It is produced exclusively from methionine (Met), an essential amino aci...
Article
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Although cancer is still one of the most significant global challenges facing public health, the world still lacks complementary approaches that would significantly enhance the efficacy of standard anticancer therapies. One of the essential strategies during cancer treatment is following a healthy diet program. The ketogenic diet (KD) has recently...
Article
Background:The use of plant for medicinal purposes has a long history worldwide. There is a lack of research that identifies the antidiabetic effect of edible Omani wild plants. Oxidative stress mediates the pathogenesis of diabetes and it has been suggested that natural antioxidants might be considered as an effective intervention for combating di...
Chapter
Full-text available
Cancer is second leading cause of death worldwide, accounting for an estimated 9.6 million deaths in year 2018, from which 70% death occurred in low- and middle-income countries. World Health Organization estimates that there will be 20 million new cases and 12 million deaths from cancer alone by the year 2020 [1]. Furthermore, the WHO reported tha...
Chapter
Full-text available
Homocysteine (HCY) is a non-protein-forming, sulfur amino acid whose metabolism is at the intersection of two metabolic pathways, remethylation and trans-sulfuration pathways. HCY is characterized by its chemical tendency to promote oxidative stress and cellular toxicity. Three major forms of homocysteine species exist in human blood circulation; a...
Chapter
Full-text available
Inflammation is a natural clinical repair response of body’s immune system to protect its tissues from various noxious stimuli that continues to remodel throughout the lifecycle because of interactions between genes, lifestyles, and environments. There is a link between inflammation, elevated plasma homocysteine levels and cardiometabolic diseases....
Chapter
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When it comes to food, there has been a noticeable increase in the consumption of snacks, fast food, sweets, meat, milk products and savory. This increase is met by a decrease in the consumption of fresh fruits and vegetables. This change is moving forward towards transforming the lifestyle, and several surveys showed that the increase in consumpti...
Chapter
Full-text available
Homocysteine (Hcy) is a sulfur-containing amino acid, which is produced during the metabolism of methionine. Impairment in one carbon metabolism (OCM) is believed to be responsible for elevated plasma homocysteine (Hcy) levels or hyperhomocysteinemia (HHcy), which is considered as an independent risk factor of coronary artery disease (CAD). There a...
Book
Elevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogen...
Article
The contamination of foods with aflatoxins, a group of carcinogenic compounds produced by some filamentous fungi belonging to Aspergillus section Flavi, is the major food safety concern worldwide. Various pre- and post-harvest techniques have been employed to minimize the level of aflatoxins in food commodities. The present study aimed to explore t...
Article
Full-text available
Background In the past infectious diseases affected the quality of lifestyle during home confinement. The study conducted examines the influence of home confinement during the COVID-19 pandemic outbreak on lifestyle, mental wellbeing, nutritional status, and sleeping pattern. Method An online multicategorical questionnaire was distributed to colle...
Article
Four types of fibers (i.e. defatted, F1; residue after alkaline digestion, F2; precipitated fibers at pH 5.5, F3; and pH 1.5, F4) were prepared from date-pits. The date-pits were first defatted and then digested by an alkaline solution. The fibers F2 showed the highest amount of cellulose (i.e. 46.0 g/100 g sample), while fibers F3 and F4 showed th...
Article
Purpose The objective of this study is to expand the understanding of the family influence on children's nutrition and physical activity patterns in Oman. Design and methods A cross-sectional research design was used in this study. We recruited 204 dyads (a mother with a child) conveniently. Research data were collected in public cycle one schools...
Article
Full-text available
Objectives: This study aimed to examine the relationship between body mass index (BMI) z-scores and lifestyle-related factors including nutrition, physical activity, screen time and time spent sleeping in 6-10-year-old Omani children. Methods: This cross-sectional study included mother-child dyads that were recruited from five provinces in Oman....
Article
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Background and objective: Leaves of basil plant (Ocimum basilicum) are often used for medicinal purposes because of their bioactive constituents, yet the antioxidant properties of this plant are not fully studied in the field of diabetes. The present study investigated the antioxidant property and anti-diabetic effect of two basil cultivars of Oci...
Preprint
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Background: In previous times, infectious diseases affected the quality of human life during home con nement. This study investigated the in uence of home con nement during the COVID-19 pandemic outbreak on lifestyle, mental wellbeing, nutritional status, and sleeping pattern.
Preprint
Full-text available
Background In previous times, infectious diseases affected the quality of human life during home confinement. This study investigated the influence of home confinement during the COVID-19 pandemic outbreak on lifestyle, mental wellbeing, nutritional status, and sleeping pattern. Method An online multicategory questionnaire was distributed to colle...
Preprint
Full-text available
Background: Nutritional knowledge is considered as an important factor in making healthy food choices, and to ensure an adequate nutrient intake in all age groups. Objective: To assess the nutritional knowledge, dietary habits, nutrient intake and nutritional status of Sultan Qaboos University students. Subjects and Methods: In a cross-sectional st...
Article
Full-text available
In a cross-sectional study, we determined the dietary patterns and nutritional status of Omani school students (12-15 years), and their association with student’s academic performance. A study questionnaire, including a semiquantitative food frequency questionnaire, was used to collect data. Results indicated that 36% of Omani school students regul...
Article
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Recently, nanoencapsulation was introduced as an efficient and promising approach for the protection, delivery, and site-specific liberation of the nutraceuticals and bioactive ingredients. Food proteins are attractive materials for developing nanocarriers to protect and deliver bioactives due to their unique functional and biological properties. F...
Article
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Purpose: Evidence from industrialized/developed countries showed that colorectal cancer (CRC) incidence rates have significantly dropped due to the widespread use of colonoscopy. In Arab countries, however, the CRC had been reported to have increased. Despite the concerted effort in the primary prevention and widespread use of colonoscopy, to our...
Article
Objective: Study the effect of Omani coffee on the glycemic responses and glycemic index (GI) of commonly consumed snack foods in Oman. Methods: We evaluated 9 Omani snack foods including doughnut, croissant, cheese, chicken and fried egg sandwiches, sambosa (vegetables), fried and boiled vermicelli, white bread with red beans for their proximate c...
Article
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Objective: To assess the role of various dietary and lifestyle modifications in the secondary prevention of biomarkers of plaque recurrence in Omani coronary revascularized patients. Methods: Seventy-two patients, from the outpatient cardiology clinic of Sultan Qaboos University Hospital, were included in the study after obtaining an informed conse...
Article
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As a major neurodevelopmental disorder, autism spectrum disorder (ASD) encompasses deficits in communication and repetitive and restricted interests or behaviors in childhood and adolescence. Its etiology may come from either a genetic, epigenetic, neurological, hormonal, or an environmental cause, generating pathways that often altogether play a s...
Article
Full-text available
Let food be the medicine and the medicine be the food" was quoted by Hippocrates more than 2000 years ago. In this context, traditional medicines of different countries have great potential for introducing new natural remedies for various human diseases. One of these remedies is date palm pollen, which is an edible component of the date palm tree,...
Article
Full-text available
Casein is an excellent carrier for curcumin, but it is susceptible to hydrolysis in gastrointestinal digestion. This study intended to design a tailored nano-carrier composed of camel casein/bovine whey protein to protect casein and curcumin during digestion. After loading curcumin to the casein, whey protein was added to solution followed by heati...
Article
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D4 dopamine receptor (D4R) activation uniquely promotes methylation of plasma membrane phospholipids, utilizing folate-derived methyl groups provided by methionine synthase (MS). We evaluated the impact of D4R expression on folate-dependent phospholipid methylation (PLM) and MS activity, as well as cellular redox and methylation status, in transfec...
Chapter
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Cooking of meat, fish, and poultry at high temperatures can result in the formation of heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), and other compounds. The formation of these compounds can vary depending on the type of meat, method of cooking, temperature, and duration of cooking as well as the level of doneness. These comp...
Chapter
Full-text available
Chronic diseases have become the largest contributor to worldwide morbidity and mortality. Healthy diet represents an effective primary intervention measure in combating the onset of chronic diseases, and epidemiological studies had documented that Mediterranean foods are associated with low incidence of chronic diseases. Mediterranean diet is a co...
Poster
Full-text available
Traditional and folk medicines of different countries have great potential for introducing new natural remedies for various human diseases. One of these remedies is date pollen, which is an edible component of the date palm tree, and has been used in Oman and other countries as a therapeutic agent for male infertility. There is a need to identify t...
Article
Full-text available
Background: Azoxymethane (AOM) is considered as an oxidizing insult and a potent carcinogenic agent that is commonly used to induce colon cancer in rats. Clinical studies continue to support the notion that different honey bee products (honey, pollen and propolis) combat cancer development, yet no recent studies conducted to examine the antioxidant...
Article
Full-text available
To talk about nutrition is to talk about life. However, arguably today, talking about nutrition seems to be no longer talking about the dietary origins of the human being, but of science which dedicates its study to food in order to improve human consumption, optimizing health-related processes, with the development, with the maintenance and/or obt...
Article
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Where to begin in trying to understand autism? Autism is so complex and so variable from child to child. The brain, too, is complex. Is it possible to comprehend the events that cause certain children to stray from the path of normal neurodevelopment? What is “neurodevelopment” anyway? There are so many autism theories: it’s the gut, it’s the immun...
Article
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In this study, the retention of vitamin C in fresh broccoli stored at different temperatures (i.e. chiller, room, cooking, and roasting or baking; 5-120°C) was investigated. The thermal stability of vitamin C in broccoli was analysed at 5, 20, 45, 60, 70, 80, 110, and 120°C. The vitamin C content was measured by the indophenol titration method. Vit...
Article
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This study aimed to understand the association between self-esteem (SE) and gender, age, body mass index (BMI) and rural-urban dichotomy among Omani teenagers. Multivariable regression analyses were conducted using generalized linear models to study the impact of gender, age, BMI, and place of residence on the SE score after adjusting for other var...
Article
Full-text available
Vitamin or mineral supplementation is considered to be the most commonly used medical treatment for autism spectrum disorder (ASD), in addition to other interventions such as neurological and psychological interventions. There is not much evidence of therapeutic efficacy between vitamin and mineral supplementation and improvements in ASD. However,...
Article
Full-text available
Background: Iron deficiency anemia is a public health problem in Oman. Although a national anemia control program was provided daily iron supplementation for pregnant women through antenatal care services, yet the prevalence of IDA is increasing. Objectives: This study is aiming to evaluate the daily intake of female Omani students at reproductive...
Article
Full-text available
Vitamin D is critical for bone and mineral metabolism. Many guidelines recommend that the target serum 25-hydroxyvitamin D [25(OH)D] concentrations should be ≥ 50 nmol/L (20ng/mL). However, the general consensus in the scientific community is that the serum concentrations below 25 to 30 nmol/L (10 to 12 ng/mL) must be prevented and treated. A signi...
Article
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Background: Dietary and lifestyle modifications play an important role in the primary prevention of CVD, however, little is known about their impact on secondary prevention. Objective: The present study aims to determine the impact of adhering to dietary and lifestyle modifications in reducing the LDL-cholesterol and its significance in secondary p...
Article
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Curcumin has a wide spectrum of biological, pharmaceutical, and antioxidant effects in cancer experimental models. Nitrosamine is commonly used as an experimental oxidizing agent which induces gastric oxidative stress and gastric carcinogenesis in rats. We examined the antioxidant potential effect of curcumin against nitrosamine-induced gastric oxi...
Article
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Background Colorectal cancer (CRC) represents a heterogeneous group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. CRC vary on the basis of both the biologic features of the disease and its associated lifestyle characteristics. The risk of CRC increases with several modifiable factors including obesity, p...
Article
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Purpose: Literature emerging from Western countries has reported increased levels of serum oxidative stress markers among polycystic ovarian syndrome (PCOS) women. In the Arab region, there is limited research about the association between oxidative stress and PCOS. This study aimed to compare sociodemographic and clinical characteristics, sex horm...
Article
Full-text available
Folate and vitamin B12 deficiency is associated with depletion of the major intracellular antioxidant glutathione, and oxidative stress is emerging as an etiological mechanism for colon cancer. Azoxymethane (AOM), a potent carcinogen, induces colon cancer in rats by causing pathophysiological changes and oxidative stress. We investigated the synerg...