Montserrat Padilla-Orozco

Montserrat Padilla-Orozco
Universidad Nacional Autónoma de México | UNAM

About

4
Publications
496
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13
Citations
Citations since 2017
4 Research Items
13 Citations
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Publications

Publications (4)
Article
Full-text available
Parkinson’s disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels of acetylcholine, disrupting the balance among these modulatory transmitters. These modifications disturb the excitatory and inhibitory balance in the striatal circuitr...
Article
Full-text available
Multi-recording techniques show evidence that neurons coordinate their firing forming ensembles and that brain networks are made by connections between ensembles. While “canonical” microcircuits are composed of interconnected principal neurons and interneurons, it is not clear how they participate in recorded neuronal ensembles: “groups of neurons...
Article
Full-text available
Adenosine A 1 and A 2A receptors are expressed in striatal projection neurons (SPNs). A 1 receptors are located in direct (dSPN) and indirect SPNs (iSNP). A 2A receptors are only present in iSPNs. Dopamine D 2 receptors are also expressed in iSPNs and interactions between D 2 and A 2A receptors have received attention. iSPNs activity increases duri...
Article
Full-text available
The striatum is the largest entrance to the basal ganglia. Diverse neuron classes make up striatal microcircuit activity, consisting in the sequential activation of neuronal ensembles. How different neuron classes participate in generating ensembles sequences is unknown. In control mus musculus brain slices in vitro, providing excitatory drive gene...

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