Morenike Coker

• Doctor of Pharmacy
• Senior Lecturer at University of Ibadan

The microbiota of medicinal plants is known to be highly specific and can contribute to medicinal activity. However, the majority of plant species have not yet been studied. Here, we investigated the phyllosphere composition of two common Nigerian medicinal plants, Euphorbia lateriflora and Ficus thonningii, by a polyphasic approach combining analy...

Background: Dermatophytic infections have been considered to be a major public health problem. The emergence of recalcitrant dermatophytosis, coupled with resistance of dermatophytes to existing antifungal agents has necessitated the search for efficacious agents. Boerhavia diffusa is used as an ethnomedicinal plant. Objective: To investigate the...

Background: Gnetum africanum and Ficus vogelii are vegetables consumed in some parts of Africa. They are used in ethno medicine for treatment of different diseases, and are particularly known to hasten wound healing. The study aimed at investigating the wound healing properties of the plants in a rat model. Materials and Methods: The powdered leave...

Background: Gnetum africanum and Ficus vogelii are vegetables consumed in some parts of Africa. They are used in ethno medicine for treatment of different diseases, and are particularly known to hasten wound healing. The study aimed at investigating the wound healing properties of the plants in a rat model. 2 Materials and Methods: The powdered lea...

Background Medicinal plant microbiota is highly specific and can contribute to medicinal activity. However, the majority of plant species have not yet been studied. Here, we investigated the phyllosphere composition of two common Nigerian medicinal plants, Euphorbia lateriflora and Ficus thonningii, by a polyphasic approach combining analyses of me...

Background: Skin sepsis is a pyodermal infection caused by Lancefield's group streptococci and Staphylococcus aureus . It is characterized by discolored and mottled skin, cellulitis, impetigo and multi-systemic collagen muscularitis and can be transmitted from person to person. Objective: This study sampled the skin of consented abattoir workers...

Background: Wound infection is the third most common nosocomial infection worldwide, with resultant high mortality and morbidity rates in developing countries. Many pathogenic microrganisms implicated in wound infections have evolved antimicrobial resistance, necessitating a focused search for important therapeutic bioactive compounds from natural...

Background: The increase in the worldwide prevalence and resistance of organisms causing urinary tract infections (UTIs) to the conventional antibiotics used in treatment has led to sub-therapeutic outcome, hence, the need to discover novel antibiotics from natural products. Ficus mucuso Welw. and Ficus vogelii Miq. have been used in ethnomedicine...

Background: Diarrhoea is one of the major health threats to the populace in the tropics, and also one of the killer diseases in children under 5 years of age. Antimicrobial resistance and its spread pose serious public health threats, hence the need for development of safer and more effective antibacterial agents. Daniella oliveri Hutch and Dalz is...

Euphorbia lateriflora is used in ethnomedicine for treating several conditions, including genital and urinary tract infections (UTI). Although ethnobotanical claims support its use in therapy, there is limited evidence on its effect on UTI, even though UTI remains a public health problem in Nigeria especially due to increasing antimicrobial resista...

Transmission of human malaria parasites (Plasmodium spp.) by Anopheles mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after antimalarial drug treatment, permitting prolonged transmission to mosquitoes even after...

We investigated antimicrobial properties of Ficus thonningii leaf extract on a cutaneous wound, using different concentrations of F. thonningii extract in an ointment base. The plant was obtained with identification number FRIN 110160. Cold maceration method of extraction was used and the extract was screened for the presence of secondary metabolit...

Background: This study examined the in vitro antibacterial property of extracts of Moringa oleifera and the effect of different concentrations of the ethyl-acetate extract on cutaneous wound using an ointment delivery base. The aim of the study was to screen the extracts with best antibacterial property and evaluate effectiveness of different conce...

Wastewater from infected leprosy patients is expected to contain considerably higher concentrations of pathogens than standard domestic wastewater and, therefore, is more infectious. Isolation of lepers’ is thought to prevent the spread of a wide range of infectious diseases that could potentially be contacted through direct or indirect exposure fr...

Women's Health and Health Behaviors Survey. The survey instrument used in the study entitled, "Self-medication with antibiotics for the treatment of menstrual symptoms in southwest Nigeria: a cross-sectional study."

Background: Self-medication with antibiotics is an important factor contributing to the development of bacterial antibiotic resistance. The purpose of this study was to evaluate the prevalence of self-medication with antibiotics for the treatment of menstrual symptoms among university women in Southwest Nigeria. Methods: A cross-sectional survey...

The kinetics of bactericidal activity of the methanolic extracts of powdered seeds of Garcinia kola (Heckel), Kola acuminata and Kola nitida obtained by soxhlet extraction, were studied using two bacterial sensitive strains of Staphylococcus aureus and Pseudomonas aeruginosa. The study showed that the three extracts at the concentrations used again...

Studies on Staphylococcusaureus and Staphylococcusintermedius from dog and cat, and also on Staphylococcusaureus from wound and pyoderma infections, have shown a correlation between the site of microbial infection and antimicrobial susceptibility. Both the methanolic extract concentrate of Garcinia kola (Heckel) seeds and natural honey have been as...

Proliferation of different brands of antibiotics including ampiclox (a notable penicillinase inactivator) was considered a relevant factor in the antibiotic resistance of Staphylococcus aureus. Consequently the antibiogram and susceptibility of 20 clinical strains and a control strain (NCTC 6571) of Staphylococcus aureus to 10 different brands of a...

This study was designed to evaluate the anti-inflammatory potential, heamatological and histological changes induced in rats due to the administration of methanolic extracts of Ficus thonningii leaves. Fifteen wistar rats were divided into 3 groups of 5 rats per group to measure the anti-inflammatory activity using the inhibition of carageenan-indu...

Previous studies have shown that antimicrobial resistance is greatly influenced by human behavior. In developing countries where access to antimicrobials is largely unregulated misinformation and misperceptions exacerbate the improper and excessive use of antibiotics. In this study we present the preliminary results of a survey designed to evaluate...

Quantities and types of solid wastes generated at Ogbomosho leprosarium (Oyo State, Nigeria) have been investigated. Data collection, through waste sampling and analysis, interviews, questionnaire surveys and field observations, was conducted between August and November 2006. Results indicate a notably low mean waste generation rate of 241.5 g/h/d,...