Moreau Kévin

Moreau Kévin
University of Gothenburg | GU · Department of Chemistry & Molecular Biology

PhD in molecular biology and bioinformatics analysis

About

10
Publications
839
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17
Citations
Introduction
After a PhD in molecular and cellular biology with a major part of my work on NGS data analysis, obtained in 2019, I moved to Sweden in Anna Reymer's team. We are working on transcriptional control at two scales, 1/ atomic level thanks to computational chemistry tools and 2/ Whole genome level thanks to bioinformatic analysis tools. We aim to understand better the functions of DNA promoting regions at a dual level to unveil new insights in the transcription field in general.

Publications

Publications (10)
Article
Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcription factors (TFs) to DNA. Despite the importance, the mechanistic details on how torsional stress i...
Preprint
Full-text available
Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcription factors (TFs) to DNA. Despite the importance, the mechanistic details on how torsional stress i...
Article
Full-text available
Activator proteins 1 (AP-1) comprise one of the largest families of eukaryotic basic leucine zipper transcription factors. Despite advances in the characterization of AP-1 DNA-binding sites, our ability to predict new binding sites and explain how the proteins achieve different gene expression levels remains limited. Here we address the role of seq...
Article
Full-text available
In eukaryotic cells, aberrant mRNPs with processing and packaging defects are targeted co-transcriptionally by a surveillance system that triggers their nuclear retention and ultimately the degradation of their mRNA component by the 3’-5’ activity of the exosome-associated exoribonuclease Rrp6 along with its associated factors Rrp47 and Mpp6. This...
Chapter
In eukaryotic cells, aberrant mRNPs with processing and packaging defects are targeted co-transcriptionally by a surveillance system that triggers their nuclear retention and ultimately the degradation of their mRNA component by the 3′–5′ activity of the exosome-associated exonuclease Rrp6. This mRNP quality control process is stimulated by the NNS...
Preprint
Full-text available
Activator proteins 1 (AP-1) comprise one of the largest families of eukaryotic basic leucine zipper transcription factors. Despite advances in the characterization of AP-1 DNA-binding sites, our ability to predict new binding sites and explain how the proteins achieve different gene expression levels remains limited. Here we address the role of seq...
Article
Full-text available
In eukaryotic cells, aberrant mRNPs with processing and packaging defects are targeted co-transcriptionallyby a surveillance system that triggers their nuclear retention and ultimately the degradation of their mRNAcomponent by the 30–50activity of the exosome-associated exonuclease Rrp6. This mRNP quality controlprocess is stimulated by the NNS com...
Article
Full-text available
Eukaryotic cells have evolved a nuclear quality control (QC) system to monitor the co-transcriptional mRNA processing and packaging reactions that lead to the formation of export-competent ribonucleoprotein particles (mRNPs). Aberrant mRNPs that fail to pass the QC steps are retained in the nucleus and eliminated by the exonuclease activity of Rrp6...
Thesis
Full-text available
La transcription des ARN messagers (ARNm), chez les eucaryotes est un processus complexe nécessitant de nombreuses étapes. En parallèle de ce mécanisme fondamentale, de nombreuses protéines vont se fixer à l’ARNm naissant afin de le maturer et de l’empaqueter pour former une particule ribonucléoprotéique (mRNP) compétente pour l’export vers le cyto...
Article
Full-text available
The alarming issue of antibiotic resistance expansion requires a continuous search for new and efficient antibacterial agents. Here we describe the design of new tools to screen for target-specific inhibitors of the bacterial Rho factor directly inside eukaryotic cells. Rho factor is a global regulator of gene expression which is essential to most...

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