Moslem Jafarisani

• Faculty Member at Shahroud University of Medical Sciences

Yogurt is a popular milk‐based product known for its nutritional benefits and effects on the large intestine. However, yogurt production faces challenges like texture, consistency, and syneresis. Hydrocolloids, such as gums and polysaccharides, can enhance yogurt's consistency and rheological properties. This research evaluates rooster comb extract...

Aim: Metal nanoclusters are emerging nanomaterials applicable for drug delivery. Here, the toxicity and oxidative stress induction of divalent cationic cadmium (Cd2+) was compared with a Cd in the form of nanocluster. Then, it was used for targeted drug delivery into breast cancer cell lines. Methods: Using a green chemistry route, a Cd nanocluster...

Objective: Rheumatoid arthritis (RA) is a common progressive autoimmune disorder that causes chronic inflammation of the joints and damage to other organs. Previous studies have reported the important role of miRNA-146a in the pathogenesis of RA. In addition, the anti-inflammatory and modulatory effects of oleuropein (OLEU) on the expression patte...

Methamphetamine (METH) abuse causes irreversible neural damages in the brain. It is well-known that Nesfatin-1, a neuropeptide involved in appetite and body weight, has a neuroprotective effect against oxidative stress and apoptotic response in dopaminergic cells. Therefore, the present study aimed to evaluate if Nesfatin-1 could antagonize the neu...

Solid supports like the extracellular matrix network are necessary for bone cell attachment and start healing in the damaged bone. Scaffolds which are made of different materials are widely used as a supportive structure in bone tissue engineering. In the current study, a 3-D Polycaprolactone/Gelatin bone scaffold was developed by blending electros...

Background: In recent years, the use of medicinal plants in developing countries has increased significantly. However, these plants can cause adverse effects on the mother and fetus. This study aimed to investigate the frequency of use, knowledge, and attitude towards the use of medicinal plants in pregnant women. Methods: This descriptive-analytic...

Introduction: Gentamicin-induced acute renal failure (ARF) has been commonly used as a suitable animal model to research acute kidney failure in an experimental study. The sulfur dioxide (SO2), a sulfur-containing gas that considered a common air pollutant, has antioxidant effects in mammals. In this study for reducing the functional and tissue dam...

A solid structure similar to an extracellular matrix network is needed for bone cells attachment and starting healing of bone damages. Different biomaterials and fabrication techniques are used for scaffold fabrication to prepare a supportive structure in bone tissue engineering. In the current study, a 3-D polycaprolactone (PCL)/gelatin scaffold w...

Fabrication method is one of the essential factors which directly affect on the properties of scaffold. Several techniques have been well established to fabricate nanofibrous scaffolds such as electrospinning. However, preparing a three-dimensional (3-D) interconnected macro-pore scaffold essential for transporting the cell metabolites and nutrient...

Introduction Cadmium (Cd) is the most dangerous heavy metal that is becoming more widespread in nature as a result of industrial activities. One of the toxic effects of Cd on the body is its neurological effect. The mechanism of these effects has been attributed to the induction of oxidative stress. Ferulla plant has antioxidant properties. In the...

Background Coronavirus pandemic has affected a large population worldwide. Currently, the standard care for individuals who are exposed is supportive care, symptomatic management, and isolation. The aim of our study was to evaluate effects of combined use of ethanol and DMSO as a nasal spray in preventing COVID-19. Methods We conducted a randomize...

Background and objective: Patients with panic disorder (PD) suffer from elevated oxidative stress as a consequence of serotonin metabolism disorder. These patients have elevated serotonin concentration and catabolism of serotonin via monoamine oxidase. The aim of the present study was to evaluate serum homocysteine concentration and its relationsh...

Renal ischemia–reperfusion (IR) is a common cause of acute renal failure and result in remote organ injury. Oxidative stress and inflammation are of the suggested causes of renal IR injury. The aim of the present study was to investigate the protective effects of vaspin as an adipokine on renal and liver injury after renal IR. 36 Male mice randomly...

The interaction between the angiotensin-converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of the spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a pivotal role in virus entry into the host cells. Since recombinant ACE2 protein has been suggested as an anti-SARS-CoV-2 therapeutic agent, this study...

The bidirectional association between the circadian system and innate-adaptive immune functions has been highlighted in many investigations. Viruses are a submicroscopic infectious agent that activate the immune system after entering the human host cell. A novel virus, so-called Coronavirus Disease 2019 (COVID-19), which has recently emerged, is an...

Human chronic myelogenous leukemia (CML) is a stem cell driven hematological malignancy which shows resistance to existing therapeutics. This property of CML accentuates the necessity to develop alternative anti-CML therapeutic agents. Herein, we have evaluated the anticancer activity of a novel anticancer peptide, Brevinin-2R and its two analogues...

Survivin is a unique member of the inhibitor of apoptosis protein family. Research has approved Survivin’s ability to interact with Smac/DIABLO, suggesting that Survivin may suppress activation of caspases indirectly. On the other hand, research has demonstrated that many drugs for cancer therapy are unsuccessful and disappointing in advanced stage...

Introduction For cartilage regeneration, stem cells are a promising cell source; however, even the advances made in the differentiation of stem cells into precursor‐differentiated cartilage cells have not been successful in reprograming these cells to achieve complete differentiation and fully functioning cells until now. Previous findings suggest...

Objective: Cardiovascular disorders are common in patients with panic disorder (PD), usually mediated by platelets. The present study was conducted to evaluate oxidative stress conditions and complete analysis of blood cells in patients with PD. Setting and sample population: Sixty healthy individuals and 60 patients were included in the study....

Drug-plasma protein interaction is a critical concern in monitoring drug circulation and drug-drug interactions. The present study aimed to investigate the interaction of psychedelic drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), 2,5-dimethoxy-4-iodoamphetamine (DOI), psilocybin, psilocin, and mescaline with human serum a...

Aim: DKK1 is reported to be produced at high levels by myeloma cells. Therefore, the applicability of DKK1 as a tumor marker for multiple myeloma (MM) diagnosis was examined. Methods: Serum samples were collected and analyzed by DKK1 concentration kit and capillary zone electrophoresis. Then, the obtained results were statically analyzed. Results:...

Therapeutic effects of saffron ingredients were studied in some diseases. The pharmacokinetics and pharmacodynamics of these ingredients were also studied, but their transport mechanism is not clearly known. Serum albumin has been known as the most important transporter of many drugs in the body that affects their disposition, transportation and bi...

Objective: Vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) play important roles in angiogenesis of different developmental mechanisms such as wound healing, embryogenesis and diseases, including different types of cancer. VEGFR2 is associated with cell proliferation, migration, and vascular permeability of endothelial cells....

Introduction:The use of siRNAforsilencinggene expressionis expandingtoday. Knock down ofvascular endothelial growth factor is one of theobjectives ofthistechnology. In this study we aimed to inhibit the expression of receptor type II of VEGF (VEGFR-2) using specific siRNA in the culture medium.Methods: First, according to the target gene sequences,...

Objective: Free radicals are generated during different reactions in cells and are potentially threats to macromolecules such as DNA and protein. Cells have established defense systems to remove these radicals. In some diseases, the systems are defective because of different damages and cells cannot remove the radicals. Plants have been used for a...

Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes. Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a...