Morten Hvidtfeldt

Morten Hvidtfeldt
Bispebjerg Hospital, Copenhagen University | bispebjerghospital · Department of Pulmonary Medicine

MD. PhD

About

46
Publications
1,680
Reads
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417
Citations
Education
August 2009 - June 2015
University of Copenhagen
Field of study
  • Medicine

Publications

Publications (46)
Article
Introduction: Severe eosinophilic asthma is characterised by frequent exacerbations and a relative insensitivity to steroids., Experimentally, smoking may induce eosinophilic airway inflammation, but the impact in patients with severe asthma is not clear. Objective: To investigate the association between smoking exposure in patients with severe...
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Full-text available
Background In vivo studies of airway pathology in obstructive lung disease are limited by poor quality of specimens obtained with forceps. Obtainment of cryobiopsies has increased diagnostic yield in cancer and interstitial lung disease but has not been used in patients with asthma. In a recent pilot study, we found mucosal cryobiopsies to be large...
Article
Introduction: Allergen exposure worsens viral-triggered asthma exacerbations and could predispose the host to secondary bacterial infections. We have previously demonstrated that exposure to house dust mite (HDM) reduced TLR3-induced IFN-β in human bronchial epithelial cells (HBECs) from healthy donors. We hypothesize that HDM sensitization in dif...
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Full-text available
Several factors significantly impact ability to produce a sputum sample after an anti-inflammatory intervention and these authors argue that the widely used complete-case analysis is inappropriate for paired sputum-based outcome measures https://bit.ly/3qN2pk5.
Article
Background Asthma is characterised by an aggravated immune response to respiratory viral infections: This phenomenon is a clinically well-recognised driver of acute exacerbations, but how different phenotypes of asthma respond immunologically to virus is unclear. Objectives To describe the association between different phenotypes and severity of a...
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Background Both anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cells (HBECs), targets for SARS-CoV-2 infectivity.Objective To investigate bronchial epithelial effects...
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Background Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the pathogenesis of asthma exacerbations. However, effects of MC mediators on bronchial epithelial immune resp...
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Rationale and objectives: Thymic stromal lymphopoietin (TSLP), an epithelial upstream cytokine, initiates production of type-2 (T2) cytokines with eosinophilia and possibly airway hyperresponsiveness (AHR) in asthma. This study aimed to determine whether tezepelumab (a human monoclonal antibody targeting TSLP) decreases AHR and airway inflammatio...
Article
Introduction: Cell differential count of induced sputum is considered the gold standard for inflammatory phenotyping of asthma but is not implemented in routine care due to its heavy time- and staff demands. Digital Cell Morphology is a technique where digital images of cells are captured and presented pre-classified as white blood cells (neutrophi...
Article
Background Type 2 low (T2-low) asthma is reported to respond less to anti-inflammatory treatment compared with Type 2 high (T2-high) asthma. Airway hyperresponsiveness (AHR) to mannitol, a marker of airway mast cell activation, may be indicative of response to treatment in patients with T2-low disease. We investigated whether AHR to mannitol improv...
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Full-text available
Background: The BREATHE study is a cross-sectional study of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities and combinations of obstructive airway disease. Design: Patients with suspicion of asthma and/or COPD and healthy controls were invited to participate in the study and had a...
Article
Background Investigating disease mechanisms and treatment responses in obstructive airway diseases with invasive sampling is hampered by the small size and mechanical artefacts that conventional forceps biopsies suffer from. Endoscopic cryobiopsies are larger and more intact and are being increasingly used. However, the technique has not yet been e...
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Full-text available
Aims Patients with atrial fibrillation (AF) are encountered and treated in different healthcare settings, which may affect the quality of care. We investigated the use of oral anticoagulant (OAC) therapy and the risk of thrombo-embolism (TE) and bleeding, according to the healthcare setting. Methods and results Using national Danish registers, we...
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Full-text available
Aim: To investigate the long-term risk of thromboembolism and serious bleeding associated with oral anticoagulation (OAC) therapy beyond 3 months after radiofrequency ablation (RFA) of atrial fibrillation (AF). Methods and results: Linking Danish administrative registries, 4050 patients undergoing first-time RFA (2000-11) were identified. Risk o...
Article
Several techniques assessing cardiac output (Q) during exercise are available. The extent to which the measurements obtained from each respective technique compares to one another, however, is unclear. We quantified Q simultaneously using four methods: the Fick method with blood obtained from the right atrium (QFick-M), Innocor (inert gas rebreathi...
Article
Frontal lobe oxygenation (Sc O2 ) is assessed by spatially resolved near-infrared spectroscopy (SR-NIRS) although it seems influenced by extra-cerebral oxygenation. We aimed to quantify the impact of extra-cerebral oxygenation on two SR-NIRS derived Sc O2 . Multiple regression analysis estimated the influence of extra-cerebral oxygenation as exempl...
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Full-text available
Dabigatran was recently approved for anticoagulation in patients with atrial fibrillation (AF); data regarding real-world use, comparative effectiveness and safety are sparse. Pharmacoepidemiological cohort study. METHODS/SETTINGS: From nationwide registers, we identified patients with an in-hospital or outpatient-clinic AF diagnosis who claimed a...
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Full-text available
Purpose: Using Danish nationwide cohort with follow-up over 10 years, we aimed to report the incidence and predictors of stroke after radiofrequency ablation (RFA) of atrial fibrillation, including post-ablation use of oral anticoagulation (OAC). Methods: Linking Danish administrative registries, 4061 AF patients undergoing first time RFA between J...
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Purpose: Safety among combinations of rate control medication in patients with atrial fibrillation is unexplored. We wanted to investigate the safety of different rate control drugs and combinations. Methods: Patients discharged from a Danish hospital with atrial fibrillation from January 1 1997 until December 31 2011 were identified using nationwi...
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Purpose: Patients with atrial fibrillation (AF) are encountered and treated in different health care settings, which may affect the quality of care. We investigated the use of antithrombotic treatment and the risk of thromboembolism and bleeding in AF patients according to health care setting. Methods: Using national Danish registers, we categorize...

Projects

Project (1)
Project
To investigate the effects of blocking TSLP on biomarkers including airway hyperresponsiveness and airway mucosal inflammation in patients with asthma To study the effects of blocking TSLP on airway epithelial gene expression To examine the effects of blocking TSLP on airway epithelial responses to viral triggers